ISMARA results: foxi1+foxi2+foxi3a+foxi3b

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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for foxi1+foxi2+foxi3a+foxi3b

Z-value: 1.31

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Transcription factors associated with foxi1+foxi2+foxi3a+foxi3b

Gene Symbol	Gene ID	Gene Info
foxi3b NCBI UniProt	ENSDARG00000009550	forkhead box I3b
foxi3a NCBI UniProt	ENSDARG00000055926	forkhead box I3a
foxi2 NCBI UniProt	ENSDARG00000069715	forkhead box I2
foxi1 NCBI UniProt	ENSDARG00000104566	forkhead box i1
foxi3b NCBI UniProt	ENSDARG00000112022	forkhead box I3b
foxi3b NCBI UniProt	ENSDARG00000112303	forkhead box I3b
foxi2 NCBI UniProt	ENSDARG00000116791	forkhead box I2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
foxi3a	dr11_v1_chr21_+_30351256_30351256	-0.50	2.2e-07	Click!
foxi3b	dr11_v1_chr14_+_34514336_34514336	-0.47	1.9e-06	Click!
foxi1	dr11_v1_chr12_-_43664682_43664682	0.35	6.0e-04	Click!
foxi2	dr11_v1_chr13_+_13578552_13578552	-0.20	5.9e-02	Click!

Activity profile of foxi1+foxi2+foxi3a+foxi3b motif

Sorted Z-values of foxi1+foxi2+foxi3a+foxi3b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_37837245 Show fit	34.17	ENSDART00000171617	epd NCBI UniProt Show fit	ependymin
chr6_-_35446110 Show fit	22.30	ENSDART00000058773	rgs16 NCBI UniProt Show fit	regulator of G protein signaling 16
chr14_-_32016615 Show fit	19.74	ENSDART00000105761	zic3 NCBI UniProt Show fit	zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr4_+_8797197 Show fit	18.75	ENSDART00000158671	sult4a1 NCBI UniProt Show fit	sulfotransferase family 4A, member 1
chr8_-_14049404 Show fit	17.49	ENSDART00000093117	atp2b3a NCBI UniProt Show fit	ATPase plasma membrane Ca2+ transporting 3a
chr16_-_17207754 Show fit	16.31	ENSDART00000063804	wu:fj39g12 NCBI UniProt Show fit	wu:fj39g12
chr10_-_24343507 Show fit	15.77	ENSDART00000002974	pitpnab NCBI UniProt Show fit	phosphatidylinositol transfer protein, alpha b
chr10_+_17850934 Show fit	14.65	ENSDART00000113666 ENSDART00000145936	phf24 NCBI UniProt Show fit	PHD finger protein 24
chr24_-_17444067 Show fit	14.51	ENSDART00000155843	cntnap2a NCBI UniProt Show fit	contactin associated protein like 2a
chr5_+_36768674 Show fit	13.90	ENSDART00000146854	mark4a NCBI UniProt Show fit	MAP/microtubule affinity-regulating kinase 4a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of foxi1+foxi2+foxi3a+foxi3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	40.4	GO:0007160	cell-matrix adhesion(GO:0007160)
0.2	38.2	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1	20.2	GO:0042391	regulation of membrane potential(GO:0042391)
0.3	19.7	GO:0009948	anterior/posterior axis specification(GO:0009948)
0.8	19.4	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.7	18.8	GO:0051923	sulfation(GO:0051923)
0.2	14.8	GO:0015914	phospholipid transport(GO:0015914)
2.9	14.5	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
1.3	13.5	GO:0050714	positive regulation of protein secretion(GO:0050714)
0.5	13.2	GO:0031114	regulation of microtubule depolymerization(GO:0031114)

Showing 1 to 10 of 110 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	59.2	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	27.5	GO:0005764	lysosome(GO:0005764)
1.8	14.5	GO:0033010	paranodal junction(GO:0033010)
0.9	14.5	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
0.1	13.2	GO:0005875	microtubule associated complex(GO:0005875)
0.0	12.8	GO:0043005	neuron projection(GO:0043005)
0.0	12.5	GO:0031012	extracellular matrix(GO:0031012)
1.5	11.9	GO:0016586	RSC complex(GO:0016586)
0.5	11.5	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.3	11.2	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	56.3	GO:0005509	calcium ion binding(GO:0005509)
0.1	24.0	GO:0008017	microtubule binding(GO:0008017)
0.1	20.2	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.0	19.1	GO:0008270	zinc ion binding(GO:0008270)
0.2	18.8	GO:0008146	sulfotransferase activity(GO:0008146)
0.6	17.5	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.1	17.0	GO:0005516	calmodulin binding(GO:0005516)
2.3	15.8	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.1	15.8	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.7	14.5	GO:0031681	G-protein beta-subunit binding(GO:0031681)

Showing 1 to 10 of 77 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.3	8.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.4	7.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	7.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.6	6.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	5.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.2	4.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	3.7	PID ARF 3PATHWAY	Arf1 pathway
0.1	3.3	PID ATM PATHWAY	ATM pathway
0.2	3.1	PID CXCR3 PATHWAY	CXCR3-mediated signaling events

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	18.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.9	14.5	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.7	9.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.5	7.5	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.5	7.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.1	6.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	6.4	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	5.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.2	4.7	REACTOME KINESINS	Genes involved in Kinesins
0.4	4.4	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway

Showing 1 to 10 of 30 entries

Results for foxi1+foxi2+foxi3a+foxi3b

Z-value: 1.31

Motif logo

Transcription factors associated with foxi1+foxi2+foxi3a+foxi3b

Activity-expression correlation:

Activity profile of foxi1+foxi2+foxi3a+foxi3b motif

Sorted Z-values of foxi1+foxi2+foxi3a+foxi3b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of foxi1+foxi2+foxi3a+foxi3b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: