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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for barx2
Z-value: 1.24
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Transcription factors associated with barx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| barx2 | dr11_v1_chr18_+_47313899_47313899 | 0.04 | 7.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_9669717 Show fit | 27.86 |
ENSDART00000004604
|
si:dkey-153k10.9 |
|
| chr11_+_30057762 Show fit | 21.46 |
ENSDART00000164139
|
Nance-Horan syndrome b (congenital cataracts and dental anomalies) |
|
| chr22_-_13851297 Show fit | 19.11 |
ENSDART00000080306
|
S100 calcium binding protein, beta (neural) |
|
| chr16_+_5774977 Show fit | 16.18 |
ENSDART00000134202
|
cholecystokinin a |
|
| chr2_-_44280061 Show fit | 15.65 |
ENSDART00000136818
|
myelin protein zero |
|
| chr23_+_40460333 Show fit | 14.42 |
ENSDART00000184658
|
SOGA family member 3b |
|
| chr8_+_31717175 Show fit | 14.31 |
ENSDART00000013434
|
3-oxoacid CoA transferase 1a |
|
| chr9_-_9348058 Show fit | 13.93 |
ENSDART00000132257
|
zgc:113337 |
|
| chr15_-_44512461 Show fit | 12.45 |
ENSDART00000155456
|
glutamate receptor, ionotropic, AMPA 4a |
|
| chr25_+_37126921 Show fit | 11.90 |
ENSDART00000124331
|
si:ch1073-174d20.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of barx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 25.1 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.1 | 16.9 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.4 | 16.2 | GO:0007586 | digestion(GO:0007586) |
| 0.1 | 15.9 | GO:0010506 | regulation of autophagy(GO:0010506) |
| 0.3 | 15.7 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 13.5 | GO:0000398 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.3 | 12.3 | GO:0035336 | long-chain fatty-acyl-CoA metabolic process(GO:0035336) |
| 2.4 | 11.9 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.5 | 11.7 | GO:0031114 | regulation of microtubule depolymerization(GO:0031114) |
| 0.6 | 11.1 | GO:0098884 | postsynaptic neurotransmitter receptor internalization(GO:0098884) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 41.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 26.4 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 21.5 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 19.8 | GO:0043005 | neuron projection(GO:0043005) |
| 0.9 | 15.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 15.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 14.1 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 13.4 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.2 | 11.9 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.6 | 11.1 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 5.0 | 25.1 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 4.8 | 19.1 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.4 | 16.2 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 12.7 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.8 | 12.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.8 | 10.2 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.5 | 10.2 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.5 | 9.9 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.1 | 9.9 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 11.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.6 | 5.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 5.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 5.3 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.1 | 5.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 4.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 4.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 3.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 19.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 8.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.6 | 8.3 | REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway |
| 0.4 | 7.8 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.4 | 5.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.6 | 5.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.2 | 5.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.5 | 5.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.3 | 5.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.3 | 5.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |