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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for atf4a+atf4b
Z-value: 1.34
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Transcription factors associated with atf4a+atf4b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000038141 | activating transcription factor 4b | |
| ENSDARG00000111939 | activating transcription factor 4a | |
| ENSDARG00000114163 | activating transcription factor 4b | |
| ENSDARG00000114542 | activating transcription factor 4b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| atf4b | dr11_v1_chr3_+_24197934_24197934 | 0.44 | 9.1e-06 | Click! |
| atf4a | dr11_v1_chr6_+_269204_269204 | -0.28 | 5.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_31119548 Show fit | 14.41 |
ENSDART00000136578
|
synapsin I |
|
| chr16_+_34523515 Show fit | 14.01 |
ENSDART00000041007
|
stathmin 1b |
|
| chr3_+_31933893 Show fit | 12.31 |
ENSDART00000146509
ENSDART00000139644 |
lin-7 homolog B (C. elegans) |
|
| chr15_-_24869826 Show fit | 11.66 |
ENSDART00000127047
|
tumor suppressor candidate 5a |
|
| chr4_+_17279966 Show fit | 11.56 |
ENSDART00000067005
ENSDART00000137487 |
branched chain amino-acid transaminase 1, cytosolic |
|
| chr19_-_9712530 Show fit | 10.65 |
ENSDART00000134816
|
solute carrier family 2 (facilitated glucose transporter), member 3a |
|
| chr15_+_29085955 Show fit | 10.24 |
ENSDART00000156799
|
si:ch211-137a8.4 |
|
| chr21_+_30502002 Show fit | 10.03 |
ENSDART00000043727
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a |
|
| chr4_+_1600034 Show fit | 9.90 |
ENSDART00000146779
|
solute carrier family 38, member 2 |
|
| chr5_-_55395964 Show fit | 9.90 |
ENSDART00000145791
|
prune homolog 2 (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of atf4a+atf4b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 33.1 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 15.7 | GO:0007420 | brain development(GO:0007420) |
| 1.4 | 15.3 | GO:0006798 | polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798) |
| 0.1 | 14.4 | GO:0099643 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 1.5 | 13.3 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 2.5 | 12.3 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 3.9 | 11.6 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 2.9 | 11.6 | GO:0009098 | leucine biosynthetic process(GO:0009098) |
| 1.7 | 10.0 | GO:0090467 | L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826) |
| 1.0 | 9.9 | GO:0006868 | glutamine transport(GO:0006868) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.0 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 18.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 17.3 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 15.3 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 14.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 3.1 | 12.3 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 9.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 7.4 | GO:0098978 | glutamatergic synapse(GO:0098978) |
| 0.1 | 7.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 6.3 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.1 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 18.4 | GO:0003779 | actin binding(GO:0003779) |
| 1.4 | 15.3 | GO:0004309 | exopolyphosphatase activity(GO:0004309) |
| 0.6 | 15.3 | GO:0008483 | transaminase activity(GO:0008483) |
| 3.1 | 12.3 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 11.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 2.9 | 11.6 | GO:0004084 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 1.4 | 10.0 | GO:0015189 | L-lysine transmembrane transporter activity(GO:0015189) |
| 0.8 | 9.9 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 0.1 | 9.8 | GO:0008146 | sulfotransferase activity(GO:0008146) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 6.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.3 | 5.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 3.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.1 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 2.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 2.1 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 2.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 1.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 25.3 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 2.5 | 24.9 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 2.9 | 14.4 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.6 | 13.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.6 | 11.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 2.5 | 9.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 2.5 | 9.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 1.9 | 5.8 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.2 | 3.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.4 | 3.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |