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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for cebpb

Z-value: 2.05

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Transcription factors associated with cebpb

Gene Symbol Gene ID Gene Info
ENSDARG00000042725 CCAAT enhancer binding protein beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cebpbdr11_v1_chr8_-_28449782_284497820.471.6e-06Click!

Activity profile of cebpb motif

Sorted Z-values of cebpb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_23440632 59.29 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr5_-_63509581 52.99 ENSDART00000097325
complement component 5
chr14_+_21106444 51.48 ENSDART00000075744
ENSDART00000132363
aldolase b, fructose-bisphosphate
chr14_+_21107032 48.36 ENSDART00000138319
ENSDART00000139103
ENSDART00000184735
aldolase b, fructose-bisphosphate
chr9_-_32847642 46.68 ENSDART00000121506
hemopexin
chr8_-_50147948 42.04 ENSDART00000149010
haptoglobin
chr13_-_20540790 41.58 ENSDART00000131467
si:ch1073-126c3.2
chr14_+_16345003 40.38 ENSDART00000003040
ENSDART00000165193
intelectin 3
chr1_-_10071422 32.84 ENSDART00000135522
ENSDART00000033118
fibrinogen alpha chain
chr16_-_16701718 31.18 ENSDART00000143550
si:dkey-8k3.2
chr20_-_40755614 30.97 ENSDART00000061247
connexin 32.3
chr20_+_10538025 29.85 ENSDART00000129762
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr6_+_22068589 28.93 ENSDART00000151205
aldehyde dehydrogenase 1 family, member L1
chr22_-_26175237 28.08 ENSDART00000108737
complement component c3b, tandem duplicate 2
chr6_+_21202639 27.81 ENSDART00000083126
cell death-inducing DFFA-like effector c
chr8_-_39739627 27.02 ENSDART00000135422
ENSDART00000067844
si:ch211-170d8.5
chr3_+_19299309 26.32 ENSDART00000046297
ENSDART00000146955
low density lipoprotein receptor a
chr20_+_10544100 25.45 ENSDART00000113927
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr3_-_40275096 25.25 ENSDART00000141578
serine hydroxymethyltransferase 1 (soluble)
chr19_-_5699703 25.06 ENSDART00000082050
zgc:174904
chr5_+_28830388 23.20 ENSDART00000149150
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr24_-_33284945 23.11 ENSDART00000155429
ENSDART00000112845
zgc:195173
chr16_-_27749172 22.48 ENSDART00000145198
STEAP family member 4
chr9_-_9989660 22.45 ENSDART00000081463
UDP glucuronosyltransferase 1 family a, b
chr22_-_26236188 22.01 ENSDART00000162640
ENSDART00000167169
ENSDART00000138595
complement component c3b, tandem duplicate 1
chr7_-_60831082 21.95 ENSDART00000073654
ENSDART00000136999
pyruvate carboxylase b
chr9_-_53062083 21.36 ENSDART00000122155
zmp:0000000936
chr5_-_69948099 21.03 ENSDART00000034639
ENSDART00000191111
UDP glucuronosyltransferase 2 family, polypeptide A4
chr2_-_32643738 20.60 ENSDART00000112452
si:dkeyp-73d8.9
chr16_+_23984179 19.22 ENSDART00000175879
apolipoprotein C-II
chr9_-_48736388 18.97 ENSDART00000022074
dehydrogenase/reductase (SDR family) member 9
chr8_+_30699429 18.68 ENSDART00000005345
ureidopropionase, beta
chr5_+_26795773 18.28 ENSDART00000145631
transcobalamin II
chr7_-_4296771 17.01 ENSDART00000128855
cerebellin 11
chr9_+_38292947 16.80 ENSDART00000146663
transcription factor CP2-like 1
chr4_-_77432218 16.71 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr16_+_50289916 16.27 ENSDART00000168861
ENSDART00000167332
hepcidin antimicrobial peptide
chr14_+_36885524 16.05 ENSDART00000032547
leukocyte cell-derived chemotaxin 2 like
chr25_-_30429607 15.81 ENSDART00000162429
ENSDART00000176535
si:ch211-93f2.1
chr5_-_56412262 14.99 ENSDART00000083079
acetyl-CoA carboxylase alpha
chr20_+_37794633 14.70 ENSDART00000022060
activating transcription factor 3
chr16_-_21785261 14.63 ENSDART00000078858
si:ch73-86n18.1
chr25_+_13191391 14.54 ENSDART00000109937
si:ch211-147m6.2
chr22_-_17595310 14.21 ENSDART00000099056
glutathione peroxidase 4a
chr18_+_15644559 14.11 ENSDART00000061794
nuclear receptor subfamily 1, group H, member 4
chr7_+_65240227 14.00 ENSDART00000168287
beta-carotene oxygenase 1, like
chr25_-_32311048 13.91 ENSDART00000181806
ENSDART00000086334

chr15_-_1885247 13.76 ENSDART00000149703
P450 (cytochrome) oxidoreductase b
chr21_-_39058490 13.59 ENSDART00000114885
aldehyde dehydrogenase 3 family, member A2b
chr2_-_127945 13.50 ENSDART00000056453
insulin-like growth factor binding protein 1b
chr15_-_29348212 13.46 ENSDART00000133117
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)
chr19_+_8606883 13.40 ENSDART00000054469
ENSDART00000185264
S100 calcium binding protein A10a
chr12_+_48390715 13.39 ENSDART00000149351
stearoyl-CoA desaturase (delta-9-desaturase)
chr7_-_7845540 13.26 ENSDART00000166280
chemokine (C-X-C motif) ligand 8b, duplicate 1
chr24_-_36727922 12.91 ENSDART00000135142
si:ch73-334d15.1
chr25_+_13191615 12.89 ENSDART00000168849
si:ch211-147m6.2
chr16_+_44298902 12.81 ENSDART00000114795
dihydropyrimidinase
chr6_+_42475730 12.74 ENSDART00000150226
macrophage stimulating 1 receptor a
chr4_-_9549693 12.56 ENSDART00000160242

chr4_-_12725513 11.66 ENSDART00000132286
microsomal glutathione S-transferase 1.2
chr25_+_31323978 11.57 ENSDART00000067030
lymphocyte-specific protein 1
chr17_-_15149192 11.46 ENSDART00000180511
ENSDART00000103405
GTP cyclohydrolase 1
chr13_+_33688474 11.02 ENSDART00000161465

chr12_+_25775734 10.82 ENSDART00000024415
ENSDART00000149198
endothelial PAS domain protein 1a
chr24_-_32582378 10.58 ENSDART00000066590
retinol dehydrogenase 12, like
chr17_-_6076266 10.55 ENSDART00000171084
epoxide hydrolase 2, cytoplasmic
chr5_-_33259079 10.36 ENSDART00000132223
interferon induced transmembrane protein 1
chr21_+_4509483 10.31 ENSDART00000025612
phytanoyl-CoA dioxygenase domain containing 1
chr1_+_14253118 10.31 ENSDART00000161996
chemokine (C-X-C motif) ligand 8a
chr10_+_4924388 10.05 ENSDART00000108595
solute carrier family 46 member 2
chr7_-_46019756 10.00 ENSDART00000162583
zgc:162297
chr24_-_32582880 9.92 ENSDART00000186307
retinol dehydrogenase 12, like
chr12_-_5120175 9.83 ENSDART00000160729
retinol binding protein 4, plasma
chr6_-_13498745 9.41 ENSDART00000027684
ENSDART00000189438
myosin light chain kinase b
chr12_-_17199381 9.38 ENSDART00000193292
lipase, gastric
chr6_-_37422841 9.30 ENSDART00000138351
cystathionase (cystathionine gamma-lyase)
chr11_+_43419809 9.30 ENSDART00000172982
solute carrier family 29 (equilibrative nucleoside transporter), member 1b
chr8_-_26961779 9.16 ENSDART00000099214
solute carrier family 16 (monocarboxylate transporter), member 1b
chr6_-_43449013 9.08 ENSDART00000122423
2-epi-5-epi-valiolone synthase
chr3_+_3641429 9.00 ENSDART00000092393
phospholipase B domain containing 1
chr22_-_17677947 8.98 ENSDART00000139911
tight junction protein 3
chr1_+_17892944 8.96 ENSDART00000013021
toll-like receptor 3
chr8_+_20438884 8.68 ENSDART00000016422
ENSDART00000133794
MAP kinase interacting serine/threonine kinase 2b
chr7_-_22790630 8.65 ENSDART00000173496
si:ch211-15b10.6
chr7_+_21787507 8.58 ENSDART00000100936
transmembrane protein 88 b
chr1_-_25177086 8.49 ENSDART00000144711
ENSDART00000177225
transmembrane protein 154
chr17_+_10318071 8.48 ENSDART00000161844
forkhead box A1
chr10_-_36808348 8.46 ENSDART00000099320
dehydrogenase/reductase (SDR family) member 13a, tandem duplicate 1
chr17_+_3124129 8.44 ENSDART00000155323
zgc:136872
chr5_+_8196264 8.29 ENSDART00000174564
ENSDART00000161261
LMBR1 domain containing 2a
chr7_+_27691647 8.19 ENSDART00000079091
cytochrome P450, family 2, subfamily R, polypeptide 1
chr21_+_20901505 8.19 ENSDART00000132741
complement component 7b
chr17_-_6076084 8.16 ENSDART00000058890
epoxide hydrolase 2, cytoplasmic
chr8_-_28349859 8.15 ENSDART00000062671
tubulin, alpha 8 like
chr20_+_36629173 7.91 ENSDART00000161241
epoxide hydrolase 1, microsomal (xenobiotic)
chr4_-_20181964 7.86 ENSDART00000022539
fibrinogen-like 2a
chr24_-_32665283 7.74 ENSDART00000038364
carbonic anhydrase II
chr19_-_15192840 7.48 ENSDART00000151337
phosphatase and actin regulator 4a
chr3_-_26204867 7.44 ENSDART00000103748
glycerophosphodiester phosphodiesterase domain containing 3a
chr4_-_19693978 7.43 ENSDART00000100974
ENSDART00000040405
staphylococcal nuclease and tudor domain containing 1
chr4_+_21866851 7.39 ENSDART00000177640
acyl-CoA synthetase short chain family member 3
chr12_+_46960579 7.38 ENSDART00000149032
ornithine aminotransferase
chr7_+_12950507 7.31 ENSDART00000067629
ENSDART00000158004
serum amyloid A
chr11_-_6265574 7.23 ENSDART00000181974
ENSDART00000104405
chemokine (C-C motif) ligand 25b
chr8_-_19280856 7.20 ENSDART00000100473
zgc:77486
chr19_+_5674907 7.12 ENSDART00000042189
pyruvate dehydrogenase kinase, isozyme 2b
chr24_-_17049270 7.00 ENSDART00000175508
methionine sulfoxide reductase B2
chr7_-_7823662 6.93 ENSDART00000167652
chemokine (C-X-C motif) ligand 8b, duplicate 3
chr21_+_17051478 6.90 ENSDART00000047201
ENSDART00000161650
ENSDART00000167298
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2a
chr18_+_17493859 6.78 ENSDART00000090754
si:dkey-102f14.5
chr15_-_17960228 6.54 ENSDART00000155898
pleckstrin homology-like domain, family B, member 1b
chr7_+_15736230 6.49 ENSDART00000109942
multiple C2 domains, transmembrane 2b
chr21_-_22715297 6.46 ENSDART00000065548
complement component 1, q subcomponent, B chain
chr12_-_22238004 6.42 ENSDART00000038310
ORMDL sphingolipid biosynthesis regulator 3
chr12_+_31616412 6.40 ENSDART00000124439
carboxypeptidase N, polypeptide 1
chr14_-_38865800 6.22 ENSDART00000173047
glutathione reductase
chr17_+_33158350 6.22 ENSDART00000104476
sorting nexin 9a
chr12_+_4920451 6.18 ENSDART00000171525
ENSDART00000159986
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr2_-_40199780 6.15 ENSDART00000113901
chemokine (C-C motif) ligand 34a, duplicate 4
chr10_-_29733194 5.98 ENSDART00000149252
si:ch73-261i21.2
chr23_-_29394505 5.63 ENSDART00000017728
phosphogluconate dehydrogenase
chr24_-_38644937 5.60 ENSDART00000170194
solute carrier family 6, member 16b
chr20_-_33675676 5.52 ENSDART00000147168
rho-associated, coiled-coil containing protein kinase 2b
chr9_+_9502610 5.44 ENSDART00000061525
ENSDART00000125174
nuclear receptor subfamily 1, group I, member 2
chr5_-_30615901 5.38 ENSDART00000147769
si:ch211-117m20.5
chr3_+_3573696 5.35 ENSDART00000169680

chr14_+_48862987 5.28 ENSDART00000167810
zgc:154054
chr21_-_22547496 5.19 ENSDART00000166835
ENSDART00000089030
myosin VB
chr5_-_43935119 5.10 ENSDART00000142271
si:ch211-204c21.1
chr3_+_19216567 4.96 ENSDART00000134433
interleukin 12 receptor, beta 2a, like
chr9_-_9225980 4.96 ENSDART00000180301
cystathionine-beta-synthase b
chr4_-_22335247 4.95 ENSDART00000192781
golgin B1
chr5_-_6745442 4.80 ENSDART00000157402
ENSDART00000128684
ENSDART00000168698
osteoclast stimulating factor 1
chr3_-_54524194 4.77 ENSDART00000155406
ENSDART00000111791
si:ch73-208g10.1
chr5_-_39474235 4.72 ENSDART00000171557
anthrax toxin receptor 2a
chr17_+_30450163 4.67 ENSDART00000104257
lipin 1
chr5_-_32336613 4.65 ENSDART00000139732
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr2_-_37277626 4.64 ENSDART00000135340
NAD kinase b
chr12_-_45304971 4.58 ENSDART00000186537
ENSDART00000126405
ferredoxin reductase
chr23_+_25305431 4.53 ENSDART00000143291
si:dkey-151g10.6
chr21_-_16219400 4.51 ENSDART00000124871
tumor necrosis factor receptor superfamily, member a
chr12_-_8070969 4.46 ENSDART00000020995
transmembrane protein 26b
chr11_-_34577034 4.44 ENSDART00000133302
ENSDART00000184367
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr18_+_2228737 4.44 ENSDART00000165301
RAB27A, member RAS oncogene family
chr14_-_38929885 4.40 ENSDART00000148737
Bruton agammaglobulinemia tyrosine kinase
chr14_+_3507326 4.36 ENSDART00000159326
glutathione S-transferase pi 1
chr20_-_32045057 4.26 ENSDART00000152970
ENSDART00000034248
RAB32a, member RAS oncogene family
chr23_+_35650771 4.25 ENSDART00000005158
cyclin T1
chr19_-_33212023 4.18 ENSDART00000189209
tribbles pseudokinase 1
chr3_+_14641962 4.17 ENSDART00000091070
zgc:158403
chr5_+_44346691 4.17 ENSDART00000034523
threonyl-tRNA synthetase
chr4_-_5595237 4.14 ENSDART00000109854
vascular endothelial growth factor Ab
chr21_-_14762944 4.13 ENSDART00000114096
arrestin domain containing 1b
chr8_+_42917515 4.07 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr1_+_55752593 4.05 ENSDART00000108838
ENSDART00000134770
trans-2,3-enoyl-CoA reductase b
chr2_+_17055069 4.02 ENSDART00000115078
thrombopoietin
chr11_+_37251825 3.97 ENSDART00000169804
interleukin 17 receptor C
chr23_+_30967686 3.94 ENSDART00000144485
si:ch211-197l9.2
chr13_-_31544365 3.94 ENSDART00000005670
dehydrogenase/reductase (SDR family) member 7
chr1_-_52222989 3.84 ENSDART00000010236
calponin 1, basic, smooth muscle, a
chr2_+_11029138 3.79 ENSDART00000138737
ENSDART00000081058
ENSDART00000153662
acyl-CoA thioesterase 11a
chr20_+_25626479 3.66 ENSDART00000143883
phosphoribosyl pyrophosphate amidotransferase
chr17_+_25519089 3.66 ENSDART00000041721
crystallin beta-gamma domain containing 1a
chr24_-_27436319 3.65 ENSDART00000171489
si:dkey-25o1.7
chr1_-_9486214 3.61 ENSDART00000137821
mical-like 2b
chr8_+_21229718 3.60 ENSDART00000100222
cryptochrome circadian clock 1ba
chr12_-_33706726 3.46 ENSDART00000153135
myosin XVB
chr25_+_35553542 3.44 ENSDART00000113723
Spi-1 proto-oncogene a
chr24_+_16983269 3.43 ENSDART00000139176
ENSDART00000023833
eukaryotic translation initiation factor 2, subunit 3 gamma
chr10_+_23099890 3.43 ENSDART00000135890
si:dkey-175g6.5
chr5_-_43935460 3.42 ENSDART00000166152
ENSDART00000188969
si:ch211-204c21.1
chr21_-_30111134 3.41 ENSDART00000014223
solute carrier family 23 (ascorbic acid transporter), member 1
chr17_-_42799104 3.37 ENSDART00000154755
protein kinase D3
chr19_-_34927201 3.37 ENSDART00000076518
Src-like-adaptor 1
chr22_+_15973122 3.34 ENSDART00000144545
ring finger and CCCH-type domains 1a
chr17_+_10501647 3.32 ENSDART00000140391
TYRO3 protein tyrosine kinase
chr6_+_8314451 3.31 ENSDART00000147793
ENSDART00000183688
glutaryl-CoA dehydrogenase a
chr13_+_41917606 3.31 ENSDART00000114741
polymerase (RNA) I polypeptide B
chr16_-_51253925 3.30 ENSDART00000050644
serpin peptidase inhibitor, clade B (ovalbumin), member 14
chr9_+_907459 3.29 ENSDART00000034850
ENSDART00000144114
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr7_+_38090515 3.16 ENSDART00000131387
CCAAT/enhancer binding protein (C/EBP), gamma
chr14_-_1098607 3.16 ENSDART00000169090
ENSDART00000158905

chr12_+_46462090 3.13 ENSDART00000130748

chr1_-_59126139 3.09 ENSDART00000156105
si:ch1073-110a20.7
chr15_-_17010358 3.09 ENSDART00000156768
huntingtin interacting protein 1
chr3_+_37649436 3.08 ENSDART00000075039
golgi SNAP receptor complex member 2
chr5_-_26181863 3.05 ENSDART00000098500
coiled-coil domain containing 125
chr23_-_25891426 3.02 ENSDART00000189907

chr16_-_32233463 2.99 ENSDART00000102016
calcium homeostasis modulator family member 6
chr1_-_18585046 2.99 ENSDART00000147228
family with sequence similarity 114, member A1
chr20_-_25533739 2.98 ENSDART00000063064
cytochrome P450, family 2, subfamily AD, polypeptide 6
chr6_+_39114345 2.98 ENSDART00000136835
G protein-coupled receptor 84
chr8_-_23599096 2.96 ENSDART00000183096
solute carrier family 38, member 5b
chr22_-_13165186 2.90 ENSDART00000105762
aryl hydrocarbon receptor 2
chr16_+_27442549 2.90 ENSDART00000015688
inversin
chr3_-_57744323 2.90 ENSDART00000101829
lectin, galactoside-binding, soluble, 3 binding protein b
chr22_-_10397600 2.83 ENSDART00000181964
ENSDART00000142886
nischarin
chr20_+_32118559 2.82 ENSDART00000026273
CD164 molecule, sialomucin
chr18_-_26797723 2.78 ENSDART00000008013
SEC11 homolog A, signal peptidase complex subunit
chr10_-_23099809 2.77 ENSDART00000148333
ENSDART00000079703
ENSDART00000162444
notchless homolog 1 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of cebpb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 28.9 GO:0009397 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
8.4 25.3 GO:0006565 L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264)
6.1 18.3 GO:0006824 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
5.6 22.5 GO:0015677 copper ion import(GO:0015677)
4.4 26.3 GO:0032367 intracellular cholesterol transport(GO:0032367)
4.3 102.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
3.9 23.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
3.7 15.0 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
3.7 18.7 GO:0019482 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
3.4 13.5 GO:0003418 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418)
3.3 13.4 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
3.0 9.0 GO:0034138 chemokine production(GO:0032602) toll-like receptor 3 signaling pathway(GO:0034138)
2.9 11.5 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
2.5 7.5 GO:0015882 L-ascorbic acid transport(GO:0015882)
2.4 7.3 GO:0006953 acute-phase response(GO:0006953)
2.4 7.2 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
2.3 16.3 GO:0032570 response to progesterone(GO:0032570)
2.2 32.8 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
2.2 41.4 GO:0042574 retinal metabolic process(GO:0042574)
2.2 6.5 GO:0006958 humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958)
2.0 14.3 GO:0019344 homoserine metabolic process(GO:0009092) cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) transsulfuration(GO:0019346)
1.9 7.7 GO:0015670 carbon dioxide transport(GO:0015670)
1.6 8.2 GO:0071295 cellular response to nutrient(GO:0031670) cellular response to vitamin(GO:0071295) cellular response to vitamin D(GO:0071305)
1.6 6.4 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
1.5 9.3 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
1.4 9.8 GO:0046865 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
1.3 5.2 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
1.3 23.1 GO:0050994 regulation of lipid catabolic process(GO:0050994)
1.2 13.5 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
1.2 22.0 GO:0046686 response to cadmium ion(GO:0046686)
1.1 4.5 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
1.1 9.0 GO:0030104 water homeostasis(GO:0030104)
1.1 7.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
1.0 5.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
1.0 19.2 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
1.0 86.3 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
1.0 4.0 GO:0030091 protein repair(GO:0030091)
1.0 9.9 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.9 8.1 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.9 18.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.9 14.1 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.9 3.4 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.9 12.8 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.8 8.5 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.7 3.0 GO:0089709 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.7 13.2 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.7 2.9 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.7 7.2 GO:0010890 regulation of sequestering of triglyceride(GO:0010889) positive regulation of sequestering of triglyceride(GO:0010890) sequestering of triglyceride(GO:0030730)
0.7 18.7 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.7 12.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.7 4.6 GO:0006741 NADP biosynthetic process(GO:0006741)
0.7 5.9 GO:0060036 notochord cell vacuolation(GO:0060036)
0.6 5.6 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.6 3.4 GO:0089700 protein kinase D signaling(GO:0089700)
0.6 1.7 GO:1902001 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) positive regulation of lipid transport(GO:0032370) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.5 6.9 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.5 4.7 GO:1901998 toxin transport(GO:1901998)
0.4 6.9 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 2.0 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.4 1.6 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.4 1.6 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.4 6.8 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.4 9.8 GO:0071456 cellular response to hypoxia(GO:0071456)
0.4 4.1 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.4 13.6 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.4 2.6 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.4 11.7 GO:0009636 response to toxic substance(GO:0009636)
0.3 1.0 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.3 3.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.3 4.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 7.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.3 2.8 GO:0006465 signal peptide processing(GO:0006465)
0.3 0.9 GO:2000726 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.3 5.5 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.3 8.2 GO:0019835 cytolysis(GO:0019835)
0.3 3.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.3 2.7 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.3 6.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.3 1.8 GO:0060143 positive regulation of syncytium formation by plasma membrane fusion(GO:0060143) positive regulation of myoblast fusion(GO:1901741)
0.2 4.6 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 2.0 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.2 0.4 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753)
0.2 9.1 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.2 0.9 GO:0032790 ribosome disassembly(GO:0032790)
0.2 4.5 GO:0002574 thrombocyte differentiation(GO:0002574)
0.2 1.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.2 4.2 GO:0048246 macrophage chemotaxis(GO:0048246)
0.2 1.0 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.2 14.7 GO:0009615 response to virus(GO:0009615)
0.2 4.2 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.2 7.1 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.2 1.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 8.4 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.2 3.4 GO:0002761 regulation of myeloid leukocyte differentiation(GO:0002761)
0.1 1.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 2.7 GO:0007032 endosome organization(GO:0007032)
0.1 6.4 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 6.2 GO:0036269 swimming behavior(GO:0036269)
0.1 9.4 GO:0001666 response to hypoxia(GO:0001666)
0.1 8.6 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 5.3 GO:0000281 mitotic cytokinesis(GO:0000281)
0.1 6.2 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.1 4.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.4 GO:0050847 osteoclast development(GO:0036035) progesterone receptor signaling pathway(GO:0050847) bone cell development(GO:0098751)
0.1 7.6 GO:0010842 retina layer formation(GO:0010842)
0.1 4.0 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 9.2 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 4.4 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.1 2.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 3.3 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 4.7 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 3.1 GO:0001878 response to yeast(GO:0001878)
0.1 1.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 4.4 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.1 8.6 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.1 3.0 GO:0032496 response to lipopolysaccharide(GO:0032496)
0.1 3.3 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.1 8.1 GO:0006979 response to oxidative stress(GO:0006979)
0.1 2.4 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.1 4.2 GO:0042493 response to drug(GO:0042493)
0.1 0.3 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1 0.5 GO:0050927 regulation of positive chemotaxis(GO:0050926) positive regulation of positive chemotaxis(GO:0050927) induction of positive chemotaxis(GO:0050930)
0.1 2.5 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 5.0 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.1 5.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 1.8 GO:0003014 renal system process(GO:0003014)
0.1 0.6 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.1 0.7 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 11.3 GO:0009725 response to hormone(GO:0009725)
0.1 0.7 GO:0008354 germ cell migration(GO:0008354)
0.0 4.3 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 2.1 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 1.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 4.5 GO:0010506 regulation of autophagy(GO:0010506)
0.0 2.3 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 7.5 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.6 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 6.2 GO:0001947 heart looping(GO:0001947)
0.0 1.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 1.4 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 4.2 GO:0001889 liver development(GO:0001889)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 1.0 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 1.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 1.4 GO:0007605 sensory perception of sound(GO:0007605)
0.0 9.6 GO:0042981 regulation of apoptotic process(GO:0042981)
0.0 0.4 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 1.7 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.3 GO:0007548 sex differentiation(GO:0007548)
0.0 2.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 12.7 GO:0006508 proteolysis(GO:0006508)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 32.8 GO:0005577 fibrinogen complex(GO:0005577)
1.9 19.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
1.6 6.4 GO:0035339 SPOTS complex(GO:0035339)
0.9 7.4 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.9 2.7 GO:0044316 cone cell pedicle(GO:0044316)
0.9 2.6 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.8 3.1 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.7 7.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.7 2.8 GO:0005787 signal peptidase complex(GO:0005787)
0.7 3.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.6 12.7 GO:0009925 basal plasma membrane(GO:0009925)
0.5 4.7 GO:0070938 contractile ring(GO:0070938)
0.5 8.2 GO:0005579 membrane attack complex(GO:0005579)
0.5 2.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.5 4.2 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.3 1.4 GO:0061689 tricellular tight junction(GO:0061689)
0.3 3.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 4.9 GO:0005801 cis-Golgi network(GO:0005801)
0.3 6.5 GO:0045180 basal cortex(GO:0045180)
0.3 344.3 GO:0005615 extracellular space(GO:0005615)
0.2 6.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 103.0 GO:0005815 microtubule organizing center(GO:0005815)
0.2 2.3 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 2.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.2 19.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 6.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 2.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 7.5 GO:0005811 lipid particle(GO:0005811)
0.1 1.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 5.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 24.2 GO:0010008 endosome membrane(GO:0010008)
0.1 1.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 3.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 13.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 9.7 GO:0030027 lamellipodium(GO:0030027)
0.1 1.0 GO:0048179 activin receptor complex(GO:0048179)
0.1 7.2 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 2.3 GO:0005861 troponin complex(GO:0005861)
0.1 27.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 6.2 GO:0005764 lysosome(GO:0005764)
0.0 5.2 GO:0016459 myosin complex(GO:0016459)
0.0 4.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.9 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0030669 clathrin coat of endocytic vesicle(GO:0030128) clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.1 GO:0016592 mediator complex(GO:0016592)
0.0 11.9 GO:0005576 extracellular region(GO:0005576)
0.0 0.3 GO:0070187 telosome(GO:0070187)
0.0 21.0 GO:0005829 cytosol(GO:0005829)
0.0 2.2 GO:0030016 myofibril(GO:0030016)
0.0 4.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.8 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 99.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
9.6 28.9 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
8.4 25.3 GO:0070905 glycine hydroxymethyltransferase activity(GO:0004372) serine binding(GO:0070905)
7.6 30.5 GO:0005153 interleukin-8 receptor binding(GO:0005153)
7.3 22.0 GO:0004736 pyruvate carboxylase activity(GO:0004736)
6.2 18.7 GO:0004301 epoxide hydrolase activity(GO:0004301)
5.6 22.5 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
4.4 17.5 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
4.3 21.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
4.2 16.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
4.1 16.3 GO:0070891 lipoteichoic acid binding(GO:0070891)
3.7 15.0 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
3.4 13.8 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
3.3 13.4 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
2.8 14.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
2.6 7.9 GO:0033961 cis-stilbene-oxide hydrolase activity(GO:0033961)
2.4 19.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
2.4 14.1 GO:0032052 bile acid binding(GO:0032052)
2.3 18.3 GO:0031419 cobalamin binding(GO:0031419)
1.8 40.4 GO:0070492 oligosaccharide binding(GO:0070492)
1.7 7.0 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
1.6 6.3 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
1.6 14.0 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
1.4 9.8 GO:0034632 retinol transporter activity(GO:0034632)
1.4 4.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
1.4 13.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
1.3 5.1 GO:0004361 glutaryl-CoA dehydrogenase activity(GO:0004361)
1.2 6.2 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
1.2 6.2 GO:0050218 propionate-CoA ligase activity(GO:0050218)
1.2 13.5 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
1.1 189.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
1.1 12.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
1.0 4.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
1.0 9.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
1.0 12.1 GO:0019238 cyclohydrolase activity(GO:0019238)
1.0 5.0 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
1.0 56.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.9 7.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.8 8.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 4.1 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.8 9.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.7 5.5 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.6 2.5 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.5 3.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.5 13.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 3.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.4 1.6 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.4 6.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4 7.5 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.4 9.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 7.7 GO:0004622 lysophospholipase activity(GO:0004622)
0.4 13.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 2.7 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.4 16.3 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 1.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.3 2.7 GO:0015232 heme transporter activity(GO:0015232)
0.3 4.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 4.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 9.6 GO:0030165 PDZ domain binding(GO:0030165)
0.3 1.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 4.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.3 12.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 3.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 7.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 8.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 3.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 6.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 2.3 GO:0008443 6-phosphofructokinase activity(GO:0003872) phosphofructokinase activity(GO:0008443)
0.2 3.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.2 1.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 3.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 11.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.2 39.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 9.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 1.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 1.7 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.2 0.8 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 4.7 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 9.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.5 GO:0070513 death domain binding(GO:0070513)
0.1 3.1 GO:0031267 small GTPase binding(GO:0031267)
0.1 8.7 GO:0003823 antigen binding(GO:0003823)
0.1 13.9 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 3.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 7.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 5.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 1.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 1.4 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 1.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.7 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 5.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.5 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.4 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 3.4 GO:0000049 tRNA binding(GO:0000049)
0.1 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1 0.6 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 13.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 5.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 0.3 GO:0050699 WW domain binding(GO:0050699)
0.1 1.6 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.1 0.4 GO:0071916 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 4.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 2.8 GO:0005178 integrin binding(GO:0005178)
0.0 5.0 GO:0019955 cytokine binding(GO:0019955)
0.0 5.8 GO:0051213 dioxygenase activity(GO:0051213)
0.0 3.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 2.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 7.6 GO:0042802 identical protein binding(GO:0042802)
0.0 3.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 2.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 2.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 4.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 1.0 GO:0042562 hormone binding(GO:0042562)
0.0 5.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.4 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 1.7 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.0 1.4 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.7 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 108.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.9 32.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.9 25.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.8 11.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.7 53.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 14.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.5 9.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 16.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.4 21.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.3 4.8 ST GA12 PATHWAY G alpha 12 Pathway
0.2 3.1 PID ARF 3PATHWAY Arf1 pathway
0.2 23.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 2.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.1 7.4 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 7.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID P73PATHWAY p73 transcription factor network
0.0 3.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 99.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
3.9 31.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
2.7 32.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
2.3 59.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
2.3 9.0 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
1.9 19.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.6 11.5 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
1.1 16.7 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
1.0 9.0 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.8 4.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.7 16.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.7 9.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.6 7.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.6 32.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.5 9.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 25.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.4 4.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 4.7 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.4 10.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 7.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.3 6.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 8.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 2.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 4.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 1.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 1.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.2 1.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 3.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.2 4.2 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 4.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 5.2 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 4.0 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 1.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 5.4 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 3.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 4.2 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors