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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for atf2+atf7a+atf7b_creb5a+creb5b

Z-value: 2.53

Motif logo

Transcription factors associated with atf2+atf7a+atf7b_creb5a+creb5b

Gene Symbol Gene ID Gene Info
ENSDARG00000011298 activating transcription factor 7a
ENSDARG00000023903 activating transcription factor 2
ENSDARG00000055481 activating transcription factor 7b
ENSDARG00000114492 activating transcription factor 7b
ENSDARG00000115171 activating transcription factor 7b
ENSDARG00000070536 cAMP responsive element binding protein 5b
ENSDARG00000099002 cAMP responsive element binding protein 5a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf7bdr11_v1_chr6_-_39631164_396311810.751.5e-18Click!
atf2dr11_v1_chr9_+_2343096_23431720.631.1e-11Click!
creb5bdr11_v1_chr16_-_20707742_207077420.594.0e-10Click!
creb5adr11_v1_chr19_-_19505167_195051670.302.9e-03Click!
atf7adr11_v1_chr23_-_27479558_27479558-0.223.0e-02Click!

Activity profile of atf2+atf7a+atf7b_creb5a+creb5b motif

Sorted Z-values of atf2+atf7a+atf7b_creb5a+creb5b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_34523515 65.64 ENSDART00000041007
stathmin 1b
chr21_-_43606502 57.71 ENSDART00000151030
si:ch73-362m14.4
chr3_-_49566364 57.56 ENSDART00000161507
zgc:153426
chr24_-_7632187 49.95 ENSDART00000041714
ATPase H+ transporting V0 subunit a1b
chr1_-_22861348 48.29 ENSDART00000139412
si:dkey-92j12.6
chr16_-_12173554 46.17 ENSDART00000110567
ENSDART00000155935
calsyntenin 3
chr9_+_7548533 45.03 ENSDART00000081543
protein tyrosine phosphatase, receptor type, Na
chr7_+_40228422 41.20 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr6_+_27667359 40.60 ENSDART00000159624
ENSDART00000049177
RAB6B, member RAS oncogene family a
chr6_+_13920479 39.10 ENSDART00000155480
protein tyrosine phosphatase, receptor type, Nb
chr9_-_296169 38.05 ENSDART00000165228
kinesin family member 5A, a
chr24_-_24163201 37.89 ENSDART00000140170
MAP7 domain containing 2b
chr10_-_24371312 37.81 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr20_+_20637866 37.01 ENSDART00000060203
ENSDART00000079079
reticulon 1b
chr15_+_28685892 36.40 ENSDART00000155815
ENSDART00000060244
neuro-oncological ventral antigen 2
chr13_+_36146415 34.12 ENSDART00000140301
si:ch211-259k16.3
chr20_+_20638034 32.35 ENSDART00000189759
reticulon 1b
chr1_-_38756870 31.21 ENSDART00000130324
ENSDART00000148404
glycoprotein M6Ab
chr24_-_24162930 30.61 ENSDART00000080602
MAP7 domain containing 2b
chr8_+_21588067 30.37 ENSDART00000172190
adherens junctions associated protein 1
chr25_+_35683956 30.03 ENSDART00000149768
kinesin family member 21A
chr20_+_29743904 29.58 ENSDART00000146366
ENSDART00000153154
kinase D-interacting substrate 220b
chr2_-_42415902 28.81 ENSDART00000142489
solute carrier organic anion transporter family member 5A1b
chr17_-_26911852 28.60 ENSDART00000045842
regulator of calcineurin 3
chr2_+_20332044 28.59 ENSDART00000112131
phospholipid phosphatase related 4a
chr17_+_8184649 28.36 ENSDART00000091818
tubby like protein 4b
chr13_-_40499296 27.86 ENSDART00000158338
Danio rerio cyclin and CBS domain divalent metal cation transport mediator 1 (cnnm1), mRNA.
chr5_-_23999777 25.82 ENSDART00000085969
MAP7 domain containing 2a
chr13_+_32446169 25.44 ENSDART00000143325
5'-nucleotidase, cytosolic IB a
chr23_-_29667716 25.43 ENSDART00000158302
ENSDART00000133902
calsyntenin 1
chr2_+_20331445 25.36 ENSDART00000186880
phospholipid phosphatase related 4a
chr8_+_44714336 24.91 ENSDART00000145801
ELMO/CED-12 domain containing 3
chr10_+_37145007 24.03 ENSDART00000131777
CUE domain containing 1a
chr8_+_39607466 23.23 ENSDART00000097427
musashi RNA-binding protein 1
chr16_+_25137483 22.96 ENSDART00000155666
zinc finger protein 576, tandem duplicate 1
chr7_-_12065668 21.81 ENSDART00000101537
mex-3 RNA binding family member B
chr6_-_48311 21.49 ENSDART00000131010
zgc:114175
chr16_-_9869056 21.38 ENSDART00000149312
neurocalcin delta a
chr2_+_35603637 21.25 ENSDART00000147278
polo-like kinase 3 (Drosophila)
chr14_-_48939560 21.12 ENSDART00000021736
short coiled-coil protein b
chr1_+_41666611 20.63 ENSDART00000145789
F-box protein 41
chr8_+_29267093 20.45 ENSDART00000077647
glutamate receptor, ionotropic, delta 2
chr23_-_4915118 20.18 ENSDART00000060714
ATPase H+ transporting accessory protein 1a
chr15_-_11341635 20.10 ENSDART00000055220
RAB30, member RAS oncogene family
chr17_+_29345606 19.67 ENSDART00000086164
potassium channel tetramerization domain containing 3
chr20_+_25911342 18.71 ENSDART00000146004
tau tubulin kinase 2b
chr13_+_23843712 18.49 ENSDART00000057611
opioid receptor, mu 1
chr15_-_12319065 18.47 ENSDART00000162973
ENSDART00000170543
FXYD domain containing ion transport regulator 6
chr11_-_44163164 18.40 ENSDART00000047126
chloride channel, voltage-sensitive 4
chr2_+_12255568 18.23 ENSDART00000184164
ENSDART00000013454
phosphoribosyl transferase domain containing 1
chr16_-_32649929 18.22 ENSDART00000136161
failed axon connections homolog b
chr22_+_1796057 17.91 ENSDART00000170834
zinc finger protein 1179
chr20_-_34801181 17.83 ENSDART00000048375
ENSDART00000132426
stathmin-like 4
chr4_-_69189894 17.72 ENSDART00000169596
si:ch211-209j12.1
chr3_+_20156956 17.71 ENSDART00000125281
nerve growth factor receptor a (TNFR superfamily, member 16)
chr17_-_15382704 17.67 ENSDART00000005313
zgc:85722
chr25_-_37084032 17.63 ENSDART00000025494
hypoxanthine phosphoribosyltransferase 1, like
chr15_+_28685625 17.18 ENSDART00000188797
ENSDART00000166036
neuro-oncological ventral antigen 2
chr13_+_28705143 17.06 ENSDART00000183338
LIM domain binding 1a
chr15_+_5028608 16.86 ENSDART00000092809
ATP-binding cassette, sub-family G (WHITE), member 1
chr13_-_40754499 16.84 ENSDART00000111641
ENSDART00000159255
MORN repeat containing 4
chr21_-_23308286 16.30 ENSDART00000184419
zinc finger and BTB domain containing 16a
chr24_+_744713 16.18 ENSDART00000067764
serine/threonine kinase 17a
chr3_-_5964557 16.18 ENSDART00000184738

chr15_+_1004680 15.98 ENSDART00000157310
si:dkey-77f5.8
chr23_-_29667544 15.78 ENSDART00000059339
calsyntenin 1
chr18_+_12058403 15.31 ENSDART00000140854
ENSDART00000193632
ENSDART00000190519
ENSDART00000190685
ENSDART00000112671
bicaudal D homolog 1a
chr25_+_28893615 15.29 ENSDART00000156994
ENSDART00000075151
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr14_+_11950011 15.11 ENSDART00000188138
FERM and PDZ domain containing 3
chr12_-_35505610 15.06 ENSDART00000105518
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr2_-_56635744 15.00 ENSDART00000167790
ENSDART00000168160
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b
chr7_-_27686021 14.38 ENSDART00000079112
ENSDART00000100989
calcitonin/calcitonin-related polypeptide, alpha
chr1_+_10305611 14.07 ENSDART00000043881
zgc:77880
chr2_+_38147761 14.05 ENSDART00000135307
spalt-like transcription factor 2
chr16_+_5184402 13.79 ENSDART00000156685
SOGA family member 3a
chr7_+_30493684 13.77 ENSDART00000027466
MINDY lysine 48 deubiquitinase 2
chr5_-_41494831 13.71 ENSDART00000051081
eukaryotic translation elongation factor 2, like 2
chr14_+_597532 13.59 ENSDART00000159805

chr8_-_24113575 13.52 ENSDART00000099692
ENSDART00000186211
DNA cross-link repair 1B
chr10_-_17170086 13.49 ENSDART00000020122
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr12_-_32066469 13.49 ENSDART00000140685
ENSDART00000062185
RAB40B, member RAS oncogene family
chr15_-_20412286 13.48 ENSDART00000008589
calcineurin-like EF-hand protein 2
chr19_-_1961024 13.37 ENSDART00000108784
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr21_-_3770636 13.35 ENSDART00000053596
secretory carrier membrane protein 1
chr8_-_25846188 13.05 ENSDART00000128829
EF-hand domain family, member D2
chr8_-_9118958 12.99 ENSDART00000037922
solute carrier family 6 (neurotransmitter transporter), member 8
chr21_-_25395223 12.90 ENSDART00000016219
protein phosphatase methylesterase 1
chr16_+_46111849 12.81 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr20_-_9462433 12.49 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr25_-_7686201 12.38 ENSDART00000157267
ENSDART00000155094
si:ch211-286c4.6
chr5_+_57743815 12.38 ENSDART00000005090
ALG9, alpha-1,2-mannosyltransferase
chr5_-_24000211 12.27 ENSDART00000188865
MAP7 domain containing 2a
chr1_-_17693273 12.23 ENSDART00000146258
cilia and flagella associated protein 97
chr15_-_27710513 12.13 ENSDART00000005641
ENSDART00000134373
LIM homeobox 1a
chr20_-_32446406 12.10 ENSDART00000026635
nuclear receptor subfamily 2, group E, member 1
chr15_-_739229 11.98 ENSDART00000153874
si:dkey-7i4.19
chr2_+_22694382 11.94 ENSDART00000139196
kinesin family member 1Ab
chr4_+_77060861 11.70 ENSDART00000174271
ENSDART00000174393
ENSDART00000150450
si:dkey-240n22.8
chr11_-_22372072 11.55 ENSDART00000065996
transmembrane protein 183A
chr20_-_3319642 11.55 ENSDART00000186743
ENSDART00000123096
myristoylated alanine-rich protein kinase C substrate a
chr17_-_20979077 11.53 ENSDART00000006676
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr7_-_33868903 11.51 ENSDART00000173500
ENSDART00000178746
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr9_+_219124 11.48 ENSDART00000161484
mitogen-activated protein kinase kinase kinase 12
chr10_+_6496185 11.46 ENSDART00000164770
receptor accessory protein 5
chr10_+_44903676 11.45 ENSDART00000158553
zgc:114173
chr20_-_24122881 11.20 ENSDART00000131857
BTB and CNC homology 1, basic leucine zipper transcription factor 2b
chr12_-_30443562 10.85 ENSDART00000020769
adrenoceptor beta 1
chr21_+_45366229 10.82 ENSDART00000029946
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
chr23_+_23183449 10.67 ENSDART00000132296
kelch-like family member 17
chr18_-_19103929 10.66 ENSDART00000188370
ENSDART00000177621
DENN/MADD domain containing 4A
chr7_+_23907692 10.63 ENSDART00000045479
synaptotagmin IV
chr8_-_410199 10.63 ENSDART00000091177
ENSDART00000122979
ENSDART00000151331
ENSDART00000151155
tripartite motif containing 36
chr22_+_2254972 10.50 ENSDART00000144906
zinc finger protein 1157
chr21_-_32374656 10.41 ENSDART00000112550
mitogen-activated protein kinase 9
chr18_+_17663898 10.29 ENSDART00000021213
copine II
chr17_+_15674052 10.14 ENSDART00000156726
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr5_-_24231139 10.12 ENSDART00000143492
SUMO1/sentrin/SMT3 specific peptidase 3a
chr1_+_9290103 9.96 ENSDART00000055009
Unc4.1 homeobox (C. elegans)
chr20_+_9211237 9.94 ENSDART00000139527
si:ch211-59d15.4
chr7_-_39203799 9.91 ENSDART00000173727
cholinergic receptor, muscarinic 4a
chr6_-_25952848 9.82 ENSDART00000076997
ENSDART00000148748
LIM domain only 4b
chr12_+_7491690 9.76 ENSDART00000152564
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr15_-_917274 9.65 ENSDART00000156624
si:dkey-77f5.15
chr2_+_42200390 9.53 ENSDART00000012919
intraflagellar transport 57 homolog (Chlamydomonas)
chr24_+_4373355 9.52 ENSDART00000179062
ENSDART00000093256
ENSDART00000138943
cyclin Y
chr20_-_18915376 9.48 ENSDART00000063725
XK, Kell blood group complex subunit-related family, member 6b
chr13_-_45475289 9.45 ENSDART00000043345
arginine/serine-rich protein 1
chr15_-_1844048 9.13 ENSDART00000102410
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr19_+_42227400 9.10 ENSDART00000131574
ENSDART00000135436
jumping translocation breakpoint
chr7_-_12909352 9.08 ENSDART00000172901
SH3-domain GRB2-like 3a
chr17_+_32500387 9.05 ENSDART00000018423
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b
chr16_-_33097398 9.01 ENSDART00000166617
dopey family member 1
chr22_+_1940595 9.01 ENSDART00000163506
zinc finger protein 1167
chr6_-_6673813 9.00 ENSDART00000150995
si:dkey-261j15.2
chr15_-_591308 9.00 ENSDART00000153884
si:ch73-144d13.5
chr4_-_73739119 8.85 ENSDART00000108669
zgc:171551
chr17_+_12698532 8.66 ENSDART00000064509
ENSDART00000136830
stathmin-like 4, like
chr22_+_2239254 8.60 ENSDART00000131396
ENSDART00000135320
zinc finger protein 1144
chr9_-_6502491 8.56 ENSDART00000102672
NCK adaptor protein 2a
chr5_-_32882162 8.52 ENSDART00000085769
leucine rich repeat and sterile alpha motif containing 1
chr20_+_41549200 8.39 ENSDART00000135715
family with sequence similarity 184, member A
chr12_-_5455936 8.37 ENSDART00000109305
TBC1 domain family, member 12b
chr21_-_5007109 8.27 ENSDART00000187042
ENSDART00000097796
ENSDART00000146766
ring finger protein 165a
chr15_-_28200049 8.26 ENSDART00000004200
sterile alpha and TIR motif containing 1
chr4_-_73825089 8.25 ENSDART00000174207
si:dkey-262g12.12
chr7_+_22616212 8.10 ENSDART00000052844
claudin 7a
chr22_-_4760187 8.09 ENSDART00000081969
RAD23 homolog A, nucleotide excision repair protein b
chr25_-_31763897 8.02 ENSDART00000041740
ubiquitin-like 7a (bone marrow stromal cell-derived)
chr6_+_21227621 8.01 ENSDART00000193583
protein kinase C, alpha
chr4_+_40953320 8.01 ENSDART00000151912
zinc finger protein 1136
chr13_-_31470439 8.01 ENSDART00000076574
reticulon 1a
chr4_+_2655358 7.98 ENSDART00000007638
B cell receptor associated protein 29
chr12_+_19305390 7.86 ENSDART00000183987
ENSDART00000066391
casein kinase 1, epsilon
chr14_+_16813816 7.82 ENSDART00000161201
LIM and calponin homology domains 1b
chr7_-_11605185 7.74 ENSDART00000169291
ENSDART00000113904
StAR-related lipid transfer (START) domain containing 5
chr8_+_21406769 7.71 ENSDART00000135766
si:dkey-163f12.6
chr22_+_2315996 7.64 ENSDART00000132489
zinc finger protein 1175
chr15_-_762319 7.63 ENSDART00000154306
ENSDART00000157492
si:dkey-7i4.16
zinc finger protein 1011
chr6_+_58832155 7.56 ENSDART00000144842
dynactin 2 (p50)
chr4_-_30362840 7.55 ENSDART00000165929
zinc finger protein 1083
chr15_+_618376 7.55 ENSDART00000156007
si:ch73-144d13.8
chr4_-_64482414 7.53 ENSDART00000159000
zinc finger protein 1105
chr7_-_26532089 7.37 ENSDART00000121698
SUMO1/sentrin/SMT3 specific peptidase 3b
chr20_+_39223235 7.35 ENSDART00000132132
RALBP1 associated Eps domain containing 1
chr6_-_48473395 7.34 ENSDART00000185096
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr25_+_7321675 7.31 ENSDART00000104712
ENSDART00000142934
high mobility group 20A
chr22_+_2819613 7.31 ENSDART00000131234
si:dkey-20i20.3
chr3_+_32403758 7.30 ENSDART00000156982
si:ch211-195b15.8
chr19_+_9174166 7.17 ENSDART00000104637
ENSDART00000150968
si:ch211-81a5.8
chr13_+_15816573 7.08 ENSDART00000137061
kinesin light chain 1a
chr17_+_15535501 7.06 ENSDART00000002932
myristoylated alanine-rich protein kinase C substrate b
chr1_-_44037843 7.04 ENSDART00000160276
si:ch73-109d9.3
chr25_-_12906872 6.93 ENSDART00000165156
ENSDART00000167449
septin 15
chr15_+_872085 6.93 ENSDART00000193867
ENSDART00000157483
ENSDART00000156324
si:dkey-7i4.9
si:dkey-77f5.13
si:dkey-7i4.11
chr23_-_17509656 6.82 ENSDART00000148423
DnaJ (Hsp40) homolog, subfamily C, member 5ab
chr19_+_2279051 6.75 ENSDART00000182103
integrin, beta 8
chr15_-_1687204 6.66 ENSDART00000155579
ENSDART00000181382
serine palmitoyltransferase, small subunit B
chr13_+_17702853 6.62 ENSDART00000145438
si:dkey-27m7.4
chr21_+_9576176 6.59 ENSDART00000161289
ENSDART00000159899
ENSDART00000162834
mitogen-activated protein kinase 10
chr15_+_903743 6.59 ENSDART00000155783
si:dkey-77f5.13
chr15_-_9421481 6.58 ENSDART00000189045
ENSDART00000177158
sacsin molecular chaperone
chr18_+_8917766 6.57 ENSDART00000145226
si:ch211-233h19.2
chr5_-_20814576 6.53 ENSDART00000098682
ENSDART00000147639
si:ch211-225b11.1
chr6_-_39893501 6.51 ENSDART00000141611
ENSDART00000135631
ENSDART00000077662
ENSDART00000130613
myosin, light chain 6, alkali, smooth muscle and non-muscle
chr2_+_301898 6.49 ENSDART00000157246
zinc finger protein 1008
chr15_-_923981 6.44 ENSDART00000155285
si:dkey-77f5.14
chr3_-_1204341 6.42 ENSDART00000089646
family with sequence similarity 234, member B
chr13_-_50672341 6.36 ENSDART00000190498

chr6_+_6802582 6.28 ENSDART00000189422
D-tyrosyl-tRNA deacylase 1
chr22_+_30330574 6.27 ENSDART00000104751
max interactor 1, dimerization protein
chr9_+_48219111 6.27 ENSDART00000111225
ENSDART00000145972
coiled-coil domain containing 173
chr24_-_18877118 6.23 ENSDART00000092783
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr4_-_30422325 6.21 ENSDART00000158444
zinc finger protein 1114
chr15_-_727479 6.18 ENSDART00000157279
si:dkey-7i4.21
chr17_-_8673567 6.16 ENSDART00000192714
ENSDART00000012546
C-terminal binding protein 2a
chr25_+_16945348 6.12 ENSDART00000016591
fibroblast growth factor 6a
chr4_+_41528590 6.08 ENSDART00000164004
zinc finger protein 1094
chr25_-_32751982 6.04 ENSDART00000012862
ISL LIM homeobox 2a
chr16_-_41131578 5.99 ENSDART00000102649
ENSDART00000145956
protein tyrosine phosphatase, non-receptor type 23, a
chr20_-_44576949 5.94 ENSDART00000148639
UBX domain protein 2A

Network of associatons between targets according to the STRING database.

First level regulatory network of atf2+atf7a+atf7b_creb5a+creb5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 41.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
9.5 38.0 GO:1990535 neuron projection maintenance(GO:1990535)
7.7 46.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
5.9 17.6 GO:0046099 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
5.3 21.3 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
4.6 18.5 GO:0038003 opioid receptor signaling pathway(GO:0038003)
4.2 16.9 GO:0010874 regulation of cholesterol efflux(GO:0010874)
4.0 12.1 GO:0060688 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
3.8 57.7 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
3.8 11.5 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
3.0 21.1 GO:0061635 regulation of protein complex stability(GO:0061635)
2.8 8.3 GO:0072526 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
2.7 13.5 GO:0031627 telomeric loop formation(GO:0031627)
2.7 13.4 GO:0030219 megakaryocyte differentiation(GO:0030219)
2.6 12.8 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
2.6 15.3 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
2.5 12.3 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
2.3 31.8 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
2.0 25.4 GO:0046085 adenosine metabolic process(GO:0046085)
1.9 92.1 GO:0007019 microtubule depolymerization(GO:0007019)
1.6 8.0 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
1.4 18.5 GO:0032481 positive regulation of type I interferon production(GO:0032481)
1.4 31.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.2 40.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
1.2 5.9 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
1.2 3.5 GO:1902410 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
1.1 20.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.1 17.2 GO:0016926 protein desumoylation(GO:0016926)
1.1 6.4 GO:0080009 mRNA methylation(GO:0080009)
1.1 5.3 GO:0034505 tooth mineralization(GO:0034505)
1.0 18.6 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.9 9.9 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.9 27.9 GO:0032482 Rab protein signal transduction(GO:0032482)
0.9 9.5 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.8 3.8 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.8 16.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.7 4.3 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.7 7.8 GO:0048041 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.7 2.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.6 5.8 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.6 5.1 GO:0021744 medulla oblongata development(GO:0021550) dorsal motor nucleus of vagus nerve development(GO:0021744)
0.6 5.0 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.6 25.8 GO:0072114 pronephros morphogenesis(GO:0072114)
0.6 37.8 GO:0015914 phospholipid transport(GO:0015914)
0.6 53.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.6 3.7 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.6 6.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.6 8.4 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.6 47.9 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.6 5.1 GO:0061709 reticulophagy(GO:0061709)
0.5 5.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.5 11.5 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.5 8.8 GO:1900151 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) positive regulation of mRNA catabolic process(GO:0061014) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.5 2.0 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.5 3.4 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.5 18.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.5 5.8 GO:0042572 retinol metabolic process(GO:0042572)
0.5 14.4 GO:0055064 chloride ion homeostasis(GO:0055064)
0.5 145.1 GO:0006470 protein dephosphorylation(GO:0006470)
0.5 1.4 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.4 1.8 GO:0010259 multicellular organism aging(GO:0010259)
0.4 15.0 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.4 2.8 GO:0034334 adherens junction maintenance(GO:0034334)
0.4 20.2 GO:0030641 regulation of cellular pH(GO:0030641)
0.4 3.1 GO:0001743 optic placode formation(GO:0001743) optic placode formation involved in camera-type eye formation(GO:0046619)
0.4 18.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.4 20.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 17.0 GO:0007254 JNK cascade(GO:0007254)
0.3 1.9 GO:0072318 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
0.3 5.0 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.3 3.0 GO:0000303 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.3 28.8 GO:0019722 calcium-mediated signaling(GO:0019722)
0.3 1.5 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.3 9.5 GO:0042073 intraciliary transport(GO:0042073) protein transport along microtubule(GO:0098840)
0.3 4.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 9.1 GO:0000281 mitotic cytokinesis(GO:0000281)
0.3 2.9 GO:0030719 P granule organization(GO:0030719)
0.3 1.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 5.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 5.3 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.2 11.0 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 4.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 0.7 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.2 14.3 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.2 2.6 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.2 0.6 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.2 2.6 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 1.9 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.2 6.8 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.2 1.5 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.2 6.8 GO:0016574 histone ubiquitination(GO:0016574)
0.2 137.4 GO:0007017 microtubule-based process(GO:0007017)
0.2 19.5 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.2 0.4 GO:0044878 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.2 8.1 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.2 0.9 GO:0055071 manganese ion homeostasis(GO:0055071)
0.2 0.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.2 8.1 GO:0006289 nucleotide-excision repair(GO:0006289)
0.2 22.1 GO:0051260 protein homooligomerization(GO:0051260)
0.2 6.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.2 0.8 GO:0032475 otolith formation(GO:0032475)
0.2 4.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.2 3.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 1.3 GO:0014004 microglia differentiation(GO:0014004)
0.2 6.8 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 13.8 GO:0010506 regulation of autophagy(GO:0010506)
0.2 16.6 GO:0006821 chloride transport(GO:0006821)
0.1 7.2 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 4.8 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.1 2.3 GO:0006265 DNA topological change(GO:0006265)
0.1 1.4 GO:0032262 pyrimidine-containing compound salvage(GO:0008655) pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.1 12.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 25.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 0.3 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 2.9 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 0.5 GO:0060546 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 1.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 3.2 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 1.2 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 3.1 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.1 15.0 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.1 7.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 13.5 GO:0072659 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.1 8.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 1.3 GO:0098508 endothelial to hematopoietic transition(GO:0098508)
0.1 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021) wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1 0.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 4.6 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 0.9 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 1.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 1.2 GO:0001843 neural tube closure(GO:0001843) primary neural tube formation(GO:0014020)
0.0 3.5 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 2.1 GO:0016575 histone deacetylation(GO:0016575)
0.0 2.3 GO:0009583 detection of light stimulus(GO:0009583)
0.0 5.4 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.8 GO:0048264 determination of ventral identity(GO:0048264)
0.0 4.8 GO:0006399 tRNA metabolic process(GO:0006399)
0.0 1.2 GO:0010842 retina layer formation(GO:0010842)
0.0 2.4 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 2.0 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.0 1.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 4.5 GO:0018193 peptidyl-amino acid modification(GO:0018193)
0.0 49.6 GO:0006355 regulation of transcription, DNA-templated(GO:0006355)
0.0 0.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 30.4 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
3.6 57.7 GO:0031209 SCAR complex(GO:0031209)
3.4 20.2 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
3.2 31.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
2.6 31.2 GO:0044295 axonal growth cone(GO:0044295)
2.2 10.8 GO:0033503 HULC complex(GO:0033503)
2.0 7.8 GO:0016460 myosin II complex(GO:0016460)
1.3 5.0 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
1.2 109.4 GO:0030141 secretory granule(GO:0030141)
1.1 4.2 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
1.1 89.3 GO:0005871 kinesin complex(GO:0005871)
0.8 17.5 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.7 5.1 GO:0071818 BAT3 complex(GO:0071818)
0.7 8.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.7 13.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.6 5.8 GO:0032021 NELF complex(GO:0032021)
0.5 9.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.5 4.2 GO:0097648 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.5 5.0 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.5 34.1 GO:0031902 late endosome membrane(GO:0031902)
0.4 117.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.4 18.5 GO:0043204 perikaryon(GO:0043204)
0.4 2.9 GO:0035517 PR-DUB complex(GO:0035517)
0.4 41.2 GO:0005802 trans-Golgi network(GO:0005802)
0.4 18.5 GO:0030496 midbody(GO:0030496)
0.3 13.5 GO:0000781 chromosome, telomeric region(GO:0000781)
0.3 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 7.2 GO:0043195 terminal bouton(GO:0043195)
0.3 10.6 GO:0035869 ciliary transition zone(GO:0035869)
0.3 0.9 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.3 1.5 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.3 1.2 GO:0070209 ASTRA complex(GO:0070209)
0.3 46.7 GO:0008021 synaptic vesicle(GO:0008021)
0.3 0.8 GO:0071141 SMAD protein complex(GO:0071141)
0.3 3.3 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.2 21.8 GO:0000922 spindle pole(GO:0000922)
0.2 12.8 GO:0005776 autophagosome(GO:0005776)
0.2 9.1 GO:0031901 early endosome membrane(GO:0031901)
0.2 130.9 GO:0043005 neuron projection(GO:0043005)
0.2 1.8 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 3.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 2.9 GO:0005869 dynactin complex(GO:0005869)
0.2 2.1 GO:0016580 Sin3 complex(GO:0016580)
0.2 5.3 GO:0016605 PML body(GO:0016605)
0.2 95.5 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.1 6.8 GO:0008305 integrin complex(GO:0008305)
0.1 16.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 11.3 GO:0005882 intermediate filament(GO:0005882)
0.1 0.8 GO:0030130 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 3.5 GO:0016342 catenin complex(GO:0016342)
0.1 0.7 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 4.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.2 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 71.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 18.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 2.8 GO:0043235 receptor complex(GO:0043235)
0.0 3.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 3.9 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 57.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
6.2 18.5 GO:0038046 enkephalin receptor activity(GO:0038046)
5.9 17.6 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
5.4 37.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
4.8 14.4 GO:0031716 calcitonin receptor binding(GO:0031716)
4.8 28.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
2.8 13.8 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
2.5 17.7 GO:0005035 death receptor activity(GO:0005035)
2.5 12.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
2.5 12.3 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
2.4 17.1 GO:0030274 LIM domain binding(GO:0030274)
2.1 31.8 GO:0051117 ATPase binding(GO:0051117)
2.1 6.3 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
2.0 7.8 GO:0032038 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
1.9 5.8 GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity(GO:0047173)
1.9 15.3 GO:0034452 dynactin binding(GO:0034452)
1.8 47.9 GO:0042577 lipid phosphatase activity(GO:0042577)
1.7 17.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.7 13.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
1.6 54.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.6 4.8 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
1.4 4.2 GO:0001734 mRNA (N6-adenosine)-methyltransferase activity(GO:0001734)
1.3 7.7 GO:0032052 bile acid binding(GO:0032052)
1.3 11.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
1.2 25.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
1.2 16.9 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
1.2 34.9 GO:0030165 PDZ domain binding(GO:0030165)
1.1 3.3 GO:0030623 U5 snRNA binding(GO:0030623)
1.1 17.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
1.0 5.9 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938) epinephrine binding(GO:0051379)
0.9 4.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.9 16.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.9 9.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.8 4.6 GO:0004743 pyruvate kinase activity(GO:0004743)
0.7 10.2 GO:0070628 proteasome binding(GO:0070628)
0.7 5.0 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.7 18.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.7 10.8 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.7 34.2 GO:0008013 beta-catenin binding(GO:0008013)
0.6 129.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 20.4 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.6 8.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.5 4.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 2.2 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.4 5.3 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.4 6.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.4 19.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.4 15.0 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.4 18.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 3.0 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 2.6 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.4 1.1 GO:0015562 inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562)
0.3 1.7 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.3 8.3 GO:0035591 signaling adaptor activity(GO:0035591)
0.3 13.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 26.1 GO:0003777 microtubule motor activity(GO:0003777)
0.3 1.4 GO:0046592 polyamine oxidase activity(GO:0046592)
0.3 1.6 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 91.9 GO:0015631 tubulin binding(GO:0015631)
0.3 3.2 GO:0005158 insulin receptor binding(GO:0005158)
0.2 24.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 5.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 5.9 GO:0004707 MAP kinase activity(GO:0004707)
0.2 10.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 3.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 2.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.2 2.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.2 7.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 0.9 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 5.9 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 48.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 55.0 GO:0003924 GTPase activity(GO:0003924)
0.1 6.8 GO:0005178 integrin binding(GO:0005178)
0.1 17.5 GO:0019901 protein kinase binding(GO:0019901)
0.1 102.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 19.5 GO:0015293 symporter activity(GO:0015293)
0.1 4.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.4 GO:0010857 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698) calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.1 9.5 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.7 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.1 1.2 GO:0070403 NAD+ binding(GO:0070403)
0.1 26.7 GO:0005096 GTPase activator activity(GO:0005096)
0.1 0.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 3.4 GO:0051287 NAD binding(GO:0051287)
0.1 1.9 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 7.7 GO:0051213 dioxygenase activity(GO:0051213)
0.1 4.1 GO:0051427 hormone receptor binding(GO:0051427)
0.1 134.3 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 2.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.8 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 5.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 29.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 8.9 GO:0003712 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 0.4 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.7 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.9 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 2.9 GO:0003774 motor activity(GO:0003774)
0.0 1.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 1.0 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.4 GO:0005227 calcium activated cation channel activity(GO:0005227)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 13.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.8 17.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.7 5.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.6 10.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.6 10.5 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.5 7.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 18.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.3 8.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 6.8 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 28.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 4.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.3 PID PLK1 PATHWAY PLK1 signaling events
0.1 4.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.7 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 17.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
1.4 16.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.9 8.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.8 10.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.8 18.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.6 5.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.6 14.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.5 8.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.5 4.2 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.4 3.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 12.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.3 6.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 12.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 10.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 2.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.2 1.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 28.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 6.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 13.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases