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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for foxh1+foxq1a+foxq1b
Z-value: 1.34
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Transcription factors associated with foxh1+foxq1a+foxq1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxh1 | dr11_v1_chr12_-_13729263_13729263 | 0.64 | 3.4e-12 | Click! |
| foxq1b | dr11_v1_chr20_+_26683933_26683940 | 0.42 | 2.0e-05 | Click! |
| foxq1a | dr11_v1_chr2_-_722156_722170 | 0.23 | 2.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_37837245 Show fit | 41.27 |
ENSDART00000171617
|
ependymin |
|
| chr17_+_15534815 Show fit | 19.29 |
ENSDART00000159426
|
myristoylated alanine-rich protein kinase C substrate b |
|
| chr4_+_8797197 Show fit | 12.37 |
ENSDART00000158671
|
sulfotransferase family 4A, member 1 |
|
| chr9_+_31282161 Show fit | 11.97 |
ENSDART00000010774
|
zic family member 2 (odd-paired homolog, Drosophila), a |
|
| chr16_-_28856112 Show fit | 11.65 |
ENSDART00000078543
|
synaptotagmin XIb |
|
| chr3_+_29714775 Show fit | 10.68 |
ENSDART00000041388
|
calcium channel, voltage-dependent, gamma subunit 2a |
|
| chr14_+_33458294 Show fit | 9.24 |
ENSDART00000075278
|
ATPase Na+/K+ transporting subunit beta 4 |
|
| chr6_-_9792004 Show fit | 9.17 |
ENSDART00000081129
|
cyclin-dependent kinase 15 |
|
| chr14_-_24410673 Show fit | 9.09 |
ENSDART00000125923
|
chemokine (C-X-C motif) ligand 14 |
|
| chr1_+_35790082 Show fit | 8.21 |
ENSDART00000085051
|
hedgehog interacting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxh1+foxq1a+foxq1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 41.3 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 1.1 | 19.2 | GO:0003382 | epithelial cell morphogenesis(GO:0003382) |
| 0.3 | 14.6 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.4 | 12.4 | GO:0051923 | sulfation(GO:0051923) |
| 2.0 | 12.0 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
| 0.3 | 12.0 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 0.1 | 11.2 | GO:0060326 | cell chemotaxis(GO:0060326) |
| 0.1 | 11.1 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.6 | 10.7 | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943) |
| 0.0 | 9.4 | GO:0060271 | cilium morphogenesis(GO:0060271) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.7 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 15.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 13.0 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.5 | 11.7 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.1 | 11.6 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.2 | 10.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.6 | 10.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 10.1 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.9 | 9.2 | GO:0090533 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
| 0.1 | 9.0 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 19.3 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 17.6 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.2 | 14.5 | GO:0016247 | channel regulator activity(GO:0016247) |
| 0.2 | 12.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 11.9 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.2 | 11.6 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 11.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 10.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.9 | 9.2 | GO:0030332 | cyclin binding(GO:0030332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.9 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 5.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.3 | 5.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.4 | 4.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 2.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 2.2 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 2.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 1.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 12.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 9.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.6 | 5.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 5.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 4.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 4.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 4.5 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.4 | 4.5 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 4.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 4.1 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |