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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for fli1b

Z-value: 2.11

Motif logo

Transcription factors associated with fli1b

Gene Symbol Gene ID Gene Info
ENSDARG00000040080 Fli-1 proto-oncogene, ETS transcription factor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
fli1bdr11_v1_chr16_+_42018041_420180420.771.3e-19Click!

Activity profile of fli1b motif

Sorted Z-values of fli1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_38285671 30.03 ENSDART00000061432
chemokine (C-C motif) ligand 38, duplicate 4
chr21_+_25765734 21.17 ENSDART00000021664
claudin b
chr14_-_40797117 20.52 ENSDART00000122369
E74-like ETS transcription factor 1
chr18_-_48517040 20.43 ENSDART00000143645
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 3
chr1_-_37383539 20.31 ENSDART00000127579
secretory calcium-binding phosphoprotein 1
chr8_+_3379815 20.02 ENSDART00000155995
zgc:136963
chr18_-_48500545 18.74 ENSDART00000058989
ENSDART00000098450
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 6
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 5
chr13_+_30696286 17.69 ENSDART00000192411
chemokine (C-X-C motif) ligand 18a, duplicate 1
chr23_-_10175898 16.71 ENSDART00000146185
keratin 5
chr17_-_37395460 15.91 ENSDART00000148160
ENSDART00000075975
cysteine-rich protein 1
chr1_-_37383741 15.48 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
secretory calcium-binding phosphoprotein 1
chr22_+_5687615 15.18 ENSDART00000133241
ENSDART00000019854
ENSDART00000138102
deoxyribonuclease 1 like 4, tandem duplicate 2
chr15_-_2652640 14.64 ENSDART00000146094
claudin f
chr21_+_22985078 14.12 ENSDART00000156491
lysophosphatidic acid receptor 6b
chr1_-_45157243 14.00 ENSDART00000131882
mucin, multiple PTS and SEA group, member 1
chr8_-_31107537 13.97 ENSDART00000098925
vestigial like 4 like
chr16_+_35401543 13.90 ENSDART00000171608
RAB42, member RAS oncogene family
chr6_-_8480815 13.77 ENSDART00000162300
RAS protein activator like 3
chr12_-_35830625 13.70 ENSDART00000180028

chr14_-_9128919 13.69 ENSDART00000108641
SH2 domain containing 1A duplicate b
chr15_+_15779184 13.42 ENSDART00000156902
si:ch211-33e4.2
chr1_-_29658721 13.14 ENSDART00000132063
si:dkey-1h24.6
chr8_-_7093507 13.09 ENSDART00000045669
si:dkey-222n6.2
chr11_+_8129536 12.78 ENSDART00000158112
ENSDART00000011183
protein kinase, cAMP-dependent, catalytic, beta a
chr15_+_20239141 12.73 ENSDART00000101152
ENSDART00000152473
serine peptidase inhibitor, Kunitz type, 2
chr15_+_11883804 12.66 ENSDART00000163255
G protein-coupled receptor 184
chr11_+_25278772 12.47 ENSDART00000188630
cylindromatosis (turban tumor syndrome), b
chr25_+_34014523 12.17 ENSDART00000182856
annexin A2a
chr15_+_28410664 12.05 ENSDART00000132028
ENSDART00000057697
ENSDART00000057257
phosphatidylinositol transfer protein, alpha a
chr2_+_48282590 12.02 ENSDART00000035338
lysophosphatidic acid receptor 5a
chr20_+_25340814 11.84 ENSDART00000063028
connective tissue growth factor a
chr16_+_11818126 11.77 ENSDART00000145727
chemokine (C-X-C motif) receptor 3, tandem duplicate 2
chr18_-_48550426 11.53 ENSDART00000145189
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr16_-_39570832 11.49 ENSDART00000039832
transforming growth factor beta receptor 2b
chr6_+_30668098 11.49 ENSDART00000112294
tetratricopeptide repeat domain 22
chr3_+_29510818 11.48 ENSDART00000055407
ENSDART00000193743
ENSDART00000123619
Rac family small GTPase 2
chr5_-_42272517 11.48 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
chr9_+_2499627 11.17 ENSDART00000160782
WAS/WASL interacting protein family, member 1a
chr12_+_22576404 11.15 ENSDART00000172053
capping protein (actin filament), gelsolin-like b
chr21_+_30794351 10.96 ENSDART00000139486
zgc:158225
chr22_-_17729778 10.89 ENSDART00000192132
si:ch73-63e15.2
chr15_+_17756113 10.89 ENSDART00000155197
si:ch211-213d14.2
chr14_+_41345175 10.85 ENSDART00000086104
NADPH oxidase 1
chr5_+_37087583 10.85 ENSDART00000049900
transgelin 2
chr7_+_39706004 10.61 ENSDART00000161856
chemokine (C-C motif) ligand 36, duplicate 1
chr9_-_31108285 10.52 ENSDART00000003193
G protein-coupled receptor 183a
chr21_-_34972872 10.50 ENSDART00000023838
lipase, member Ia
chr7_+_20017211 10.38 ENSDART00000100808
B-cell CLL/lymphoma 6, member B
chr5_+_46277593 10.25 ENSDART00000045598
zgc:110626
chr15_+_36054864 10.15 ENSDART00000156697
collagen, type IV, alpha 3
chr6_-_29195642 10.04 ENSDART00000078625
dermatopontin
chr18_-_6982499 9.98 ENSDART00000101525
si:dkey-266m15.6
chr3_+_22377312 9.96 ENSDART00000155597
Rho GTPase activating protein 27, like
chr23_+_42813415 9.96 ENSDART00000055577
myosin, light chain 9a, regulatory
chr16_+_38201840 9.96 ENSDART00000044971
myosin IE, b
chr2_+_22495274 9.92 ENSDART00000167915
leucine rich repeat containing 8 VRAC subunit Da
chr1_+_36674584 9.89 ENSDART00000186772
ENSDART00000192274
endothelin receptor type Aa
chr7_-_22981796 9.84 ENSDART00000167565
si:dkey-171c9.3
chr19_-_13808630 9.73 ENSDART00000166895
ENSDART00000187670
connective tissue growth factor b
chr1_-_40735381 9.70 ENSDART00000093269
zgc:153642
chr3_-_32603191 9.69 ENSDART00000150997
si:ch73-248e21.7
chr7_+_17816006 9.68 ENSDART00000080834
echinoderm microtubule associated protein like 3
chr22_-_28650442 9.61 ENSDART00000019846
collagen, type VIII, alpha 1b
chr5_+_30741730 9.45 ENSDART00000098246
ENSDART00000186992
ENSDART00000182533
finTRIM family, member 83
chr16_-_51271962 9.40 ENSDART00000164021
ENSDART00000046420
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 1
chr7_+_19482084 9.27 ENSDART00000173873
si:ch211-212k18.7
chr21_-_25295087 9.25 ENSDART00000087910
ENSDART00000147860
suppression of tumorigenicity 14 (colon carcinoma) b
chr5_-_26834511 9.18 ENSDART00000136713
ENSDART00000192932
ENSDART00000113246
si:ch211-102c2.4
chr15_+_17251191 9.15 ENSDART00000156587
si:ch73-223p23.2
chr4_+_14957360 9.12 ENSDART00000002770
ENSDART00000111882
ENSDART00000148292
tetraspanin 33a
chr15_-_43284021 9.02 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr3_+_3545825 8.97 ENSDART00000109060

chr24_-_20192996 8.93 ENSDART00000011143
myeloid differentiation primary response 88
chr1_+_1904419 8.91 ENSDART00000142874
si:ch211-132g1.4
chr2_-_37862380 8.89 ENSDART00000186005
si:ch211-284o19.8
chr3_+_24655643 8.87 ENSDART00000126148
zmp:0000000912
chr8_-_13029297 8.84 ENSDART00000144305
DENN/MADD domain containing 2Da
chr9_-_34368842 8.84 ENSDART00000140349
CD247 antigen like
chr10_+_8875195 8.82 ENSDART00000141045
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 3
chr10_-_20650302 8.77 ENSDART00000142028
ENSDART00000064662
Ras association (RalGDS/AF-6) domain family member 2b
chr12_-_28983584 8.76 ENSDART00000112374
zgc:171713
chr15_+_22014029 8.76 ENSDART00000079504
ankyrin repeat and kinase domain containing 1
chr16_-_26676685 8.74 ENSDART00000103431
epithelial splicing regulatory protein 1
chr16_+_3982590 8.71 ENSDART00000149295
zinc finger CCCH-type containing 12A
chr16_+_42018041 8.59 ENSDART00000134010
ENSDART00000102789
Fli-1 proto-oncogene, ETS transcription factor b
chr16_-_51299061 8.58 ENSDART00000148677
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr23_-_14825450 8.58 ENSDART00000188009
Src-like-adaptor 2
chr14_-_11456724 8.57 ENSDART00000110424
si:ch211-153b23.4
chr19_-_325584 8.55 ENSDART00000134266
glycerol-3-phosphate dehydrogenase 1c
chr17_+_31363000 8.53 ENSDART00000062900
inositol-trisphosphate 3-kinase A
chr20_-_26066020 8.52 ENSDART00000078559
myc target 1a
chr1_-_18848955 8.43 ENSDART00000109294
ENSDART00000146410
zgc:195282
chr14_+_22076596 8.41 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
solute carrier family 43 (amino acid system L transporter), member 1a
chr9_+_35860975 8.41 ENSDART00000134447
regulator of calcineurin 1a
chr17_-_2039511 8.37 ENSDART00000160223
serine peptidase inhibitor, Kunitz type 1 a
chr3_+_53240562 8.29 ENSDART00000031234
syntaxin binding protein 2
chr22_-_13165186 8.13 ENSDART00000105762
aryl hydrocarbon receptor 2
chr17_-_21368775 8.11 ENSDART00000058027
shootin 1
chr17_-_7733037 8.04 ENSDART00000064657
syntaxin 11a
chr11_+_22109887 7.99 ENSDART00000122136
si:dkey-91m3.1
chr1_+_1896737 7.96 ENSDART00000152442
si:ch211-132g1.6
chr24_-_6078222 7.92 ENSDART00000146830
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr16_-_10316359 7.91 ENSDART00000104025
flotillin 1b
chr5_+_20421539 7.87 ENSDART00000164499
selectin P ligand
chr25_+_35553542 7.86 ENSDART00000113723
Spi-1 proto-oncogene a
chr12_+_20552190 7.82 ENSDART00000113224
guanine nucleotide binding protein (G protein), alpha 13a
chr8_-_14209852 7.80 ENSDART00000005359
differentially expressed in FDCP 6a homolog (mouse)
chr11_-_18384534 7.79 ENSDART00000156499
protein kinase C, delta b
chr20_-_21672970 7.69 ENSDART00000133286
si:ch211-207i1.2
chr8_-_30242706 7.61 ENSDART00000139864
ENSDART00000143809
zgc:162939
chr1_+_1915967 7.57 ENSDART00000131463
si:ch211-132g1.1
chr8_-_18010735 7.52 ENSDART00000125014
acyl-CoA thioesterase 11b
chr6_+_2030703 7.52 ENSDART00000109679
ENSDART00000187502
ENSDART00000191165
ENSDART00000187544
quattro
chr11_+_21137948 7.47 ENSDART00000110673
interleukin 10
chr3_-_36364903 7.43 ENSDART00000028883
guanine nucleotide binding protein (G protein), alpha 13b
chr13_+_32144370 7.42 ENSDART00000020270
odd-skipped related transciption factor 1
chr13_+_39532050 7.41 ENSDART00000019379
MARVEL domain containing 1
chr14_-_36799280 7.37 ENSDART00000168615
ring finger protein 130
chr18_-_40856354 7.34 ENSDART00000098865
vasodilator stimulated phosphoprotein b
chr7_+_17816470 7.32 ENSDART00000173807
echinoderm microtubule associated protein like 3
chr16_-_9802449 7.31 ENSDART00000081208
TAP binding protein (tapasin)-like
chr9_-_9419704 7.28 ENSDART00000138996
si:ch211-214p13.9
chr11_-_29916607 7.28 ENSDART00000138912
ENSDART00000079152
vascular endothelial growth factor D
chr5_-_26879302 7.27 ENSDART00000098571
ENSDART00000139086
zgc:64051
chr14_+_34501245 7.23 ENSDART00000131424
lymphocyte cytosolic protein 2b
chr13_-_42749916 7.21 ENSDART00000140019
calpain 2, (m/II) large subunit a
chr22_-_18164671 7.17 ENSDART00000014057
regulatory factor X-associated ankyrin-containing protein
chr25_+_14109626 7.14 ENSDART00000109883
actin, alpha, cardiac muscle 1c
chr24_-_40726073 7.07 ENSDART00000168100
slow myosin heavy chain 2
chr3_+_3598555 7.07 ENSDART00000191152

chr17_+_10242166 6.99 ENSDART00000170420
C-type lectin domain containing 14A
chr10_-_15849027 6.99 ENSDART00000184682
tight junction protein 2a (zona occludens 2)
chr7_-_26601307 6.99 ENSDART00000188934
phospholipid scramblase 3b
chr9_-_11550711 6.95 ENSDART00000093343
FEV (ETS oncogene family)
chr8_+_25342896 6.90 ENSDART00000129032

chr5_-_41049690 6.88 ENSDART00000174936
ENSDART00000135030
PDZ domain containing 2
chr7_+_20563305 6.88 ENSDART00000169661
si:dkey-19b23.10
chr5_-_34616599 6.82 ENSDART00000050271
ENSDART00000097975
hexosaminidase B (beta polypeptide)
chr7_-_51461649 6.82 ENSDART00000193947
ENSDART00000174328
Rho GTPase activating protein 36
chr16_+_38277339 6.78 ENSDART00000085143
BCL2 interacting protein like
chr14_-_34605607 6.77 ENSDART00000191608
actin filament associated protein 1-like 1a
chr9_+_13985567 6.72 ENSDART00000102296
CD28 molecule
chr13_-_15986871 6.72 ENSDART00000189394
IKAROS family zinc finger 1 (Ikaros)
chr18_+_27598755 6.71 ENSDART00000193808
CD82 molecule b
chr3_+_27713610 6.67 ENSDART00000019004
Rho GDP dissociation inhibitor (GDI) gamma
chr11_+_24313931 6.64 ENSDART00000017599
ENSDART00000166045
RAS (RAD and GEM)-like GTP-binding 1
chr8_+_21254192 6.57 ENSDART00000167718
inositol 1,4,5-trisphosphate receptor, type 3
chr8_-_19975087 6.54 ENSDART00000182220
leupaxin
chr15_-_551177 6.53 ENSDART00000066774
ENSDART00000154617
transgelin
chr19_-_12404590 6.50 ENSDART00000103703
finTRIM family, member 56
chr9_+_14010823 6.48 ENSDART00000143837
si:ch211-67e16.3
chr16_-_51253925 6.47 ENSDART00000050644
serpin peptidase inhibitor, clade B (ovalbumin), member 14
chr3_+_42090418 6.45 ENSDART00000109392
ENSDART00000157164
sorting nexin 8a
chr2_-_24069331 6.42 ENSDART00000156972
ENSDART00000181691
ENSDART00000157041
solute carrier family 12 (potassium/chloride transporter), member 7a
chr24_-_11069237 6.37 ENSDART00000127398

chr1_-_8653385 6.31 ENSDART00000193041
actin, beta 1
chr7_+_26545502 6.29 ENSDART00000140528
tyrosine kinase, non-receptor, 1
chr14_+_6287871 6.28 ENSDART00000105344
TBC1 domain family, member 2
chr5_+_27898226 6.27 ENSDART00000098604
ENSDART00000180251
ADAM metallopeptidase domain 28
chr22_-_18164835 6.25 ENSDART00000143189
regulatory factor X-associated ankyrin-containing protein
chr16_+_53125918 6.21 ENSDART00000102170

chr19_+_43297546 6.20 ENSDART00000168002
lysosomal protein transmembrane 5
chr5_-_69716501 6.19 ENSDART00000158956
MOB kinase activator 1A
chr18_-_22094102 6.17 ENSDART00000100904
par-6 family cell polarity regulator alpha
chr19_+_3849378 6.15 ENSDART00000166218
ENSDART00000159228
organic solute carrier partner 1a
chr3_+_34877066 6.15 ENSDART00000161963
integrin, alpha 3a
chr15_+_36096689 6.13 ENSDART00000049849
collagen, type IV, alpha 3
chr9_+_54179306 6.07 ENSDART00000189829
thymosin, beta 4 x
chr11_+_25139495 6.06 ENSDART00000168368
si:ch211-25d12.7
chr3_-_40528333 6.05 ENSDART00000193047
actin, beta 2
chr6_-_55423220 6.04 ENSDART00000158929
cathepsin A
chr3_-_36839115 6.03 ENSDART00000154553
receptor (G protein-coupled) activity modifying protein 2
chr19_-_34927201 5.99 ENSDART00000076518
Src-like-adaptor 1
chr22_-_31517300 5.99 ENSDART00000164799
solute carrier family 6 (neurotransmitter transporter), member 6b
chr7_+_11543999 5.99 ENSDART00000173676
interleukin 16
chr8_-_19280856 5.98 ENSDART00000100473
zgc:77486
chr3_+_24641489 5.94 ENSDART00000055590
ENSDART00000186635
zgc:113411
chr20_-_463786 5.91 ENSDART00000032212
fyn-related Src family tyrosine kinase
chr9_+_13999620 5.87 ENSDART00000143229
cd28-like molecule
chr14_-_34059681 5.82 ENSDART00000003993
IL2 inducible T cell kinase
chr22_+_20710434 5.81 ENSDART00000135521
PEAK family member 3
chr4_-_22310956 5.79 ENSDART00000162585
hematopoietic cell-specific Lyn substrate 1
chr5_+_21181047 5.77 ENSDART00000088506
Rho GTPase activating protein 25
chr23_+_26009266 5.76 ENSDART00000054025
si:dkey-78k11.9
chr17_+_33453689 5.76 ENSDART00000156894
Ras and Rab interactor 3
chr18_+_49969568 5.75 ENSDART00000126916
MOB kinase activator 2b
chr18_-_16801033 5.75 ENSDART00000100100
adrenomedullin b
chr9_+_23772516 5.72 ENSDART00000183126
si:ch211-219a4.3
chr15_-_4528326 5.72 ENSDART00000158122
ENSDART00000155619
ENSDART00000128602
transcription factor Dp-2
chr15_-_20180475 5.69 ENSDART00000048183
exocyst complex component 3-like 2b
chr21_+_30306369 5.69 ENSDART00000145050
ENSDART00000059420
lymphocyte cytosolic protein 2a
chr8_-_4586696 5.68 ENSDART00000143511
ENSDART00000134324
glycoprotein Ib (platelet), beta polypeptide
chr5_+_22133153 5.68 ENSDART00000016214
moesin a
chr1_+_36665555 5.65 ENSDART00000128557
ENSDART00000010632
endothelin receptor type Aa
chr24_-_31904924 5.63 ENSDART00000156060
ENSDART00000129741
ENSDART00000154276
si:ch73-78o10.1
chr4_-_13973213 5.62 ENSDART00000067177
ENSDART00000144127
prickle homolog 1b
chr1_+_49510209 5.62 ENSDART00000052998
si:dkeyp-80c12.4
chr18_+_16744307 5.60 ENSDART00000179872
ENSDART00000133490
lymphatic vessel endothelial hyaluronic receptor 1b
chr17_-_37795865 5.60 ENSDART00000025853
zinc finger protein 36, C3H type-like 1a
chr16_-_51288178 5.55 ENSDART00000079864
zgc:173729

Network of associatons between targets according to the STRING database.

First level regulatory network of fli1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.9 GO:0071236 cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
3.9 11.8 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
3.8 15.2 GO:0031584 activation of phospholipase D activity(GO:0031584)
3.5 10.5 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
2.9 11.8 GO:0042117 monocyte activation(GO:0042117)
2.8 8.4 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
2.6 7.9 GO:1901890 positive regulation of cell junction assembly(GO:1901890)
2.6 15.5 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
2.5 7.4 GO:0048389 intermediate mesoderm development(GO:0048389)
2.4 12.1 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
2.3 11.5 GO:2000389 neutrophil extravasation(GO:0072672) regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
2.2 8.7 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
2.1 8.5 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
2.0 8.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
2.0 7.9 GO:0045123 cellular extravasation(GO:0045123)
1.9 15.4 GO:0042554 superoxide anion generation(GO:0042554)
1.9 9.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
1.8 3.6 GO:0006884 cell volume homeostasis(GO:0006884)
1.8 5.4 GO:0043455 regulation of secondary metabolic process(GO:0043455)
1.7 5.2 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
1.7 12.0 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
1.7 5.1 GO:1990575 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
1.7 6.8 GO:0006598 polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447)
1.6 4.9 GO:1905072 cardiac jelly development(GO:1905072)
1.4 8.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.4 5.4 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
1.4 5.4 GO:0002637 regulation of immunoglobulin production(GO:0002637) positive regulation of immunoglobulin production(GO:0002639)
1.3 4.0 GO:0050853 B cell receptor signaling pathway(GO:0050853)
1.2 12.5 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
1.2 6.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
1.2 8.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.1 11.4 GO:0051601 exocyst localization(GO:0051601)
1.1 5.6 GO:0051148 negative regulation of muscle cell differentiation(GO:0051148)
1.0 7.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
1.0 17.1 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
1.0 40.6 GO:0002548 monocyte chemotaxis(GO:0002548)
1.0 7.9 GO:0097535 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.9 5.4 GO:0032218 riboflavin transport(GO:0032218)
0.9 4.4 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.9 8.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.8 3.4 GO:0001712 ectodermal cell fate commitment(GO:0001712) ectodermal cell fate specification(GO:0001715) ectodermal cell differentiation(GO:0010668) regulation of ectodermal cell fate specification(GO:0042665) regulation of ectoderm development(GO:2000383)
0.8 3.4 GO:0099563 modification of synaptic structure(GO:0099563)
0.8 13.3 GO:0050927 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.8 3.1 GO:0006272 leading strand elongation(GO:0006272)
0.8 5.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.8 8.3 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.7 30.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.7 2.2 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.7 35.8 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.7 5.0 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.7 7.6 GO:0001541 ovarian follicle development(GO:0001541) ovulation cycle process(GO:0022602) ovulation cycle(GO:0042698)
0.7 1.3 GO:0003091 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.7 2.0 GO:0003071 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.7 4.0 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.7 53.6 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.6 5.6 GO:0021535 cell migration in hindbrain(GO:0021535)
0.6 6.8 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.6 6.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.6 6.0 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.6 4.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.6 4.6 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.6 2.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.6 8.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.6 2.2 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.6 28.3 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.6 12.7 GO:0030183 B cell differentiation(GO:0030183)
0.5 2.2 GO:0046324 regulation of glucose import(GO:0046324)
0.5 3.6 GO:0034341 response to interferon-gamma(GO:0034341) cellular response to interferon-gamma(GO:0071346)
0.5 8.8 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.5 4.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.5 6.1 GO:0051122 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.5 7.9 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.5 2.9 GO:0070254 mucus secretion(GO:0070254)
0.5 2.0 GO:0098751 bone cell development(GO:0098751)
0.5 3.4 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.5 18.4 GO:0030199 collagen fibril organization(GO:0030199)
0.5 9.4 GO:0010737 protein kinase A signaling(GO:0010737)
0.5 7.3 GO:0001843 neural tube closure(GO:0001843)
0.4 0.4 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.4 2.2 GO:0045822 negative regulation of heart contraction(GO:0045822) negative regulation of blood circulation(GO:1903523)
0.4 4.0 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.4 2.2 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.4 9.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.4 2.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.4 8.4 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.4 32.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.4 5.7 GO:0061154 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.4 2.0 GO:0048903 anterior lateral line neuromast hair cell differentiation(GO:0048903)
0.4 8.3 GO:0002761 regulation of myeloid leukocyte differentiation(GO:0002761)
0.4 5.4 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.4 5.8 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.4 1.2 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.4 2.3 GO:0071800 podosome assembly(GO:0071800)
0.4 2.3 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.4 1.5 GO:0010259 multicellular organism aging(GO:0010259)
0.4 4.1 GO:0008078 mesodermal cell migration(GO:0008078)
0.4 8.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 5.5 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.4 5.4 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)
0.4 33.2 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179) response to transforming growth factor beta(GO:0071559) cellular response to transforming growth factor beta stimulus(GO:0071560)
0.4 5.0 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.4 3.2 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.3 25.0 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.3 2.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 1.0 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.3 2.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.3 7.7 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.3 24.7 GO:0030048 actin filament-based movement(GO:0030048)
0.3 6.2 GO:0001841 neural tube formation(GO:0001841)
0.3 3.2 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.3 4.7 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 2.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 9.0 GO:0051014 actin filament severing(GO:0051014)
0.3 6.8 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.3 4.0 GO:0051639 actin filament network formation(GO:0051639)
0.3 0.8 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320) messenger ribonucleoprotein complex assembly(GO:1990120)
0.3 1.6 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.3 1.8 GO:0001938 regulation of endothelial cell proliferation(GO:0001936) positive regulation of endothelial cell proliferation(GO:0001938)
0.3 3.7 GO:0032264 IMP salvage(GO:0032264)
0.2 1.6 GO:0006621 protein retention in ER lumen(GO:0006621)
0.2 4.4 GO:1902622 regulation of neutrophil migration(GO:1902622)
0.2 3.7 GO:0002574 thrombocyte differentiation(GO:0002574)
0.2 0.7 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.2 0.9 GO:0034164 regulation of toll-like receptor 9 signaling pathway(GO:0034163) negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.2 2.3 GO:0031274 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.2 2.9 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.2 4.5 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 7.2 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.2 1.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 6.6 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.2 0.8 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 9.0 GO:0045010 actin nucleation(GO:0045010)
0.2 1.6 GO:0006203 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.2 8.7 GO:0050727 regulation of inflammatory response(GO:0050727)
0.2 1.0 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.2 4.4 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.2 1.9 GO:0051893 cell-substrate adherens junction assembly(GO:0007045) adherens junction assembly(GO:0034333) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.2 3.0 GO:0016926 protein desumoylation(GO:0016926)
0.2 1.3 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.2 3.7 GO:0030041 actin filament polymerization(GO:0030041)
0.2 2.4 GO:0003313 heart rudiment development(GO:0003313)
0.2 3.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 8.2 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.2 1.7 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.2 16.4 GO:0031101 fin regeneration(GO:0031101)
0.2 2.0 GO:0060021 palate development(GO:0060021)
0.2 6.0 GO:0072348 sulfur compound transport(GO:0072348)
0.2 3.5 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation(GO:0050731)
0.2 3.8 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.1 4.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 5.0 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 1.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 13.5 GO:0008064 regulation of actin polymerization or depolymerization(GO:0008064) regulation of actin filament length(GO:0030832)
0.1 7.6 GO:0016575 histone deacetylation(GO:0016575)
0.1 10.7 GO:0001817 regulation of cytokine production(GO:0001817)
0.1 1.5 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 1.5 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 37.4 GO:0043087 regulation of GTPase activity(GO:0043087)
0.1 1.8 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 0.8 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 3.7 GO:0051923 sulfation(GO:0051923)
0.1 1.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 11.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 1.0 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 4.2 GO:0002224 toll-like receptor signaling pathway(GO:0002224)
0.1 3.7 GO:0006270 DNA replication initiation(GO:0006270)
0.1 2.6 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.1 0.2 GO:0042306 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.1 4.3 GO:0030336 negative regulation of cell migration(GO:0030336) negative regulation of cell motility(GO:2000146)
0.1 5.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 0.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 3.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 2.4 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 3.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 9.7 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 3.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.7 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 1.0 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.1 2.8 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 5.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 16.5 GO:0045087 innate immune response(GO:0045087)
0.1 4.0 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.1 7.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.7 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 0.5 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 1.1 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 2.4 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 19.8 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.1 1.2 GO:0048570 notochord morphogenesis(GO:0048570)
0.1 2.6 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.1 5.6 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 1.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 2.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.1 2.3 GO:0009395 phospholipid catabolic process(GO:0009395)
0.1 5.7 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.1 5.4 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 3.0 GO:0001570 vasculogenesis(GO:0001570)
0.1 4.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.1 GO:0015780 nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 4.1 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.1 2.8 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 1.4 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.1 17.3 GO:0006955 immune response(GO:0006955)
0.1 1.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.8 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.1 0.6 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 2.3 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 4.9 GO:0002040 sprouting angiogenesis(GO:0002040)
0.1 0.8 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 3.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 3.4 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 2.3 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.0 0.8 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.0 3.1 GO:0007416 synapse assembly(GO:0007416)
0.0 0.6 GO:0036065 fucosylation(GO:0036065)
0.0 5.6 GO:0001525 angiogenesis(GO:0001525)
0.0 1.2 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.7 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.2 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 1.1 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.3 GO:0019430 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 5.6 GO:0051301 cell division(GO:0051301)
0.0 0.6 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.7 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 1.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.3 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 1.4 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 0.1 GO:0031333 negative regulation of protein complex assembly(GO:0031333)
0.0 1.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.9 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.0 1.1 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 1.5 GO:0001503 ossification(GO:0001503)
0.0 1.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 0.2 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.3 GO:0043410 positive regulation of MAPK cascade(GO:0043410)
0.0 0.8 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.3 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.4 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.0 0.1 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.5 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 4.8 GO:0000226 microtubule cytoskeleton organization(GO:0000226)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 33.8 GO:0045095 keratin filament(GO:0045095)
2.9 8.8 GO:0032998 Fc receptor complex(GO:0032997) Fc-epsilon receptor I complex(GO:0032998)
2.9 5.8 GO:0001891 phagocytic cup(GO:0001891)
2.5 12.4 GO:0097433 dense body(GO:0097433)
2.0 7.9 GO:0016600 flotillin complex(GO:0016600)
1.9 15.4 GO:0043020 NADPH oxidase complex(GO:0043020)
1.8 7.3 GO:0019815 B cell receptor complex(GO:0019815)
1.8 10.8 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
1.7 15.2 GO:0031526 brush border membrane(GO:0031526)
1.6 9.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.2 3.6 GO:0034709 methylosome(GO:0034709)
1.2 4.7 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
1.0 13.4 GO:0002102 podosome(GO:0002102)
0.8 6.1 GO:0001772 immunological synapse(GO:0001772)
0.7 12.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.7 8.1 GO:0044295 axonal growth cone(GO:0044295)
0.6 2.4 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.6 8.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.6 2.2 GO:0035339 SPOTS complex(GO:0035339)
0.5 1.6 GO:0032584 growth cone membrane(GO:0032584)
0.5 2.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.5 2.1 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.5 8.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.5 1.4 GO:1902560 GMP reductase complex(GO:1902560)
0.5 1.9 GO:0016460 myosin II complex(GO:0016460)
0.5 6.5 GO:0000815 ESCRT III complex(GO:0000815)
0.4 56.1 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.4 7.0 GO:0031209 SCAR complex(GO:0031209)
0.4 2.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.4 11.3 GO:0000145 exocyst(GO:0000145)
0.4 44.4 GO:0005884 actin filament(GO:0005884)
0.4 19.6 GO:0030496 midbody(GO:0030496)
0.4 2.1 GO:0031262 Ndc80 complex(GO:0031262)
0.3 1.0 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3 1.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.3 8.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.3 22.3 GO:0072686 mitotic spindle(GO:0072686)
0.3 3.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 3.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 29.6 GO:0005604 basement membrane(GO:0005604)
0.3 1.8 GO:0070876 SOSS complex(GO:0070876)
0.3 13.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.3 4.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.3 0.8 GO:1990879 CST complex(GO:1990879)
0.3 0.8 GO:0042382 paraspeckles(GO:0042382)
0.3 1.9 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 1.5 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.3 1.8 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2 4.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 17.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 11.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 3.9 GO:0005685 U1 snRNP(GO:0005685)
0.2 4.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 3.5 GO:0030315 T-tubule(GO:0030315)
0.2 1.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 53.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 22.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 14.3 GO:0030027 lamellipodium(GO:0030027)
0.2 3.1 GO:0043209 myelin sheath(GO:0043209)
0.2 1.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 1.3 GO:0000813 ESCRT I complex(GO:0000813)
0.2 4.0 GO:0031594 neuromuscular junction(GO:0031594)
0.2 9.5 GO:0022626 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.2 0.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 1.1 GO:1990130 Iml1 complex(GO:1990130)
0.1 2.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.7 GO:0070390 transcription export complex 2(GO:0070390)
0.1 1.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.7 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 6.6 GO:0016529 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.1 15.4 GO:0016459 myosin complex(GO:0016459)
0.1 2.4 GO:0016282 eukaryotic 43S preinitiation complex(GO:0016282)
0.1 7.9 GO:0030018 Z disc(GO:0030018)
0.1 1.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 8.1 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.1 6.0 GO:0031902 late endosome membrane(GO:0031902)
0.1 1.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 8.3 GO:0005882 intermediate filament(GO:0005882)
0.1 6.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 96.5 GO:0005615 extracellular space(GO:0005615)
0.1 3.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 2.7 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 7.8 GO:0005938 cell cortex(GO:0005938)
0.0 0.4 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 2.9 GO:0031201 SNARE complex(GO:0031201)
0.0 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 5.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 10.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 2.1 GO:0005925 focal adhesion(GO:0005925)
0.0 4.6 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 2.2 GO:0014069 postsynaptic density(GO:0014069)
0.0 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 3.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.9 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 15.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
3.6 50.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
2.9 8.8 GO:0019767 immunoglobulin receptor activity(GO:0019763) IgE receptor activity(GO:0019767)
2.9 11.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.8 8.4 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
2.8 14.0 GO:0001223 transcription coactivator binding(GO:0001223)
2.6 12.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
2.5 12.4 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
2.4 7.3 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
2.3 7.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
2.2 15.5 GO:0004962 endothelin receptor activity(GO:0004962)
2.1 8.5 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
1.9 5.8 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
1.9 11.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.8 16.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.8 10.5 GO:0008142 oxysterol binding(GO:0008142)
1.7 12.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
1.7 17.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
1.6 11.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
1.4 8.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
1.4 4.1 GO:0008179 adenylate cyclase binding(GO:0008179)
1.2 5.0 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
1.2 6.1 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
1.2 6.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
1.2 6.0 GO:0042609 CD4 receptor binding(GO:0042609)
1.1 4.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.0 3.1 GO:0045545 syndecan binding(GO:0045545)
1.0 14.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
1.0 3.0 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
1.0 6.8 GO:0019809 spermidine binding(GO:0019809)
1.0 15.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.9 12.2 GO:0055102 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.9 58.3 GO:0008009 chemokine activity(GO:0008009)
0.9 5.4 GO:0032217 riboflavin transporter activity(GO:0032217)
0.8 9.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.8 5.4 GO:0031779 melanocortin receptor binding(GO:0031779)
0.8 6.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.7 7.3 GO:0005522 profilin binding(GO:0005522)
0.7 10.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.7 2.8 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.7 4.0 GO:0019215 intermediate filament binding(GO:0019215)
0.6 3.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.6 1.9 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
0.6 6.8 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.6 5.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.6 2.3 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.5 6.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.5 1.6 GO:0043621 protein self-association(GO:0043621)
0.5 8.4 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.5 3.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.5 1.4 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.5 1.9 GO:0032034 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
0.5 1.9 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.5 1.9 GO:0047611 acetylspermidine deacetylase activity(GO:0047611)
0.5 1.9 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.5 12.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.5 53.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 36.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 3.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.4 8.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 7.7 GO:0072542 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.4 3.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.4 5.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.4 6.2 GO:0005080 protein kinase C binding(GO:0005080)
0.4 3.0 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.4 1.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.4 1.5 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.4 2.9 GO:0008515 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.4 3.6 GO:0050700 CARD domain binding(GO:0050700)
0.4 5.0 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.4 6.0 GO:0015026 coreceptor activity(GO:0015026)
0.3 8.7 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.3 7.3 GO:0051018 protein kinase A binding(GO:0051018)
0.3 2.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 3.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 11.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 1.6 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.3 6.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.3 1.2 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.3 1.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.3 2.8 GO:0070700 BMP receptor binding(GO:0070700)
0.3 33.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 9.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 0.8 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.3 9.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 1.6 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 0.7 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.2 12.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 7.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 2.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 7.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.5 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 3.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.2 2.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 2.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 1.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 3.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 3.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 8.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 8.6 GO:0000049 tRNA binding(GO:0000049)
0.2 2.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 28.4 GO:0000149 SNARE binding(GO:0000149)
0.2 60.3 GO:0051015 actin filament binding(GO:0051015)
0.2 4.1 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 1.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.2 8.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.2 0.9 GO:0008430 selenium binding(GO:0008430)
0.2 0.8 GO:0046592 polyamine oxidase activity(GO:0046592)
0.2 6.0 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 1.3 GO:0015250 water channel activity(GO:0015250)
0.1 1.9 GO:0005537 mannose binding(GO:0005537)
0.1 1.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 2.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 2.9 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 28.1 GO:0019901 protein kinase binding(GO:0019901)
0.1 1.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 70.1 GO:0005198 structural molecule activity(GO:0005198)
0.1 1.7 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1 6.1 GO:0017124 SH3 domain binding(GO:0017124)
0.1 1.6 GO:0070035 ATP-dependent DNA helicase activity(GO:0004003) ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.1 2.7 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 1.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 1.8 GO:0051117 ATPase binding(GO:0051117)
0.1 3.1 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 1.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 2.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 7.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 5.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 37.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 0.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 2.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 1.9 GO:0070411 I-SMAD binding(GO:0070411)
0.1 3.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.8 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.8 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 1.1 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.1 25.8 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 2.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.8 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.7 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 20.6 GO:0003779 actin binding(GO:0003779)
0.1 0.9 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 2.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 4.2 GO:0005126 cytokine receptor binding(GO:0005126)
0.1 4.3 GO:0019955 cytokine binding(GO:0019955)
0.1 6.3 GO:0005125 cytokine activity(GO:0005125)
0.1 6.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 3.1 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.1 4.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 3.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.8 GO:0051427 hormone receptor binding(GO:0051427)
0.1 0.6 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.5 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.8 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 9.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 7.0 GO:0042277 peptide binding(GO:0042277)
0.0 0.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.9 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 1.5 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 1.1 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 1.4 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 3.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.0 GO:0015216 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleoside transmembrane transporter activity(GO:0015211) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.7 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
1.1 33.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
1.0 2.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.8 10.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.7 10.4 PID ALK2 PATHWAY ALK2 signaling events
0.6 6.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.6 21.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.5 2.2 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.5 3.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.5 24.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.5 5.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.5 6.2 PID RHOA PATHWAY RhoA signaling pathway
0.5 10.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 6.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 11.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.5 24.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.4 6.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.4 8.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 1.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.4 7.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4 5.6 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.4 3.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.4 6.4 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.3 16.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 2.5 PID CD40 PATHWAY CD40/CD40L signaling
0.3 2.2 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 9.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.3 7.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 2.3 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.3 2.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.3 2.6 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.3 5.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.3 4.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 6.6 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 6.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 2.9 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 2.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 5.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 2.3 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.8 PID BMP PATHWAY BMP receptor signaling
0.1 2.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 1.9 PID AP1 PATHWAY AP-1 transcription factor network
0.1 2.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 6.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 12.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.8 PID E2F PATHWAY E2F transcription factor network
0.1 1.9 PID BARD1 PATHWAY BARD1 signaling events
0.1 1.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.9 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 0.9 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 2.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.3 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.2 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.2 6.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.2 7.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
1.2 5.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.1 5.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.1 6.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
1.0 8.9 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.9 11.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.8 13.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.8 6.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.8 6.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.7 7.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.7 5.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.6 3.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.5 5.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.5 3.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.5 3.8 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.4 8.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.4 20.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.4 2.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 5.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 1.0 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.3 2.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.3 4.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 3.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.3 31.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 1.9 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.3 3.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 4.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 4.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 3.8 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.2 17.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 3.6 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.2 3.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.2 3.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 4.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 6.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 2.8 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.2 1.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 7.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.0 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 4.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 9.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 5.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.0 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 2.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 0.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 4.1 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.1 2.9 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 1.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 2.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 2.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 2.8 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 0.9 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 0.9 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.1 2.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.4 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.1 0.7 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 2.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.3 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME S PHASE Genes involved in S Phase