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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for elf2a+elf2b
Z-value: 3.05
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Transcription factors associated with elf2a+elf2b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000019459 | E74-like factor 2a (ets domain transcription factor) | |
| ENSDARG00000079626 | E74-like factor 2b (ets domain transcription factor) | |
| ENSDARG00000117064 | E74-like factor 2b (ets domain transcription factor) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| elf2b | dr11_v1_chr1_-_13989643_13989643 | 0.82 | 7.5e-24 | Click! |
| elf2a | dr11_v1_chr14_-_46070802_46070802 | 0.80 | 2.1e-22 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_-_6982499 Show fit | 22.52 |
ENSDART00000101525
|
si:dkey-266m15.6 |
|
| chr1_-_45177373 Show fit | 22.46 |
ENSDART00000143142
ENSDART00000034549 |
zgc:111983 |
|
| chr4_-_76383223 Show fit | 19.55 |
ENSDART00000161866
ENSDART00000168456 ENSDART00000174287 ENSDART00000174048 |
zgc:123107 |
|
| chr15_+_42573909 Show fit | 19.51 |
ENSDART00000181801
|
zgc:110333 |
|
| chr16_-_45001842 Show fit | 18.53 |
ENSDART00000037797
|
sulfotransferase family 2, cytosolic sulfotransferase 3 |
|
| chr22_+_5478353 Show fit | 17.75 |
ENSDART00000160596
|
tubulin polymerization promoting protein |
|
| chr1_-_26026956 Show fit | 17.18 |
ENSDART00000102346
|
si:ch211-145b13.6 |
|
| chr14_-_33277743 Show fit | 15.85 |
ENSDART00000048130
|
START domain containing 14 |
|
| chr24_-_26328721 Show fit | 13.96 |
ENSDART00000125468
|
apolipoprotein Db |
|
| chr15_-_2652640 Show fit | 13.95 |
ENSDART00000146094
|
claudin f |
Network of associatons between targets according to the STRING database.
First level regulatory network of elf2a+elf2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 88.2 | GO:0000377 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.2 | 41.1 | GO:0045324 | late endosome to vacuole transport(GO:0045324) |
| 2.8 | 30.9 | GO:0018120 | peptidyl-arginine ADP-ribosylation(GO:0018120) |
| 0.7 | 30.8 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.3 | 26.7 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.3 | 25.1 | GO:0061640 | cytoskeleton-dependent cytokinesis(GO:0061640) |
| 0.9 | 23.1 | GO:0030497 | fatty acid elongation(GO:0030497) |
| 0.1 | 22.9 | GO:0043087 | regulation of GTPase activity(GO:0043087) |
| 0.9 | 22.6 | GO:1903845 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.3 | 22.6 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 94.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.5 | 65.2 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.4 | 52.5 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.4 | 47.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 34.7 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.5 | 34.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.1 | 34.4 | GO:0009986 | cell surface(GO:0009986) |
| 1.5 | 31.5 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.5 | 29.9 | GO:0031901 | early endosome membrane(GO:0031901) |
| 2.0 | 28.5 | GO:0000815 | ESCRT III complex(GO:0000815) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 61.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 60.5 | GO:0008289 | lipid binding(GO:0008289) |
| 0.2 | 43.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 41.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 2.8 | 30.9 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.2 | 28.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 26.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 24.0 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 0.5 | 23.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 1.2 | 20.9 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 45.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.7 | 28.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.6 | 19.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.3 | 18.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 16.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 2.0 | 15.7 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.6 | 15.0 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.9 | 13.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 1.0 | 13.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.6 | 12.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.7 | 23.7 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.3 | 23.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.8 | 21.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 1.2 | 19.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 1.1 | 18.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.5 | 18.6 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.3 | 17.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.0 | 14.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 1.3 | 14.4 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |