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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for dlx1a
Z-value: 1.32
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Transcription factors associated with dlx1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| dlx1a | dr11_v1_chr9_+_3388099_3388099 | 0.01 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_12011390 Show fit | 20.04 |
ENSDART00000187403
|
si:dkey-202l22.6 |
|
| chr15_-_46779934 Show fit | 15.67 |
ENSDART00000085136
|
chloride channel 2c |
|
| chr15_-_12011202 Show fit | 13.11 |
ENSDART00000160427
ENSDART00000168715 |
si:dkey-202l22.6 |
|
| chr5_+_56023186 Show fit | 10.36 |
ENSDART00000156230
|
frizzled class receptor 9a |
|
| chr24_-_27452488 Show fit | 10.22 |
ENSDART00000136433
|
chemokine (C-C motif) ligand 34b, duplicate 8 |
|
| chr4_+_73085993 Show fit | 10.11 |
ENSDART00000165749
|
si:ch73-170d6.2 |
|
| chr12_+_22580579 Show fit | 9.62 |
ENSDART00000171725
ENSDART00000192290 |
capping protein (actin filament), gelsolin-like b |
|
| chr22_-_30770751 Show fit | 9.44 |
ENSDART00000172115
|
|
|
| chr23_+_20110086 Show fit | 9.08 |
ENSDART00000054664
|
troponin C type 1b (slow) |
|
| chr22_+_19407531 Show fit | 8.73 |
ENSDART00000141060
|
si:dkey-78l4.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of dlx1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.7 | GO:0006508 | proteolysis(GO:0006508) |
| 0.4 | 26.2 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.4 | 25.6 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.5 | 24.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.5 | 16.3 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 1.0 | 15.7 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.0 | 12.8 | GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188) |
| 3.8 | 11.3 | GO:0002369 | T cell cytokine production(GO:0002369) |
| 0.2 | 10.9 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.3 | 10.1 | GO:0007044 | cell-substrate junction assembly(GO:0007044) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 87.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 25.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 14.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 14.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 13.6 | GO:0000323 | lytic vacuole(GO:0000323) |
| 0.3 | 13.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 13.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 13.0 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 11.5 | GO:0044420 | extracellular matrix component(GO:0044420) |
| 0.2 | 10.1 | GO:0001726 | ruffle(GO:0001726) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 27.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 23.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 20.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 19.7 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 16.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.9 | 15.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.5 | 14.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.5 | 14.0 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.1 | 12.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 9.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 8.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.4 | 8.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.4 | 8.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 7.4 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 6.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.4 | 5.8 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 5.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.2 | 5.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 19.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 12.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.8 | 10.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.3 | 10.8 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.3 | 9.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.3 | 8.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.6 | 7.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 6.2 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 5.1 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |