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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for fev+fli1a_erg_etv2
Z-value: 1.43
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Transcription factors associated with fev+fli1a_erg_etv2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000009242 | FEV transcription factor, ETS family member | |
| ENSDARG00000054632 | Fli-1 proto-oncogene, ETS transcription factor a | |
| ENSDARG00000077304 | ETS transcription factor ERG | |
| ENSDARG00000053868 | ETS variant transcription factor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| etv2 | dr11_v1_chr16_-_42013858_42013858 | 0.47 | 2.0e-06 | Click! |
| erg | dr11_v1_chr10_-_167782_167782 | 0.42 | 3.0e-05 | Click! |
| fli1a | dr11_v1_chr18_+_48428126_48428126 | 0.39 | 9.7e-05 | Click! |
| fev | dr11_v1_chr9_-_11549379_11549379 | 0.30 | 3.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of fev+fli1a_erg_etv2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 49.1 | GO:0009617 | response to bacterium(GO:0009617) |
| 0.5 | 35.7 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.5 | 35.2 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) |
| 0.6 | 30.1 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.1 | 28.6 | GO:0006955 | immune response(GO:0006955) |
| 0.7 | 28.2 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.3 | 27.6 | GO:0009410 | response to xenobiotic stimulus(GO:0009410) |
| 0.7 | 26.8 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.2 | 25.4 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 1.0 | 24.1 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 169.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 86.1 | GO:0005576 | extracellular region(GO:0005576) |
| 0.3 | 81.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.2 | 76.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.5 | 71.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 33.5 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 4.4 | 26.6 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.2 | 26.3 | GO:0005884 | actin filament(GO:0005884) |
| 0.5 | 23.8 | GO:0005902 | microvillus(GO:0005902) |
| 2.9 | 23.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 150.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 58.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 43.5 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.2 | 41.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 36.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 30.9 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.5 | 30.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.6 | 26.5 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 2.9 | 23.3 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.3 | 23.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.8 | 19.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 19.2 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.4 | 16.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.3 | 15.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 13.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.9 | 12.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.3 | 12.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.5 | 12.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 10.2 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 76.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.5 | 75.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 8.0 | 32.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.2 | 25.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 15.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.7 | 15.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.3 | 13.9 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.7 | 11.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 11.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.3 | 10.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |