ISMARA results: gsx2+pnx

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gsx2+pnx

Z-value: 1.17

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Transcription factors associated with gsx2+pnx

Gene Symbol	Gene ID	Gene Info
pnx NCBI UniProt	ENSDARG00000025899	posterior neuron-specific homeobox
gsx2 NCBI UniProt	ENSDARG00000043322	GS homeobox 2
gsx2 NCBI UniProt	ENSDARG00000116417	GS homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
gsx2	dr11_v1_chr20_-_22484621_22484621	-0.25	1.5e-02	Click!
pnx	dr11_v1_chr10_+_2799285_2799285	0.05	6.1e-01	Click!

Activity profile of gsx2+pnx motif

Sorted Z-values of gsx2+pnx motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_51597677 Show fit	17.50	ENSDART00000048210 ENSDART00000184797	ckmt2b NCBI UniProt Show fit	creatine kinase, mitochondrial 2b (sarcomeric)
chr20_+_26966725 Show fit	16.33	ENSDART00000029781	ahsa1a NCBI UniProt Show fit	AHA1, activator of heat shock protein ATPase homolog 1a
chr25_+_29160102 Show fit	15.45	ENSDART00000162854	pkmb NCBI UniProt Show fit	pyruvate kinase M1/2b
chr2_+_55982300 Show fit	14.86	ENSDART00000183903	nmrk2 NCBI UniProt Show fit	nicotinamide riboside kinase 2
chr23_+_20110086 Show fit	13.77	ENSDART00000054664	tnnc1b NCBI UniProt Show fit	troponin C type 1b (slow)
chr25_+_31267268 Show fit	13.64	ENSDART00000181239	tnni2a.3 NCBI UniProt Show fit	troponin I type 2a (skeletal, fast), tandem duplicate 3
chr13_+_22479988 Show fit	12.24	ENSDART00000188182 ENSDART00000192972 ENSDART00000178372	ldb3a NCBI UniProt Show fit	LIM domain binding 3a
chr25_+_35019693 Show fit	11.10	ENSDART00000046218	flnca NCBI UniProt Show fit	filamin C, gamma a (actin binding protein 280)
chr25_+_31277415 Show fit	10.13	ENSDART00000036275	tnni2a.4 NCBI UniProt Show fit	troponin I type 2a (skeletal, fast), tandem duplicate 4
chr15_-_12011390 Show fit	9.82	ENSDART00000187403	si:dkey-202l22.6 NCBI UniProt Show fit	si:dkey-202l22.6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of gsx2+pnx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	52.6	GO:0003009	skeletal muscle contraction(GO:0003009)
1.3	17.5	GO:0006603	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
1.5	16.3	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.2	15.4	GO:0032869	cellular response to insulin stimulus(GO:0032869)
0.1	14.6	GO:0001756	somitogenesis(GO:0001756)
0.1	11.9	GO:0015718	monocarboxylic acid transport(GO:0015718)
1.2	11.1	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.2	8.8	GO:0031102	neuron projection regeneration(GO:0031102)
1.4	8.6	GO:0071691	cardiac muscle thin filament assembly(GO:0071691)
0.2	8.3	GO:0030968	endoplasmic reticulum unfolded protein response(GO:0030968)

Showing 1 to 10 of 128 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	52.6	GO:0005861	troponin complex(GO:0005861)
0.3	33.9	GO:0030018	Z disc(GO:0030018)
0.0	20.8	GO:0005739	mitochondrion(GO:0005739)
0.0	19.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.7	14.4	GO:0031430	M band(GO:0031430)
0.1	11.9	GO:0001726	ruffle(GO:0001726)
0.1	11.4	GO:0016324	apical plasma membrane(GO:0016324)
0.0	8.5	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	8.1	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	7.6	GO:0022626	cytosolic ribosome(GO:0022626)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	23.5	GO:0051015	actin filament binding(GO:0051015)
1.3	17.5	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
1.2	17.4	GO:0051879	Hsp90 protein binding(GO:0051879)
0.1	16.7	GO:0003779	actin binding(GO:0003779)
2.6	15.4	GO:0004743	pyruvate kinase activity(GO:0004743)
2.1	14.9	GO:0050262	ribosylnicotinamide kinase activity(GO:0050262)
0.5	13.8	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	12.8	GO:0008201	heparin binding(GO:0008201)
0.6	12.2	GO:0051371	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
1.0	11.9	GO:0015129	lactate transmembrane transporter activity(GO:0015129)

Showing 1 to 10 of 90 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	13.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.3	9.0	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.2	7.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	5.3	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.4	5.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	3.9	NABA COLLAGENS	Genes encoding collagen proteins
0.1	3.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	2.5	PID P53 REGULATION PATHWAY	p53 pathway
0.0	2.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	2.0	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	19.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.7	11.9	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.2	11.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.3	8.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.6	8.0	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.6	6.8	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	3.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	2.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	1.9	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1	1.9	REACTOME MYOGENESIS	Genes involved in Myogenesis

Showing 1 to 10 of 30 entries

Results for gsx2+pnx

Z-value: 1.17

Motif logo

Transcription factors associated with gsx2+pnx

Activity-expression correlation:

Activity profile of gsx2+pnx motif

Sorted Z-values of gsx2+pnx motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of gsx2+pnx

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: