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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for ctcf
Z-value: 1.28
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Transcription factors associated with ctcf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ctcf | dr11_v1_chr18_+_22285992_22286029 | 0.42 | 2.5e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_2886937 Show fit | 10.83 |
ENSDART00000063533
|
aquaporin 12 |
|
| chr15_+_47525073 Show fit | 10.22 |
ENSDART00000067583
|
SID1 transmembrane family, member 2 |
|
| chr4_-_17409533 Show fit | 9.24 |
ENSDART00000011943
|
phenylalanine hydroxylase |
|
| chr20_-_30931139 Show fit | 8.18 |
ENSDART00000006778
ENSDART00000146376 |
acetyl-CoA acetyltransferase 2 |
|
| chr16_+_11558868 Show fit | 8.00 |
ENSDART00000112497
ENSDART00000180445 |
zgc:198329 |
|
| chr9_+_21148318 Show fit | 7.46 |
ENSDART00000035428
|
hydroxyacid oxidase 2 (long chain) |
|
| chr6_-_42388608 Show fit | 7.06 |
ENSDART00000049425
|
Sec61 translocon alpha 1 subunit, like |
|
| chr21_-_19918286 Show fit | 6.72 |
ENSDART00000180816
|
protein phosphatase 1, regulatory subunit 3B |
|
| chr13_+_1369003 Show fit | 6.31 |
ENSDART00000146082
|
interferon gamma receptor 1 |
|
| chr8_-_38317914 Show fit | 6.31 |
ENSDART00000125920
|
PDZ and LIM domain 2 (mystique) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ctcf
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | GO:0050658 | nucleic acid transport(GO:0050657) RNA transport(GO:0050658) establishment of RNA localization(GO:0051236) |
| 0.2 | 10.8 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
| 0.8 | 9.8 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.8 | 9.2 | GO:1902221 | L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 0.2 | 8.2 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 1.0 | 7.1 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
| 2.2 | 6.7 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 1.7 | 6.6 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.3 | 6.3 | GO:0098508 | endothelial to hematopoietic transition(GO:0098508) |
| 2.0 | 6.1 | GO:0006145 | allantoin catabolic process(GO:0000256) purine nucleobase catabolic process(GO:0006145) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 13.0 | GO:0000323 | lytic vacuole(GO:0000323) |
| 0.1 | 11.0 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 9.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.2 | 7.1 | GO:0005784 | Sec61 translocon complex(GO:0005784) |
| 0.3 | 6.8 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784) |
| 0.4 | 6.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 6.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 6.2 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.1 | 5.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 17.3 | GO:0022884 | macromolecule transmembrane transporter activity(GO:0022884) |
| 1.2 | 9.8 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 1.0 | 9.2 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 2.7 | 8.2 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.1 | 7.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.3 | 7.5 | GO:0010181 | FMN binding(GO:0010181) |
| 0.0 | 7.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.4 | 6.7 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.2 | 6.6 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 6.6 | GO:0019901 | protein kinase binding(GO:0019901) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.3 | 6.3 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.2 | 4.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 4.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 3.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 2.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 2.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 1.8 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 1.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.2 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 8.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 6.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.9 | 6.3 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.8 | 6.1 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 5.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.4 | 5.0 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.5 | 4.7 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 4.4 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.2 | 3.9 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |