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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for foxb1b+foxb2
Z-value: 1.29
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Transcription factors associated with foxb1b+foxb2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxb1b | dr11_v1_chr7_+_29461060_29461060 | 0.68 | 3.5e-14 | Click! |
| foxb2 | dr11_v1_chr8_-_38506339_38506339 | 0.61 | 8.4e-11 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_-_19953089 Show fit | 18.22 |
ENSDART00000153828
|
ATPase plasma membrane Ca2+ transporting 3b |
|
| chr23_-_27633730 Show fit | 10.51 |
ENSDART00000103639
|
ADP-ribosylation factor 3a |
|
| chr6_+_36942966 Show fit | 10.24 |
ENSDART00000028895
|
neuronal growth regulator 1 |
|
| chr20_-_34801181 Show fit | 9.87 |
ENSDART00000048375
ENSDART00000132426 |
stathmin-like 4 |
|
| chr4_+_8797197 Show fit | 9.80 |
ENSDART00000158671
|
sulfotransferase family 4A, member 1 |
|
| chr12_+_28367557 Show fit | 9.75 |
ENSDART00000066294
|
cyclin-dependent kinase 5, regulatory subunit 1b (p35) |
|
| chr14_-_7885707 Show fit | 9.34 |
ENSDART00000029981
|
protein phosphatase 3, catalytic subunit, beta isozyme |
|
| chr14_-_26177156 Show fit | 9.32 |
ENSDART00000014149
|
FAT atypical cadherin 2 |
|
| chr19_+_10396042 Show fit | 9.25 |
ENSDART00000028048
ENSDART00000151735 |
NECAP endocytosis associated 1 |
|
| chr23_-_29502287 Show fit | 8.89 |
ENSDART00000141075
ENSDART00000053807 |
kinesin family member 1B |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxb1b+foxb2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 20.8 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 20.3 | GO:0006397 | mRNA processing(GO:0006397) |
| 1.0 | 15.2 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 4.9 | 14.8 | GO:0048917 | posterior lateral line ganglion development(GO:0048917) |
| 0.0 | 14.2 | GO:0031175 | neuron projection development(GO:0031175) |
| 0.3 | 12.4 | GO:0021854 | hypothalamus development(GO:0021854) |
| 1.9 | 11.6 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.7 | 11.6 | GO:0035268 | protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502) |
| 0.1 | 11.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 10.1 | GO:0032147 | activation of protein kinase activity(GO:0032147) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.1 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 26.1 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 25.1 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 25.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 16.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 16.0 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.1 | 16.0 | GO:0098791 | Golgi subcompartment(GO:0098791) |
| 3.1 | 15.5 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.3 | 11.8 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.1 | 11.8 | GO:0005681 | spliceosomal complex(GO:0005681) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 48.7 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 21.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.7 | 19.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 16.9 | GO:0060090 | binding, bridging(GO:0060090) |
| 1.2 | 15.5 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.0 | 15.5 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.4 | 14.8 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 14.1 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.7 | 11.5 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 10.0 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.7 | 9.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 6.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 5.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 5.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 4.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 4.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 4.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 3.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 15.2 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.2 | 14.4 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.1 | 13.0 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 2.4 | 9.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.5 | 9.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.9 | 7.7 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.2 | 5.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.3 | 4.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 4.8 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.4 | 4.7 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |