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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for grhl1

Z-value: 4.15

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Transcription factors associated with grhl1

Gene Symbol Gene ID Gene Info
ENSDARG00000061391 grainyhead-like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
grhl1dr11_v1_chr17_-_32413147_324131470.864.0e-28Click!

Activity profile of grhl1 motif

Sorted Z-values of grhl1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_12360409 87.74 ENSDART00000164596
transmembrane protease, serine 13a
chr9_-_30264415 86.84 ENSDART00000060150
MID1 interacting protein 1a
chr15_+_42560354 79.94 ENSDART00000059484
zgc:110333
chr16_-_9675982 75.55 ENSDART00000113724
mal, T cell differentiation protein 2 (gene/pseudogene)
chr12_-_28794957 74.02 ENSDART00000020667
oxysterol binding protein-like 7
chr21_+_11244068 71.31 ENSDART00000163432
AT-rich interaction domain 6
chr7_+_22657566 69.46 ENSDART00000141048
plac8 onzin related protein 5
chr24_+_38671054 65.02 ENSDART00000154214
si:ch73-70c5.1
chr8_-_24252933 59.77 ENSDART00000057624
zgc:110353
chr10_-_36793412 59.37 ENSDART00000185966
dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 2
chr6_+_23057311 57.50 ENSDART00000026448
envoplakin a
chr16_+_35905031 56.36 ENSDART00000162411
SH3 domain containing 21
chr22_+_19552987 56.13 ENSDART00000105315
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr8_+_3405612 55.50 ENSDART00000163437
zgc:112433
chr17_+_28102487 54.69 ENSDART00000131638
ENSDART00000076265
zgc:91908
chr15_+_41919484 54.27 ENSDART00000099821
ENSDART00000146246
NACHT, LRR and PYD domains-containing protein 16
chr5_-_57686487 49.39 ENSDART00000074264
cytokine receptor family member B12
chr3_-_16537441 49.13 ENSDART00000080749
ENSDART00000133824
eps8-like1
chr5_-_37900350 47.86 ENSDART00000084839
ENSDART00000084841
ENSDART00000133437
transmembrane protease, serine 13b
chr16_+_17715243 47.65 ENSDART00000149437
ENSDART00000149596
si:dkey-87o1.2
chr23_-_22650668 45.42 ENSDART00000132733
carbonic anhydrase VI
chr5_-_6567464 45.25 ENSDART00000184985
tankyrase 1 binding protein 1
chr4_-_9780931 44.75 ENSDART00000134280
ENSDART00000150664
ENSDART00000150304
ENSDART00000080744
SVOP-like
chr22_+_25672155 44.23 ENSDART00000087769
si:ch211-250e5.2
chr10_-_22127942 44.19 ENSDART00000133374
plac8 onzin related protein 2
chr15_+_22014029 43.98 ENSDART00000079504
ankyrin repeat and kinase domain containing 1
chr23_-_22650992 42.44 ENSDART00000079007
carbonic anhydrase VI
chr22_+_22021936 41.93 ENSDART00000149586
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
chr16_-_31976269 41.04 ENSDART00000139664
serine/threonine/tyrosine kinase 1
chr5_+_58665648 40.73 ENSDART00000167481
zgc:194948
chr19_-_32500373 40.72 ENSDART00000052104
alpha-L-fucosidase 1, tandem duplicate 1
chr13_+_42544009 40.58 ENSDART00000145409
si:dkey-221j11.3
chr16_+_23431189 40.58 ENSDART00000004679
ictacalcin
chr3_-_18756076 39.83 ENSDART00000055766
zgc:113333
chr7_+_19835569 39.71 ENSDART00000149812
ovo-like zinc finger 1a
chr4_+_76722754 39.48 ENSDART00000153867
membrane-spanning 4-domains, subfamily A, member 17A.3
chr1_-_48933 38.08 ENSDART00000171162
immunoglobulin-like domain containing receptor 1a
chr3_-_18755651 37.59 ENSDART00000145277
zgc:113333
chr8_-_36399884 36.87 ENSDART00000108538
si:zfos-2070c2.3
chr2_+_5521671 36.75 ENSDART00000099647
ENSDART00000138443
cytokine receptor family member B16
chr19_-_41472228 35.27 ENSDART00000113388
distal-less homeobox 5a
chr3_-_29977495 31.40 ENSDART00000077111
hydroxysteroid (17-beta) dehydrogenase 14
chr21_+_25625026 31.29 ENSDART00000134678
ovo-like zinc finger 1b
chr2_-_47620806 30.41 ENSDART00000038228
adaptor-related protein complex 1, sigma 3 subunit, b
chr21_-_3700334 28.98 ENSDART00000137844
ATPase phospholipid transporting 8B1
chr25_-_24202576 28.78 ENSDART00000048507
UEV and lactate/malate dehyrogenase domains
chr22_-_22337382 28.46 ENSDART00000144684
si:ch211-129c21.1
chr21_-_13668358 27.78 ENSDART00000180323
patatin-like phospholipase domain containing 7a
chr5_-_29570141 27.75 ENSDART00000043259
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2
chr4_-_26413391 26.76 ENSDART00000145955
beta-1,4-N-acetyl-galactosaminyl transferase 3a
chr6_+_30668098 26.40 ENSDART00000112294
tetratricopeptide repeat domain 22
chr10_+_4924388 26.25 ENSDART00000108595
solute carrier family 46 member 2
chr13_+_18533005 24.31 ENSDART00000136024
finTRIM family, member 14-like
chr12_+_30360579 22.89 ENSDART00000152900
si:ch211-225b10.3
chr16_+_7154753 22.67 ENSDART00000163281
ENSDART00000168274
BMP binding endothelial regulator
chr16_-_28091597 22.58 ENSDART00000166595

chr17_+_22102791 22.20 ENSDART00000047772
mal, T cell differentiation protein
chr14_+_146857 22.11 ENSDART00000122521

chr4_-_12725513 21.37 ENSDART00000132286
microsomal glutathione S-transferase 1.2
chr16_+_53526135 21.24 ENSDART00000083558
sphingomyelin phosphodiesterase 5
chr7_-_24193051 21.20 ENSDART00000169737
ENSDART00000171085
si:ch211-216p19.6
chr15_+_509126 20.10 ENSDART00000102274
finTRIM family, member 86
chr4_+_4232562 19.85 ENSDART00000177529
small lysine rich protein 1
chr2_-_58075414 19.80 ENSDART00000161920
nectin cell adhesion molecule 4
chr9_-_40014339 19.63 ENSDART00000166918
si:zfos-1425h8.1
chr21_+_5801105 16.53 ENSDART00000151225
ENSDART00000184487
cyclin G2
chr12_+_31673588 13.76 ENSDART00000152971
dynamin binding protein
chr15_+_41901970 13.73 ENSDART00000152724
si:ch211-191a16.5
chr9_-_14108896 13.65 ENSDART00000135209
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr7_-_56606752 13.20 ENSDART00000138714
sulfotransferase family 5A, member 1
chr3_+_34140507 12.52 ENSDART00000131802
si:dkey-204f11.64
chr14_+_45702521 11.36 ENSDART00000112470
coiled-coil domain containing 88B
chr8_-_13029297 10.86 ENSDART00000144305
DENN/MADD domain containing 2Da
chr2_-_17827983 10.05 ENSDART00000166518
protein tyrosine phosphatase, receptor type, f, b
chr15_+_41901710 10.04 ENSDART00000159874
si:ch211-191a16.5
chr25_+_15994100 9.83 ENSDART00000144723
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr13_-_30161684 9.42 ENSDART00000040409
pyrophosphatase (inorganic) 1b
chr19_-_10432134 8.72 ENSDART00000081440
interleukin 11b
chr3_-_32831429 8.63 ENSDART00000184932
zgc:153733
chr4_-_14954327 8.54 ENSDART00000182729
solute carrier family 26 (anion exchanger), member 5
chr3_+_37196258 8.33 ENSDART00000187944
ENSDART00000185896
formin-like 1a
chr12_+_4036409 8.18 ENSDART00000106650
zgc:123217
chr12_+_30705769 7.12 ENSDART00000186448
ENSDART00000066259
potassium channel, subfamily K, member 1a
chr3_-_32831971 7.06 ENSDART00000075270
zgc:153733
chr12_+_30706158 6.99 ENSDART00000133869
potassium channel, subfamily K, member 1a
chr1_-_31105376 6.65 ENSDART00000132466
protein phosphatase 1 regulatory subunit 9A-like B
chr14_-_33945692 6.53 ENSDART00000168546
ENSDART00000189778
zinc finger, DHHC-type containing 24
chr22_-_14361022 6.40 ENSDART00000140224
si:dkeyp-122a9.2
chr4_-_14954029 6.10 ENSDART00000038642
solute carrier family 26 (anion exchanger), member 5
chr1_-_47161996 5.12 ENSDART00000053153
major histocompatibility complex class I ZBA
chr16_-_10837245 5.09 ENSDART00000036891
Rab acceptor 1 (prenylated)
chr15_+_29276508 4.64 ENSDART00000170537
ENSDART00000126559
RAP1 GTPase activating protein 2a
chr15_-_5901514 4.63 ENSDART00000155252
si:ch73-281n10.2
chr23_-_19225709 3.88 ENSDART00000080099
O-acyl-ADP-ribose deacylase 1
chr2_-_58201173 3.79 ENSDART00000166282
purine nucleoside phosphorylase 5b
chr24_+_42074143 3.73 ENSDART00000170514
DNA topoisomerase I mitochondrial
chr11_-_42417194 3.69 ENSDART00000191086
ENSDART00000076650
ENSDART00000165903
ENSDART00000104444
sarcolemma associated protein a
chr11_-_45140227 3.56 ENSDART00000184062
calcium activated nucleotidase 1b
chr11_-_17964525 3.38 ENSDART00000018948
cytokine inducible SH2-containing protein b
chr1_-_9858508 2.28 ENSDART00000147904
mitotic arrest deficient 1 like 1
chr5_+_4006837 2.24 ENSDART00000138862
phosphatidylinositol glycan anchor biosynthesis, class W
chr24_-_8412526 1.67 ENSDART00000150055
solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
chr3_-_30186296 0.44 ENSDART00000134395
ENSDART00000077057
ENSDART00000017422
TBC1 domain family, member 17
chr20_+_20731052 0.33 ENSDART00000047662
protein phosphatase 1, regulatory subunit 13Bb
chr8_+_8459192 0.29 ENSDART00000140942
ENSDART00000014939
catechol-O-methyltransferase a
chr22_-_13649588 0.28 ENSDART00000131877
si:ch211-279g13.1

Network of associatons between targets according to the STRING database.

First level regulatory network of grhl1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.1 75.5 GO:0045056 transcytosis(GO:0045056)
6.8 40.7 GO:0006004 fucose metabolic process(GO:0006004)
5.7 28.5 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
5.7 39.7 GO:0070285 pigment cell development(GO:0070285)
4.6 27.7 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
4.4 35.3 GO:0021628 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
3.7 14.6 GO:0019532 oxalate transport(GO:0019532)
3.1 59.4 GO:0042574 retinal metabolic process(GO:0042574)
2.1 21.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.9 41.9 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
1.7 87.9 GO:0036269 swimming behavior(GO:0036269)
1.5 86.8 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
1.3 15.7 GO:0001881 receptor recycling(GO:0001881)
1.3 57.5 GO:0045103 intermediate filament-based process(GO:0045103) intermediate filament cytoskeleton organization(GO:0045104)
1.1 10.1 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.9 29.0 GO:0045332 phospholipid translocation(GO:0045332)
0.6 21.9 GO:0043049 otic placode formation(GO:0043049)
0.6 49.4 GO:0007596 blood coagulation(GO:0007596)
0.6 14.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.5 22.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.5 13.2 GO:0051923 sulfation(GO:0051923)
0.4 13.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 16.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.3 31.3 GO:0009913 epidermal cell differentiation(GO:0009913)
0.3 66.5 GO:0006869 lipid transport(GO:0006869)
0.3 2.3 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.2 3.7 GO:0006265 DNA topological change(GO:0006265)
0.2 11.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.2 6.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 9.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 95.4 GO:0005975 carbohydrate metabolic process(GO:0005975)
0.1 8.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 24.2 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 143.8 GO:0006508 proteolysis(GO:0006508)
0.1 2.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 4.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 6.6 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 68.2 GO:0015031 protein transport(GO:0015031)
0.1 13.8 GO:0072001 kidney development(GO:0001822) renal system development(GO:0072001)
0.0 3.4 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.3 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 54.5 GO:0035556 intracellular signal transduction(GO:0035556)
0.0 3.7 GO:0006936 muscle contraction(GO:0006936)
0.0 23.7 GO:0006468 protein phosphorylation(GO:0006468)
0.0 56.9 GO:0006357 regulation of transcription from RNA polymerase II promoter(GO:0006357)
0.0 5.1 GO:0006955 immune response(GO:0006955)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 74.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
1.1 13.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.9 22.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.8 54.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 75.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.5 57.5 GO:0005882 intermediate filament(GO:0005882)
0.5 21.2 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.5 26.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.4 16.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 14.1 GO:0043204 perikaryon(GO:0043204)
0.3 58.4 GO:0098791 Golgi subcompartment(GO:0098791)
0.3 30.4 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.2 93.0 GO:0009986 cell surface(GO:0009986)
0.2 59.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 59.4 GO:0005874 microtubule(GO:0005874)
0.1 38.5 GO:0005764 lysosome(GO:0005764)
0.1 9.8 GO:0048786 presynaptic active zone(GO:0048786)
0.1 6.6 GO:0014069 postsynaptic density(GO:0014069)
0.1 115.7 GO:0005576 extracellular region(GO:0005576)
0.1 69.9 GO:0005886 plasma membrane(GO:0005886)
0.1 3.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 11.4 GO:0005813 centrosome(GO:0005813)
0.1 369.5 GO:0016021 integral component of membrane(GO:0016021)
0.0 2.3 GO:0000776 kinetochore(GO:0000776)
0.0 171.3 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.6 40.7 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
9.6 57.5 GO:0019215 intermediate filament binding(GO:0019215)
8.6 77.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
5.9 59.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
5.4 26.8 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
5.0 75.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
4.7 41.9 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
3.1 87.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
2.7 74.0 GO:0015248 sterol transporter activity(GO:0015248)
2.4 9.4 GO:0004427 inorganic diphosphatase activity(GO:0004427)
2.2 56.1 GO:0016229 steroid dehydrogenase activity(GO:0016229)
1.6 27.7 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
1.5 21.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
1.4 40.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.9 14.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.9 3.7 GO:0033149 FFAT motif binding(GO:0033149)
0.8 14.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.7 47.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.7 86.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.6 21.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 12.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.6 22.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.6 1.7 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.5 13.7 GO:0016208 AMP binding(GO:0016208)
0.5 28.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 95.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 3.8 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.4 3.6 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.3 11.4 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.3 16.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 28.8 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.2 4.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 29.3 GO:0000287 magnesium ion binding(GO:0000287)
0.2 13.2 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 6.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 10.1 GO:0008201 heparin binding(GO:0008201)
0.1 65.6 GO:0008270 zinc ion binding(GO:0008270)
0.1 24.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 165.8 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0 8.7 GO:0005125 cytokine activity(GO:0005125)
0.0 15.0 GO:0051015 actin filament binding(GO:0051015)
0.0 2.2 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 31.4 GO:0016491 oxidoreductase activity(GO:0016491)
0.0 39.3 GO:0004672 protein kinase activity(GO:0004672)
0.0 40.7 GO:0022857 transmembrane transporter activity(GO:0022857)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 5.1 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 13.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 22.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 87.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
2.8 45.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.6 29.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase