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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for atf5a+atf5b
Z-value: 1.45
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Transcription factors associated with atf5a+atf5b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| atf5a | dr11_v1_chr5_-_30418636_30418636 | 0.73 | 1.1e-16 | Click! |
| atf5b | dr11_v1_chr15_-_17868870_17868870 | 0.17 | 1.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of atf5a+atf5b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.1 | GO:0050767 | regulation of neurogenesis(GO:0050767) |
| 0.7 | 28.2 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.1 | 25.6 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 1.4 | 23.1 | GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943) |
| 2.0 | 21.7 | GO:0097104 | presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105) |
| 3.4 | 20.7 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
| 0.3 | 19.9 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.4 | 18.4 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 1.7 | 18.3 | GO:0019883 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.1 | 17.3 | GO:0007018 | microtubule-based movement(GO:0007018) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 26.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 1.5 | 26.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 25.7 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.5 | 23.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 19.9 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 19.2 | GO:0030141 | secretory granule(GO:0030141) |
| 0.2 | 17.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 17.0 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 16.1 | GO:0009986 | cell surface(GO:0009986) |
| 1.6 | 12.6 | GO:0016586 | RSC complex(GO:0016586) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 34.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 32.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.4 | 31.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 5.6 | 28.2 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 1.8 | 26.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.6 | 25.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 23.1 | GO:0001159 | core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.8 | 21.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.8 | 21.5 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 1.5 | 18.1 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 12.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 9.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.9 | 9.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 8.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.7 | 7.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 7.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 6.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 4.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.8 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 9.7 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.9 | 9.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.4 | 9.3 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.7 | 8.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.9 | 6.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 6.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 6.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.5 | 2.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |