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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hnf1a

Z-value: 5.58

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Transcription factors associated with hnf1a

Gene Symbol Gene ID Gene Info
ENSDARG00000009470 HNF1 homeobox a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf1adr11_v1_chr8_+_39802506_398025060.791.8e-21Click!

Activity profile of hnf1a motif

Sorted Z-values of hnf1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_23625351 217.40 ENSDART00000192588
ENSDART00000163423
complement factor H like 4
chr1_+_10051763 206.15 ENSDART00000011701
fibrinogen beta chain
chr5_+_32345187 176.04 ENSDART00000147132
complement component 9
chr5_+_28830643 153.92 ENSDART00000051448
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr5_+_45677781 151.59 ENSDART00000163120
ENSDART00000126537
group-specific component (vitamin D binding protein)
chr5_+_28830388 142.20 ENSDART00000149150
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr22_-_24757785 140.44 ENSDART00000078225
vitellogenin 5
chr9_-_9982696 138.09 ENSDART00000192548
ENSDART00000125852
UDP glucuronosyltransferase 1 family a, b
chr5_+_28848870 137.09 ENSDART00000149563
zgc:174259
chr5_+_28849155 133.52 ENSDART00000079090
zgc:174259
chr21_+_40092301 131.66 ENSDART00000145150
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a
chr13_+_23988442 129.06 ENSDART00000010918
angiotensinogen
chr22_-_23748284 127.02 ENSDART00000162005
complement factor H like 2
chr22_-_23668356 124.67 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
complement factor H
chr22_-_24738188 121.31 ENSDART00000050238
vitellogenin 1
chr20_-_40750953 118.16 ENSDART00000061256
connexin 28.9
chr22_-_24791505 116.44 ENSDART00000136837
vitellogenin 4
chr22_-_23706771 113.23 ENSDART00000159771
complement factor H like 1
chr2_-_5475910 113.11 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr20_+_10544100 109.79 ENSDART00000113927
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_+_21867307 108.30 ENSDART00000126629
cerebellin 17
chr22_-_24858042 105.66 ENSDART00000137998
ENSDART00000078216
ENSDART00000138378
vitellogenin 7
chr12_-_6172154 105.36 ENSDART00000185434
apobec1 complementation factor
chr12_-_6177894 104.54 ENSDART00000152292
apobec1 complementation factor
chr24_-_17039638 103.69 ENSDART00000048823
complement component 8, gamma polypeptide
chr13_-_40726865 101.74 ENSDART00000099847
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr5_+_28858345 101.09 ENSDART00000111180
si:ch211-186e20.2
chr22_+_12770877 94.32 ENSDART00000044683
formimidoyltransferase cyclodeaminase
chr23_+_25856541 91.81 ENSDART00000145426
ENSDART00000028236
hepatocyte nuclear factor 4, alpha
chr2_-_41942666 91.21 ENSDART00000075673
Epstein-Barr virus induced 3
chr17_+_4030493 90.60 ENSDART00000151849
hydroxyacid oxidase (glycolate oxidase) 1
chr11_-_23332592 85.50 ENSDART00000125024
golgi transport 1A
chr7_-_4296771 85.20 ENSDART00000128855
cerebellin 11
chr22_-_23781083 83.79 ENSDART00000166563
ENSDART00000170458
ENSDART00000166158
ENSDART00000171246
complement factor H like 3
chr1_-_12126535 82.87 ENSDART00000164817
ENSDART00000015251
microsomal triglyceride transfer protein
chr2_-_5466708 81.54 ENSDART00000136682
protein C (inactivator of coagulation factors Va and VIIIa), a
chr22_-_17595310 78.18 ENSDART00000099056
glutathione peroxidase 4a
chr1_-_59348118 77.19 ENSDART00000170901
cytochrome P450, family 3, subfamily A, polypeptide 65
chr21_-_45920 76.51 ENSDART00000040422
betaine-homocysteine methyltransferase
chr18_+_15644559 72.24 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr22_-_24818066 69.55 ENSDART00000143443
vitellogenin 6
chr16_-_17200120 68.28 ENSDART00000147739
glyceraldehyde-3-phosphate dehydrogenase
chr4_+_18804317 68.23 ENSDART00000101043
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr5_+_26795773 66.44 ENSDART00000145631
transcobalamin II
chr2_+_26647472 66.35 ENSDART00000145415
ENSDART00000157409
tocopherol (alpha) transfer protein
chr21_+_38002879 64.46 ENSDART00000065183
claudin 2
chr7_-_35066457 60.20 ENSDART00000058067
zgc:112160
chr22_-_17611742 60.13 ENSDART00000144031
glutathione peroxidase 4a
chr11_-_37997419 60.02 ENSDART00000102870
solute carrier family 41 (magnesium transporter), member 1
chr5_+_9382301 58.07 ENSDART00000124017
UDP glucuronosyltransferase 2 family, polypeptide A7
chr9_+_21151138 55.97 ENSDART00000133903
hydroxyacid oxidase 2 (long chain)
chr2_-_127945 54.06 ENSDART00000056453
insulin-like growth factor binding protein 1b
chr9_-_34269066 52.90 ENSDART00000059955
immunoglobulin-like domain containing receptor 1b
chr6_+_30456788 51.80 ENSDART00000121492

chr24_-_4765740 51.69 ENSDART00000121576
carboxypeptidase B1 (tissue)
chr15_+_9297340 50.08 ENSDART00000055554
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr12_-_20373058 48.38 ENSDART00000066382
aquaporin 8a, tandem duplicate 1
chr3_+_15505275 47.47 ENSDART00000141714
nuclear protein 1
chr5_+_9377005 47.26 ENSDART00000124924
UDP glucuronosyltransferase 2 family, polypeptide A7
chr7_-_29534001 47.07 ENSDART00000124028
annexin A2b
chr23_+_26491931 46.69 ENSDART00000190124
ENSDART00000132905
si:ch73-206d17.1
chr7_-_10560964 45.93 ENSDART00000172761
ENSDART00000170476
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr8_-_40555340 44.94 ENSDART00000163348
NPC1 like intracellular cholesterol transporter 1
chr7_-_61901695 44.50 ENSDART00000110328
SH3 domain and tetratricopeptide repeats 1
chr5_+_1877464 43.17 ENSDART00000050658
zgc:101699
chr3_-_16250527 42.37 ENSDART00000146699
ENSDART00000141181
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr5_+_57480014 42.13 ENSDART00000135520
si:ch211-202f5.3
chr9_-_9977827 41.08 ENSDART00000187315
ENSDART00000010246
UDP glucuronosyltransferase 1 family a, b
chr15_-_33964897 40.09 ENSDART00000172075
ENSDART00000158126
ENSDART00000160456
lipolysis stimulated lipoprotein receptor
chr13_+_2394264 40.01 ENSDART00000168595
ELOVL fatty acid elongase 5
chr25_+_23280220 39.56 ENSDART00000153940
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr2_-_43635777 39.36 ENSDART00000148633
integrin, beta 1b.1
chr25_+_31323978 38.93 ENSDART00000067030
lymphocyte-specific protein 1
chr24_-_23675446 38.32 ENSDART00000066644
hepatocyte nuclear factor 4, gamma
chr3_+_49521106 38.22 ENSDART00000162799
crumbs homolog 3a
chr15_-_33965440 37.92 ENSDART00000163841
lipolysis stimulated lipoprotein receptor
chr3_+_26734162 37.80 ENSDART00000114552
si:dkey-202l16.5
chr6_+_41039166 37.65 ENSDART00000125659
ectonucleoside triphosphate diphosphohydrolase 8
chr9_-_35633827 37.21 ENSDART00000077745
zona pellucida glycoprotein 2, like 1
chr8_-_2616326 37.19 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr5_+_9417409 36.46 ENSDART00000125421
ENSDART00000130265
UDP glucuronosyltransferase 2 family, polypeptide B5
chr16_+_11623956 36.42 ENSDART00000137788
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr3_+_31039923 36.40 ENSDART00000147706
cytochrome c oxidase subunit VIa polypeptide 2
chr6_-_59563597 35.68 ENSDART00000166311
inhibin beta E subunit
chr6_-_39344259 35.67 ENSDART00000104074
zgc:158846
chr9_+_29994439 34.44 ENSDART00000012447
transmembrane protein 30C
chr23_-_20345473 33.40 ENSDART00000140935
si:rp71-17i16.6
chr11_-_40647190 32.47 ENSDART00000173217
ENSDART00000173276
ENSDART00000147264
family with sequence similarity 213, member B
chr22_-_36770649 32.27 ENSDART00000169442
aminoacylase 1
chr13_-_42579437 32.20 ENSDART00000135172
family with sequence similarity 83, member Ha
chr14_-_11507211 32.20 ENSDART00000186873
ENSDART00000109181
ENSDART00000186166
ENSDART00000186986
zgc:174917
chr6_+_34028532 31.07 ENSDART00000155827
si:ch73-185c24.2
chr2_-_24402341 30.89 ENSDART00000155442
ENSDART00000088572
zgc:154006
chr5_-_30620625 30.69 ENSDART00000098273
transcobalamin like
chr12_+_2648043 29.99 ENSDART00000082220
growth differentiation factor 2
chr20_+_6543674 29.61 ENSDART00000134204
tensin 3, tandem duplicate 1
chr4_-_56954002 29.13 ENSDART00000160934
si:dkey-269o24.1
chr8_+_17869225 28.56 ENSDART00000080079
solute carrier family 44, member 5b
chr11_+_43419809 28.20 ENSDART00000172982
solute carrier family 29 (equilibrative nucleoside transporter), member 1b
chr20_-_7293837 26.12 ENSDART00000100060
desmocollin 2 like
chr6_+_8622228 24.23 ENSDART00000110470
thrombospondin-type laminin G domain and EAR repeats a
chr3_+_49097775 23.92 ENSDART00000169185
zgc:123284
chr5_+_9405283 23.87 ENSDART00000127306
UDP glucuronosyltransferase 2 family, polypeptide A7
chr17_+_30591287 22.25 ENSDART00000154243
si:dkey-190l8.2
chr20_-_25481306 21.97 ENSDART00000182495
si:dkey-183n20.15
chr25_-_37191929 21.94 ENSDART00000128108
urate (5-hydroxyiso-) hydrolase b
chr21_+_25236297 21.73 ENSDART00000112783
transmembrane protein 45B
chr16_-_9675982 20.39 ENSDART00000113724
mal, T cell differentiation protein 2 (gene/pseudogene)
chr2_+_17055069 20.01 ENSDART00000115078
thrombopoietin
chr4_-_12766418 19.66 ENSDART00000024312
deoxyribose-phosphate aldolase (putative)
chr13_-_23666579 19.30 ENSDART00000192457
ENSDART00000179777
mitogen-activated protein kinase kinase kinase 21
chr16_+_11603096 19.09 ENSDART00000146286
si:dkey-11o1.3
chr12_+_5209822 18.30 ENSDART00000152610
si:ch211-197g18.2
chr24_-_34680956 17.99 ENSDART00000171009
catenin (cadherin-associated protein), alpha 1
chr11_-_27962757 17.85 ENSDART00000147386
endothelin converting enzyme 1
chr16_-_42894628 17.72 ENSDART00000045600
hemochromatosis type 2
chr5_+_9428876 17.09 ENSDART00000081791
UDP glucuronosyltransferase 2 family, polypeptide A7
chr5_-_30715225 16.40 ENSDART00000016758
finTRIM family, member 82
chr25_+_4091067 16.30 ENSDART00000104926
EPS8 like 2
chr8_+_1187928 16.28 ENSDART00000127252
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr14_-_41556720 16.18 ENSDART00000149244
integrin, alpha 6, like
chr3_+_12718100 16.13 ENSDART00000162343
ENSDART00000192425
cytochrome P450, family 2, subfamily k, polypeptide 20
chr2_+_27855102 15.97 ENSDART00000150330
bucky ball
chr25_-_27541621 15.06 ENSDART00000130678
sperm adhesion molecule 1
chr23_-_31060350 14.59 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
chr23_-_29394505 14.55 ENSDART00000017728
phosphogluconate dehydrogenase
chr8_+_999421 13.25 ENSDART00000149528
fatty acid binding protein 1b, tandem duplicate 1
chr10_-_41664427 12.93 ENSDART00000150213
gamma-glutamyltransferase 1b
chr4_-_14470071 12.88 ENSDART00000143773
plexin b2a
chr25_+_29474583 12.77 ENSDART00000191189
interleukin 17 receptor E-like
chr16_+_4138331 12.69 ENSDART00000192403
ENSDART00000193036
metal-regulatory transcription factor 1
chr15_+_27364394 12.66 ENSDART00000122101
T-box 2b
chr7_+_2849020 12.66 ENSDART00000168695

chr22_-_36750589 12.50 ENSDART00000010824
aminoacylase 1
chr18_+_15683157 12.35 ENSDART00000140933
si:ch211-264e16.2
chr25_+_19238175 12.29 ENSDART00000110730
ENSDART00000193619
ENSDART00000154420
diphosphoinositol pentakisphosphate kinase 1b
chr8_-_13013123 12.28 ENSDART00000147802
DENN/MADD domain containing 2Da
chr1_-_9134045 12.09 ENSDART00000142132
partner and localizer of BRCA2
chr4_+_7827261 12.05 ENSDART00000129568
phytanoyl-CoA 2-hydroxylase
chr17_+_1496107 11.81 ENSDART00000187804

chr6_-_32087108 11.44 ENSDART00000150934
ENSDART00000130627
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
chr25_+_29474982 10.92 ENSDART00000130410
interleukin 17 receptor E-like
chr14_-_32884138 10.72 ENSDART00000105726
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr17_+_15388479 10.35 ENSDART00000052439
si:ch211-266g18.6
chr15_-_17869115 10.33 ENSDART00000112838
activating transcription factor 5b
chr12_+_31673588 10.32 ENSDART00000152971
dynamin binding protein
chr9_+_30720048 9.94 ENSDART00000146115
Kruppel-like factor 12b
chr15_-_23467750 9.72 ENSDART00000148804
PDZ domain containing 3a
chr9_+_29323163 9.69 ENSDART00000184908
oxoglutarate (alpha-ketoglutarate) receptor 1b
chr6_-_43283122 9.67 ENSDART00000186022
FERM domain containing 4Ba
chr15_-_17868870 9.67 ENSDART00000170950
activating transcription factor 5b
chr12_+_13091842 9.43 ENSDART00000185477
ENSDART00000181435
ENSDART00000124799
si:ch211-103b1.2
chr7_+_40205394 9.43 ENSDART00000173742
ENSDART00000148390
non-SMC condensin II complex, subunit G2
chr10_+_7255695 9.41 ENSDART00000161506
ENSDART00000181304
fucosyltransferase 10
chr18_+_13182528 9.35 ENSDART00000166298
zgc:56622
chr25_-_27541288 9.23 ENSDART00000187245
sperm adhesion molecule 1
chr25_+_34915762 8.94 ENSDART00000191776
syntrophin, beta 2
chr19_-_22387141 8.93 ENSDART00000151234
epiplakin 1
chr3_-_31715714 8.83 ENSDART00000051542
coiled-coil domain containing 47
chr15_+_29283981 8.63 ENSDART00000099895
RAP1 GTPase activating protein 2a
chr3_-_6191950 8.41 ENSDART00000161931
si:ch73-144l3.1
chr15_+_14109652 7.81 ENSDART00000156370
chloride channel accessory 1
chr14_+_8504410 7.69 ENSDART00000123364
vascular endothelial growth factor Ba
chr19_-_15229421 7.66 ENSDART00000055619
phosphatase and actin regulator 4a
chr6_-_37744430 7.10 ENSDART00000150177
ENSDART00000149722
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr3_-_41535647 7.02 ENSDART00000153723
ENSDART00000154198
si:ch211-222n22.1
chr17_-_34952562 6.90 ENSDART00000021128
kinase D-interacting substrate 220a
chr20_-_42534504 6.87 ENSDART00000132310
regulatory factor X, 6
chr25_-_7670616 6.41 ENSDART00000131583
ENSDART00000142794
Bet1 golgi vesicular membrane trafficking protein-like
chr21_+_21803363 6.30 ENSDART00000081184
sialidase 3 (membrane sialidase), tandem duplicate 3
chr23_+_33752275 6.19 ENSDART00000007260
si:ch211-210c8.6
chr3_-_53092509 5.57 ENSDART00000062081
lysophosphatidic acid receptor 2a
chr21_+_21803596 5.51 ENSDART00000084600
ENSDART00000184899
sialidase 3 (membrane sialidase), tandem duplicate 3
chr23_-_24394719 5.44 ENSDART00000044918
eph receptor A2 b
chr14_+_46118834 5.39 ENSDART00000124417
ENSDART00000017785
N(alpha)-acetyltransferase 15, NatA auxiliary subunit a
chr2_-_58183499 5.12 ENSDART00000172281
ENSDART00000186262
si:ch1073-185p12.2
chr24_+_5811808 5.00 ENSDART00000132428
si:ch211-157j23.3
chr11_-_12800945 4.90 ENSDART00000191178
taxilin gamma
chr12_+_6117682 4.87 ENSDART00000146650
N-acylsphingosine amidohydrolase 2
chr22_-_26005894 4.79 ENSDART00000105088
platelet-derived growth factor alpha polypeptide a
chr10_-_40503395 4.77 ENSDART00000134499
ENSDART00000193101
si:dkey-181m19.17
chr24_-_20016817 4.73 ENSDART00000082201
ENSDART00000189448
solute carrier family 22 member 13b
chr21_-_44104600 4.73 ENSDART00000044599
organic anion transporter X
chr24_-_32665283 4.72 ENSDART00000038364
carbonic anhydrase II
chr4_+_57881965 4.63 ENSDART00000162234
si:dkeyp-44b5.4
chr10_-_34915886 4.61 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr21_-_31286428 4.41 ENSDART00000185334
carbonic anhydrase IV c
chr11_-_12801157 4.13 ENSDART00000103449
taxilin gamma
chr16_-_29403711 3.97 ENSDART00000175571
toll-like receptor 18
chr1_+_218524 3.78 ENSDART00000109529
transmembrane and coiled-coil domains 3
chr6_+_20647155 3.65 ENSDART00000193477
solute carrier family 19 (folate transporter), member 1
chr18_+_33310811 3.48 ENSDART00000131587
vomeronasal 2 receptor, a16
chr2_+_49417900 3.45 ENSDART00000122742
ENSDART00000160783
RAR-related orphan receptor C b
chr13_+_48617974 3.44 ENSDART00000168596
si:ch1073-268j14.1
chr2_-_16216568 3.41 ENSDART00000173758
Rho guanine nucleotide exchange factor (GEF) 4
chr9_+_27339505 3.40 ENSDART00000011822
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr5_+_45322734 3.34 ENSDART00000084411
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr5_+_70271799 3.19 ENSDART00000101316
zinc finger protein 618
chr22_-_26100282 3.04 ENSDART00000166075
platelet-derived growth factor alpha polypeptide a
chr19_+_20274491 2.95 ENSDART00000090860
ENSDART00000151693
oxidoreductase NAD-binding domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
58.7 176.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
31.4 94.3 GO:0019557 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
30.4 91.2 GO:0033210 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
22.1 66.4 GO:0006824 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
19.3 134.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
15.0 209.9 GO:0016556 mRNA modification(GO:0016556)
14.5 566.3 GO:0032355 response to estradiol(GO:0032355)
13.7 206.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
12.1 1038.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
10.4 82.9 GO:0001579 medium-chain fatty acid transport(GO:0001579)
9.4 47.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
8.3 91.8 GO:0070365 hepatocyte differentiation(GO:0070365)
7.9 206.7 GO:0051180 vitamin transport(GO:0051180)
6.6 45.9 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
5.5 60.0 GO:0010960 magnesium ion homeostasis(GO:0010960)
5.2 26.1 GO:0002159 desmosome assembly(GO:0002159)
5.1 76.5 GO:0009086 methionine biosynthetic process(GO:0009086)
4.9 54.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
4.7 28.2 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
4.5 72.2 GO:0050728 negative regulation of inflammatory response(GO:0050728)
4.1 20.4 GO:0045056 transcytosis(GO:0045056)
3.4 10.3 GO:0072068 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
3.2 194.6 GO:0007596 blood coagulation(GO:0007596)
3.2 12.7 GO:0071276 cellular response to cadmium ion(GO:0071276)
3.0 68.2 GO:0015701 bicarbonate transport(GO:0015701)
2.9 52.9 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
2.8 36.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
2.7 16.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
2.7 10.7 GO:0051503 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
2.7 16.0 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
2.3 6.9 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
2.2 37.7 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
2.0 44.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
2.0 19.7 GO:0009264 deoxyribonucleotide catabolic process(GO:0009264) deoxyribose phosphate catabolic process(GO:0046386)
1.9 95.3 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
1.9 68.3 GO:0050821 protein stabilization(GO:0050821)
1.8 38.2 GO:1902017 regulation of cilium assembly(GO:1902017)
1.8 43.2 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
1.7 39.6 GO:0048844 artery morphogenesis(GO:0048844)
1.6 7.8 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
1.4 149.7 GO:0009410 response to xenobiotic stimulus(GO:0009410)
1.3 8.9 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.2 14.5 GO:0006098 pentose-phosphate shunt(GO:0006098)
1.2 17.9 GO:0016486 peptide hormone processing(GO:0016486)
1.1 11.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
1.1 7.7 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.1 129.9 GO:0006979 response to oxidative stress(GO:0006979)
1.0 11.8 GO:0009313 oligosaccharide catabolic process(GO:0009313)
1.0 20.0 GO:0002574 thrombocyte differentiation(GO:0002574)
0.9 12.3 GO:0006020 inositol metabolic process(GO:0006020)
0.9 21.9 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.9 19.3 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.8 2.5 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.8 5.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.8 7.7 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.7 3.7 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.7 9.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.7 69.2 GO:0007492 endoderm development(GO:0007492)
0.7 30.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.6 9.4 GO:0036065 fucosylation(GO:0036065)
0.5 18.2 GO:0045103 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
0.5 7.1 GO:0015693 magnesium ion transport(GO:0015693)
0.4 10.3 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.4 9.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.4 36.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 3.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 9.4 GO:0030261 chromosome condensation(GO:0030261)
0.2 1.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 0.6 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.2 14.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.2 57.9 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.2 0.7 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.2 2.5 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.1 6.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 4.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 11.3 GO:0001894 tissue homeostasis(GO:0001894)
0.1 6.1 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.3 GO:0097095 frontonasal suture morphogenesis(GO:0097095)
0.1 12.1 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.1 26.7 GO:0006520 cellular amino acid metabolic process(GO:0006520)
0.1 4.3 GO:0048545 response to steroid hormone(GO:0048545)
0.1 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.6 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 10.3 GO:0072001 kidney development(GO:0001822) renal system development(GO:0072001)
0.0 2.5 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.0 14.7 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway(GO:0007169)
0.0 28.1 GO:0016192 vesicle-mediated transport(GO:0016192)
0.0 2.0 GO:0034101 erythrocyte differentiation(GO:0030218) erythrocyte homeostasis(GO:0034101)
0.0 3.3 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
68.7 206.2 GO:0005577 fibrinogen complex(GO:0005577)
58.7 176.0 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
7.0 76.8 GO:0045095 keratin filament(GO:0045095)
2.6 36.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
2.3 44.1 GO:0030057 desmosome(GO:0030057)
2.0 6.1 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
2.0 16.0 GO:0032019 mitochondrial cloud(GO:0032019)
1.5 12.4 GO:0030428 cell septum(GO:0030428)
1.2 55.7 GO:0032587 ruffle membrane(GO:0032587)
1.2 9.4 GO:0000796 condensin complex(GO:0000796)
1.1 1489.9 GO:0005615 extracellular space(GO:0005615)
1.1 5.4 GO:0031415 NatA complex(GO:0031415)
1.0 9.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.9 6.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.8 105.0 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.8 86.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.8 47.1 GO:0005604 basement membrane(GO:0005604)
0.6 62.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 109.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.5 67.0 GO:0005770 late endosome(GO:0005770)
0.5 9.6 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 8.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.4 25.3 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 42.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 264.5 GO:0005794 Golgi apparatus(GO:0005794)
0.3 40.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 13.1 GO:0016324 apical plasma membrane(GO:0016324)
0.2 104.5 GO:0005576 extracellular region(GO:0005576)
0.2 128.1 GO:0005739 mitochondrion(GO:0005739)
0.1 10.3 GO:0070382 exocytic vesicle(GO:0070382)
0.1 708.8 GO:0016021 integral component of membrane(GO:0016021)
0.1 7.7 GO:0030027 lamellipodium(GO:0030027)
0.1 89.1 GO:0005829 cytosol(GO:0005829)
0.1 1.3 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.3 GO:0005921 gap junction(GO:0005921)
0.0 50.9 GO:0044428 nuclear part(GO:0044428)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
79.1 553.4 GO:0045735 nutrient reservoir activity(GO:0045735)
50.5 151.6 GO:0005499 vitamin D binding(GO:0005499)
33.9 101.7 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
27.7 138.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
23.6 94.3 GO:0016841 ammonia-lyase activity(GO:0016841)
20.7 82.9 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
17.1 68.3 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
14.4 72.2 GO:0032052 bile acid binding(GO:0032052)
9.1 36.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
9.0 1038.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
8.5 76.5 GO:0008172 S-methyltransferase activity(GO:0008172)
8.3 66.4 GO:0031419 cobalamin binding(GO:0031419)
7.9 39.4 GO:0098639 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
6.9 41.1 GO:0019215 intermediate filament binding(GO:0019215)
6.7 146.6 GO:0010181 FMN binding(GO:0010181)
6.2 361.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
5.4 48.4 GO:0015250 water channel activity(GO:0015250)
4.9 54.1 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
4.1 16.3 GO:0005463 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
4.1 44.8 GO:0004046 aminoacylase activity(GO:0004046)
3.9 43.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
3.6 47.1 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
3.2 9.7 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
3.1 12.3 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
3.0 209.9 GO:0003727 single-stranded RNA binding(GO:0003727)
2.9 55.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
2.7 10.7 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
2.5 91.2 GO:0017046 peptide hormone binding(GO:0017046)
2.4 42.4 GO:0033691 sialic acid binding(GO:0033691)
2.2 37.7 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
2.1 19.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
2.0 51.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
2.0 23.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
1.9 40.0 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.9 9.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
1.5 12.4 GO:0004100 chitin synthase activity(GO:0004100)
1.4 12.9 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
1.4 20.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.2 19.7 GO:0016832 aldehyde-lyase activity(GO:0016832)
1.2 3.6 GO:0008518 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
1.2 93.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
1.2 21.9 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
1.1 254.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
1.1 11.8 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.0 65.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.9 66.3 GO:0019842 vitamin binding(GO:0019842)
0.9 13.2 GO:0005504 fatty acid binding(GO:0005504)
0.9 120.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.9 7.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.8 35.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.8 4.9 GO:0017040 ceramidase activity(GO:0017040)
0.8 9.4 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.7 9.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.7 19.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 7.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.7 45.9 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.6 11.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.6 2.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.6 3.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.5 42.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 5.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 7.7 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.4 10.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 7.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.3 18.0 GO:0008013 beta-catenin binding(GO:0008013)
0.3 9.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 14.5 GO:0050661 NADP binding(GO:0050661)
0.3 5.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.3 2.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.3 3.7 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 6.9 GO:0030165 PDZ domain binding(GO:0030165)
0.2 30.0 GO:0008083 growth factor activity(GO:0008083)
0.2 3.8 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.1 20.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 20.0 GO:0005179 hormone activity(GO:0005179)
0.1 19.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 9.0 GO:0019905 syntaxin binding(GO:0019905)
0.1 6.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 60.0 GO:0005198 structural molecule activity(GO:0005198)
0.1 6.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 72.5 GO:0005102 receptor binding(GO:0005102)
0.1 4.4 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.1 4.8 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 2.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.3 GO:0042803 protein homodimerization activity(GO:0042803)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 206.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
4.6 91.2 PID IL27 PATHWAY IL27-mediated signaling events
4.3 129.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
3.4 72.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
3.1 109.8 PID HNF3A PATHWAY FOXA1 transcription factor network
2.8 38.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
2.6 91.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
2.1 309.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.4 30.0 PID ALK1 PATHWAY ALK1 signaling events
0.9 58.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.9 18.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.6 6.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 9.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 11.3 PID BMP PATHWAY BMP receptor signaling
0.3 55.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.2 12.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 8.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
31.2 124.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
18.7 206.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
12.2 279.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
8.3 82.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
7.2 64.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
7.1 35.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
6.8 130.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
5.3 149.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
5.0 40.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
3.4 68.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
3.2 76.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
2.5 55.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
2.1 10.7 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
1.7 129.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
1.7 109.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
1.1 156.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
1.0 183.2 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.7 18.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.7 16.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.6 20.0 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.6 12.1 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.6 3.4 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.5 17.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.4 6.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 4.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.3 11.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 4.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 14.5 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 3.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK