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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for atf1
Z-value: 2.02
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Transcription factors associated with atf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| atf1 | dr11_v1_chr6_-_39521832_39521832 | 0.61 | 6.4e-11 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_12385308 Show fit | 38.69 |
ENSDART00000080927
|
synaptosomal-associated protein, 25b |
|
| chr6_+_27667359 Show fit | 30.65 |
ENSDART00000159624
ENSDART00000049177 |
RAB6B, member RAS oncogene family a |
|
| chr2_-_11512819 Show fit | 30.23 |
ENSDART00000142013
|
proenkephalin a |
|
| chr20_+_34913069 Show fit | 24.62 |
ENSDART00000007584
|
synaptosomal-associated protein, 25a |
|
| chr16_-_29437373 Show fit | 22.12 |
ENSDART00000148405
|
si:ch211-113g11.6 |
|
| chr5_+_3501859 Show fit | 20.90 |
ENSDART00000080486
|
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1 |
|
| chr23_-_4915118 Show fit | 20.88 |
ENSDART00000060714
|
ATPase H+ transporting accessory protein 1a |
|
| chr24_-_7632187 Show fit | 19.60 |
ENSDART00000041714
|
ATPase H+ transporting V0 subunit a1b |
|
| chr24_-_6158933 Show fit | 19.57 |
ENSDART00000021609
|
glutamate decarboxylase 2 |
|
| chr23_-_29667716 Show fit | 19.38 |
ENSDART00000158302
ENSDART00000133902 |
calsyntenin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of atf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 47.0 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.1 | 41.1 | GO:0006470 | protein dephosphorylation(GO:0006470) |
| 2.8 | 38.7 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 1.1 | 36.1 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.3 | 33.8 | GO:0048675 | axon extension(GO:0048675) |
| 0.5 | 30.9 | GO:0048841 | regulation of axon extension involved in axon guidance(GO:0048841) |
| 7.6 | 30.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.3 | 30.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 1.0 | 28.0 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.9 | 27.8 | GO:0030641 | regulation of cellular pH(GO:0030641) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 77.1 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 10.6 | 63.3 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.6 | 50.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 39.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.4 | 31.9 | GO:0030141 | secretory granule(GO:0030141) |
| 0.8 | 30.8 | GO:0043679 | axon terminus(GO:0043679) |
| 0.2 | 26.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.6 | 26.3 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.2 | 26.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.4 | 26.2 | GO:0031902 | late endosome membrane(GO:0031902) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 80.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 3.6 | 46.6 | GO:0031628 | opioid receptor binding(GO:0031628) |
| 0.0 | 42.2 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 41.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 38.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 38.4 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.1 | 37.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 32.9 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.3 | 30.2 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.2 | 28.4 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 38.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.0 | 21.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 1.2 | 18.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 1.1 | 14.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.3 | 12.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.5 | 10.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.6 | 10.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 8.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.4 | 8.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 8.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.6 | 28.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 1.6 | 27.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 1.8 | 19.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 1.9 | 18.8 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 3.7 | 18.6 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 5.7 | 17.1 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 1.0 | 17.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.4 | 14.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.4 | 13.7 | REACTOME PEPTIDE HORMONE BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |