ISMARA results: gfi1aa+gfi1ab

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gfi1aa+gfi1ab

Z-value: 2.37

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Transcription factors associated with gfi1aa+gfi1ab

Gene Symbol	Gene ID	Gene Info
gfi1aa NCBI UniProt	ENSDARG00000020746	growth factor independent 1A transcription repressor a
gfi1ab NCBI UniProt	ENSDARG00000044457	growth factor independent 1A transcription repressor b
gfi1ab NCBI UniProt	ENSDARG00000114140	growth factor independent 1A transcription repressor b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
gfi1aa	dr11_v1_chr2_+_10771787_10771787	0.77	1.1e-19	Click!
gfi1ab	dr11_v1_chr6_-_29007493_29007493	-0.09	4.0e-01	Click!

Activity profile of gfi1aa+gfi1ab motif

Sorted Z-values of gfi1aa+gfi1ab motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_15433671 Show fit	43.08	ENSDART00000149568	fabp7a NCBI UniProt Show fit	fatty acid binding protein 7, brain, a
chr17_+_15433518 Show fit	42.74	ENSDART00000026180	fabp7a NCBI UniProt Show fit	fatty acid binding protein 7, brain, a
chr9_-_18877597 Show fit	34.13	ENSDART00000099446	kctd4 NCBI UniProt Show fit	potassium channel tetramerization domain containing 4
chr18_-_1185772 Show fit	33.40	ENSDART00000143245	nptnb NCBI UniProt Show fit	neuroplastin b
chr18_+_22793465 Show fit	30.77	ENSDART00000149685	gnao1a NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr21_+_26697536 Show fit	30.66	ENSDART00000004109	gng3 NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), gamma 3
chr14_+_35806605 Show fit	30.29	ENSDART00000173093	gria2b NCBI UniProt Show fit	glutamate receptor, ionotropic, AMPA 2b
chr5_+_64732270 Show fit	24.44	ENSDART00000134241	olfm1a NCBI UniProt Show fit	olfactomedin 1a
chr15_-_24869826 Show fit	23.88	ENSDART00000127047	tusc5a NCBI UniProt Show fit	tumor suppressor candidate 5a
chr7_-_22132265 Show fit	22.45	ENSDART00000125284 ENSDART00000112978	nlgn2a NCBI UniProt Show fit	neuroligin 2a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of gfi1aa+gfi1ab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	56.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.0	45.1	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.3	39.6	GO:0051260	protein homooligomerization(GO:0051260)
1.9	37.4	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.6	37.0	GO:0050919	negative chemotaxis(GO:0050919)
2.0	35.2	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208)
3.6	32.3	GO:1902868	positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.7	31.9	GO:0007019	microtubule depolymerization(GO:0007019)
1.0	28.5	GO:0070593	dendrite self-avoidance(GO:0070593)
0.2	26.1	GO:0070588	calcium ion transmembrane transport(GO:0070588)

Showing 1 to 10 of 251 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	67.7	GO:0048788	cytoskeleton of presynaptic active zone(GO:0048788)
0.2	51.3	GO:0030424	axon(GO:0030424)
1.0	49.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
1.0	43.6	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	39.2	GO:0000139	Golgi membrane(GO:0000139)
0.0	38.7	GO:0005887	integral component of plasma membrane(GO:0005887)
2.2	37.5	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
0.1	37.3	GO:0043005	neuron projection(GO:0043005)
0.4	34.7	GO:0005871	kinesin complex(GO:0005871)
1.0	30.4	GO:0031594	neuromuscular junction(GO:0031594)

Showing 1 to 10 of 117 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.7	85.8	GO:0005504	fatty acid binding(GO:0005504)
0.8	48.4	GO:0044325	ion channel binding(GO:0044325)
2.8	41.6	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
7.7	38.7	GO:0051430	mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.8	37.5	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.4	36.3	GO:0019888	protein phosphatase regulator activity(GO:0019888)
2.9	35.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.6	34.9	GO:0030215	semaphorin receptor binding(GO:0030215)
0.7	29.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.9	28.5	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)

Showing 1 to 10 of 189 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	22.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	12.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	12.0	PID EPHB FWD PATHWAY	EPHB forward signaling
0.7	11.6	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	11.2	PID AP1 PATHWAY	AP-1 transcription factor network
0.4	9.5	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.2	8.6	PID IL12 2PATHWAY	IL12-mediated signaling events
0.2	8.4	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.9	7.8	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.4	7.8	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	46.6	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.8	21.0	REACTOME AMYLOIDS	Genes involved in Amyloids
0.2	17.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3	16.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.3	15.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.6	13.2	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
1.4	12.5	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
1.4	12.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.5	10.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.8	10.2	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis

Showing 1 to 10 of 57 entries

Results for gfi1aa+gfi1ab

Z-value: 2.37

Motif logo

Transcription factors associated with gfi1aa+gfi1ab

Activity-expression correlation:

Activity profile of gfi1aa+gfi1ab motif

Sorted Z-values of gfi1aa+gfi1ab motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of gfi1aa+gfi1ab

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: