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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for cdc5l
Z-value: 1.19
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Transcription factors associated with cdc5l
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| cdc5l | dr11_v1_chr17_+_5061135_5061135 | 0.46 | 2.5e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_33606739 Show fit | 10.68 |
ENSDART00000026464
|
cofilin 1 (non-muscle), like |
|
| chr1_-_45177373 Show fit | 7.72 |
ENSDART00000143142
ENSDART00000034549 |
zgc:111983 |
|
| chr18_+_7591381 Show fit | 6.52 |
ENSDART00000136313
|
si:dkeyp-1h4.6 |
|
| chr15_-_12360409 Show fit | 6.04 |
ENSDART00000164596
|
transmembrane protease, serine 13a |
|
| chr24_-_26310854 Show fit | 5.97 |
ENSDART00000080113
|
apolipoprotein Db |
|
| chr7_+_14291323 Show fit | 5.27 |
ENSDART00000053521
|
Rh family, C glycoprotein a |
|
| chr12_-_30549022 Show fit | 4.98 |
ENSDART00000102474
|
zgc:158404 |
|
| chr16_-_46567344 Show fit | 4.77 |
ENSDART00000127721
|
si:dkey-152b24.7 |
|
| chr6_-_49063085 Show fit | 4.39 |
ENSDART00000156124
|
si:ch211-105j21.9 |
|
| chr3_+_62161184 Show fit | 4.18 |
ENSDART00000090370
ENSDART00000192665 |
NADPH oxidase organizer 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of cdc5l
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.7 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 9.6 | GO:0006413 | translational initiation(GO:0006413) |
| 0.2 | 6.2 | GO:0007568 | aging(GO:0007568) |
| 0.5 | 5.9 | GO:0072595 | maintenance of protein localization in organelle(GO:0072595) |
| 0.0 | 5.8 | GO:0007264 | small GTPase mediated signal transduction(GO:0007264) |
| 0.0 | 5.4 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.7 | 5.3 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.8 | 4.8 | GO:0097250 | mitochondrial respiratory chain supercomplex assembly(GO:0097250) |
| 0.2 | 4.8 | GO:0019827 | stem cell population maintenance(GO:0019827) |
| 0.2 | 4.7 | GO:0048570 | notochord morphogenesis(GO:0048570) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 8.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 7.4 | GO:0005764 | lysosome(GO:0005764) |
| 0.2 | 6.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 6.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 5.6 | GO:0005819 | spindle(GO:0005819) |
| 0.7 | 4.8 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.2 | 4.4 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 4.4 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.0 | 4.4 | GO:0048475 | membrane coat(GO:0030117) coated membrane(GO:0048475) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.2 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 10.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 8.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 7.6 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 7.4 | GO:0008289 | lipid binding(GO:0008289) |
| 0.1 | 6.8 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.1 | 6.2 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 1.9 | 5.7 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.2 | 5.3 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.1 | 5.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.7 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 5.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 4.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.4 | 3.8 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 3.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 2.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 2.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 2.6 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 7.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 6.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.2 | 5.6 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.2 | 4.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.3 | 4.3 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 4.3 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 4.2 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.4 | 3.8 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 3.6 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |