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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for foxd3
Z-value: 1.42
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Transcription factors associated with foxd3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxd3 | dr11_v1_chr6_-_32093830_32093830 | -0.43 | 1.8e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_24559947 Show fit | 10.75 |
ENSDART00000169847
|
WD repeat domain 47b |
|
| chr24_+_25692802 Show fit | 10.30 |
ENSDART00000190493
|
calcium/calmodulin-dependent protein kinase II inhibitor 2 |
|
| chr7_-_49594995 Show fit | 9.50 |
ENSDART00000174161
ENSDART00000109147 |
BR serine/threonine kinase 2b |
|
| chr12_+_28888975 Show fit | 9.17 |
ENSDART00000076362
|
phosphorylase kinase, gamma 2 (testis) |
|
| chr20_-_28800999 Show fit | 8.05 |
ENSDART00000049462
|
RAB15, member RAS oncogene family |
|
| chr11_+_35364445 Show fit | 7.22 |
ENSDART00000125766
|
CaM kinase-like vesicle-associated b |
|
| chr5_+_36768674 Show fit | 7.13 |
ENSDART00000146854
|
MAP/microtubule affinity-regulating kinase 4a |
|
| chr1_+_16396870 Show fit | 7.05 |
ENSDART00000189245
ENSDART00000113266 |
mitochondrial calcium uptake family, member 3a |
|
| chr9_+_31282161 Show fit | 6.57 |
ENSDART00000010774
|
zic family member 2 (odd-paired homolog, Drosophila), a |
|
| chr2_+_34967022 Show fit | 6.52 |
ENSDART00000134926
|
astrotactin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxd3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.6 | 24.3 | GO:0046883 | regulation of hormone secretion(GO:0046883) |
| 1.7 | 12.1 | GO:0033278 | cell proliferation in midbrain(GO:0033278) |
| 0.4 | 11.8 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 3.8 | 11.4 | GO:0060838 | lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845) |
| 0.1 | 11.0 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 10.0 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 9.6 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.1 | 9.3 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.1 | 8.8 | GO:0006836 | neurotransmitter transport(GO:0006836) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.8 | GO:0005874 | microtubule(GO:0005874) |
| 0.3 | 21.9 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 17.1 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 15.9 | GO:0005813 | centrosome(GO:0005813) |
| 0.4 | 15.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.2 | 11.8 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 11.0 | GO:0005770 | late endosome(GO:0005770) |
| 0.8 | 9.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 8.6 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.5 | 8.4 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.6 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.2 | 16.9 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.8 | 16.6 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.1 | 15.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 15.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.4 | 11.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 11.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 1.7 | 10.3 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858) |
| 0.7 | 10.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 9.9 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.3 | 11.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 8.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 3.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 3.2 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 3.1 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 3.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 2.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.7 | 9.2 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 8.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.5 | 8.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 1.2 | 7.2 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.2 | 6.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 1.5 | 5.9 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.3 | 4.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 4.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 4.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |