Project

PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

Navigation
Downloads

Results for foxa_foxa1_foxa2

Z-value: 2.57

Motif logo

Transcription factors associated with foxa_foxa1_foxa2

Gene Symbol Gene ID Gene Info
ENSDARG00000087094 forkhead box A sequence
ENSDARG00000110743 forkhead box A sequence
ENSDARG00000115019 forkhead box A sequence
ENSDARG00000102138 forkhead box A1
ENSDARG00000003411 forkhead box A2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxa2dr11_v1_chr17_-_42568498_425684980.843.5e-26Click!
foxa1dr11_v1_chr17_+_10318071_103180710.581.2e-09Click!
foxadr11_v1_chr14_-_33981544_339815440.084.3e-01Click!

Activity profile of foxa_foxa1_foxa2 motif

Sorted Z-values of foxa_foxa1_foxa2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_6142433 84.64 ENSDART00000054084
ENSDART00000136986
transthyretin (prealbumin, amyloidosis type I)
chr5_+_28830643 68.08 ENSDART00000051448
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr16_+_23978978 68.02 ENSDART00000058964
ENSDART00000135084
apolipoprotein A-II
chr22_-_36856405 66.57 ENSDART00000029588
kininogen 1
chr5_+_28830388 63.86 ENSDART00000149150
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_+_10134345 63.40 ENSDART00000100725
alpha-2-HS-glycoprotein 2
chr5_+_28857969 62.21 ENSDART00000149850
si:ch211-186e20.2
chr16_-_54455573 61.37 ENSDART00000075275
pyruvate kinase L/R
chr5_+_28848870 59.80 ENSDART00000149563
zgc:174259
chr5_+_28849155 58.15 ENSDART00000079090
zgc:174259
chr23_+_28770225 57.63 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr5_+_28797771 56.55 ENSDART00000188845
ENSDART00000149066
si:ch211-186e20.7
chr5_+_28858345 45.89 ENSDART00000111180
si:ch211-186e20.2
chr2_+_16781015 43.46 ENSDART00000155147
ENSDART00000003845
transferrin-a
chr2_+_16780643 42.49 ENSDART00000125647
ENSDART00000108611
ENSDART00000181245
ENSDART00000163194
transferrin-a
chr6_-_55864687 41.34 ENSDART00000160991
cytochrome P450, family 24, subfamily A, polypeptide 1
chr15_+_14856307 40.70 ENSDART00000167213
diablo, IAP-binding mitochondrial protein a
chr10_+_17026870 37.76 ENSDART00000184529
ENSDART00000157480

chr4_-_16824556 37.13 ENSDART00000165289
ENSDART00000185839
glycogen synthase 2
chr4_-_16824231 36.77 ENSDART00000014007
glycogen synthase 2
chr12_+_31616412 35.69 ENSDART00000124439
carboxypeptidase N, polypeptide 1
chr10_+_26747755 30.73 ENSDART00000100329
coagulation factor IXb
chr22_-_24967348 29.42 ENSDART00000153490
ENSDART00000084871
family with sequence similarity 20, member C like
chr16_-_31661536 28.97 ENSDART00000169973
wu:fd46c06
chr10_+_7709724 28.93 ENSDART00000097670
gamma-glutamyl carboxylase
chr23_+_44881020 28.03 ENSDART00000149355
si:ch73-361h17.1
chr20_+_23440632 27.64 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr14_-_36799280 26.63 ENSDART00000168615
ring finger protein 130
chr23_-_31763753 25.34 ENSDART00000053399
aldehyde dehydrogenase 8 family, member A1
chr6_+_6780873 22.85 ENSDART00000011865
Sec23 homolog B, COPII coat complex component
chr4_+_1530287 21.18 ENSDART00000067446
solute carrier family 38, member 4
chr17_+_24036791 20.99 ENSDART00000140767
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2b
chr21_+_27416284 20.58 ENSDART00000077593
ENSDART00000108763
complement factor B
chr4_+_18806251 19.46 ENSDART00000138662
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr7_+_69019851 19.25 ENSDART00000162891

chr20_+_26881600 18.04 ENSDART00000174799
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr2_+_1486822 17.94 ENSDART00000132500
complement component 8, alpha polypeptide
chr2_+_1487118 17.81 ENSDART00000147283
complement component 8, alpha polypeptide
chr13_+_23988442 17.04 ENSDART00000010918
angiotensinogen
chr16_+_14588141 17.02 ENSDART00000140469
ENSDART00000059984
ENSDART00000167411
ENSDART00000133566
DEP domain containing MTOR-interacting protein
chr8_+_30709685 16.96 ENSDART00000133989
ureidopropionase, beta
chr5_+_65991152 16.69 ENSDART00000097756
lipocalin 15
chr24_+_26887487 16.62 ENSDART00000189425

chr4_+_2230701 16.34 ENSDART00000080439
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr18_-_6803424 15.85 ENSDART00000142647
si:dkey-266m15.5
chr21_+_40092301 15.83 ENSDART00000145150
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2a
chr2_-_38035235 15.56 ENSDART00000075904
cerebellin 5
chr3_+_46762703 15.49 ENSDART00000133283
protein kinase C substrate 80K-H
chr3_-_55525627 15.28 ENSDART00000189234
testis expressed 2
chr14_+_15155684 14.93 ENSDART00000167966
zgc:158852
chr23_+_39606108 14.71 ENSDART00000109464
G0/G1 switch 2
chr24_+_22056386 14.57 ENSDART00000132390
ankyrin repeat domain 33ba
chr11_-_3629201 14.46 ENSDART00000136577
ENSDART00000132121
inter-alpha-trypsin inhibitor heavy chain 3a
chr5_+_32345187 14.44 ENSDART00000147132
complement component 9
chr1_-_25177086 14.31 ENSDART00000144711
ENSDART00000177225
transmembrane protein 154
chr23_-_33750307 14.17 ENSDART00000162772
bridging integrator 2a
chr5_-_66160415 14.16 ENSDART00000073895
membrane bound O-acyltransferase domain containing 4
chr15_+_36187434 13.80 ENSDART00000181536
ENSDART00000099501
ENSDART00000154432
mannan-binding lectin serine peptidase 1
chr23_-_33750135 13.77 ENSDART00000187641
bridging integrator 2a
chr25_-_13188678 13.63 ENSDART00000125754
si:ch211-147m6.1
chr8_+_49570884 13.41 ENSDART00000182117
ENSDART00000108613
RAS and EF-hand domain containing
chr20_-_36809059 13.39 ENSDART00000062925
solute carrier family 25, member 27
chr19_+_7636941 13.35 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cingulin b
chr16_-_21785261 13.35 ENSDART00000078858
si:ch73-86n18.1
chr16_-_17713859 13.30 ENSDART00000149275
zgc:174935
chr21_-_39081107 13.26 ENSDART00000075935
vitronectin b
chr2_-_43168292 13.18 ENSDART00000132588
cAMP responsive element modulator a
chr18_-_14777092 13.18 ENSDART00000144660
metastasis suppressor 1-like a
chr4_+_17310143 13.17 ENSDART00000004717
insulin-like growth factor 1
chr20_-_19365875 12.87 ENSDART00000063703
ENSDART00000187707
ENSDART00000161065
si:dkey-71h2.2
chr24_-_26369185 12.75 ENSDART00000080039
leucine rich repeat containing 31
chr5_+_45677781 12.75 ENSDART00000163120
ENSDART00000126537
group-specific component (vitamin D binding protein)
chr23_-_25686894 12.63 ENSDART00000181420
ENSDART00000088208
low density lipoprotein receptor-related protein 1Ab
chr13_-_8692860 12.62 ENSDART00000058107
multiple coagulation factor deficiency 2
chr2_+_30969029 12.32 ENSDART00000085242
lipin 2
chr14_+_32918484 12.30 ENSDART00000105721
ligand of numb-protein X 2b
chr7_+_48805534 12.15 ENSDART00000145375
ENSDART00000148744
carnitine palmitoyltransferase 1Aa (liver)
chr11_+_41936435 12.13 ENSDART00000173103
aldehyde dehydrogenase 4 family, member A1
chr7_+_48805725 11.91 ENSDART00000166543
carnitine palmitoyltransferase 1Aa (liver)
chr9_-_38036984 11.68 ENSDART00000134574
3-hydroxyacyl-CoA dehydratase 2
chr13_-_40726865 11.46 ENSDART00000099847
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr13_-_8692432 11.29 ENSDART00000058106
multiple coagulation factor deficiency 2
chr12_-_22238004 11.29 ENSDART00000038310
ORMDL sphingolipid biosynthesis regulator 3
chr22_-_26236188 11.28 ENSDART00000162640
ENSDART00000167169
ENSDART00000138595
complement component c3b, tandem duplicate 1
chr3_+_19299309 11.24 ENSDART00000046297
ENSDART00000146955
low density lipoprotein receptor a
chr11_-_4235811 10.96 ENSDART00000121716
si:ch211-236d3.4
chr24_-_29963858 10.78 ENSDART00000183442

chr22_+_24559947 10.74 ENSDART00000169847
WD repeat domain 47b
chr5_-_31773208 10.71 ENSDART00000137556
ENSDART00000122066
family with sequence similarity 102, member Ab
chr11_+_13223625 10.08 ENSDART00000161275
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr11_+_25430851 9.91 ENSDART00000164999
ENSDART00000126403
si:dkey-13a21.4
chr4_-_17725008 9.82 ENSDART00000016658
choline phosphotransferase 1
chr17_-_26867725 9.73 ENSDART00000153590
si:dkey-221l4.10
chr24_-_31306724 9.71 ENSDART00000165399
acid phosphatase 5b, tartrate resistant
chr4_+_5868034 9.61 ENSDART00000166591
UTP20 small subunit (SSU) processome component
chr11_-_15296805 9.53 ENSDART00000124968
ribophorin II
chr19_-_46091497 9.53 ENSDART00000178772
ENSDART00000167255
phosphatidylserine synthase 1b
si:dkey-108k24.2
chr18_+_17611627 9.53 ENSDART00000046891
cholesteryl ester transfer protein, plasma
chr24_-_25461267 9.43 ENSDART00000105820
membrane-bound transcription factor peptidase, site 2
chr2_-_5475910 9.32 ENSDART00000100954
ENSDART00000172143
ENSDART00000132496
protein C (inactivator of coagulation factors Va and VIIIa), a
protein C (inactivator of coagulation factors Va and VIIIa), a
chr7_-_31759394 9.18 ENSDART00000193040
immunoglobulin superfamily, DCC subclass, member 4
chr2_+_31671545 9.04 ENSDART00000145446
atypical chemokine receptor 4a
chr16_-_25606235 8.78 ENSDART00000192741
zgc:110410
chr20_+_6590220 8.76 ENSDART00000136567
tensin 3, tandem duplicate 2
chr2_+_11028923 8.74 ENSDART00000076725
acyl-CoA thioesterase 11a
chr4_-_8040436 8.72 ENSDART00000113033
si:ch211-240l19.6
chr5_-_31772559 8.65 ENSDART00000183879
family with sequence similarity 102, member Ab
chr10_-_5135788 8.41 ENSDART00000108587
ENSDART00000138537
SEC31 homolog A, COPII coat complex component
chr11_+_18612421 8.23 ENSDART00000110621
nuclear receptor coactivator 3
chr5_-_34875858 8.21 ENSDART00000085086
Rho guanine nucleotide exchange factor (GEF) 28
chr14_-_11529311 8.21 ENSDART00000127208
si:ch211-153b23.7
chr10_+_11260170 8.20 ENSDART00000155742
hydroxysteroid dehydrogenase like 2
chr9_+_33154841 8.13 ENSDART00000132465
dopey family member 2
chr21_-_11856143 8.12 ENSDART00000151204
ubiquitin-conjugating enzyme E2R 2
chr24_+_37723362 8.07 ENSDART00000136836
RAB11 family interacting protein 3 (class II)
chr15_-_28247583 8.06 ENSDART00000112967
Rab interacting lysosomal protein
chr19_-_42588510 7.82 ENSDART00000102583
synaptotagmin-like 1
chr21_-_26028205 7.76 ENSDART00000034875
stromal cell-derived factor 2
chr13_-_33207367 7.75 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
thyroid hormone receptor interactor 11
chr19_-_7272921 7.75 ENSDART00000102075
ENSDART00000132887
ENSDART00000130234
ENSDART00000193535
ENSDART00000136528
retinoid x receptor, beta a
chr2_-_5466708 7.70 ENSDART00000136682
protein C (inactivator of coagulation factors Va and VIIIa), a
chr15_-_25365319 7.68 ENSDART00000152651
clustered mitochondria (cluA/CLU1) homolog a
chr23_-_10722664 7.61 ENSDART00000146526
ENSDART00000129022
ENSDART00000104985
forkhead box P1a
chr18_-_18543358 7.55 ENSDART00000126460
interleukin 34
chr6_-_9565526 7.37 ENSDART00000151470
mitogen-activated protein kinase kinase kinase 2
chr16_-_25606889 7.35 ENSDART00000077447
ENSDART00000131528
zgc:110410
chr18_-_40901707 7.28 ENSDART00000139352
forkhead box G1c
chr24_-_2843107 7.26 ENSDART00000165290
cytochrome b5 type A (microsomal)
chr23_+_24085531 7.02 ENSDART00000139710
tubulin tyrosine ligase-like family, member 10
chr14_-_30390145 6.96 ENSDART00000045423
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr2_+_20539402 6.96 ENSDART00000129585
si:ch73-14h1.2
chr10_-_3416258 6.92 ENSDART00000005168
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr10_+_41199660 6.92 ENSDART00000125314
adrenoceptor beta 3b
chr7_+_9904627 6.71 ENSDART00000172824
ceramide synthase 3a
chr22_-_17595310 6.67 ENSDART00000099056
glutathione peroxidase 4a
chr17_-_30652738 6.66 ENSDART00000154960
SH3 and SYLF domain containing 1
chr18_-_44847855 6.50 ENSDART00000086823
signal recognition particle receptor (docking protein)
chr8_-_25605537 6.47 ENSDART00000005906
serine/threonine kinase 38a
chr12_-_1361517 6.45 ENSDART00000188297

chr21_-_11855828 6.42 ENSDART00000081666
ubiquitin-conjugating enzyme E2R 2
chr17_-_23709347 6.41 ENSDART00000124661
3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr12_-_28537615 6.40 ENSDART00000067762
si:ch211-94l19.4
chr25_-_12805295 6.30 ENSDART00000157629
carbonic anhydrase Va
chr18_+_40354998 6.22 ENSDART00000098791
ENSDART00000049171
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr16_+_52105227 6.14 ENSDART00000150025
ENSDART00000097863
si:ch73-373m9.1
chr14_+_32926385 6.11 ENSDART00000139159
ligand of numb-protein X 2b
chr11_-_11336986 6.08 ENSDART00000016677
zgc:77929
chr16_-_34477805 6.08 ENSDART00000136546
serine incorporator 2, like
chr4_+_5848229 6.07 ENSDART00000161101
ENSDART00000067357
LYR motif containing 5a
chr11_+_44503774 5.95 ENSDART00000169295
endoplasmic reticulum oxidoreductase beta
chr5_+_34622320 5.90 ENSDART00000141338
ectodermal-neural cortex 1
chr11_+_35171406 5.89 ENSDART00000110839
MON1 secretory trafficking family member A
chr21_-_22398985 5.88 ENSDART00000138128
si:ch73-112l6.1
chr5_-_16351306 5.82 ENSDART00000168643

chr16_-_25608453 5.68 ENSDART00000140140
zgc:110410
chr13_+_18545819 5.68 ENSDART00000101859
ENSDART00000110197
ENSDART00000136064
zgc:154058
chr25_-_13188214 5.66 ENSDART00000187298
si:ch211-147m6.1
chr15_-_30816370 5.54 ENSDART00000142982
ENSDART00000050649
ENSDART00000136901
ENSDART00000100194
musashi RNA-binding protein 2b
chr23_-_10723009 5.26 ENSDART00000189721
forkhead box P1a
chr24_+_7782313 5.15 ENSDART00000111090
protein tyrosine phosphatase, receptor type, h
chr8_+_24747865 5.14 ENSDART00000078656
solute carrier family 16, member 4
chr20_-_52928541 5.03 ENSDART00000162812
farnesyl-diphosphate farnesyltransferase 1
chr18_-_24988645 4.99 ENSDART00000136434
ENSDART00000085735
chromodomain helicase DNA binding protein 2
chr20_-_10288156 4.97 ENSDART00000064110
si:dkey-63b1.1
chr10_+_11261576 4.97 ENSDART00000155333
hydroxysteroid dehydrogenase like 2
chr18_-_6855991 4.97 ENSDART00000135206
protein phosphatase 6, regulatory subunit 2b
chr13_-_18345854 4.90 ENSDART00000080107
si:dkey-228d14.5
chr17_+_32158951 4.89 ENSDART00000165348
ENSDART00000108736
ADAM metallopeptidase domain 12
chr17_+_32623931 4.86 ENSDART00000144217
cathepsin Ba
chr20_-_25902141 4.84 ENSDART00000142611
ENSDART00000024821
ELM2 and Myb/SANT-like domain containing 1a
chr16_+_19637384 4.81 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
metastasis associated in colon cancer 1
chr16_+_19029297 4.78 ENSDART00000115263
ENSDART00000114954
Rap guanine nucleotide exchange factor (GEF) 5b
chr8_-_29822527 4.70 ENSDART00000167487
solute carrier family 20 (phosphate transporter), member 2
chr9_-_29497916 4.68 ENSDART00000060246
DnaJ (Hsp40) homolog, subfamily C, member 3a
chr7_-_28549361 4.65 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
suppression of tumorigenicity 5
chr21_-_20840714 4.63 ENSDART00000144861
ENSDART00000139430
complement component 6
chr15_-_25365570 4.61 ENSDART00000152754
clustered mitochondria (cluA/CLU1) homolog a
chr22_-_24285432 4.59 ENSDART00000164083
si:ch211-117l17.4
chr22_+_105376 4.53 ENSDART00000059140
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr15_-_23793641 4.31 ENSDART00000122891
transmembrane protein 97
chr7_+_61184551 4.30 ENSDART00000190788
zgc:194930
chr7_+_9308625 4.28 ENSDART00000084598
selenoprotein S
chr3_-_55537096 4.26 ENSDART00000123544
ENSDART00000188752
testis expressed 2
chr6_-_43677125 4.20 ENSDART00000150128
forkhead box P1b
chr17_+_25519089 4.17 ENSDART00000041721
crystallin beta-gamma domain containing 1a
chr1_-_31856622 4.07 ENSDART00000065125
5'-nucleotidase, cytosolic IIb
chr2_-_42492201 4.07 ENSDART00000180762
ENSDART00000009093
extended synaptotagmin-like protein 2a
chr8_-_1219815 4.06 ENSDART00000016800
ENSDART00000149969
zinc finger protein 367
chr16_-_21038015 4.03 ENSDART00000059239
sorting nexin 10b
chr2_-_29994726 3.99 ENSDART00000163350
canopy1
chr15_-_8191841 3.80 ENSDART00000156663
BTB and CNC homology 1, basic leucine zipper transcription factor 1 a
chr15_+_38299563 3.76 ENSDART00000099375
si:dkey-24p1.6
chr21_+_26071874 3.74 ENSDART00000003001
ENSDART00000146573
ribosomal protein L23a
chr3_-_56871330 3.72 ENSDART00000014103
zgc:112148
chr7_-_71384391 3.64 ENSDART00000112841
coiled-coil domain containing 149a
chr14_-_28052474 3.59 ENSDART00000172948
ENSDART00000135337
si:ch211-220e11.3
zgc:64189
chr7_+_58730201 3.58 ENSDART00000073640
pleiomorphic adenoma gene 1
chr8_-_25771474 3.55 ENSDART00000193883
suppressor of variegation 3-9 homolog 1b
chr17_+_33415319 3.49 ENSDART00000140805
ENSDART00000025501
ENSDART00000146447
synaptosomal-associated protein 23.1
chr10_-_13343831 3.46 ENSDART00000135941
interleukin 11 receptor, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa_foxa1_foxa2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.8 41.3 GO:0010430 fatty acid omega-oxidation(GO:0010430)
9.8 68.6 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
8.5 84.6 GO:0072337 modified amino acid transport(GO:0072337)
8.4 25.3 GO:0097053 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
8.1 40.7 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
7.8 85.9 GO:0019731 antibacterial humoral response(GO:0019731)
7.4 29.4 GO:0070166 enamel mineralization(GO:0070166)
6.2 524.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
4.8 28.9 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
4.8 14.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
4.7 27.9 GO:0071800 podosome assembly(GO:0071800)
3.6 57.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
3.4 17.0 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
3.2 77.9 GO:0009749 response to glucose(GO:0009749)
3.2 9.5 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
2.8 11.3 GO:2000303 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
2.5 10.1 GO:0032782 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
2.5 7.6 GO:0045649 regulation of macrophage differentiation(GO:0045649)
2.4 12.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
2.4 24.1 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
2.1 6.4 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
2.1 31.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
1.9 9.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
1.9 11.2 GO:0032367 intracellular cholesterol transport(GO:0032367)
1.8 10.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.7 3.3 GO:1904292 regulation of ERAD pathway(GO:1904292)
1.6 16.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
1.5 21.0 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
1.4 38.4 GO:0019835 cytolysis(GO:0019835)
1.1 3.3 GO:0019323 pentose catabolic process(GO:0019323)
1.0 8.2 GO:0090385 phagosome-lysosome fusion(GO:0090385)
1.0 12.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
1.0 5.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
1.0 14.2 GO:0032094 response to food(GO:0032094)
1.0 2.0 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
1.0 9.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.9 61.4 GO:0006096 glycolytic process(GO:0006096)
0.9 2.7 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.9 5.3 GO:1902023 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.8 19.5 GO:0015701 bicarbonate transport(GO:0015701)
0.8 13.4 GO:0009409 response to cold(GO:0009409)
0.8 35.7 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.7 58.8 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.7 47.8 GO:0007596 blood coagulation(GO:0007596)
0.7 7.4 GO:0045453 bone resorption(GO:0045453)
0.7 13.2 GO:0097178 ruffle assembly(GO:0097178)
0.7 18.4 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.6 9.7 GO:0031641 regulation of myelination(GO:0031641)
0.6 3.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.6 5.0 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.6 14.1 GO:0006491 N-glycan processing(GO:0006491)
0.6 8.9 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.6 12.8 GO:0051180 vitamin transport(GO:0051180)
0.5 1.0 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.5 15.0 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.5 11.7 GO:0030497 fatty acid elongation(GO:0030497)
0.5 2.3 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.5 23.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.4 1.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.4 1.2 GO:0072111 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.4 3.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.4 0.7 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.3 15.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.3 1.7 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.3 1.3 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.3 2.0 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.3 2.0 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 21.3 GO:0006956 complement activation(GO:0006956) protein activation cascade(GO:0072376)
0.3 1.5 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.3 2.1 GO:0032185 septin ring organization(GO:0031106) septin cytoskeleton organization(GO:0032185)
0.3 9.1 GO:0032526 response to retinoic acid(GO:0032526)
0.3 1.8 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 2.8 GO:0021683 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 1.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 0.8 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.2 2.1 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.2 0.7 GO:0006589 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.2 0.9 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 4.7 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.2 5.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 1.3 GO:0007100 mitotic centrosome separation(GO:0007100) centrosome separation(GO:0051299)
0.2 3.2 GO:0031167 rRNA methylation(GO:0031167)
0.2 8.6 GO:0032465 regulation of cytokinesis(GO:0032465)
0.2 1.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 3.0 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.2 3.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 1.6 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.1 2.8 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 2.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 2.0 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 9.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 11.1 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.4 GO:0060631 regulation of meiosis I(GO:0060631)
0.1 0.6 GO:0052651 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 3.9 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.6 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 0.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 6.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 2.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 10.4 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.1 3.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.5 GO:0043029 T cell homeostasis(GO:0043029)
0.1 5.1 GO:0042310 vasoconstriction(GO:0042310)
0.1 4.3 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 0.9 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.1 6.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.1 0.8 GO:0031179 peptide modification(GO:0031179)
0.1 0.9 GO:0044090 positive regulation of vacuole organization(GO:0044090)
0.1 0.8 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 4.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.1 2.3 GO:0016082 synaptic vesicle priming(GO:0016082)
0.1 0.4 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 1.0 GO:0071357 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 7.7 GO:0007030 Golgi organization(GO:0007030)
0.1 9.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 3.7 GO:0006623 protein targeting to vacuole(GO:0006623)
0.1 1.1 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 1.9 GO:0034112 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.1 5.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 0.3 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.1 1.2 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 2.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 2.5 GO:0003309 type B pancreatic cell differentiation(GO:0003309)
0.1 4.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 1.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 7.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 1.9 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.1 12.2 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.1 0.5 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 2.6 GO:0050727 regulation of inflammatory response(GO:0050727)
0.1 3.0 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.1 1.7 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.1 6.2 GO:0031101 fin regeneration(GO:0031101)
0.1 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.2 GO:0061015 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.1 1.9 GO:0007031 peroxisome organization(GO:0007031)
0.1 1.0 GO:0031297 replication fork processing(GO:0031297)
0.1 0.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 7.9 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.4 GO:1902534 macromitophagy(GO:0000423) lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) single-organism membrane invagination(GO:1902534)
0.0 4.0 GO:0070121 Kupffer's vesicle development(GO:0070121)
0.0 0.7 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 7.1 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 1.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 3.0 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.3 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.9 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.2 GO:0035475 angioblast cell migration involved in selective angioblast sprouting(GO:0035475)
0.0 0.5 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.4 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 4.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 3.4 GO:0010506 regulation of autophagy(GO:0010506)
0.0 8.4 GO:0006869 lipid transport(GO:0006869)
0.0 0.7 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.4 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.5 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.3 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.6 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.8 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 1.0 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.4 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 0.3 GO:0032438 melanosome organization(GO:0032438)
0.0 0.4 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 1.7 GO:0006413 translational initiation(GO:0006413)
0.0 3.8 GO:1904888 cranial skeletal system development(GO:1904888)
0.0 0.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 5.3 GO:0006955 immune response(GO:0006955)
0.0 0.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.4 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
4.0 27.9 GO:0001891 phagocytic cup(GO:0001891)
3.9 15.5 GO:0017177 glucosidase II complex(GO:0017177)
3.2 9.7 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
2.8 11.3 GO:0035339 SPOTS complex(GO:0035339)
2.7 40.4 GO:0005579 membrane attack complex(GO:0005579)
1.7 76.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.5 31.3 GO:0030127 COPII vesicle coat(GO:0030127)
1.1 3.4 GO:0031213 RSF complex(GO:0031213)
1.0 13.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.9 2.7 GO:0070578 RISC-loading complex(GO:0070578)
0.8 84.2 GO:0055037 recycling endosome(GO:0055037)
0.7 9.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.7 2.0 GO:0043614 multi-eIF complex(GO:0043614)
0.6 9.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.6 11.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.6 2.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.5 625.5 GO:0005615 extracellular space(GO:0005615)
0.4 2.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.4 11.8 GO:0030686 90S preribosome(GO:0030686)
0.3 2.5 GO:0031526 brush border membrane(GO:0031526)
0.2 34.1 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.2 22.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.2 1.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 1.0 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 6.7 GO:0032587 ruffle membrane(GO:0032587)
0.2 104.5 GO:0005576 extracellular region(GO:0005576)
0.1 15.1 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.8 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 8.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.8 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 2.4 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 2.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 11.8 GO:0005769 early endosome(GO:0005769)
0.1 10.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 1.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 7.5 GO:0016459 myosin complex(GO:0016459)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 50.7 GO:0005794 Golgi apparatus(GO:0005794)
0.1 0.5 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 3.7 GO:0031201 SNARE complex(GO:0031201)
0.0 38.0 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.4 GO:0071797 LUBAC complex(GO:0071797)
0.0 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 9.1 GO:0005730 nucleolus(GO:0005730)
0.0 0.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 5.0 GO:0005764 lysosome(GO:0005764)
0.0 23.4 GO:0005739 mitochondrion(GO:0005739)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0000796 condensin complex(GO:0000796)
0.0 2.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 0.5 GO:0030496 midbody(GO:0030496)
0.0 0.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.0 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
21.2 84.6 GO:0070324 thyroid hormone binding(GO:0070324)
18.5 73.9 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
10.3 41.3 GO:0070643 vitamin D 25-hydroxylase activity(GO:0070643)
10.2 61.4 GO:0004743 pyruvate kinase activity(GO:0004743)
7.2 28.9 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
5.4 16.3 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
4.3 12.8 GO:0005499 vitamin D binding(GO:0005499)
4.0 465.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
3.8 11.5 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
3.4 24.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
3.1 125.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
2.9 11.7 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
2.8 11.2 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
2.5 10.1 GO:0015126 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
2.1 6.4 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
2.0 9.8 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
1.7 5.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
1.6 13.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
1.6 11.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
1.6 12.7 GO:0003993 acid phosphatase activity(GO:0003993)
1.5 21.0 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
1.3 6.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.3 35.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.3 5.1 GO:0051380 norepinephrine binding(GO:0051380)
1.1 10.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
1.0 19.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
1.0 9.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.8 2.5 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.8 37.5 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.8 3.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.8 5.3 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.7 16.9 GO:0031267 small GTPase binding(GO:0031267)
0.7 2.7 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) pre-miRNA binding(GO:0070883)
0.6 9.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.6 1.9 GO:0045545 syndecan binding(GO:0045545)
0.6 3.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.6 11.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.6 3.1 GO:0031769 glucagon receptor binding(GO:0031769)
0.6 1.8 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.6 141.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.6 13.6 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.6 7.8 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.5 2.1 GO:0015369 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.5 13.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.5 5.9 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 6.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.4 3.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.4 3.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.4 1.2 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.4 2.3 GO:0008126 acetylesterase activity(GO:0008126)
0.3 1.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 4.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.3 10.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 14.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 11.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 0.8 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.3 1.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 0.8 GO:0052726 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.2 14.1 GO:0008374 O-acyltransferase activity(GO:0008374)
0.2 0.7 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.2 0.7 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.2 0.9 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 6.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 0.9 GO:0097108 hedgehog family protein binding(GO:0097108)
0.2 3.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 20.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 0.8 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.2 2.0 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.2 17.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 4.0 GO:0003785 actin monomer binding(GO:0003785)
0.2 21.7 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 4.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 8.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 3.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 4.7 GO:0051087 chaperone binding(GO:0051087)
0.1 2.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.6 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.1 4.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.8 GO:0008312 7S RNA binding(GO:0008312)
0.1 7.3 GO:0009055 electron carrier activity(GO:0009055)
0.1 4.6 GO:0005109 frizzled binding(GO:0005109)
0.1 6.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.0 GO:0070411 I-SMAD binding(GO:0070411)
0.1 2.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 7.6 GO:0003724 RNA helicase activity(GO:0003724)
0.1 0.8 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.1 6.1 GO:0019902 phosphatase binding(GO:0019902)
0.1 3.7 GO:0019843 rRNA binding(GO:0019843)
0.1 1.1 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 2.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.4 GO:0016421 CoA carboxylase activity(GO:0016421)
0.1 41.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 3.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.9 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 20.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 7.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)
0.0 3.5 GO:0019955 cytokine binding(GO:0019955)
0.0 7.6 GO:0005125 cytokine activity(GO:0005125)
0.0 11.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 11.4 GO:0003774 motor activity(GO:0003774)
0.0 8.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 18.9 GO:0008289 lipid binding(GO:0008289)
0.0 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.0 GO:0043022 ribosome binding(GO:0043022)
0.0 0.4 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 1.0 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.1 GO:0033745 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.0 3.0 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 1.5 GO:0030276 clathrin binding(GO:0030276)
0.0 1.8 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0008061 chitin binding(GO:0008061)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 2.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.6 GO:0044325 ion channel binding(GO:0044325)
0.0 0.8 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 66.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
3.3 147.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.6 241.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.5 18.2 ST G ALPHA S PATHWAY G alpha s Pathway
1.3 10.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.6 10.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.5 13.2 PID IGF1 PATHWAY IGF1 pathway
0.4 19.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.3 7.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 1.8 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 1.7 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.1 2.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 0.9 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.4 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 0.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 2.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 2.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.6 PID E2F PATHWAY E2F transcription factor network
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.2 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 92.0 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
6.8 68.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
4.4 66.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
4.4 30.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
4.2 54.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
3.7 84.6 REACTOME AMYLOIDS Genes involved in Amyloids
3.5 62.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
2.1 17.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
2.0 17.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
1.9 54.1 REACTOME STEROID HORMONES Genes involved in Steroid hormones
1.6 24.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
1.6 72.9 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
1.2 13.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
1.1 28.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
1.1 9.5 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.9 9.4 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.8 38.1 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.7 4.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.6 10.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 6.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.5 35.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.4 2.9 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.3 4.5 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 1.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.2 2.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.2 2.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 1.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 1.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.2 24.9 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 8.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 7.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 2.0 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 1.6 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 0.9 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 2.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.7 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.9 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.0 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.9 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 2.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 1.0 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.3 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle