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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for en1a

Z-value: 1.29

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Transcription factors associated with en1a

Gene Symbol Gene ID Gene Info
ENSDARG00000014321 engrailed homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
en1adr11_v1_chr9_-_785444_785444-0.636.5e-12Click!

Activity profile of en1a motif

Sorted Z-values of en1a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_26018424 19.78 ENSDART00000089332
acyl-CoA synthetase bubblegum family member 1
chr2_-_51794472 17.87 ENSDART00000186652

chr16_+_23924040 17.71 ENSDART00000161124
si:dkey-7f3.14
chr24_-_24983047 16.49 ENSDART00000066631
solute carrier family 51, alpha subunit
chr10_+_28428222 16.40 ENSDART00000135003
si:ch211-222e20.4
chr25_-_26018240 16.16 ENSDART00000150800
acyl-CoA synthetase bubblegum family member 1
chr8_-_50147948 15.87 ENSDART00000149010
haptoglobin
chr20_-_25518488 14.40 ENSDART00000186993
cytochrome P450, family 2, subfamily N, polypeptide 13
chr13_-_34858500 12.98 ENSDART00000184843
serine palmitoyltransferase, long chain base subunit 3
chr14_-_21123551 12.48 ENSDART00000171679
ENSDART00000165882
si:dkey-74k8.4
chr23_+_28770225 12.13 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr13_-_15700060 12.08 ENSDART00000170689
ENSDART00000010986
ENSDART00000101741
ENSDART00000139124
creatine kinase, brain a
chr2_-_1514001 11.58 ENSDART00000057736
complement component 8, beta polypeptide
chr20_+_43942278 11.48 ENSDART00000100571
chloride intracellular channel 5b
chr15_+_14854666 11.31 ENSDART00000163066
diablo, IAP-binding mitochondrial protein a
chr9_-_9998087 11.28 ENSDART00000124423
UDP glucuronosyltransferase 1 family a, b
chr3_+_12732382 10.82 ENSDART00000158403
cytochrome P450, family 2, subfamily k, polypeptide 19
chr25_-_13023569 10.11 ENSDART00000167232
chemokine (C-C motif) ligand 39, duplicate 1
chr3_-_3939785 9.92 ENSDART00000049593
un-named sa1506
chr11_-_669558 9.10 ENSDART00000173450
peroxisome proliferator-activated receptor gamma
chr20_+_34845672 9.07 ENSDART00000128895
elastin microfibril interfacer 1a
chr7_+_30178453 8.73 ENSDART00000174420
si:ch211-107o10.3
chr10_+_38708099 8.41 ENSDART00000172306
transmembrane protease, serine 2
chr7_+_49664174 8.18 ENSDART00000137059
ENSDART00000131210
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7b
chr7_+_44713135 8.18 ENSDART00000170721
si:dkey-56m19.5
chr16_+_26017360 8.09 ENSDART00000149466
protease, serine, 59, tandem duplicate 2
chr3_+_26345732 7.87 ENSDART00000128613
ribosomal protein S15a
chr11_-_669270 7.71 ENSDART00000172834
peroxisome proliferator-activated receptor gamma
chr5_-_44843738 7.25 ENSDART00000003926
fructose-1,6-bisphosphatase 1a
chr7_-_10560964 6.97 ENSDART00000172761
ENSDART00000170476
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr7_-_20582842 6.86 ENSDART00000169750
ENSDART00000111719
si:dkey-19b23.11
chr2_+_26498446 6.15 ENSDART00000078412
ribosomal protein S8a
chr12_-_26537145 6.10 ENSDART00000138437
ENSDART00000163931
ENSDART00000132737
acyl-CoA synthetase family member 2
chr5_+_22459087 5.99 ENSDART00000134781

chr16_+_23383316 5.96 ENSDART00000103220
keratinocyte associated protein 2
chr25_-_30357027 5.88 ENSDART00000171137
protein disulfide isomerase family A, member 3
chr18_-_14901437 5.78 ENSDART00000145842
ENSDART00000008035
TraB domain containing
chr9_+_21277846 5.73 ENSDART00000139620
ENSDART00000110996
ENSDART00000111899
large tumor suppressor kinase 2
chr5_-_8164439 5.61 ENSDART00000189912
solute carrier family 1 (glial high affinity glutamate transporter), member 3a
chr17_+_3128273 5.37 ENSDART00000122453
zgc:136872
chr5_-_30615901 5.10 ENSDART00000147769
si:ch211-117m20.5
chr19_+_43780970 5.03 ENSDART00000063870
ribosomal protein L11
chr14_-_38872536 4.91 ENSDART00000184315
ENSDART00000127479
glutathione reductase
chr9_+_3113211 4.89 ENSDART00000139476
protein phosphatase 1 regulatory subunit 9A-like A
chr20_+_36629173 4.86 ENSDART00000161241
epoxide hydrolase 1, microsomal (xenobiotic)
chr6_+_23122789 4.83 ENSDART00000049226
ENSDART00000067560
acyl-CoA oxidase 1, palmitoyl
chr6_+_46320693 4.82 ENSDART00000128621
ENSDART00000155917
si:dkeyp-67f1.2
chr9_+_23003208 4.80 ENSDART00000021060
ELL associated factor 2
chr23_-_33738945 4.79 ENSDART00000136386
si:ch211-210c8.7
chr22_-_31020690 4.79 ENSDART00000130604
ssu-2 homolog, tandem duplicate 4
chr17_-_6076266 4.72 ENSDART00000171084
epoxide hydrolase 2, cytoplasmic
chr12_-_8070969 4.64 ENSDART00000020995
transmembrane protein 26b
chr4_+_28997595 4.62 ENSDART00000133357
si:dkey-13e3.1
chr17_-_8886735 4.51 ENSDART00000121997
NK-lysin tandem duplicate 3
chr13_+_15190677 4.38 ENSDART00000142240
ENSDART00000129045
mitochondrial antiviral signaling protein
chr14_-_11529311 4.36 ENSDART00000127208
si:ch211-153b23.7
chr5_+_9360394 4.34 ENSDART00000124642

chr16_-_21489514 4.29 ENSDART00000149525
ENSDART00000148517
ENSDART00000146914
ENSDART00000186493
ENSDART00000193081
ENSDART00000186017
membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr14_+_45732081 4.28 ENSDART00000110103
coiled-coil domain containing 88B
chr4_-_52165969 4.22 ENSDART00000171130
si:dkeyp-44b5.4
chr2_-_24398324 4.20 ENSDART00000165226
zgc:154006
chr23_-_10722664 4.16 ENSDART00000146526
ENSDART00000129022
ENSDART00000104985
forkhead box P1a
chr13_+_11876437 4.13 ENSDART00000179753
tripartite motif containing 8a
chr17_-_6349044 4.07 ENSDART00000081707
organic cation transporter 2
chr3_+_12784460 4.05 ENSDART00000168382
cytochrome P450, family 2, subfamily K, polypeptide 8
chr19_-_32914227 4.05 ENSDART00000186115
ENSDART00000124246
metadherin a
chr1_-_11607062 3.95 ENSDART00000158253
si:dkey-26i13.6
chr12_-_30540699 3.89 ENSDART00000167712
ENSDART00000102464
zgc:153920
chr5_-_69716501 3.88 ENSDART00000158956
MOB kinase activator 1A
chr16_-_5873866 3.85 ENSDART00000136936
trafficking protein, kinesin binding 1a
chr18_-_43866526 3.84 ENSDART00000111309
trehalase (brush-border membrane glycoprotein)
chr15_+_15779184 3.81 ENSDART00000156902
si:ch211-33e4.2
chr14_+_9432627 3.78 ENSDART00000042727
si:dkeyp-86f7.4
chr1_+_58205904 3.69 ENSDART00000147324
si:dkey-222h21.12
chr24_-_2423791 3.67 ENSDART00000190402
ras responsive element binding protein 1a
chr5_-_65021736 3.66 ENSDART00000162368
ENSDART00000161876
annexin A1c
chr2_+_38025260 3.65 ENSDART00000075905
heterogeneous nuclear ribonucleoprotein C
chr4_+_66853199 3.60 ENSDART00000170223
si:dkey-29m1.2
chr2_+_49631850 3.57 ENSDART00000114274
ENSDART00000114516
si:dkey-53k12.18
chr2_+_45441563 3.57 ENSDART00000151882
si:ch211-66k16.27
chr1_+_22654875 3.54 ENSDART00000019698
ENSDART00000161874
annexin A5b
chr5_-_38197080 3.51 ENSDART00000140708
si:ch211-284e13.9
chr19_-_18626515 3.50 ENSDART00000160624
ribosomal protein S18
chr11_-_3907937 3.47 ENSDART00000082409
ribophorin I
chr16_-_46578523 3.47 ENSDART00000131061
si:dkey-152b24.6
chr3_-_4557653 3.45 ENSDART00000111305
finTRIM family, member 50
chr6_+_6822592 3.41 ENSDART00000151057
si:ch211-85n16.4
chr2_+_36114194 3.39 ENSDART00000113547
T-cell receptor alpha joining 39
chr23_+_42819221 3.39 ENSDART00000180495
myosin, light chain 9a, regulatory
chr23_+_44374041 3.34 ENSDART00000136056
eph receptor B4b
chr9_+_38408991 3.32 ENSDART00000045588
cytochrome P450, family 27, subfamily A, polypeptide 7
chr17_-_23631400 3.32 ENSDART00000079563
Fas cell surface death receptor
chr7_+_38507006 3.27 ENSDART00000173830
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr2_+_30969029 3.22 ENSDART00000085242
lipin 2
chr3_-_4579214 3.16 ENSDART00000164456
finTRIM family, member 50
chr17_-_6076084 3.16 ENSDART00000058890
epoxide hydrolase 2, cytoplasmic
chr8_+_25616946 3.15 ENSDART00000133983
solute carrier family 38, member 5a
chr9_-_17417628 3.13 ENSDART00000060425
ENSDART00000141997
finTRIM family, member 53
chr1_-_48922273 3.11 ENSDART00000150254
si:ch211-112b1.2
chr9_+_44994214 3.09 ENSDART00000141434
retinol saturase (all-trans-retinol 13,14-reductase) like
chr7_-_34265481 3.08 ENSDART00000173596
si:ch211-98n17.5
chr7_-_60096318 2.97 ENSDART00000189125

chr7_+_49695904 2.97 ENSDART00000183550
ENSDART00000126991
achaete-scute family bHLH transcription factor 1b
chr17_+_42274825 2.92 ENSDART00000020156
paired box 1a
chr19_+_4076259 2.92 ENSDART00000160633
zgc:173581
chr4_-_17805128 2.90 ENSDART00000128988
Spi-2 proto-oncogene
chr2_+_22495274 2.85 ENSDART00000167915
leucine rich repeat containing 8 VRAC subunit Da
chr3_-_32934359 2.80 ENSDART00000124160
amine oxidase, copper containing 2
chr15_-_20233105 2.74 ENSDART00000123910
protein phosphatase 1, regulatory (inhibitor) subunit 14Ab
chr1_-_55131439 2.72 ENSDART00000074083
RAB1A, member RAS oncogene family a
chr12_-_44018667 2.70 ENSDART00000170692
si:dkey-201i2.4
chr2_+_36606019 2.70 ENSDART00000098415
inhibitor of growth family, member 5b
chr1_-_11606903 2.67 ENSDART00000136093
si:dkey-26i13.6
chr18_-_17513426 2.66 ENSDART00000146725
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr8_-_38403018 2.65 ENSDART00000134100
sorbin and SH3 domain containing 3
chr18_-_7422787 2.58 ENSDART00000081386
si:dkey-30c15.12
chr12_+_17754859 2.55 ENSDART00000112119
basic helix-loop-helix family, member a15
chr23_-_28120058 2.50 ENSDART00000087815
beta-1,4-N-acetyl-galactosaminyl transferase 1a
chr9_+_55857193 2.50 ENSDART00000160980
septin 10
chr22_+_19220459 2.49 ENSDART00000163070
si:dkey-21e2.7
chr2_+_45479841 2.42 ENSDART00000151856
si:ch211-66k16.28
chr17_-_45734459 2.42 ENSDART00000137807
ADP-ribosylation factor 6b
chr13_-_1130096 2.41 ENSDART00000010261
partner of NOB1 homolog
chr8_-_1267247 2.40 ENSDART00000150064
cell division cycle 14B
chr2_-_3045861 2.39 ENSDART00000105818
ENSDART00000187575
guanylate kinase 1a
chr7_-_24373662 2.39 ENSDART00000173865
si:dkey-11k2.7
chr17_-_45734231 2.36 ENSDART00000074873
ADP-ribosylation factor 6b
chr11_+_24716837 2.35 ENSDART00000145217
zgc:153953
chr10_-_21542702 2.33 ENSDART00000146761
ENSDART00000134502
zgc:165539
chr23_-_20363261 2.33 ENSDART00000054651
si:rp71-17i16.5
chr22_+_1123873 2.32 ENSDART00000137708
si:ch1073-181h11.2
chr8_+_40284973 2.30 ENSDART00000018401
ORAI calcium release-activated calcium modulator 1a
chr2_+_32780138 2.28 ENSDART00000082250
zgc:136930
chr3_-_13921173 2.26 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
chr20_+_51833030 2.26 ENSDART00000074330
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A
chr22_-_23228669 2.25 ENSDART00000079536
NIMA-related kinase 7
chr4_-_75707991 2.24 ENSDART00000166358
ENSDART00000160021
si:dkey-165o8.2
chr9_+_38420028 2.21 ENSDART00000135748
cytochrome P450, family 27, subfamily A, polypeptide 1, gene 2
chr3_+_23768898 2.20 ENSDART00000110682
homeobox B1a
chr8_+_43852743 2.18 ENSDART00000186485

chr1_+_12009673 2.18 ENSDART00000080100
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr3_+_14543953 2.18 ENSDART00000161710
erythropoietin receptor
chr13_+_18311410 2.17 ENSDART00000036718
ENSDART00000132073
eukaryotic translation initiation factor 4E family member 1c
chr4_+_57099307 2.17 ENSDART00000131654
si:ch211-238e22.2
chr9_+_1313418 2.17 ENSDART00000191361
caspase 8, apoptosis-related cysteine peptidase, like 2
chr2_-_6518785 2.15 ENSDART00000146108
regulator of G protein signaling 1
chr22_-_37738203 2.12 ENSDART00000143190
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr6_+_58725653 2.12 ENSDART00000190584
immunoglobulin superfamily, member 8
chr5_-_57723929 2.08 ENSDART00000144237
grass carp reovirus (GCRV)-induced gene 2p
chr16_-_41535690 2.06 ENSDART00000102662
ribonuclease P/MRP 25 subunit-like
chr12_+_9342502 2.05 ENSDART00000152808
potassium voltage-gated channel, subfamily H (eag-related), member 6b
chr1_-_11627289 2.05 ENSDART00000163312
si:dkey-26i13.3
chr18_+_41232719 2.05 ENSDART00000138552
ENSDART00000145863
thyroid hormone receptor interactor 12
chr11_-_13611132 1.95 ENSDART00000113055
si:ch211-1a19.2
chr20_-_27152495 1.94 ENSDART00000020710
BTB (POZ) domain containing 7
chr6_+_21684296 1.90 ENSDART00000057223
Ras homolog, mTORC1 binding like 1
chr2_-_6519017 1.87 ENSDART00000181716
regulator of G protein signaling 1
chr1_+_2301961 1.87 ENSDART00000108919
ENSDART00000143361
ENSDART00000142944
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr12_+_1385192 1.87 ENSDART00000160788
phosphatidylethanolamine N-methyltransferase
chr18_+_19456648 1.85 ENSDART00000079695
zwilch kinetochore protein
chr7_-_39751540 1.84 ENSDART00000016803
GrpE-like 1, mitochondrial
chr7_+_17120811 1.83 ENSDART00000147140
protein arginine methyltransferase 3
chr11_+_13176568 1.83 ENSDART00000125371
ENSDART00000123257
MAP kinase interacting serine/threonine kinase 1
chr20_-_20312789 1.83 ENSDART00000114779
si:ch211-212g7.6
chr25_-_3836597 1.82 ENSDART00000115154
si:ch211-247i17.1
chr10_+_38512270 1.82 ENSDART00000109752
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a
chr9_-_30555725 1.82 ENSDART00000079222
chromatin assembly factor 1, subunit B
chr1_-_18585046 1.79 ENSDART00000147228
family with sequence similarity 114, member A1
chr23_+_1730663 1.76 ENSDART00000149545
transglutaminase 1, K polypeptide
chr14_+_26247319 1.75 ENSDART00000192793
coiled-coil domain containing 69
chr15_-_1485086 1.75 ENSDART00000191651
si:dkeyp-97b10.3
chr2_-_26590628 1.74 ENSDART00000025120
NDC1 transmembrane nucleoporin
chr21_-_21570134 1.71 ENSDART00000174388
odorant receptor, family H, subfamily 133, member 4
chr10_-_16062565 1.69 ENSDART00000188728
si:dkey-184a18.5
chr23_-_26120281 1.68 ENSDART00000133372
ENSDART00000103872
regulator of complement activation group 2 gene 1
chr19_-_29832876 1.67 ENSDART00000005119
eukaryotic translation initiation factor 3, subunit I
chr7_-_17297156 1.67 ENSDART00000161336
novel immune-type receptor 11a
chr3_+_16663373 1.67 ENSDART00000100961
zgc:55558
chr17_-_465285 1.66 ENSDART00000168718
cholinergic receptor, muscarinic 5a
chr22_+_25733817 1.65 ENSDART00000176962
ENSDART00000187865
si:dkeyp-98a7.9
chr7_+_31879986 1.64 ENSDART00000138491
myosin binding protein C, cardiac
chr3_-_26184018 1.64 ENSDART00000191604
si:ch211-11k18.4
chr15_+_25158104 1.62 ENSDART00000128267
info solute carrier family 35, member F2, like
chr18_+_33322515 1.62 ENSDART00000136603
vomeronasal 2 receptor, a18
chr4_+_77905736 1.60 ENSDART00000144471
si:zfos-2131b9.2
chr2_-_985417 1.60 ENSDART00000140540
si:ch211-241e1.3
chr2_-_3616363 1.60 ENSDART00000144699
phosphotriesterase related
chr11_-_6880725 1.59 ENSDART00000007204
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
chr20_-_37813863 1.58 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr6_-_2134581 1.57 ENSDART00000175478
V-set and transmembrane domain containing 2 like
chr12_-_30523216 1.56 ENSDART00000152896
ENSDART00000153191
pleckstrin homology domain containing, family S member 1
chr7_+_53199763 1.55 ENSDART00000160097
cadherin 28
chr7_-_73856073 1.55 ENSDART00000181793

chr5_-_68022631 1.54 ENSDART00000143199
WAS protein family, member 3a
chr12_-_10381282 1.52 ENSDART00000152788
marker of proliferation Ki-67
chr10_-_39052264 1.51 ENSDART00000144036
immunoglobulin superfamily, member 5a
chr25_+_20140926 1.51 ENSDART00000121989
caldesmon 1b
chr22_+_835728 1.51 ENSDART00000003325
DENN/MADD domain containing 2Db
chr25_+_19095231 1.49 ENSDART00000154066
interferon stimulated exonuclease gene
chr10_-_40429747 1.48 ENSDART00000150613
trace amine associated receptor 20r

Network of associatons between targets according to the STRING database.

First level regulatory network of en1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 GO:0005986 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
2.3 11.3 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
2.0 6.0 GO:0042543 protein N-linked glycosylation via arginine(GO:0042543)
1.8 5.5 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378) vitamin D biosynthetic process(GO:0042368) cellular alcohol metabolic process(GO:0044107) cellular alcohol biosynthetic process(GO:0044108)
1.6 35.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
1.6 4.8 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
1.3 13.0 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
1.3 3.8 GO:0005991 disaccharide metabolic process(GO:0005984) trehalose metabolic process(GO:0005991)
1.2 4.8 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
1.2 16.8 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
1.2 16.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.0 7.0 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.9 12.1 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.9 1.8 GO:0006670 sphingosine metabolic process(GO:0006670)
0.9 4.4 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus(GO:0039528) cellular response to virus(GO:0098586)
0.8 3.3 GO:0070227 lymphocyte apoptotic process(GO:0070227)
0.8 3.2 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.8 12.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.7 2.2 GO:0060292 long term synaptic depression(GO:0060292)
0.6 3.9 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.6 3.7 GO:1900138 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) negative regulation of phospholipase activity(GO:0010519) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) regulation of leukocyte apoptotic process(GO:2000106) positive regulation of leukocyte apoptotic process(GO:2000108) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.6 29.2 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.5 5.7 GO:0046620 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.5 3.7 GO:0031179 peptide modification(GO:0031179)
0.5 1.4 GO:0090266 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.4 3.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.4 12.6 GO:0019835 cytolysis(GO:0019835)
0.4 2.0 GO:0003210 cardiac atrium formation(GO:0003210)
0.4 7.9 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.4 3.5 GO:0050819 negative regulation of coagulation(GO:0050819)
0.3 2.0 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.3 2.2 GO:0021661 rhombomere 4 development(GO:0021570) rhombomere 4 morphogenesis(GO:0021661)
0.3 4.8 GO:0014812 muscle cell migration(GO:0014812)
0.3 2.7 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.2 2.4 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.2 10.1 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 1.9 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 2.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 0.7 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 5.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.2 1.1 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.2 1.9 GO:0072395 signal transduction involved in cell cycle checkpoint(GO:0072395)
0.2 6.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 1.0 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.2 3.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.2 2.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 2.7 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 4.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 4.8 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.2 1.4 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 4.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.2 4.9 GO:0009636 response to toxic substance(GO:0009636)
0.2 1.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 1.7 GO:0006999 nuclear pore organization(GO:0006999)
0.1 2.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 2.7 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.1 0.8 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 2.3 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.8 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 0.7 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.1 1.5 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.7 GO:2001239 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 0.7 GO:0050927 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.1 1.8 GO:0018149 peptide cross-linking(GO:0018149)
0.1 3.6 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 1.2 GO:0061154 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.1 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.1 2.3 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.1 0.3 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 3.3 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.5 GO:2000290 regulation of myotome development(GO:2000290)
0.1 6.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.8 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 1.7 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.1 3.4 GO:0045766 positive regulation of angiogenesis(GO:0045766)
0.1 0.4 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.1 1.3 GO:1990798 pancreas regeneration(GO:1990798)
0.1 1.8 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.3 GO:0032447 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1 3.0 GO:0021575 hindbrain morphogenesis(GO:0021575)
0.1 1.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.1 1.9 GO:0061138 morphogenesis of a branching epithelium(GO:0061138)
0.1 8.2 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 1.1 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) response to interleukin-15(GO:0070672) cellular response to interleukin-15(GO:0071350)
0.1 1.9 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.4 GO:0046850 regulation of bone remodeling(GO:0046850)
0.0 3.2 GO:0009062 fatty acid catabolic process(GO:0009062)
0.0 1.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 2.5 GO:0031017 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.0 0.4 GO:1900186 optomotor response(GO:0071632) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 1.8 GO:0030199 collagen fibril organization(GO:0030199)
0.0 2.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 1.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 4.1 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.8 GO:0031936 nucleosome positioning(GO:0016584) negative regulation of chromatin silencing(GO:0031936)
0.0 0.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 5.9 GO:0006457 protein folding(GO:0006457)
0.0 5.0 GO:0030218 erythrocyte differentiation(GO:0030218)
0.0 3.1 GO:0009308 amine metabolic process(GO:0009308)
0.0 1.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.5 GO:0036065 fucosylation(GO:0036065)
0.0 1.5 GO:0001570 vasculogenesis(GO:0001570)
0.0 0.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.8 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.0 1.2 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 2.5 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 2.2 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 1.2 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.7 GO:0001757 somite specification(GO:0001757) segment specification(GO:0007379)
0.0 2.4 GO:0001756 somitogenesis(GO:0001756)
0.0 3.6 GO:0006954 inflammatory response(GO:0006954)
0.0 4.5 GO:0009617 response to bacterium(GO:0009617)
0.0 6.5 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 1.1 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 1.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 31.6 GO:0006508 proteolysis(GO:0006508)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0071156 regulation of cell cycle arrest(GO:0071156)
0.0 3.0 GO:0006631 fatty acid metabolic process(GO:0006631)
0.0 0.6 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.1 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 1.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 2.2 GO:0048793 pronephros development(GO:0048793)
0.0 0.6 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 4.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.8 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 1.6 GO:0006364 rRNA processing(GO:0006364)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 13.0 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.8 2.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.7 11.6 GO:0005579 membrane attack complex(GO:0005579)
0.6 4.8 GO:0032783 ELL-EAF complex(GO:0032783)
0.5 1.8 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.5 1.8 GO:0033186 CAF-1 complex(GO:0033186)
0.4 1.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.3 2.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 14.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.8 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 3.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 3.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 2.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 1.4 GO:0031262 Ndc80 complex(GO:0031262)
0.2 1.0 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.5 GO:0031213 RSF complex(GO:0031213)
0.2 0.9 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 2.7 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 3.5 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 12.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.5 GO:0031209 SCAR complex(GO:0031209)
0.1 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.1 5.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 5.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 7.3 GO:0000922 spindle pole(GO:0000922)
0.1 1.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 4.1 GO:0016342 catenin complex(GO:0016342)
0.1 2.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.5 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.3 GO:0071439 clathrin complex(GO:0071439)
0.1 2.6 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 0.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 1.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 44.5 GO:0005615 extracellular space(GO:0005615)
0.0 2.5 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.7 GO:0005643 nuclear pore(GO:0005643)
0.0 5.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 1.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.0 GO:0005845 mRNA cap binding complex(GO:0005845)
0.0 2.3 GO:0005882 intermediate filament(GO:0005882)
0.0 2.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 2.0 GO:0016607 nuclear speck(GO:0016607)
0.0 0.6 GO:0030286 dynein complex(GO:0030286)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:0031526 brush border membrane(GO:0031526)
0.0 2.5 GO:0030425 dendrite(GO:0030425)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 16.8 GO:0070644 vitamin D response element binding(GO:0070644)
2.8 35.9 GO:0016405 CoA-ligase activity(GO:0016405)
2.6 7.9 GO:0004301 epoxide hydrolase activity(GO:0004301)
2.4 7.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
2.0 6.1 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
1.9 13.0 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
1.8 5.5 GO:0031073 vitamin D3 25-hydroxylase activity(GO:0030343) cholesterol 26-hydroxylase activity(GO:0031073)
1.6 4.9 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
1.3 3.8 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.0 4.9 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
1.0 4.8 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.9 12.1 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.8 4.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.7 3.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.6 3.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.6 10.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.6 2.8 GO:0008131 primary amine oxidase activity(GO:0008131)
0.5 2.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.5 1.8 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.5 5.9 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 29.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.4 3.7 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.3 1.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.3 3.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 2.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 1.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.2 0.8 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.2 47.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.7 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 11.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 0.6 GO:0048030 disaccharide binding(GO:0048030)
0.2 1.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 3.9 GO:0050811 GABA receptor binding(GO:0050811)
0.2 0.7 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.2 5.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 1.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 3.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 1.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 1.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 2.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 2.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.6 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 1.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 4.8 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 22.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.8 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 2.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 3.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 3.6 GO:0019003 GDP binding(GO:0019003)
0.1 0.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.1 1.2 GO:0045503 dynein light chain binding(GO:0045503)
0.1 1.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.3 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 4.8 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.8 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.5 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 3.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 2.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.5 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 4.9 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 0.7 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 5.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 3.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.1 GO:0015026 coreceptor activity(GO:0015026)
0.1 3.3 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)
0.0 4.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.6 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 1.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.5 GO:0004532 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 0.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 4.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 1.5 GO:0019956 chemokine binding(GO:0019956) C-C chemokine binding(GO:0019957)
0.0 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 3.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 2.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 2.0 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 1.7 GO:0005254 chloride channel activity(GO:0005254)
0.0 9.9 GO:0005525 GTP binding(GO:0005525)
0.0 2.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 2.1 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.8 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 16.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 3.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 8.4 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 2.2 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 5.0 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.1 PID ARF6 PATHWAY Arf6 signaling events
0.1 15.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.8 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.2 PID EPO PATHWAY EPO signaling pathway
0.1 1.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 4.0 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 3.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 2.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 12.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 11.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.6 3.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.5 4.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.5 9.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.4 3.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.4 16.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 5.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 4.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.3 5.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.3 13.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 1.8 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 2.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 9.2 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 0.9 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 1.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 4.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 3.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 1.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 3.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.0 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 2.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation