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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for hmx4

Z-value: 1.36

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Transcription factors associated with hmx4

Gene Symbol Gene ID Gene Info
ENSDARG00000007941 H6 family homeobox 4
ENSDARG00000115000 H6 family homeobox 4
ENSDARG00000116208 H6 family homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx4dr11_v1_chr1_-_40911332_409113320.141.9e-01Click!

Activity profile of hmx4 motif

Sorted Z-values of hmx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_14234076 13.06 ENSDART00000040049
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr13_+_22659153 11.57 ENSDART00000143906
ENSDART00000140472
ENSDART00000078877
ENSDART00000182469
synuclein, gamma a
chr1_-_14233815 11.34 ENSDART00000044896
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr20_-_29418620 10.81 ENSDART00000172634
ryanodine receptor 3
chr2_-_21352101 10.71 ENSDART00000057021
hedgehog acyltransferase like, a
chr20_-_29420713 10.27 ENSDART00000147464
ryanodine receptor 3
chr19_+_233143 10.04 ENSDART00000175273
synaptic Ras GTPase activating protein 1a
chr18_+_5549672 9.28 ENSDART00000184970
nicotinamide nucleotide transhydrogenase 2
chr2_-_49978227 7.77 ENSDART00000142835
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1b
chr1_-_25911292 7.74 ENSDART00000145012
ubiquitin specific peptidase 53b
chr12_-_10220036 7.52 ENSDART00000134619
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr13_-_7031033 7.50 ENSDART00000193211

chr1_+_8662530 7.43 ENSDART00000054989
fascin actin-bundling protein 1b
chr18_+_39067575 7.31 ENSDART00000077724
guanine nucleotide binding protein (G protein), beta 5b
chr17_+_27434626 6.92 ENSDART00000052446
vestigial-like family member 2b
chr12_+_6391243 6.57 ENSDART00000152765
protein kinase, cGMP-dependent, type Ib
chr17_-_16133249 6.56 ENSDART00000030919
prepronociceptin a
chr19_+_12762887 6.45 ENSDART00000139909
melanocortin 5a receptor
chr15_+_19544052 6.40 ENSDART00000062560
zgc:77784
chr16_-_26074529 6.38 ENSDART00000148653
ENSDART00000148923
transmembrane protein 145
chr15_-_27710513 6.24 ENSDART00000005641
ENSDART00000134373
LIM homeobox 1a
chr7_-_18168493 6.08 ENSDART00000127428
pellino E3 ubiquitin protein ligase family member 3
chr12_-_26415499 5.73 ENSDART00000185779
synaptopodin 2-like b
chr3_-_28750495 5.70 ENSDART00000054408
gsg1-like
chr20_-_32112818 5.59 ENSDART00000142653
glutamate receptor, metabotropic 1a
chr9_-_6927587 5.43 ENSDART00000059092
transmembrane protein 182a
chr1_+_59154521 5.35 ENSDART00000130089
ENSDART00000152456
heme-binding protein soul5, like
chr10_-_43655449 5.28 ENSDART00000099134
myocyte enhancer factor 2ca
chr17_+_1323699 5.25 ENSDART00000172540
adenylosuccinate synthase like 1
chr7_+_22543963 5.24 ENSDART00000101528
cholinergic receptor, nicotinic, beta 1 (muscle)
chr13_-_36545258 5.23 ENSDART00000186171

chr18_-_14941840 5.05 ENSDART00000091729
megalencephalic leukoencephalopathy with subcortical cysts 1
chr16_+_5774977 5.04 ENSDART00000134202
cholecystokinin a
chr25_-_225964 5.01 ENSDART00000193424

chr6_+_59967994 5.01 ENSDART00000050457
zgc:65895
chr13_+_3667230 5.00 ENSDART00000131553
ENSDART00000189841
ENSDART00000183554
ENSDART00000018737
QKI, KH domain containing, RNA binding b
chr1_+_38776294 4.97 ENSDART00000170546
WD repeat domain 17
chr8_+_7144066 4.96 ENSDART00000146306
solute carrier family 6 (neurotransmitter transporter), member 6a
chr4_-_4119396 4.95 ENSDART00000067409
ENSDART00000138221
leiomodin 2 (cardiac) b
chr2_-_36925561 4.92 ENSDART00000187690
microtubule-associated protein 1Sb
chr23_+_44307996 4.87 ENSDART00000042430
discs, large homolog 4b (Drosophila)
chr22_-_26945493 4.86 ENSDART00000077411
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
chr13_-_40120252 4.81 ENSDART00000157852
cartilage acidic protein 1b
chr22_-_12160283 4.81 ENSDART00000146785
ENSDART00000128176
transmembrane protein 163b
chr4_-_9592402 4.78 ENSDART00000114060
cerebral dopamine neurotrophic factor
chr8_-_32497815 4.76 ENSDART00000122359
si:dkey-164f24.2
chr2_-_1279387 4.74 ENSDART00000192210

chr20_-_35052823 4.72 ENSDART00000153033
kinesin family member 26Bb
chr14_+_8275115 4.70 ENSDART00000129055
neuregulin 2b
chr23_+_19564392 4.68 ENSDART00000144746
ATPase H+ transporting accessory protein 1 like b
chr3_+_54012708 4.64 ENSDART00000154542
olfactomedin 2a
chr14_-_34044369 4.64 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cytoplasmic FMR1 interacting protein 2
chr21_+_9628854 4.62 ENSDART00000161753
ENSDART00000160711
mitogen-activated protein kinase 10
chr3_+_16265924 4.60 ENSDART00000122519
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
chr13_-_2520843 4.56 ENSDART00000187313
ENSDART00000170333
COX20 cytochrome c oxidase assembly factor
chr23_+_32039386 4.54 ENSDART00000133801
myosin light chain kinase 2
chr7_-_10606 4.52 ENSDART00000192650
ENSDART00000186761

chr5_-_64431927 4.40 ENSDART00000158248
bromodomain containing 3b
chr7_+_19552381 4.33 ENSDART00000169060
si:ch211-212k18.5
chr12_-_33357655 4.32 ENSDART00000066233
ENSDART00000148165
solute carrier family 16 (monocarboxylate transporter), member 3
chr8_-_32497581 4.27 ENSDART00000176298
ENSDART00000183340
si:dkey-164f24.2
chr6_-_8277221 4.25 ENSDART00000053869
solute carrier family 44 (choline transporter), member 2
chr21_+_34167178 4.22 ENSDART00000158308
transient receptor potential cation channel, subfamily C, member 5b
chr12_+_6214041 4.19 ENSDART00000179759
protein kinase, cGMP-dependent, type Ib
chr8_+_1651821 4.16 ENSDART00000060865
ENSDART00000186304
RAS protein activator like 1b (GAP1 like)
chr19_+_30633453 4.12 ENSDART00000052124
family with sequence similarity 49, member A-like
chr17_-_15657029 4.00 ENSDART00000153925
fucosyltransferase 9a
chr3_+_37827373 3.96 ENSDART00000039517
acid-sensing (proton-gated) ion channel 2
chr6_-_40744720 3.89 ENSDART00000154916
ENSDART00000186922
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr19_-_13774502 3.89 ENSDART00000159711
erythrocyte membrane protein band 4.1a
chr19_+_46113828 3.86 ENSDART00000159331
ENSDART00000161826
RNA binding motif protein 24a
chr18_-_46763170 3.86 ENSDART00000171880
delta/notch-like EGF repeat containing
chr10_+_7671260 3.80 ENSDART00000157608
family with sequence similarity 136, member A
chr9_+_34380299 3.80 ENSDART00000131705
lysosomal-associated membrane protein 1
chr6_+_39836474 3.77 ENSDART00000112637
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr3_-_30061985 3.75 ENSDART00000189583
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr4_+_3287819 3.74 ENSDART00000168633

chr13_-_3370638 3.74 ENSDART00000029649
parkin RBR E3 ubiquitin protein ligase
chr21_-_23475361 3.73 ENSDART00000156658
ENSDART00000157454
neural cell adhesion molecule 1a
chr16_+_32559821 3.73 ENSDART00000093250
POU class 3 homeobox 2b
chr3_-_22191132 3.71 ENSDART00000154226
ENSDART00000155528
ENSDART00000155190
microtubule-associated protein tau b
chr13_-_992458 3.69 ENSDART00000114655
beaded filament structural protein 1
chr3_+_37824268 3.63 ENSDART00000137038
acid-sensing (proton-gated) ion channel 2
chr12_-_17810543 3.63 ENSDART00000090484
tectonin beta-propeller repeat containing 1a
chr25_-_6082509 3.62 ENSDART00000104755
cytoplasmic polyadenylation element binding protein 1a
chr5_-_46273938 3.60 ENSDART00000080033
si:ch211-130m23.3
chr10_-_26793448 3.58 ENSDART00000141955
MCF.2 cell line derived transforming sequence b
chr5_-_30176970 3.56 ENSDART00000098300
ADAM metallopeptidase with thrombospondin type 1 motif, 8a
chr5_-_33460959 3.56 ENSDART00000085636
si:ch211-182d3.1
chr22_-_14367966 3.50 ENSDART00000188796
low density lipoprotein receptor-related protein 1Ba
chr1_-_25438934 3.48 ENSDART00000111686
FH2 domain containing 1
chr9_+_46644633 3.44 ENSDART00000160285
solute carrier family 4 (anion exchanger), member 3
chr3_-_28209001 3.44 ENSDART00000151178
RNA binding fox-1 homolog 1
chr17_-_53308832 3.40 ENSDART00000171946
ENSDART00000168269
si:ch1073-416d2.4
chr4_+_10017049 3.37 ENSDART00000144175
coiled-coil domain containing 136b
chr16_+_46148990 3.35 ENSDART00000083919
synaptic vesicle glycoprotein 2A
chr2_-_11662851 3.33 ENSDART00000145108
zgc:110130
chr8_-_43997538 3.25 ENSDART00000186449
RIMS binding protein 2
chr3_-_60571218 3.23 ENSDART00000178981
si:ch73-366l1.5
chr17_+_23937262 3.23 ENSDART00000113276
si:ch211-189k9.2
chr23_-_35347714 3.20 ENSDART00000161770
ENSDART00000165615
copine family member IX
chr18_+_50275933 3.20 ENSDART00000143911
si:dkey-105e17.1
chr25_+_17689565 3.19 ENSDART00000171965
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18a
chr12_+_21299338 3.17 ENSDART00000074540
ENSDART00000133188
carbonic anhydrase Xa
chr2_-_11512819 3.17 ENSDART00000142013
proenkephalin a
chr7_-_69983948 3.17 ENSDART00000185827
potassium voltage-gated channel interacting protein 4
chr17_-_5769196 3.16 ENSDART00000113885
si:dkey-100n19.2
chr14_+_33722950 3.14 ENSDART00000075312
apelin
chr5_-_35953472 3.12 ENSDART00000143448
relaxin/insulin-like family peptide receptor 2, like
chr18_+_50276653 3.07 ENSDART00000192120
si:dkey-105e17.1
chr15_-_47193564 3.03 ENSDART00000172453
limbic system-associated membrane protein
chr1_-_10841348 3.00 ENSDART00000148305
dystrophin
chr9_-_44642108 2.98 ENSDART00000086202
phosphodiesterase 1A, calmodulin-dependent
chr9_-_362971 2.95 ENSDART00000168944
si:dkey-11f4.7
chr11_+_30162407 2.90 ENSDART00000190333
ENSDART00000127502
cyclin-dependent kinase-like 5
chr7_+_33279108 2.85 ENSDART00000084530
coronin, actin binding protein, 2Ba
chr16_-_27138478 2.84 ENSDART00000147438
transmembrane protein 245
chr14_-_2221877 2.83 ENSDART00000106704
protocadherin 2 alpha b 1
chr22_+_396840 2.82 ENSDART00000163198
capping protein (actin filament) muscle Z-line, beta
chr23_+_13721826 2.82 ENSDART00000142494
zinc finger and BTB domain containing 46
chr13_+_51869025 2.81 ENSDART00000187066

chr2_+_20331445 2.77 ENSDART00000186880
phospholipid phosphatase related 4a
chr17_+_5768608 2.75 ENSDART00000157039
retinitis pigmentosa 1-like 1a
chr9_-_23217196 2.74 ENSDART00000083567
kinesin family member 5C
chr8_+_23916647 2.69 ENSDART00000143152
copine Va
chr9_+_38888025 2.69 ENSDART00000148306
microtubule-associated protein 2
chr9_+_31222026 2.67 ENSDART00000145573
citrate lyase beta like
chr17_-_3291369 2.67 ENSDART00000181840

chr1_-_25438737 2.65 ENSDART00000134470
FH2 domain containing 1
chr1_+_176583 2.65 ENSDART00000168760
ENSDART00000160425
lysosomal associated membrane protein 1
chr18_+_50276337 2.64 ENSDART00000140352
si:dkey-105e17.1
chr21_+_31838386 2.64 ENSDART00000135591
si:ch211-12m10.1
chr20_+_36820965 2.64 ENSDART00000153085
ENSDART00000062935
hdc homolog, cell cycle regulator
chr15_-_34326461 2.62 ENSDART00000156682
diacylglycerol kinase, beta
chr4_+_5741733 2.59 ENSDART00000110243
POU class 3 homeobox 2a
chr9_-_29427576 2.58 ENSDART00000065929
heparan sulfate 6-O-sulfotransferase 3b
chr11_+_30161699 2.58 ENSDART00000190504
cyclin-dependent kinase-like 5
chr18_-_6460102 2.56 ENSDART00000137037
IQ motif and Sec7 domain 3b
chr3_+_62356578 2.54 ENSDART00000157030
IQ motif containing K
chr20_-_35052464 2.49 ENSDART00000037195
kinesin family member 26Bb
chr2_+_16487443 2.39 ENSDART00000114980

chr2_+_15776649 2.37 ENSDART00000156535
vav 3 guanine nucleotide exchange factor b
chr25_+_35774544 2.36 ENSDART00000034737
ENSDART00000188162
copine VIII
chr9_-_41784799 2.36 ENSDART00000144573
ENSDART00000112542
ENSDART00000190486
obscurin-like 1b
chr22_+_39074688 2.34 ENSDART00000153547
inositol hexakisphosphate kinase 1
chr15_+_20548212 2.34 ENSDART00000193519
ENSDART00000169941
ENSDART00000187940
ENSDART00000183871
small G protein signaling modulator 2
chr7_+_19882066 2.33 ENSDART00000111144
transmembrane protein 151A
chr7_-_33960170 2.31 ENSDART00000180766
SKI family transcriptional corepressor 1a
chr7_-_35379899 2.26 ENSDART00000183484
solute carrier family 6 (neurotransmitter transporter), member 2
chr3_+_52545400 2.24 ENSDART00000184183
solute carrier family 27 (fatty acid transporter), member 1a
chr22_-_10826 2.22 ENSDART00000125700
mitochondrial ribosomal protein L20
chr14_-_36397768 2.20 ENSDART00000185199
ENSDART00000052562
spermatogenesis associated 4
chr9_-_21231297 2.20 ENSDART00000162578
phospholipase A1 member A
chr17_-_38887424 2.20 ENSDART00000141177
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4a
chr3_-_18373425 2.18 ENSDART00000178522
sperm associated antigen 9a
chr20_-_43723860 2.18 ENSDART00000122051
Mix paired-like homeobox
chr14_+_33723309 2.15 ENSDART00000132488
apelin
chr6_+_58406014 2.14 ENSDART00000044241
potassium voltage-gated channel, KQT-like subfamily, member 2b
chr7_+_25858380 2.13 ENSDART00000148780
ENSDART00000079218
myotubularin related protein 1a
chr7_-_38687431 2.12 ENSDART00000074490
apelin receptor 2
chr9_+_4252839 2.12 ENSDART00000169740
kalirin RhoGEF kinase a
chr20_-_28698172 2.11 ENSDART00000190635
signal-induced proliferation-associated 1 like 1
chr3_-_33422738 2.10 ENSDART00000075493
coiled-coil domain containing 103
chr16_-_28709874 2.09 ENSDART00000127753
ADAM metallopeptidase domain 15
chr13_+_38814521 2.08 ENSDART00000110976
collagen, type XIX, alpha 1
chr8_+_8532407 2.04 ENSDART00000169276
ENSDART00000138993
glutamate receptor, metabotropic 6a
chr1_-_59313465 2.02 ENSDART00000158067
ENSDART00000159419
thioredoxin domain containing 11
chr12_+_19036380 2.02 ENSDART00000153086
ENSDART00000181060
potassium channel tetramerization domain containing 17
chr20_+_54356272 1.99 ENSDART00000145735
zinc finger protein 410
chr17_+_27723490 1.95 ENSDART00000123588
ENSDART00000170462
ENSDART00000169708
QKI, KH domain containing, RNA binding a
chr3_+_59784632 1.95 ENSDART00000084729
platelet/endothelial cell adhesion molecule 1
chr23_-_30076950 1.93 ENSDART00000180139
calmodulin binding transcription activator 1a
chr3_+_41731527 1.88 ENSDART00000049007
ENSDART00000187866
carbohydrate (chondroitin 4) sulfotransferase 12a
chr3_+_16976095 1.88 ENSDART00000112450
caveolae associated protein 1a
chr3_-_31115601 1.88 ENSDART00000139090
ADP-ribosylation factor-like 6 interacting protein 1
chr5_-_30176349 1.88 ENSDART00000186584
ADAM metallopeptidase with thrombospondin type 1 motif, 8a
chr22_+_3238474 1.86 ENSDART00000157954
si:ch1073-178p5.3
chr17_-_20430177 1.86 ENSDART00000114236
sortilin related VPS10 domain containing receptor 3b
chr6_-_37469775 1.86 ENSDART00000156546
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr15_+_1167119 1.85 ENSDART00000093152
G elongation factor, mitochondrial 1
chr5_+_9037650 1.84 ENSDART00000158226
si:ch211-155m12.1
chr5_-_12407194 1.83 ENSDART00000125291
kinase suppressor of ras 2
chr18_-_11060548 1.81 ENSDART00000146692
tetraspanin 9a
chr12_+_26621906 1.80 ENSDART00000158440
ENSDART00000046959
Rho GTPase activating protein 12b
chr6_+_32497493 1.76 ENSDART00000184819
KN motif and ankyrin repeat domains 4
chr20_-_16078741 1.76 ENSDART00000021550
Ral GEF with PH domain and SH3 binding motif 2
chr7_+_54605640 1.76 ENSDART00000168474
fibroblast growth factor 3
chr1_+_157793 1.73 ENSDART00000152205
cullin 4A
chr6_+_149405 1.71 ENSDART00000161154
ferredoxin 1-like
chr16_+_22345513 1.70 ENSDART00000078000
zgc:123238
chr5_-_12093618 1.68 ENSDART00000161542
leucine rich repeat containing 74B
chr19_+_5604241 1.67 ENSDART00000011025
WAS/WASL interacting protein family, member 2b
chr1_-_9123465 1.64 ENSDART00000081337
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1a
chr5_-_23117078 1.64 ENSDART00000051529
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr3_-_5067585 1.63 ENSDART00000169609
thyrotrophic embryonic factor b
chr15_+_21276735 1.62 ENSDART00000111213
ubiquitin associated and SH3 domain containing Bb
chr21_-_37790727 1.62 ENSDART00000162907
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr6_+_10037252 1.61 ENSDART00000018503
ENSDART00000149537
succinate-CoA ligase, ADP-forming, beta subunit
chr23_+_2560005 1.59 ENSDART00000186906
gamma-glutamyltransferase 7
chr10_+_8680730 1.58 ENSDART00000011987
islet1, like

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0050748 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
2.3 9.3 GO:0006740 NADPH regeneration(GO:0006740)
2.1 6.2 GO:0097376 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
1.8 5.3 GO:0036076 ligamentous ossification(GO:0036076)
1.6 4.9 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
1.3 3.9 GO:0098528 skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle cell differentiation(GO:2001014)
1.3 3.9 GO:0014014 negative regulation of gliogenesis(GO:0014014)
1.2 3.7 GO:0021961 posterior commissure morphogenesis(GO:0021961)
1.2 4.9 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
1.2 6.1 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
1.2 3.5 GO:0051934 synaptic transmission, dopaminergic(GO:0001963) norepinephrine transport(GO:0015874) dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
1.1 4.3 GO:0015871 choline transport(GO:0015871)
1.0 7.8 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.9 5.3 GO:0090134 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.7 2.1 GO:0036159 inner dynein arm assembly(GO:0036159)
0.7 2.0 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.6 1.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.6 1.8 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.6 21.1 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.6 7.7 GO:0010996 response to auditory stimulus(GO:0010996)
0.6 1.8 GO:0021985 neurohypophysis development(GO:0021985)
0.6 4.6 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.6 2.8 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.5 1.4 GO:0070131 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.5 5.1 GO:0034394 protein localization to cell surface(GO:0034394)
0.4 2.2 GO:0031649 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.4 2.7 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.4 4.6 GO:0001964 startle response(GO:0001964)
0.4 3.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.4 3.7 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.4 1.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.4 2.2 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.3 2.9 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.3 5.2 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.3 2.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 3.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.3 4.6 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3 3.4 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.3 7.1 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.2 3.0 GO:0007525 somatic muscle development(GO:0007525)
0.2 4.0 GO:0036065 fucosylation(GO:0036065)
0.2 0.7 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.2 5.5 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 2.0 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 8.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2 3.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.2 1.3 GO:0006574 valine catabolic process(GO:0006574)
0.2 5.9 GO:0006828 manganese ion transport(GO:0006828)
0.2 3.4 GO:0086001 cardiac muscle cell action potential(GO:0086001)
0.2 3.9 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.2 10.4 GO:1901214 regulation of neuron death(GO:1901214)
0.2 2.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.2 4.9 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.2 3.7 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.2 4.8 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.2 1.5 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.2 7.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 4.8 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.7 GO:0035522 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 9.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.2 3.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.2 1.1 GO:0021982 pineal gland development(GO:0021982)
0.2 3.0 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.2 0.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 1.1 GO:0009249 protein lipoylation(GO:0009249)
0.1 4.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 1.1 GO:0006537 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.1 1.0 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.1 5.0 GO:0072348 sulfur compound transport(GO:0072348)
0.1 1.3 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.1 7.4 GO:0051017 actin filament bundle assembly(GO:0051017)
0.1 5.0 GO:0007586 digestion(GO:0007586)
0.1 0.4 GO:1902746 negative regulation of epithelial cell differentiation(GO:0030857) regulation of lens fiber cell differentiation(GO:1902746)
0.1 2.0 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.1 2.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 2.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.1 0.8 GO:0006211 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.1 1.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 2.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 1.3 GO:0002031 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.1 0.4 GO:0032801 receptor catabolic process(GO:0032801)
0.1 1.4 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 1.2 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 1.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.8 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 5.4 GO:0007254 JNK cascade(GO:0007254)
0.1 3.9 GO:0021761 limbic system development(GO:0021761) hypothalamus development(GO:0021854)
0.1 1.5 GO:1902307 positive regulation of sodium ion transport(GO:0010765) positive regulation of potassium ion transport(GO:0043268) positive regulation of potassium ion transmembrane transport(GO:1901381) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 9.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.3 GO:0050795 regulation of behavior(GO:0050795)
0.1 7.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.1 4.3 GO:0001885 endothelial cell development(GO:0001885)
0.1 1.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.2 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 5.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 4.7 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 1.1 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 0.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 1.5 GO:0034453 microtubule anchoring(GO:0034453)
0.1 7.6 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.1 7.5 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 0.7 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 3.9 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 0.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.1 0.6 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 1.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 2.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0061055 myotome development(GO:0061055)
0.1 4.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.5 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.2 GO:0043476 pigment accumulation(GO:0043476)
0.0 0.2 GO:0060420 regulation of heart growth(GO:0060420)
0.0 0.8 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 1.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 2.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 2.4 GO:0010842 retina layer formation(GO:0010842)
0.0 0.3 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.5 GO:0006611 protein export from nucleus(GO:0006611)
0.0 2.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.8 GO:0001706 endoderm formation(GO:0001706)
0.0 1.7 GO:0071600 otic vesicle morphogenesis(GO:0071600)
0.0 5.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 1.3 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 9.7 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 1.9 GO:0030166 proteoglycan biosynthetic process(GO:0030166)
0.0 1.2 GO:0036269 swimming behavior(GO:0036269)
0.0 4.2 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 1.0 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 7.0 GO:0007018 microtubule-based movement(GO:0007018)
0.0 1.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.8 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.0 3.1 GO:0006821 chloride transport(GO:0006821)
0.0 0.3 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.0 1.6 GO:0071482 cellular response to light stimulus(GO:0071482)
0.0 2.1 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.4 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 1.7 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.6 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 1.4 GO:0007098 centrosome cycle(GO:0007098)
0.0 1.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.0 GO:0022900 electron transport chain(GO:0022900)
0.0 4.8 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.0 1.6 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.5 GO:0031398 positive regulation of protein ubiquitination(GO:0031398)
0.0 1.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.1 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 3.9 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 1.1 GO:0007283 spermatogenesis(GO:0007283)
0.0 1.0 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.4 GO:1990573 potassium ion import(GO:0010107) potassium ion import across plasma membrane(GO:1990573)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 1.2 GO:0001756 somitogenesis(GO:0001756)
0.0 0.6 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.9 GO:0034765 regulation of ion transmembrane transport(GO:0034765)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 21.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
1.8 5.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.8 4.7 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.7 2.8 GO:0008290 F-actin capping protein complex(GO:0008290)
0.5 1.6 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.5 21.3 GO:0043679 axon terminus(GO:0043679)
0.5 3.0 GO:0005784 Sec61 translocon complex(GO:0005784)
0.5 1.8 GO:1990909 Wnt signalosome(GO:1990909)
0.4 5.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.4 1.5 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 4.8 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 2.1 GO:0043194 axon initial segment(GO:0043194)
0.3 4.6 GO:0031209 SCAR complex(GO:0031209)
0.3 0.8 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 1.7 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.2 3.8 GO:0071564 npBAF complex(GO:0071564)
0.2 3.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 0.6 GO:0010369 chromocenter(GO:0010369)
0.2 10.5 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 3.5 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.2 1.4 GO:0035253 ciliary rootlet(GO:0035253)
0.2 2.1 GO:0036157 outer dynein arm(GO:0036157)
0.2 7.4 GO:0030426 growth cone(GO:0030426)
0.1 2.2 GO:0036038 MKS complex(GO:0036038)
0.1 3.0 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 9.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.7 GO:0035517 PR-DUB complex(GO:0035517)
0.1 3.6 GO:0000421 autophagosome membrane(GO:0000421)
0.1 7.9 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 5.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 5.0 GO:0005930 axoneme(GO:0005930)
0.1 1.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 1.2 GO:0042555 MCM complex(GO:0042555)
0.1 0.2 GO:0031251 PAN complex(GO:0031251)
0.1 1.5 GO:0045180 basal cortex(GO:0045180)
0.1 3.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.4 GO:0036126 sperm flagellum(GO:0036126)
0.1 7.8 GO:0034703 cation channel complex(GO:0034703)
0.1 3.4 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1 14.1 GO:0005911 cell-cell junction(GO:0005911)
0.1 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 3.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 4.2 GO:0030018 Z disc(GO:0030018)
0.0 2.0 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 27.8 GO:0043005 neuron projection(GO:0043005)
0.0 14.8 GO:0045202 synapse(GO:0045202)
0.0 1.6 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0070390 transcription export complex 2(GO:0070390)
0.0 7.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.8 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 10.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.0 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 1.0 GO:0005814 centriole(GO:0005814)
0.0 0.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 21.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
3.9 11.6 GO:1903136 cuprous ion binding(GO:1903136)
2.3 9.3 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
1.8 10.8 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
1.8 5.3 GO:0031704 apelin receptor binding(GO:0031704)
1.3 3.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.2 3.5 GO:0005330 dopamine transmembrane transporter activity(GO:0005329) dopamine:sodium symporter activity(GO:0005330) norepinephrine transmembrane transporter activity(GO:0005333) norepinephrine:sodium symporter activity(GO:0005334)
1.1 4.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.9 2.7 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.8 5.6 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.7 9.7 GO:0031628 opioid receptor binding(GO:0031628)
0.7 6.4 GO:0004977 melanocortin receptor activity(GO:0004977)
0.6 7.6 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.6 4.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.5 1.6 GO:0000035 acyl binding(GO:0000035)
0.5 1.6 GO:0004775 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.5 24.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.5 1.9 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.5 4.6 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.4 2.2 GO:0008432 JUN kinase binding(GO:0008432)
0.4 2.6 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.4 2.1 GO:0060182 apelin receptor activity(GO:0060182)
0.4 1.5 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.4 4.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.4 5.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.3 4.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 1.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.3 4.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.3 2.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 3.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 1.5 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.3 1.8 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.3 3.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.3 2.0 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.3 4.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.3 0.8 GO:0005499 vitamin D binding(GO:0005499)
0.3 5.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 2.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 0.7 GO:0019777 Atg12 transferase activity(GO:0019777)
0.2 1.2 GO:1990518 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.2 4.9 GO:0042056 chemoattractant activity(GO:0042056)
0.2 3.0 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 5.5 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.2 5.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 0.6 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.2 3.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 0.8 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.2 1.2 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.2 0.5 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.2 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 3.4 GO:0005523 tropomyosin binding(GO:0005523)
0.2 0.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 2.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.1 5.0 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.1 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 1.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 3.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 5.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.1 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 2.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.8 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 3.4 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.1 2.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 2.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 2.0 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.4 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1 0.6 GO:0004104 cholinesterase activity(GO:0004104)
0.1 2.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.5 GO:0050699 WW domain binding(GO:0050699)
0.1 1.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 9.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.5 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 1.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 9.8 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.1 0.8 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 8.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.4 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 7.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 20.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 15.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 7.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 6.8 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 2.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.0 11.4 GO:0008017 microtubule binding(GO:0008017)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 1.0 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 4.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0035497 cAMP response element binding(GO:0035497)
0.0 13.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 18.8 GO:0003779 actin binding(GO:0003779)
0.0 1.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.4 GO:0046332 SMAD binding(GO:0046332)
0.0 1.4 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.7 GO:0008198 ferrous iron binding(GO:0008198) 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 1.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 1.1 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 4.0 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 3.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 4.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 1.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 2.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 3.9 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.4 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 1.7 NABA COLLAGENS Genes encoding collagen proteins
0.1 2.7 PID LKB1 PATHWAY LKB1 signaling events
0.1 1.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 3.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.6 PID RHOA PATHWAY RhoA signaling pathway
0.0 3.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.2 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.5 4.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 5.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3 4.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 1.8 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 4.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 1.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 3.6 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.2 3.9 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.5 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 3.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 5.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.0 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.1 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 2.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 1.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression