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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for gfi1aa+gfi1ab

Z-value: 2.37

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Transcription factors associated with gfi1aa+gfi1ab

Gene Symbol Gene ID Gene Info
ENSDARG00000020746 growth factor independent 1A transcription repressor a
ENSDARG00000044457 growth factor independent 1A transcription repressor b
ENSDARG00000114140 growth factor independent 1A transcription repressor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gfi1aadr11_v1_chr2_+_10771787_107717870.771.1e-19Click!
gfi1abdr11_v1_chr6_-_29007493_29007493-0.094.0e-01Click!

Activity profile of gfi1aa+gfi1ab motif

Sorted Z-values of gfi1aa+gfi1ab motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_15433671 43.08 ENSDART00000149568
fatty acid binding protein 7, brain, a
chr17_+_15433518 42.74 ENSDART00000026180
fatty acid binding protein 7, brain, a
chr9_-_18877597 34.13 ENSDART00000099446
potassium channel tetramerization domain containing 4
chr18_-_1185772 33.40 ENSDART00000143245
neuroplastin b
chr18_+_22793465 30.77 ENSDART00000149685
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr21_+_26697536 30.66 ENSDART00000004109
guanine nucleotide binding protein (G protein), gamma 3
chr14_+_35806605 30.29 ENSDART00000173093
glutamate receptor, ionotropic, AMPA 2b
chr5_+_64732270 24.44 ENSDART00000134241
olfactomedin 1a
chr15_-_24869826 23.88 ENSDART00000127047
tumor suppressor candidate 5a
chr7_-_22132265 22.45 ENSDART00000125284
ENSDART00000112978
neuroligin 2a
chr6_+_40354424 20.55 ENSDART00000047416
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr24_-_8729531 20.44 ENSDART00000082346
transcription factor AP-2 alpha
chr16_-_29437373 19.81 ENSDART00000148405
si:ch211-113g11.6
chr3_+_40170216 18.73 ENSDART00000011568
synaptogyrin 3a
chr3_-_36440705 18.64 ENSDART00000162875
rogdi homolog (Drosophila)
chr17_-_36936649 18.54 ENSDART00000145236
dihydropyrimidinase-like 5a
chr25_+_21829777 18.40 ENSDART00000027393
creatine kinase, mitochondrial 1
chr1_-_31505144 18.01 ENSDART00000087115
regulating synaptic membrane exocytosis 1b
chr2_-_16562505 17.65 ENSDART00000156406
ATPase Na+/K+ transporting subunit beta 3a
chr20_+_18580176 17.52 ENSDART00000185310
si:dkeyp-72h1.1
chr8_-_14052349 17.21 ENSDART00000135811
ATPase plasma membrane Ca2+ transporting 3a
chr3_+_54168007 17.20 ENSDART00000109894
olfactomedin 2a
chr4_+_8168514 16.93 ENSDART00000150830
ninjurin 2
chr4_+_11375894 16.76 ENSDART00000190471
ENSDART00000143963
piccolo presynaptic cytomatrix protein a
chr17_-_36936856 16.70 ENSDART00000010274
ENSDART00000188887
dihydropyrimidinase-like 5a
chr17_+_26569601 16.45 ENSDART00000153897
neuron-derived neurotrophic factor , like
chr18_+_26895994 16.34 ENSDART00000098347
cholesterol 25-hydroxylase like 1, tandem duplicate 2
chr18_-_38088099 16.00 ENSDART00000146120
leucine zipper protein 2
chr24_-_29997145 15.86 ENSDART00000135094
palmdelphin b
chr17_+_12698532 15.78 ENSDART00000064509
ENSDART00000136830
stathmin-like 4, like
chr17_-_12385308 15.77 ENSDART00000080927
synaptosomal-associated protein, 25b
chr7_-_51546386 15.68 ENSDART00000174306
NHS-like 2
chr15_-_19250543 15.39 ENSDART00000092705
ENSDART00000138895
immunoglobulin superfamily, member 9Ba
chr13_+_27951688 15.35 ENSDART00000050303
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr22_+_18389271 15.03 ENSDART00000088270
YjeF N-terminal domain containing 3
chr15_+_36115955 14.98 ENSDART00000032702
somatostatin 1, tandem duplicate 2
chr13_+_51579851 14.76 ENSDART00000163847
NK6 homeobox 2
chr17_-_8638713 14.75 ENSDART00000148971
C-terminal binding protein 2a
chr2_-_31735142 14.34 ENSDART00000130903
RALY RNA binding protein like
chr22_-_11493236 14.33 ENSDART00000002691
tetraspanin 7b
chr7_-_26408472 14.24 ENSDART00000111494
galactose-3-O-sulfotransferase 4
chr13_-_27660955 14.19 ENSDART00000188651
ENSDART00000134494
regulating synaptic membrane exocytosis 1a
chr4_+_6643421 14.12 ENSDART00000099462
G protein-coupled receptor 85
chr15_+_22311803 14.12 ENSDART00000150182
hepatic and glial cell adhesion molecule a
chr10_+_23022263 13.98 ENSDART00000138955
si:dkey-175g6.2
chr14_-_40389699 13.96 ENSDART00000181581
ENSDART00000173398
protocadherin 19
chr23_-_29505463 13.79 ENSDART00000050915
kinesin family member 1B
chr16_+_39159752 13.45 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr13_+_15816573 13.39 ENSDART00000137061
kinesin light chain 1a
chr23_-_21453614 13.31 ENSDART00000079274
hairy-related 4, tandem duplicate 1
chr4_-_7212875 12.90 ENSDART00000161297
leucine rich repeat neuronal 3b
chr7_+_26629084 12.90 ENSDART00000101044
ENSDART00000173765
heat shock factor binding protein 1a
chr5_+_58372164 12.89 ENSDART00000057910
neurogranin (protein kinase C substrate, RC3) a
chr19_-_30562648 12.84 ENSDART00000171006
hippocalcin like 4
chr23_+_19594608 12.83 ENSDART00000134865
sarcolemma associated protein b
chr19_-_15335787 12.65 ENSDART00000187131
human immunodeficiency virus type I enhancer binding protein 3a
chr7_+_38716048 12.65 ENSDART00000024590
synaptotagmin XIII
chr5_-_35252761 12.58 ENSDART00000051278
transportin 1
chr12_+_25600685 12.55 ENSDART00000077157
SIX homeobox 3b
chr9_+_23255410 12.48 ENSDART00000113241
ENSDART00000137231
transmembrane protein 163a
chr23_+_41799748 12.47 ENSDART00000144257
prodynorphin
chr15_+_5901970 12.46 ENSDART00000114134
tryptophan rich basic protein
chr1_+_14283692 12.41 ENSDART00000017679
protein phosphatase 2, regulatory subunit B, gamma a
chr17_-_17130942 12.41 ENSDART00000064241
neurexin 3a
chr2_-_9915814 12.32 ENSDART00000091644
ENSDART00000177556
abl-interactor 1b
chr15_-_44601331 12.29 ENSDART00000161514
zgc:165508
chr7_-_27686021 12.26 ENSDART00000079112
ENSDART00000100989
calcitonin/calcitonin-related polypeptide, alpha
chr6_+_40523370 12.17 ENSDART00000033819
protein kinase C, delta a
chr25_-_19090479 12.13 ENSDART00000027465
ENSDART00000177670
calcium channel, voltage-dependent, alpha 2/delta subunit 4b
chr10_-_34871737 11.95 ENSDART00000138755
doublecortin-like kinase 1a
chr25_+_19999623 11.90 ENSDART00000026401
zgc:194665
chr24_+_14713776 11.81 ENSDART00000134475
ganglioside induced differentiation associated protein 1
chr11_-_4235811 11.74 ENSDART00000121716
si:ch211-236d3.4
chr4_+_17336557 11.74 ENSDART00000111650
pro-melanin-concentrating hormone
chr10_+_29431529 11.71 ENSDART00000158154
discs, large homolog 2 (Drosophila)
chr5_-_10946232 11.68 ENSDART00000163139
ENSDART00000031265
reticulon 4 receptor
chr23_+_22200467 11.58 ENSDART00000025414
solute carrier family 2 (facilitated glucose transporter), member 1a
chr6_-_14040136 11.51 ENSDART00000065361
ENSDART00000179765
ets variant 5b
chr25_-_15049694 11.44 ENSDART00000162485
ENSDART00000164384
ENSDART00000165632
ENSDART00000159490
paired box 6a
chr22_-_20575679 11.36 ENSDART00000089033
leucine rich repeat and Ig domain containing 3a
chr5_-_23362602 11.34 ENSDART00000137120
glutamate receptor, ionotropic, AMPA 3a
chr14_-_32403554 11.33 ENSDART00000172873
ENSDART00000173408
ENSDART00000173114
ENSDART00000185594
ENSDART00000186762
ENSDART00000010982
fibroblast growth factor 13a
chr13_-_27767330 11.30 ENSDART00000131631
ENSDART00000112553
ENSDART00000189911
regulating synaptic membrane exocytosis 1a
chr10_-_27046639 11.28 ENSDART00000041841
cornichon family AMPA receptor auxiliary protein 2
chr12_+_21299338 11.24 ENSDART00000074540
ENSDART00000133188
carbonic anhydrase Xa
chr2_+_22702488 11.10 ENSDART00000076647
kinesin family member 1Ab
chr24_-_6501211 11.08 ENSDART00000186241
ENSDART00000109040
ENSDART00000136154
G protein-coupled receptor 158a
chr14_+_49135264 11.04 ENSDART00000084119
si:ch1073-44g3.1
chr5_+_70155935 11.01 ENSDART00000165570
regulator of G protein signaling 3a
chr21_-_4032650 10.90 ENSDART00000151648
netrin g2b
chr3_-_35800221 10.82 ENSDART00000031390
CASK interacting protein 1
chr7_-_23996133 10.80 ENSDART00000173761
si:dkey-183c6.8
chr6_-_42073367 10.79 ENSDART00000154304
glutamate receptor, metabotropic 2a
chr10_-_22057001 10.67 ENSDART00000016575
T cell leukemia homeobox 3b
chr14_-_40390757 10.52 ENSDART00000149443
protocadherin 19
chr10_+_21722892 10.49 ENSDART00000162855
protocadherin 1 gamma 13
chr5_+_43965078 10.29 ENSDART00000113502
ENSDART00000187143
si:dkey-84j12.1
chr11_-_23080970 10.25 ENSDART00000127791
ATPase plasma membrane Ca2+ transporting 2
chr9_-_27442339 10.11 ENSDART00000138602
syntaxin binding protein 5-like
chr17_-_26911852 10.08 ENSDART00000045842
regulator of calcineurin 3
chr2_-_3678029 9.94 ENSDART00000146861
matrix metallopeptidase 16b (membrane-inserted)
chr19_-_9503473 9.88 ENSDART00000091615
intermediate filament family orphan 1a
chr25_-_7520937 9.87 ENSDART00000170050
cyclin-dependent kinase inhibitor 1Cb
chr25_-_13381854 9.86 ENSDART00000164621
ENSDART00000169129
NDRG family member 4
chr20_-_29864390 9.79 ENSDART00000161834
ENSDART00000132278
ring finger protein 144ab
chr12_+_19305390 9.75 ENSDART00000183987
ENSDART00000066391
casein kinase 1, epsilon
chr6_-_11792152 9.60 ENSDART00000183403
membrane-associated ring finger (C3HC4) 7
chr18_+_38749547 9.54 ENSDART00000143735
si:ch211-215d8.2
chr12_-_31103187 9.44 ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
ENSDART00000122972
ENSDART00000153068
transcription factor 7 like 2
chr25_+_14017609 9.34 ENSDART00000129105
ENSDART00000125733
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
chr19_+_4912817 9.32 ENSDART00000101658
ENSDART00000165082
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr6_+_55277419 9.25 ENSDART00000083670

chr8_+_32516160 9.24 ENSDART00000061786
neuronal calcium sensor 1b
chr8_+_54081819 9.21 ENSDART00000005857
ENSDART00000161795
prickle homolog 2a
chr2_-_32558795 9.20 ENSDART00000140026
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr13_-_18691041 9.14 ENSDART00000057867
sideroflexin 3
chr5_+_38276582 9.11 ENSDART00000158532
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr18_-_8396192 9.08 ENSDART00000193830
si:ch211-220f12.4
chr17_+_9308425 8.99 ENSDART00000188283
ENSDART00000183311
neuronal PAS domain protein 3
chr2_+_49522178 8.98 ENSDART00000056254
signal transducing adaptor family member 2a
chr1_-_26023678 8.95 ENSDART00000054202
si:ch211-145b13.5
chr9_-_48214216 8.94 ENSDART00000012938
phosphoglycerate dehydrogenase
chr5_-_66702479 8.88 ENSDART00000129197
meningioma 1b
chr21_-_23475361 8.84 ENSDART00000156658
ENSDART00000157454
neural cell adhesion molecule 1a
chr10_+_26515946 8.81 ENSDART00000134276
synaptojanin 1
chr8_+_47342586 8.71 ENSDART00000007624
phospholipase C, eta 2a
chr2_-_34555945 8.70 ENSDART00000056671
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr24_+_4977862 8.68 ENSDART00000114537
zic family member 4
chr24_-_8729716 8.57 ENSDART00000183624
transcription factor AP-2 alpha
chr11_+_25112269 8.56 ENSDART00000147546
ndrg family member 3a
chr6_+_54888493 8.53 ENSDART00000113331
neuron navigator 1b
chr16_-_34338537 8.50 ENSDART00000142223
human immunodeficiency virus type I enhancer binding protein 3b
chr1_+_15226268 8.38 ENSDART00000109911
heparan-alpha-glucosaminide N-acetyltransferase
chr23_+_24611747 8.36 ENSDART00000134978
NCK-associated protein 5-like
chr3_+_17951790 8.30 ENSDART00000164663
ATP citrate lyase a
chr7_-_69983948 8.28 ENSDART00000185827
potassium voltage-gated channel interacting protein 4
chr8_-_40271264 8.23 ENSDART00000188931
lysine (K)-specific demethylase 2Ba
chr13_-_29406534 8.19 ENSDART00000100877
zgc:153142
chr3_+_50312422 8.12 ENSDART00000157689
growth arrest-specific 7a
chr2_-_10062575 8.09 ENSDART00000091726
family with sequence similarity 78, member B a
chr8_-_7308373 8.06 ENSDART00000132009
ENSDART00000145345
glutamate receptor interacting protein 2a
chr1_-_20271138 8.02 ENSDART00000185931
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr22_-_16758438 8.01 ENSDART00000132829
PATJ, crumbs cell polarity complex component
chr18_+_22793743 7.93 ENSDART00000150106
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr3_+_37197686 7.85 ENSDART00000151144
formin-like 1a
chr25_-_518656 7.83 ENSDART00000156421
myosin IXAb
chr22_-_22416337 7.78 ENSDART00000142947
ENSDART00000089569
calmodulin regulated spectrin-associated protein family, member 2a
chr11_-_43473824 7.77 ENSDART00000179561
transmembrane protein 63Bb
chr18_+_19419120 7.77 ENSDART00000025107
mitogen-activated protein kinase kinase 1
chr14_-_7245971 7.75 ENSDART00000108796
storkhead box 2b
chr1_+_10003193 7.72 ENSDART00000162675
tripartite motif containing 2b
chr10_+_44584614 7.71 ENSDART00000163523
seizure related 6 homolog (mouse)-like
chr21_-_36972127 7.70 ENSDART00000100310
drebrin 1
chr13_-_10261383 7.69 ENSDART00000080808
SIX homeobox 3a
chr20_-_15132151 7.68 ENSDART00000063884
si:dkey-239i20.4
chr14_-_2032753 7.68 ENSDART00000111335
protocadherin 2 gamma 5
chr4_-_69189894 7.62 ENSDART00000169596
si:ch211-209j12.1
chr15_-_9272328 7.62 ENSDART00000172114
calmodulin 2a (phosphorylase kinase, delta)
chr4_+_4803698 7.57 ENSDART00000129252
solute carrier family 13 (sodium/sulfate symporter), member 4
chr15_-_25629046 7.48 ENSDART00000155880
TAO kinase 1a
chr19_+_13099541 7.47 ENSDART00000171607
ENSDART00000165448
ENSDART00000170365
regulating synaptic membrane exocytosis 2b
chr8_-_19216657 7.46 ENSDART00000135096
ENSDART00000135869
ENSDART00000145951
si:ch73-222f22.2
si:ch73-222f22.2
chr5_-_38384289 7.46 ENSDART00000135260
misshapen-like kinase 1
chr2_+_45484183 7.43 ENSDART00000183490
si:ch211-66k16.28
chr19_+_9455218 7.42 ENSDART00000139385
si:ch211-288g17.3
chr20_+_26939742 7.41 ENSDART00000138369
ENSDART00000062061
ENSDART00000152992
cell division cycle associated 4
chr4_+_9279784 7.40 ENSDART00000014897
SLIT-ROBO Rho GTPase activating protein 1b
chr20_-_37629084 7.40 ENSDART00000141734
human immunodeficiency virus type I enhancer binding protein 2a
chr22_-_18491813 7.40 ENSDART00000105419
si:ch211-212d10.2
chr5_+_57773222 7.33 ENSDART00000135344
protein phosphatase 2, regulatory subunit A, beta a
chr13_-_23756700 7.28 ENSDART00000057612
regulator of G protein signaling 17
chr20_+_34717403 7.26 ENSDART00000034252
prepronociceptin b
chr18_-_21267103 7.24 ENSDART00000136285
purine nucleoside phosphorylase 6
chr12_+_16087077 7.18 ENSDART00000141898
zinc finger protein 281b
chr8_+_20951590 7.18 ENSDART00000138728
si:dkeyp-82a1.1
chr19_+_27448625 7.17 ENSDART00000052352
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr10_-_25852517 7.17 ENSDART00000191551
transient receptor potential cation channel, subfamily C, member 4a
chr6_+_58698475 7.11 ENSDART00000056138
immunoglobulin superfamily, member 8
chr24_+_4978055 7.10 ENSDART00000045813
zic family member 4
chr2_+_38881165 7.08 ENSDART00000141850
capping protein regulator and myosin 1 linker 3
chr20_-_48485354 7.04 ENSDART00000124040
ENSDART00000148437
insulinoma-associated 1a
chr9_-_10145795 7.04 ENSDART00000004745
ENSDART00000143295
histamine N-methyltransferase
chr19_-_28130658 7.02 ENSDART00000079114
iroquois homeobox 1b
chr3_-_42086577 6.95 ENSDART00000083111
ENSDART00000187312
tweety family member 3a
chr11_-_39044595 6.93 ENSDART00000065461
claudin 19
chr2_-_36819624 6.92 ENSDART00000140844
SLIT and NTRK-like family, member 3b
chr15_-_26636826 6.89 ENSDART00000087632
solute carrier family 47 (multidrug and toxin extrusion), member 4
chr10_+_13279079 6.86 ENSDART00000135082
transmembrane protein 267
chr13_+_3667230 6.85 ENSDART00000131553
ENSDART00000189841
ENSDART00000183554
ENSDART00000018737
QKI, KH domain containing, RNA binding b
chr7_+_1521834 6.81 ENSDART00000174007
si:cabz01102082.1
chr24_+_5840258 6.80 ENSDART00000087034
transient receptor potential cation channel, subfamily C, member 1
chr2_-_37043905 6.79 ENSDART00000056514
guanine nucleotide binding protein (G protein), gamma 7
chr13_-_24218795 6.76 ENSDART00000136217
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
chr9_+_17787864 6.73 ENSDART00000013111
diacylglycerol kinase, eta
chr23_+_21455152 6.66 ENSDART00000158511
ENSDART00000161321
ENSDART00000160731
ENSDART00000137573
hairy-related 4, tandem duplicate 2
chr14_+_33722950 6.64 ENSDART00000075312
apelin
chr14_-_33265068 6.63 ENSDART00000147038
glycerophosphodiester phosphodiesterase domain containing 2
chr8_+_16758304 6.62 ENSDART00000133514
ELOVL fatty acid elongase 7a
chr14_+_33525196 6.57 ENSDART00000085335
zinc finger, DHHC-type containing 9
chr9_-_16877456 6.55 ENSDART00000161105
ENSDART00000160869
F-box and leucine-rich repeat protein 3a

Network of associatons between targets according to the STRING database.

First level regulatory network of gfi1aa+gfi1ab

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0048917 posterior lateral line ganglion development(GO:0048917)
3.8 15.0 GO:0010874 regulation of cholesterol efflux(GO:0010874)
3.6 32.3 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
3.4 13.5 GO:0060074 synapse maturation(GO:0060074)
3.0 8.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
2.9 8.8 GO:0021961 posterior commissure morphogenesis(GO:0021961)
2.6 18.5 GO:0060221 retinal rod cell differentiation(GO:0060221)
2.6 56.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
2.4 9.4 GO:0010226 response to lithium ion(GO:0010226)
2.3 7.0 GO:0001692 histamine metabolic process(GO:0001692)
2.3 6.8 GO:0071470 cellular response to osmotic stress(GO:0071470)
2.2 11.0 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
2.2 15.3 GO:0021534 cell proliferation in hindbrain(GO:0021534)
2.1 14.7 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
2.0 22.4 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
2.0 20.2 GO:0021631 optic nerve morphogenesis(GO:0021631)
2.0 35.2 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
1.9 24.4 GO:0014034 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
1.9 37.4 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
1.8 5.5 GO:0015808 L-alanine transport(GO:0015808)
1.8 25.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.8 5.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
1.8 5.3 GO:0010847 regulation of chromatin assembly(GO:0010847)
1.8 5.3 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
1.8 5.3 GO:0036315 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
1.7 16.8 GO:1904071 presynaptic active zone assembly(GO:1904071)
1.6 4.8 GO:0042373 vitamin K metabolic process(GO:0042373)
1.6 7.8 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
1.4 11.6 GO:0046323 glucose import(GO:0046323)
1.4 18.4 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
1.4 9.9 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
1.3 4.0 GO:0051973 positive regulation of telomerase activity(GO:0051973)
1.3 20.9 GO:0046549 retinal cone cell development(GO:0046549)
1.3 5.1 GO:0060300 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
1.3 6.4 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
1.3 6.4 GO:0007412 axon target recognition(GO:0007412)
1.3 5.1 GO:0007638 mechanosensory behavior(GO:0007638)
1.3 12.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
1.2 12.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
1.2 4.7 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
1.2 12.9 GO:0034605 cellular response to heat(GO:0034605)
1.2 4.6 GO:0006598 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
1.0 45.1 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
1.0 9.2 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
1.0 5.0 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
1.0 14.8 GO:0003310 pancreatic A cell differentiation(GO:0003310)
1.0 28.5 GO:0070593 dendrite self-avoidance(GO:0070593)
0.9 13.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.9 7.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.9 2.6 GO:2000252 negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252)
0.9 5.2 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.8 11.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.8 5.8 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.8 5.8 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.8 5.8 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.8 8.9 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.8 11.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.8 5.6 GO:0018344 protein geranylgeranylation(GO:0018344)
0.8 4.7 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.8 2.4 GO:0003403 optic vesicle formation(GO:0003403)
0.8 12.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.8 11.6 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.8 2.3 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.8 2.3 GO:1904869 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.8 6.1 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.7 7.4 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.7 7.4 GO:0071941 nitrogen cycle metabolic process(GO:0071941) reactive nitrogen species metabolic process(GO:2001057)
0.7 2.2 GO:1990359 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.7 10.9 GO:0008354 germ cell migration(GO:0008354)
0.7 2.2 GO:0015074 DNA integration(GO:0015074)
0.7 11.5 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.7 2.1 GO:0035046 pronuclear migration(GO:0035046)
0.7 15.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.7 31.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.7 2.0 GO:0039529 RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.7 2.0 GO:0051039 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.6 9.4 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.6 6.2 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.6 7.4 GO:0001964 startle response(GO:0001964)
0.6 3.1 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.6 19.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.6 4.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.6 37.0 GO:0050919 negative chemotaxis(GO:0050919)
0.6 4.2 GO:0003321 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996) positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) positive regulation of heart rate(GO:0010460)
0.6 13.0 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.6 3.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.6 9.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.6 12.9 GO:0015701 bicarbonate transport(GO:0015701)
0.6 2.8 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.6 3.3 GO:0045687 positive regulation of glial cell differentiation(GO:0045687) positive regulation of oligodendrocyte differentiation(GO:0048714)
0.5 2.2 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.5 14.0 GO:0006828 manganese ion transport(GO:0006828)
0.5 12.6 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.5 9.4 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.5 5.7 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.5 19.9 GO:0001841 neural tube formation(GO:0001841)
0.5 1.5 GO:2000257 regulation of protein activation cascade(GO:2000257)
0.5 2.0 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.5 4.9 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.5 3.0 GO:0050795 regulation of behavior(GO:0050795)
0.5 3.4 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.5 3.9 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.5 3.8 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.5 19.5 GO:0016126 sterol biosynthetic process(GO:0016126)
0.5 3.3 GO:2001270 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.5 6.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.5 1.4 GO:1903673 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.5 13.1 GO:0055064 chloride ion homeostasis(GO:0055064)
0.4 2.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.4 1.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.4 3.7 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.4 2.9 GO:0070207 protein homotrimerization(GO:0070207)
0.4 4.4 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231) mitotic spindle midzone assembly(GO:0051256)
0.4 8.4 GO:0043153 entrainment of circadian clock(GO:0009649) entrainment of circadian clock by photoperiod(GO:0043153)
0.4 2.8 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.4 6.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.4 21.0 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.4 2.7 GO:0035305 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.4 5.0 GO:0009648 photoperiodism(GO:0009648)
0.4 2.3 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 1.5 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.4 2.6 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.4 14.2 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.4 6.4 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.3 1.4 GO:0072314 glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.3 3.8 GO:0035587 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.3 8.2 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.3 6.1 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.3 0.6 GO:0003404 optic vesicle morphogenesis(GO:0003404)
0.3 39.6 GO:0051260 protein homooligomerization(GO:0051260)
0.3 5.8 GO:0007631 feeding behavior(GO:0007631)
0.3 2.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 6.6 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 3.5 GO:0021684 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) cerebellar granule cell differentiation(GO:0021707)
0.3 12.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.3 4.1 GO:0090309 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.3 9.9 GO:0030574 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.3 0.9 GO:1903537 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.3 0.6 GO:0051972 regulation of telomerase activity(GO:0051972)
0.3 2.1 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.3 11.2 GO:0036269 swimming behavior(GO:0036269)
0.3 10.6 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 2.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.3 1.9 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.3 1.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.3 0.8 GO:0000212 meiotic spindle organization(GO:0000212)
0.3 1.9 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.3 0.8 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
0.3 3.4 GO:0010717 regulation of epithelial to mesenchymal transition(GO:0010717)
0.2 4.1 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.2 6.8 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.2 22.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 8.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 2.3 GO:0046850 regulation of bone remodeling(GO:0046850)
0.2 3.4 GO:0033344 cholesterol efflux(GO:0033344)
0.2 24.7 GO:0032147 activation of protein kinase activity(GO:0032147)
0.2 10.4 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.2 3.6 GO:0002574 thrombocyte differentiation(GO:0002574)
0.2 6.8 GO:0050708 regulation of protein secretion(GO:0050708)
0.2 3.8 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.2 2.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.2 14.9 GO:0051170 nuclear import(GO:0051170)
0.2 3.7 GO:0046660 female sex differentiation(GO:0046660)
0.2 4.5 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.2 7.7 GO:0001764 neuron migration(GO:0001764)
0.2 3.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.2 19.0 GO:0008360 regulation of cell shape(GO:0008360)
0.2 3.2 GO:0031297 replication fork processing(GO:0031297)
0.2 6.2 GO:0001878 response to yeast(GO:0001878)
0.2 26.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 2.9 GO:0014029 neural crest formation(GO:0014029)
0.2 12.6 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
0.2 1.9 GO:0050936 xanthophore differentiation(GO:0050936)
0.2 1.6 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.2 4.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 1.3 GO:0034063 stress granule assembly(GO:0034063)
0.2 3.9 GO:0003171 atrioventricular valve development(GO:0003171)
0.1 0.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 1.2 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228) synaptic transmission, GABAergic(GO:0051932)
0.1 4.0 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 3.2 GO:0002097 tRNA wobble base modification(GO:0002097)
0.1 16.0 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.1 2.5 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.1 3.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 24.5 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 3.6 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.1 1.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 3.2 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 5.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 5.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 5.4 GO:0007254 JNK cascade(GO:0007254)
0.1 0.6 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.1 2.9 GO:0048264 determination of ventral identity(GO:0048264)
0.1 3.0 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.8 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.1 0.4 GO:0048478 replication fork protection(GO:0048478)
0.1 1.1 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 8.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 4.2 GO:0032456 endocytic recycling(GO:0032456)
0.1 2.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.1 0.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.7 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.1 4.9 GO:0045214 sarcomere organization(GO:0045214)
0.1 1.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 12.6 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.1 5.7 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 0.8 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 3.5 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 3.0 GO:0050684 regulation of mRNA processing(GO:0050684)
0.1 0.5 GO:0035475 angioblast cell migration involved in selective angioblast sprouting(GO:0035475)
0.1 9.2 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 3.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 0.6 GO:0003315 heart rudiment formation(GO:0003315)
0.1 0.3 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.1 3.5 GO:0035082 axoneme assembly(GO:0035082)
0.1 1.1 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 2.0 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 1.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.1 0.5 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 2.3 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.1 1.2 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.1 4.4 GO:0006821 chloride transport(GO:0006821)
0.1 1.8 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.1 4.4 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 2.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.3 GO:0008217 regulation of blood pressure(GO:0008217)
0.1 0.4 GO:1905066 regulation of Wnt signaling pathway involved in heart development(GO:0003307) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 2.4 GO:0061572 actin filament bundle organization(GO:0061572)
0.0 0.7 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.8 GO:0035459 cargo loading into vesicle(GO:0035459)
0.0 0.7 GO:0006265 DNA topological change(GO:0006265)
0.0 2.5 GO:0060215 primitive hemopoiesis(GO:0060215)
0.0 0.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.2 GO:0019835 cytolysis(GO:0019835)
0.0 1.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 3.2 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 1.1 GO:0031647 regulation of protein stability(GO:0031647)
0.0 0.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 21.3 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 3.2 GO:0008033 tRNA processing(GO:0008033)
0.0 0.2 GO:0045444 fat cell differentiation(GO:0045444)
0.0 1.6 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.3 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 2.5 GO:0055080 cation homeostasis(GO:0055080)
0.0 0.4 GO:0072666 protein targeting to vacuole(GO:0006623) establishment of protein localization to vacuole(GO:0072666)
0.0 1.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.4 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 22.7 GO:0060077 inhibitory synapse(GO:0060077)
4.7 18.6 GO:0043291 RAVE complex(GO:0043291)
2.6 15.8 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
2.4 9.4 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
2.3 67.7 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788)
2.2 37.5 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
2.2 6.5 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
1.8 5.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
1.5 12.2 GO:0001772 immunological synapse(GO:0001772)
1.4 4.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
1.4 5.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
1.4 4.1 GO:1990745 EARP complex(GO:1990745)
1.3 5.1 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
1.2 8.5 GO:0043194 axon initial segment(GO:0043194)
1.2 5.9 GO:0042824 MHC class I peptide loading complex(GO:0042824)
1.0 49.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.0 43.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.0 22.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
1.0 30.4 GO:0031594 neuromuscular junction(GO:0031594)
0.9 2.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.9 9.4 GO:1904949 ATPase dependent transmembrane transport complex(GO:0098533) ATPase complex(GO:1904949)
0.9 12.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.8 12.5 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.8 7.8 GO:0036449 microtubule minus-end(GO:0036449)
0.8 3.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.7 4.4 GO:0016589 NURF complex(GO:0016589)
0.7 2.8 GO:0097255 R2TP complex(GO:0097255)
0.7 4.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.7 21.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.6 1.2 GO:0035253 ciliary rootlet(GO:0035253)
0.6 11.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.6 19.7 GO:0043679 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.6 9.2 GO:0071564 npBAF complex(GO:0071564)
0.6 2.8 GO:0005899 insulin receptor complex(GO:0005899)
0.5 3.5 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.5 10.9 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.5 8.3 GO:0035371 microtubule plus-end(GO:0035371) microtubule end(GO:1990752)
0.5 3.6 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.4 4.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.4 8.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.4 6.6 GO:0016363 nuclear matrix(GO:0016363)
0.4 3.7 GO:0089701 U2AF(GO:0089701)
0.4 34.7 GO:0005871 kinesin complex(GO:0005871)
0.4 11.8 GO:0035861 site of double-strand break(GO:0035861)
0.4 13.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 19.2 GO:0030426 growth cone(GO:0030426)
0.4 3.5 GO:0034451 centriolar satellite(GO:0034451)
0.4 13.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 2.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 4.6 GO:0048179 activin receptor complex(GO:0048179)
0.3 2.2 GO:0030897 HOPS complex(GO:0030897)
0.3 3.3 GO:0044545 NSL complex(GO:0044545)
0.3 4.0 GO:0070187 telosome(GO:0070187)
0.3 14.6 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.3 2.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 3.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 8.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 4.5 GO:0070822 Sin3-type complex(GO:0070822)
0.2 51.3 GO:0030424 axon(GO:0030424)
0.2 5.0 GO:0030427 site of polarized growth(GO:0030427)
0.2 4.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 5.5 GO:0034702 ion channel complex(GO:0034702)
0.2 3.7 GO:0030008 TRAPP complex(GO:0030008)
0.2 14.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 6.8 GO:0098978 glutamatergic synapse(GO:0098978)
0.2 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 7.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.4 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.2 12.6 GO:0043025 neuronal cell body(GO:0043025)
0.2 2.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.2 7.1 GO:0042734 presynaptic membrane(GO:0042734)
0.2 14.0 GO:0034703 cation channel complex(GO:0034703)
0.2 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 3.6 GO:0035102 PRC1 complex(GO:0035102)
0.2 2.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 25.8 GO:0036477 dendrite(GO:0030425) somatodendritic compartment(GO:0036477)
0.1 0.4 GO:0032997 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
0.1 0.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 10.1 GO:0031201 SNARE complex(GO:0031201)
0.1 2.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 37.3 GO:0043005 neuron projection(GO:0043005)
0.1 11.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 0.6 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 8.0 GO:0031902 late endosome membrane(GO:0031902)
0.1 5.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 4.1 GO:0072686 mitotic spindle(GO:0072686)
0.1 2.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 23.4 GO:0005911 cell-cell junction(GO:0005911)
0.1 1.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.6 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.1 39.2 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.4 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 5.9 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.1 22.1 GO:0031012 extracellular matrix(GO:0031012)
0.1 26.7 GO:0005794 Golgi apparatus(GO:0005794)
0.1 2.7 GO:0016592 mediator complex(GO:0016592)
0.1 0.2 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 5.8 GO:0043235 receptor complex(GO:0043235)
0.1 1.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.1 13.8 GO:0045202 synapse(GO:0045202)
0.0 1.5 GO:0030175 filopodium(GO:0030175)
0.0 3.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.2 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0060091 radial spoke(GO:0001534) kinocilium(GO:0060091)
0.0 0.7 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 38.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 13.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 2.2 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.0 0.8 GO:0045495 pole plasm(GO:0045495)
0.0 0.5 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 38.7 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
6.1 18.4 GO:0031716 calcitonin receptor binding(GO:0031716)
5.7 85.8 GO:0005504 fatty acid binding(GO:0005504)
3.8 15.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
2.9 35.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
2.8 41.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.5 19.7 GO:0031628 opioid receptor binding(GO:0031628)
2.4 14.6 GO:0022889 serine transmembrane transporter activity(GO:0022889)
2.3 16.3 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
2.2 6.5 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
2.1 6.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
2.0 5.9 GO:0046978 TAP1 binding(GO:0046978)
1.8 5.5 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
1.8 37.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.7 5.1 GO:0031701 angiotensin receptor binding(GO:0031701)
1.7 10.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
1.6 11.3 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
1.6 14.2 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
1.6 4.7 GO:0031704 apelin receptor binding(GO:0031704)
1.5 10.8 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
1.4 18.4 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
1.4 5.6 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
1.3 18.0 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596)
1.3 17.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.2 9.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
1.2 10.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
1.1 8.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.1 9.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.1 3.2 GO:0052717 tRNA-specific adenosine-34 deaminase activity(GO:0052717)
1.1 5.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
1.1 7.4 GO:0098809 nitrite reductase activity(GO:0098809)
1.0 6.3 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
1.0 8.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.0 9.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
1.0 12.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.9 27.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.9 16.8 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.9 5.4 GO:0008142 oxysterol binding(GO:0008142)
0.9 22.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.9 2.6 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.9 7.8 GO:0030507 spectrin binding(GO:0030507)
0.9 28.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.9 13.7 GO:0048495 Roundabout binding(GO:0048495)
0.9 7.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.8 48.4 GO:0044325 ion channel binding(GO:0044325)
0.8 7.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.8 21.0 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.8 7.0 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.8 25.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.8 5.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.7 6.0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.7 7.4 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.7 12.6 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.7 29.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 6.5 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.7 6.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.7 8.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.7 4.6 GO:0019809 spermidine binding(GO:0019809)
0.7 3.9 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.7 15.0 GO:0016854 racemase and epimerase activity(GO:0016854)
0.6 15.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.6 8.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.6 10.1 GO:0045159 myosin II binding(GO:0045159)
0.6 15.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.6 34.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.6 2.8 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.5 2.2 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.5 11.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 5.4 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.5 12.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.5 4.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.5 3.6 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.5 4.7 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.5 3.1 GO:0008126 acetylesterase activity(GO:0008126)
0.5 7.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.5 3.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.5 9.4 GO:0001671 ATPase activator activity(GO:0001671)
0.5 5.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.5 10.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.5 2.3 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.4 6.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.4 5.2 GO:0042285 xylosyltransferase activity(GO:0042285)
0.4 6.7 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.4 12.8 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.4 36.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.4 10.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.4 1.5 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.4 7.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.4 3.7 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.3 11.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 2.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 7.7 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.3 0.9 GO:0031530 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.3 2.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.3 6.6 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 12.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 6.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.3 11.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 4.6 GO:0017002 activin-activated receptor activity(GO:0017002)
0.3 1.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.3 2.5 GO:0016918 retinal binding(GO:0016918)
0.2 18.3 GO:0051287 NAD binding(GO:0051287)
0.2 7.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 1.0 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.2 5.7 GO:0031267 small GTPase binding(GO:0031267)
0.2 4.8 GO:0048038 quinone binding(GO:0048038)
0.2 1.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 0.7 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.2 10.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 1.1 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.2 1.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 7.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 2.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.2 3.9 GO:0005272 sodium channel activity(GO:0005272)
0.2 1.9 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.2 1.5 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.2 11.0 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.2 8.2 GO:0032452 histone demethylase activity(GO:0032452)
0.2 18.0 GO:0008201 heparin binding(GO:0008201)
0.2 9.8 GO:0008013 beta-catenin binding(GO:0008013)
0.2 1.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 1.0 GO:0038132 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.2 1.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 14.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 16.9 GO:0005179 hormone activity(GO:0005179)
0.2 1.7 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 3.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 2.4 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.2 10.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 3.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 4.2 GO:0004707 MAP kinase activity(GO:0004707)
0.2 9.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 0.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.2 2.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 3.6 GO:0035591 signaling adaptor activity(GO:0035591)
0.1 0.4 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
0.1 3.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 6.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.3 GO:0051787 misfolded protein binding(GO:0051787)
0.1 4.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 3.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.1 18.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.8 GO:0008143 poly(A) binding(GO:0008143)
0.1 1.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 2.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.7 GO:0034452 dynactin binding(GO:0034452)
0.1 3.1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.6 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.1 9.0 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 1.4 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.1 GO:0005487 nuclear export signal receptor activity(GO:0005049) nucleocytoplasmic transporter activity(GO:0005487)
0.1 14.4 GO:0060090 binding, bridging(GO:0060090)
0.1 2.6 GO:0005112 Notch binding(GO:0005112)
0.1 5.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 14.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 4.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 18.8 GO:0042802 identical protein binding(GO:0042802)
0.1 15.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 5.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.1 2.3 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 3.4 GO:0008066 glutamate receptor activity(GO:0008066)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 4.4 GO:0003678 DNA helicase activity(GO:0003678)
0.1 4.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 1.5 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.1 1.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.1 5.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 5.6 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 1.2 GO:0016878 acid-thiol ligase activity(GO:0016878)
0.1 1.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.4 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 6.0 GO:0042393 histone binding(GO:0042393)
0.0 0.8 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 1.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 14.4 GO:0015631 tubulin binding(GO:0015631)
0.0 0.6 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 14.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.1 GO:0000049 tRNA binding(GO:0000049)
0.0 2.5 GO:0008168 methyltransferase activity(GO:0008168)
0.0 16.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.9 GO:0003682 chromatin binding(GO:0003682)
0.0 5.2 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.8 5.7 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.7 11.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.5 22.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.4 2.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 12.0 PID EPHB FWD PATHWAY EPHB forward signaling
0.4 7.8 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.4 9.5 PID FAS PATHWAY FAS (CD95) signaling pathway
0.3 2.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2 11.2 PID AP1 PATHWAY AP-1 transcription factor network
0.2 12.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.2 4.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 8.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 4.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 3.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 8.4 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 4.2 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 5.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.2 5.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 3.1 PID FGF PATHWAY FGF signaling pathway
0.1 4.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID ATR PATHWAY ATR signaling pathway
0.0 0.5 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 2.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.6 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 46.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
1.4 12.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
1.4 12.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
1.3 7.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.9 8.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.8 10.2 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.8 21.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.7 4.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.7 5.8 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.7 7.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.7 5.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.7 9.2 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.6 8.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.6 4.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.6 4.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.6 13.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.5 10.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.5 4.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.4 2.5 REACTOME OPSINS Genes involved in Opsins
0.4 4.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 4.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.4 5.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.4 6.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 3.8 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.3 16.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 1.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.3 5.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 6.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 2.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 15.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.3 5.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 17.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 7.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 6.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 3.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 1.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 9.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 1.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 2.6 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.2 2.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 1.3 REACTOME SHC MEDIATED SIGNALLING Genes involved in SHC-mediated signalling
0.1 4.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.5 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 3.4 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 5.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 4.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.7 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1 1.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.9 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.4 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway