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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for atf1

Z-value: 2.02

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Transcription factors associated with atf1

Gene Symbol Gene ID Gene Info
ENSDARG00000044301 activating transcription factor 1
ENSDARG00000109865 activating transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
atf1dr11_v1_chr6_-_39521832_395218320.616.4e-11Click!

Activity profile of atf1 motif

Sorted Z-values of atf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_12385308 38.69 ENSDART00000080927
synaptosomal-associated protein, 25b
chr6_+_27667359 30.65 ENSDART00000159624
ENSDART00000049177
RAB6B, member RAS oncogene family a
chr2_-_11512819 30.23 ENSDART00000142013
proenkephalin a
chr20_+_34913069 24.62 ENSDART00000007584
synaptosomal-associated protein, 25a
chr16_-_29437373 22.12 ENSDART00000148405
si:ch211-113g11.6
chr5_+_3501859 20.90 ENSDART00000080486
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr23_-_4915118 20.88 ENSDART00000060714
ATPase H+ transporting accessory protein 1a
chr24_-_7632187 19.60 ENSDART00000041714
ATPase H+ transporting V0 subunit a1b
chr24_-_6158933 19.57 ENSDART00000021609
glutamate decarboxylase 2
chr23_-_29667716 19.38 ENSDART00000158302
ENSDART00000133902
calsyntenin 1
chr9_-_296169 18.70 ENSDART00000165228
kinesin family member 5A, a
chr23_+_28731379 18.34 ENSDART00000047378
cortistatin
chr2_-_42415902 17.84 ENSDART00000142489
solute carrier organic anion transporter family member 5A1b
chr12_-_19103490 17.67 ENSDART00000060561
cold shock domain containing C2, RNA binding a
chr7_+_29133321 17.48 ENSDART00000052346
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
chr4_+_9669717 17.43 ENSDART00000004604
si:dkey-153k10.9
chr7_+_39166460 17.29 ENSDART00000052318
ENSDART00000146635
ENSDART00000173877
ENSDART00000173767
ENSDART00000173600
midkine a
chr10_-_22845485 17.13 ENSDART00000079454
vesicle-associated membrane protein 2
chr7_+_26224211 16.86 ENSDART00000173999
VGF nerve growth factor inducible
chr3_+_15907297 16.86 ENSDART00000139206
mitogen-activated protein kinase 8 interacting protein 3
chr25_-_37084032 16.58 ENSDART00000025494
hypoxanthine phosphoribosyltransferase 1, like
chr19_+_24882845 16.48 ENSDART00000010580
si:ch211-195b13.1
chr20_+_20637866 15.99 ENSDART00000060203
ENSDART00000079079
reticulon 1b
chr7_+_40228422 15.65 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr19_-_43552252 15.52 ENSDART00000138308
G protein-coupled receptor 186
chr15_-_163586 15.44 ENSDART00000163597
septin-4
chr4_-_12388535 14.94 ENSDART00000017180
RERG/RAS-like a
chr10_-_24371312 14.83 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr20_+_29743904 14.78 ENSDART00000146366
ENSDART00000153154
kinase D-interacting substrate 220b
chr1_-_56223913 14.76 ENSDART00000019573
zgc:65894
chr20_+_20638034 14.23 ENSDART00000189759
reticulon 1b
chr6_-_31348999 14.20 ENSDART00000153734
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_-_20979077 14.09 ENSDART00000006676
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr16_+_34523515 14.01 ENSDART00000041007
stathmin 1b
chr15_-_27710513 13.95 ENSDART00000005641
ENSDART00000134373
LIM homeobox 1a
chr5_+_37056818 13.83 ENSDART00000036760
tubulin polymerization-promoting protein family member 2
chr5_-_45877387 13.76 ENSDART00000183714
ENSDART00000041503
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr3_-_49566364 13.47 ENSDART00000161507
zgc:153426
chr16_-_9869056 13.17 ENSDART00000149312
neurocalcin delta a
chr19_+_10396042 13.14 ENSDART00000028048
ENSDART00000151735
NECAP endocytosis associated 1
chr1_-_38756870 12.89 ENSDART00000130324
ENSDART00000148404
glycoprotein M6Ab
chr14_-_2270973 12.67 ENSDART00000180729
protocadherin 2 alpha b 9
chr17_-_26911852 12.59 ENSDART00000045842
regulator of calcineurin 3
chr12_-_30443562 12.47 ENSDART00000020769
adrenoceptor beta 1
chr15_+_28685892 12.46 ENSDART00000155815
ENSDART00000060244
neuro-oncological ventral antigen 2
chr16_+_36906693 12.37 ENSDART00000160645
si:ch73-215d9.1
chr20_+_41549200 12.26 ENSDART00000135715
family with sequence similarity 184, member A
chr17_+_15535501 12.23 ENSDART00000002932
myristoylated alanine-rich protein kinase C substrate b
chr20_+_38724575 12.18 ENSDART00000015095
ENSDART00000152972
urotensin 1
chr14_-_7888748 12.08 ENSDART00000166293
protein phosphatase 3, catalytic subunit, beta isozyme
chr5_-_45876908 11.78 ENSDART00000188229
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr22_-_29922872 11.53 ENSDART00000020249
dual specificity phosphatase 5
chr6_+_24817852 11.47 ENSDART00000165609
BarH-like homeobox 2
chr25_-_31863374 11.45 ENSDART00000028338
secretory carrier membrane protein 5a
chr21_-_43606502 11.27 ENSDART00000151030
si:ch73-362m14.4
chr18_-_14743659 11.05 ENSDART00000125979
teashirt zinc finger homeobox 3a
chr23_-_29667544 10.96 ENSDART00000059339
calsyntenin 1
chr14_-_48939560 10.94 ENSDART00000021736
short coiled-coil protein b
chr24_-_21172122 10.90 ENSDART00000154259
ATPase H+ transporting V1 subunit Ab
chr22_+_1796057 10.87 ENSDART00000170834
zinc finger protein 1179
chr8_+_21588067 10.84 ENSDART00000172190
adherens junctions associated protein 1
chr18_+_40381102 10.80 ENSDART00000136588
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like
chr21_-_23308286 10.78 ENSDART00000184419
zinc finger and BTB domain containing 16a
chr11_-_13341483 10.73 ENSDART00000164978
microtubule associated serine/threonine kinase 3b
chr18_-_22094102 10.71 ENSDART00000100904
par-6 family cell polarity regulator alpha
chr18_+_21408794 10.71 ENSDART00000140161
N-terminal EF-hand calcium binding protein 2
chr19_+_46222428 10.52 ENSDART00000183984
vacuolar protein sorting 28 (yeast)
chr19_+_16222618 10.46 ENSDART00000137189
ENSDART00000169246
ENSDART00000190583
ENSDART00000189521
protein tyrosine phosphatase, receptor type, U, a
chr20_-_9462433 10.22 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr3_+_32933663 10.22 ENSDART00000112742
neighbor of brca1 gene 1b
chr5_-_20814576 10.21 ENSDART00000098682
ENSDART00000147639
si:ch211-225b11.1
chr2_+_20332044 10.11 ENSDART00000112131
phospholipid phosphatase related 4a
chr3_-_1204341 10.11 ENSDART00000089646
family with sequence similarity 234, member B
chr10_-_36591511 10.06 ENSDART00000063347
solute carrier family 1 (glial high affinity glutamate transporter), member 3b
chr3_-_13147310 10.06 ENSDART00000160840
protein kinase, cAMP-dependent, regulatory, type I, beta
chr16_-_45069882 9.98 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr1_-_22861348 9.94 ENSDART00000139412
si:dkey-92j12.6
chr20_+_3108597 9.89 ENSDART00000133435
si:ch73-212j7.1
chr10_+_23022263 9.88 ENSDART00000138955
si:dkey-175g6.2
chr8_-_17067364 9.85 ENSDART00000132687
RAB3C, member RAS oncogene family
chr7_-_12065668 9.74 ENSDART00000101537
mex-3 RNA binding family member B
chr8_-_54223316 9.67 ENSDART00000018054
thyrotropin-releasing hormone
chr1_+_45323400 9.65 ENSDART00000148906
ENSDART00000132366
epithelial membrane protein 1
chr11_+_4026229 9.64 ENSDART00000041417
calcium/calmodulin-dependent protein kinase Ib
chr1_+_9290103 9.60 ENSDART00000055009
Unc4.1 homeobox (C. elegans)
chr2_+_35603637 9.57 ENSDART00000147278
polo-like kinase 3 (Drosophila)
chr11_+_40649412 9.57 ENSDART00000043016
ENSDART00000134560
solute carrier family 45, member 1
chr4_-_69189894 9.49 ENSDART00000169596
si:ch211-209j12.1
chr10_+_37145007 9.36 ENSDART00000131777
CUE domain containing 1a
chr17_-_15382704 9.34 ENSDART00000005313
zgc:85722
chr25_-_31763897 9.33 ENSDART00000041740
ubiquitin-like 7a (bone marrow stromal cell-derived)
chr6_+_23809163 9.30 ENSDART00000170402
glutamate-ammonia ligase (glutamine synthase) b
chr1_+_10305611 9.27 ENSDART00000043881
zgc:77880
chr4_-_5764255 9.20 ENSDART00000113864
failed axon connections homolog a
chr2_+_20331445 9.17 ENSDART00000186880
phospholipid phosphatase related 4a
chr9_+_22632126 9.07 ENSDART00000139434
ets variant 5a
chr9_-_54840124 8.95 ENSDART00000137214
ENSDART00000085693
glycoprotein M6Bb
chr25_+_35683956 8.72 ENSDART00000149768
kinesin family member 21A
chr9_+_22631672 8.64 ENSDART00000101770
ENSDART00000126015
ENSDART00000145005
ets variant 5a
chr19_-_32888758 8.62 ENSDART00000052080
lysosomal protein transmembrane 4 beta
chr6_-_25952848 8.61 ENSDART00000076997
ENSDART00000148748
LIM domain only 4b
chr17_+_8184649 8.61 ENSDART00000091818
tubby like protein 4b
chr25_-_23052707 8.58 ENSDART00000024633
dual specificity phosphatase 8a
chr17_-_11329959 8.49 ENSDART00000015418
interferon regulatory factor 2 binding protein-like
chr16_+_25137483 8.46 ENSDART00000155666
zinc finger protein 576, tandem duplicate 1
chr12_+_27243059 8.42 ENSDART00000066269
ADP-ribosylation factor-like 4D
chr13_-_40499296 8.41 ENSDART00000158338
Danio rerio cyclin and CBS domain divalent metal cation transport mediator 1 (cnnm1), mRNA.
chr12_-_41618844 8.34 ENSDART00000160054
dihydropyrimidinase-like 4
chr4_+_73973242 8.32 ENSDART00000182529

chr8_-_39984593 8.26 ENSDART00000140127
aspartate beta-hydroxylase domain containing 2
chr22_-_38621438 8.15 ENSDART00000098330
natriuretic peptide C
chr12_+_16953415 8.09 ENSDART00000020824
pantothenate kinase 1b
chr5_-_24000211 8.09 ENSDART00000188865
MAP7 domain containing 2a
chr16_-_17162843 8.04 ENSDART00000089386
intermediate filament family orphan 1b
chr20_-_1191910 7.93 ENSDART00000043218
ubiquitin-conjugating enzyme E2, J1
chr20_+_45741566 7.92 ENSDART00000113454
chromogranin B
chr8_-_17771755 7.92 ENSDART00000063592
protein kinase C, zeta
chr13_-_4333181 7.85 ENSDART00000122406
zinc finger protein 318
chr5_-_9540641 7.84 ENSDART00000124384
ENSDART00000160079
cyclin G associated kinase
chr17_+_28005763 7.82 ENSDART00000155838
leucine zipper protein 1
chr5_+_62374092 7.78 ENSDART00000082965

chr16_-_54942532 7.77 ENSDART00000078887
ENSDART00000101402
transmembrane protein 222a
chr6_+_23809501 7.73 ENSDART00000168701
glutamate-ammonia ligase (glutamine synthase) b
chr24_-_6375774 7.70 ENSDART00000013294
annexin A13
chr7_+_13382852 7.70 ENSDART00000166318
diacylglycerol lipase, alpha
chr21_-_14878220 7.68 ENSDART00000131237
unc-51 like autophagy activating kinase 1
chr9_-_48296469 7.61 ENSDART00000058255
Bardet-Biedl syndrome 5
chr21_+_11684830 7.60 ENSDART00000147473
proprotein convertase subtilisin/kexin type 1
chr23_+_17354154 7.55 ENSDART00000155808
zgc:194282
chr19_-_12193622 7.48 ENSDART00000041960
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_-_48805181 7.44 ENSDART00000015884
milk fat globule-EGF factor 8 protein a
chr10_+_42374957 7.41 ENSDART00000147926
zgc:86599
chr4_-_16124417 7.41 ENSDART00000128079
ENSDART00000077664
ATPase plasma membrane Ca2+ transporting 1a
chr4_-_25515513 7.40 ENSDART00000142276
ENSDART00000044043
RNA binding motif protein 17
chr25_-_24074500 7.36 ENSDART00000040410
tyrosine hydroxylase
chr20_-_44576949 7.36 ENSDART00000148639
UBX domain protein 2A
chr13_+_28705143 7.33 ENSDART00000183338
LIM domain binding 1a
chr15_-_762319 7.26 ENSDART00000154306
ENSDART00000157492
si:dkey-7i4.16
zinc finger protein 1011
chr2_+_22694382 7.23 ENSDART00000139196
kinesin family member 1Ab
chr24_+_12989727 7.16 ENSDART00000126842
ENSDART00000129309
hypothetical protein FLJ11011-like (H. sapiens)
chr4_+_77060861 7.13 ENSDART00000174271
ENSDART00000174393
ENSDART00000150450
si:dkey-240n22.8
chr15_-_1687204 7.13 ENSDART00000155579
ENSDART00000181382
serine palmitoyltransferase, small subunit B
chr17_+_32500387 7.09 ENSDART00000018423
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b
chr24_-_8261786 7.06 ENSDART00000106388
eukaryotic translation elongation factor 1 epsilon 1
chr23_+_19590006 7.05 ENSDART00000021231
sarcolemma associated protein b
chr23_-_30764319 6.97 ENSDART00000075918
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr3_-_21137362 6.94 ENSDART00000104051
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr2_+_41524238 6.90 ENSDART00000122860
ENSDART00000017977
activin A receptor, type 1 like
chr22_-_36829006 6.90 ENSDART00000170256
ENSDART00000086064
microtubule-associated protein 1Sa
chr14_+_31618982 6.89 ENSDART00000026195
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6a
chr5_+_57743815 6.88 ENSDART00000005090
ALG9, alpha-1,2-mannosyltransferase
chr2_+_12255568 6.88 ENSDART00000184164
ENSDART00000013454
phosphoribosyl transferase domain containing 1
chr11_-_6970107 6.87 ENSDART00000171255
si:ch211-43f4.1
chr3_-_11624694 6.80 ENSDART00000127157
hepatic leukemia factor a
chr9_-_18743012 6.80 ENSDART00000131626
TSC22 domain family, member 1
chr3_-_21037840 6.79 ENSDART00000002393
RUN domain containing 3Aa
chr19_+_45970692 6.79 ENSDART00000158781
si:ch211-153f2.7
chr6_-_46403475 6.78 ENSDART00000154148
calcium/calmodulin-dependent protein kinase Ia
chr22_+_2709467 6.77 ENSDART00000141416
zinc finger protein 1171
chr7_+_15872357 6.76 ENSDART00000165757
paired box 6b
chr14_+_23970818 6.75 ENSDART00000123338
ENSDART00000124944
kinesin family member 3A
chr3_-_45308394 6.74 ENSDART00000155324
3-phosphoinositide dependent protein kinase 1a
chr9_-_18742704 6.70 ENSDART00000145401
TSC22 domain family, member 1
chr2_-_58201173 6.67 ENSDART00000166282
purine nucleoside phosphorylase 5b
chr9_+_6997861 6.62 ENSDART00000190491
inositol polyphosphate-4-phosphatase type I Aa
chr19_-_10395683 6.62 ENSDART00000109488
zgc:194578
chr11_-_18800299 6.61 ENSDART00000156276
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr24_+_4977862 6.59 ENSDART00000114537
zic family member 4
chr9_+_6998082 6.54 ENSDART00000092480
ENSDART00000135576
ENSDART00000188884
inositol polyphosphate-4-phosphatase type I Aa
chr17_+_29345606 6.53 ENSDART00000086164
potassium channel tetramerization domain containing 3
chr6_-_58828398 6.53 ENSDART00000090634
kinesin family member 5A, b
chr9_+_42546504 6.50 ENSDART00000192224
GULP, engulfment adaptor PTB domain containing 1a
chr15_+_1004680 6.50 ENSDART00000157310
si:dkey-77f5.8
chr24_+_32472155 6.48 ENSDART00000098859
neuronal differentiation 6a
chr15_-_739229 6.46 ENSDART00000153874
si:dkey-7i4.19
chr5_-_23999777 6.46 ENSDART00000085969
MAP7 domain containing 2a
chr9_-_31524907 6.45 ENSDART00000142904
ENSDART00000127214
ENSDART00000133427
ENSDART00000146268
ENSDART00000182541
ENSDART00000184736
transmembrane and tetratricopeptide repeat containing 4
chr18_+_17493859 6.44 ENSDART00000090754
si:dkey-102f14.5
chr18_-_21859019 6.43 ENSDART00000100885
neuritin 1-like a
chr14_-_33454595 6.41 ENSDART00000109615
ENSDART00000173267
ENSDART00000185737
ENSDART00000190989
transmembrane protein 255A
chr12_-_10421955 6.41 ENSDART00000052004
zgc:153595
chr14_+_36226243 6.37 ENSDART00000052569
paired-like homeodomain 2
chr7_+_67486807 6.36 ENSDART00000159989
copine VII
chr9_-_11655031 6.30 ENSDART00000044314
integrin, alpha V
chr16_+_24681177 6.24 ENSDART00000058956
ENSDART00000189335
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like
chr3_-_62393449 6.24 ENSDART00000101870
ENSDART00000140782
ENSDART00000181704
protein Z, vitamin K-dependent plasma glycoprotein a
chr12_+_32159272 6.19 ENSDART00000153167
hepatic leukemia factor b
chr12_-_35505610 6.14 ENSDART00000105518
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr1_+_41666611 6.14 ENSDART00000145789
F-box protein 41
chr1_-_19215336 6.10 ENSDART00000162949
ENSDART00000170680
protein tyrosine phosphatase, receptor type, D, b
chr21_+_11685009 6.10 ENSDART00000014668
proprotein convertase subtilisin/kexin type 1
chr12_-_41619257 6.08 ENSDART00000162967
dihydropyrimidinase-like 4
chr4_-_2525916 6.07 ENSDART00000134123
ENSDART00000132581
ENSDART00000019508
cysteine and glycine-rich protein 2
chr15_+_5116179 6.06 ENSDART00000101937
phosphoglucomutase 2-like 1
chr6_-_6673813 5.99 ENSDART00000150995
si:dkey-261j15.2
chr20_-_21994901 5.96 ENSDART00000004984
dishevelled associated activator of morphogenesis 1b
chr8_+_44714336 5.95 ENSDART00000145801
ELMO/CED-12 domain containing 3
chr13_+_23843712 5.95 ENSDART00000057611
opioid receptor, mu 1
chr15_-_28200049 5.92 ENSDART00000004200
sterile alpha and TIR motif containing 1
chr22_-_718615 5.87 ENSDART00000149320
ADP-ribosylation factor-like 8A

Network of associatons between targets according to the STRING database.

First level regulatory network of atf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 30.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
6.5 19.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
6.2 18.6 GO:1903792 negative regulation of anion transport(GO:1903792)
5.5 16.6 GO:0032263 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
5.2 47.0 GO:0099640 axo-dendritic protein transport(GO:0099640)
5.0 15.1 GO:0061217 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
3.7 22.0 GO:0072318 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
2.8 38.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
2.5 12.5 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
2.5 7.4 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
2.4 17.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
2.4 9.6 GO:0048313 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
2.0 5.9 GO:0019364 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
1.9 5.8 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.9 11.7 GO:0021534 cell proliferation in hindbrain(GO:0021534)
1.9 7.7 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
1.9 7.6 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
1.9 5.6 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
1.8 20.0 GO:0060217 hemangioblast cell differentiation(GO:0060217)
1.8 7.3 GO:0021742 abducens nucleus development(GO:0021742)
1.8 16.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
1.7 6.9 GO:0071788 endoplasmic reticulum tubular network maintenance(GO:0071788)
1.6 10.9 GO:0061635 regulation of protein complex stability(GO:0061635)
1.5 10.7 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
1.5 5.9 GO:0038003 opioid receptor signaling pathway(GO:0038003)
1.5 7.4 GO:0034505 tooth mineralization(GO:0034505)
1.4 4.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.3 18.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
1.3 13.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
1.2 3.7 GO:0044878 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
1.2 8.3 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
1.1 17.1 GO:0035493 SNARE complex assembly(GO:0035493)
1.1 4.5 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
1.1 10.0 GO:0008216 spermidine metabolic process(GO:0008216)
1.1 12.2 GO:0050714 positive regulation of protein secretion(GO:0050714)
1.1 25.5 GO:0015701 bicarbonate transport(GO:0015701)
1.1 4.4 GO:0071632 optomotor response(GO:0071632)
1.1 14.4 GO:0032481 positive regulation of type I interferon production(GO:0032481)
1.1 3.3 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
1.1 3.3 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
1.1 36.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
1.1 3.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
1.1 6.4 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
1.0 6.3 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
1.0 16.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
1.0 17.3 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
1.0 5.0 GO:1903146 regulation of mitophagy(GO:1903146)
1.0 5.0 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
1.0 28.0 GO:0016082 synaptic vesicle priming(GO:0016082)
1.0 13.7 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
1.0 3.9 GO:0006272 leading strand elongation(GO:0006272)
0.9 3.7 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.9 13.7 GO:0016486 peptide hormone processing(GO:0016486)
0.9 4.5 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.9 27.8 GO:0030641 regulation of cellular pH(GO:0030641)
0.9 4.4 GO:0042772 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.9 4.3 GO:0071543 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.9 5.1 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.8 4.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.8 3.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.8 14.4 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.8 3.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.8 12.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.8 3.1 GO:0019884 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.8 2.3 GO:0000103 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.8 3.1 GO:0010737 protein kinase A signaling(GO:0010737)
0.8 11.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.7 3.0 GO:0070987 error-free translesion synthesis(GO:0070987)
0.7 2.1 GO:0048569 post-embryonic organ development(GO:0048569)
0.7 2.1 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.7 3.5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.7 4.0 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.7 5.3 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.7 2.0 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.6 5.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.6 10.7 GO:0008089 anterograde axonal transport(GO:0008089)
0.6 6.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.6 12.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.6 6.1 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.6 2.4 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
0.6 5.5 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) single-organism membrane invagination(GO:1902534)
0.6 3.6 GO:0045899 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.6 2.9 GO:0000012 single strand break repair(GO:0000012)
0.6 4.5 GO:0014004 microglia differentiation(GO:0014004)
0.6 7.9 GO:0090049 regulation of cell migration involved in sprouting angiogenesis(GO:0090049)
0.6 5.6 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.6 2.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.5 2.7 GO:0046485 ether lipid metabolic process(GO:0046485)
0.5 4.8 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.5 3.2 GO:0080009 mRNA methylation(GO:0080009)
0.5 4.7 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.5 2.6 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.5 2.0 GO:0061709 reticulophagy(GO:0061709)
0.5 4.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.5 3.3 GO:2001271 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.5 6.9 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.5 30.9 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.4 1.8 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.4 6.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.4 20.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 8.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.4 7.1 GO:0043506 activation of JUN kinase activity(GO:0007257) regulation of JUN kinase activity(GO:0043506) positive regulation of JUN kinase activity(GO:0043507)
0.4 5.7 GO:0034030 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.4 25.8 GO:0015914 phospholipid transport(GO:0015914)
0.4 4.9 GO:0048696 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.4 4.0 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.4 2.0 GO:0023041 neuronal signal transduction(GO:0023041)
0.4 14.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.4 4.4 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.4 4.4 GO:0034312 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.4 5.1 GO:0042572 retinol metabolic process(GO:0042572)
0.4 12.1 GO:0048263 determination of dorsal identity(GO:0048263)
0.4 16.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 1.5 GO:0010259 multicellular organism aging(GO:0010259)
0.4 4.6 GO:0051893 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.4 3.8 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.4 5.3 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.4 2.9 GO:0006513 protein monoubiquitination(GO:0006513)
0.4 1.8 GO:0019348 dolichol metabolic process(GO:0019348)
0.4 1.8 GO:0072575 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.3 1.4 GO:0010586 miRNA metabolic process(GO:0010586)
0.3 4.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 1.7 GO:0051591 negative regulation of neurotransmitter secretion(GO:0046929) negative regulation of neurotransmitter transport(GO:0051589) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 3.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 1.7 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.3 7.3 GO:0060541 respiratory system development(GO:0060541)
0.3 3.3 GO:2000780 negative regulation of DNA repair(GO:0045738) negative regulation of double-strand break repair(GO:2000780)
0.3 33.8 GO:0048675 axon extension(GO:0048675)
0.3 3.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.3 5.1 GO:0016926 protein desumoylation(GO:0016926)
0.3 0.9 GO:0046048 ribonucleoside diphosphate catabolic process(GO:0009191) pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.3 1.5 GO:0010447 response to acidic pH(GO:0010447)
0.3 2.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.3 1.5 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3 8.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.3 30.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.3 0.8 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.3 1.3 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.3 1.5 GO:0036372 opsin transport(GO:0036372)
0.3 11.9 GO:0001841 neural tube formation(GO:0001841)
0.2 7.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 3.9 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.2 1.9 GO:0021550 medulla oblongata development(GO:0021550) dorsal motor nucleus of vagus nerve development(GO:0021744)
0.2 24.5 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.2 3.1 GO:0006346 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.2 3.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 4.8 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 1.6 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.2 2.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.2 17.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 0.7 GO:0065001 specification of axis polarity(GO:0065001) positive regulation of feeding behavior(GO:2000253)
0.2 3.7 GO:1900151 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) positive regulation of mRNA catabolic process(GO:0061014) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.2 1.7 GO:0051597 response to methylmercury(GO:0051597)
0.2 2.1 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.2 2.3 GO:0030719 P granule organization(GO:0030719)
0.2 1.6 GO:0042438 melanin biosynthetic process(GO:0042438)
0.2 1.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 2.2 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.2 2.6 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.2 3.5 GO:0048844 artery morphogenesis(GO:0048844)
0.2 1.9 GO:0050684 regulation of mRNA processing(GO:0050684)
0.2 11.8 GO:0006096 glycolytic process(GO:0006096)
0.2 6.1 GO:0072114 pronephros morphogenesis(GO:0072114)
0.2 0.6 GO:0032239 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833)
0.2 10.7 GO:0043488 regulation of mRNA stability(GO:0043488)
0.2 2.6 GO:0040019 positive regulation of embryonic development(GO:0040019)
0.2 1.7 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.2 3.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 13.6 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.2 10.2 GO:0001819 positive regulation of cytokine production(GO:0001819)
0.2 2.5 GO:0042407 cristae formation(GO:0042407)
0.2 4.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.2 2.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 1.9 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.2 5.2 GO:0098840 protein transport along microtubule(GO:0098840)
0.2 2.1 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.2 0.6 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.2 1.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 0.8 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.2 1.2 GO:0010507 negative regulation of autophagy(GO:0010507)
0.2 1.8 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.1 41.1 GO:0006470 protein dephosphorylation(GO:0006470)
0.1 0.6 GO:0051661 Golgi localization(GO:0051645) maintenance of centrosome location(GO:0051661)
0.1 1.8 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 1.0 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.7 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 10.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 0.6 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 1.0 GO:0001780 neutrophil homeostasis(GO:0001780)
0.1 1.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.5 GO:0046324 regulation of glucose import(GO:0046324)
0.1 2.4 GO:0016584 nucleosome positioning(GO:0016584)
0.1 6.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.6 GO:0009268 response to pH(GO:0009268)
0.1 1.1 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 1.9 GO:0035459 cargo loading into vesicle(GO:0035459)
0.1 4.5 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.1 4.5 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.1 3.6 GO:0048278 vesicle docking(GO:0048278)
0.1 6.0 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 3.4 GO:0060972 left/right pattern formation(GO:0060972)
0.1 2.1 GO:0010043 response to zinc ion(GO:0010043)
0.1 3.3 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.1 2.1 GO:0030183 B cell differentiation(GO:0030183)
0.1 6.4 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 2.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 10.3 GO:0016236 macroautophagy(GO:0016236)
0.1 0.7 GO:0072028 nephron morphogenesis(GO:0072028)
0.1 2.7 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.1 3.8 GO:0016311 dephosphorylation(GO:0016311)
0.1 6.1 GO:0045214 sarcomere organization(GO:0045214)
0.1 2.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 2.2 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 18.6 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.1 3.6 GO:0030901 midbrain development(GO:0030901)
0.1 1.6 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.5 GO:0060841 venous blood vessel development(GO:0060841)
0.1 1.2 GO:0046549 retinal cone cell development(GO:0046549)
0.1 0.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 3.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 3.5 GO:0007254 JNK cascade(GO:0007254)
0.1 2.1 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.1 0.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 2.7 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 1.8 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.1 13.3 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.1 1.2 GO:0071025 RNA surveillance(GO:0071025)
0.1 3.0 GO:0010950 positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952)
0.1 6.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 6.9 GO:0016579 protein deubiquitination(GO:0016579)
0.1 15.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 3.1 GO:0007338 single fertilization(GO:0007338)
0.1 0.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 2.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.5 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.1 1.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 0.2 GO:0010939 regulation of necrotic cell death(GO:0010939) regulation of necroptotic process(GO:0060544) negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.1 6.0 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.1 8.6 GO:0030334 regulation of cell migration(GO:0030334)
0.1 3.2 GO:0008217 regulation of blood pressure(GO:0008217)
0.1 1.3 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 1.5 GO:1903322 positive regulation of protein ubiquitination(GO:0031398) positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.1 1.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.2 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.6 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 14.5 GO:0008380 RNA splicing(GO:0008380)
0.0 2.4 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 4.7 GO:0006821 chloride transport(GO:0006821)
0.0 5.2 GO:0006936 muscle contraction(GO:0006936)
0.0 4.8 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 1.0 GO:0016574 histone ubiquitination(GO:0016574)
0.0 1.2 GO:0051028 mRNA transport(GO:0051028)
0.0 0.8 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 3.6 GO:0007626 locomotory behavior(GO:0007626)
0.0 0.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 2.6 GO:0050769 positive regulation of neurogenesis(GO:0050769)
0.0 0.2 GO:0090311 regulation of histone deacetylation(GO:0031063) regulation of protein deacetylation(GO:0090311)
0.0 0.2 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 1.1 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 0.4 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 4.8 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.6 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.0 0.6 GO:0001757 somite specification(GO:0001757) segment specification(GO:0007379)
0.0 0.5 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.7 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.0 1.3 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.2 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.0 1.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.6 GO:0044782 cilium organization(GO:0044782)
0.0 1.7 GO:0016573 histone acetylation(GO:0016573)
0.0 2.6 GO:0006338 chromatin remodeling(GO:0006338)
0.0 1.1 GO:0007498 mesoderm development(GO:0007498)
0.0 5.8 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 3.2 GO:0006869 lipid transport(GO:0006869)
0.0 1.7 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.3 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.6 63.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
3.5 20.9 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
2.7 10.8 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
2.0 12.1 GO:0005955 calcineurin complex(GO:0005955)
1.4 5.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.4 12.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.4 6.9 GO:0070724 BMP receptor complex(GO:0070724)
1.4 13.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
1.3 5.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
1.2 4.6 GO:0016460 myosin II complex(GO:0016460)
1.1 8.6 GO:0034464 BBSome(GO:0034464)
1.1 12.9 GO:0044295 axonal growth cone(GO:0044295)
1.0 17.8 GO:0000813 ESCRT I complex(GO:0000813)
1.0 9.8 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.9 4.7 GO:0033503 HULC complex(GO:0033503)
0.9 10.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.9 3.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.8 3.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.8 30.8 GO:0043679 axon terminus(GO:0043679)
0.8 3.0 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.8 3.0 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.7 3.0 GO:0008537 proteasome activator complex(GO:0008537)
0.7 11.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.7 11.3 GO:0031209 SCAR complex(GO:0031209)
0.7 4.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.7 4.1 GO:0000938 GARP complex(GO:0000938)
0.6 26.3 GO:0030125 clathrin vesicle coat(GO:0030125)
0.6 5.6 GO:0089701 U2AF(GO:0089701)
0.6 50.8 GO:0005871 kinesin complex(GO:0005871)
0.6 3.5 GO:0070062 extracellular exosome(GO:0070062)
0.5 3.7 GO:0035517 PR-DUB complex(GO:0035517)
0.5 17.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.5 12.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.5 1.9 GO:0030896 checkpoint clamp complex(GO:0030896)
0.4 3.6 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.4 3.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.4 26.2 GO:0031902 late endosome membrane(GO:0031902)
0.4 3.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.4 2.4 GO:0016589 NURF complex(GO:0016589)
0.4 1.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.4 2.6 GO:0071818 BAT3 complex(GO:0071818)
0.4 15.1 GO:0043204 perikaryon(GO:0043204)
0.4 31.9 GO:0030141 secretory granule(GO:0030141)
0.4 23.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 4.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 3.4 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.3 5.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.3 3.7 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 2.1 GO:0005682 U5 snRNP(GO:0005682)
0.2 23.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 26.6 GO:0005802 trans-Golgi network(GO:0005802)
0.2 3.0 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.2 2.4 GO:0061617 MICOS complex(GO:0061617)
0.2 4.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.2 11.1 GO:0005776 autophagosome(GO:0005776)
0.2 4.3 GO:0005686 U2 snRNP(GO:0005686)
0.2 6.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 0.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.2 0.6 GO:0034518 RNA cap binding complex(GO:0034518)
0.2 2.3 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.2 6.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 7.6 GO:0030426 growth cone(GO:0030426)
0.2 1.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 3.9 GO:0008278 cohesin complex(GO:0008278)
0.2 4.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 1.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 39.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 26.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 5.0 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 2.3 GO:0005869 dynactin complex(GO:0005869)
0.1 4.0 GO:0005876 spindle microtubule(GO:0005876)
0.1 3.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 2.1 GO:0015030 Cajal body(GO:0015030)
0.1 21.3 GO:0008021 synaptic vesicle(GO:0008021)
0.1 2.7 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 6.9 GO:0043025 neuronal cell body(GO:0043025)
0.1 3.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 9.4 GO:0030133 transport vesicle(GO:0030133)
0.1 4.5 GO:0031201 SNARE complex(GO:0031201)
0.1 1.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.1 GO:0017119 Golgi transport complex(GO:0017119)
0.1 10.3 GO:0016324 apical plasma membrane(GO:0016324)
0.1 4.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 4.6 GO:0000922 spindle pole(GO:0000922)
0.1 1.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 19.6 GO:0005874 microtubule(GO:0005874)
0.1 2.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 1.4 GO:0000178 exosome (RNase complex)(GO:0000178)
0.1 4.5 GO:0016592 mediator complex(GO:0016592)
0.1 21.2 GO:0043005 neuron projection(GO:0043005)
0.1 3.4 GO:0008305 integrin complex(GO:0008305)
0.1 5.7 GO:0045111 intermediate filament(GO:0005882) intermediate filament cytoskeleton(GO:0045111)
0.1 1.2 GO:0030496 midbody(GO:0030496)
0.1 4.0 GO:0030018 Z disc(GO:0030018)
0.1 0.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 77.1 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 5.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 1.2 GO:0035861 site of double-strand break(GO:0035861)
0.0 3.3 GO:0016607 nuclear speck(GO:0016607)
0.0 20.3 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 1.5 GO:0032432 actin filament bundle(GO:0032432)
0.0 1.7 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
5.5 16.6 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
3.9 19.5 GO:0008432 JUN kinase binding(GO:0008432)
3.6 46.6 GO:0031628 opioid receptor binding(GO:0031628)
2.5 15.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
2.5 10.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
2.5 12.5 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
2.4 17.0 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
2.1 14.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
2.0 12.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
2.0 80.4 GO:0017075 syntaxin-1 binding(GO:0017075)
2.0 5.9 GO:0038046 enkephalin receptor activity(GO:0038046)
1.9 13.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
1.8 25.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.8 12.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.7 5.1 GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity(GO:0047173)
1.6 11.5 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
1.6 4.8 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
1.5 4.5 GO:0071568 UFM1 transferase activity(GO:0071568)
1.4 6.9 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.4 4.1 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
1.3 18.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.3 11.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.2 14.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
1.2 3.5 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
1.2 4.6 GO:0032028 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
1.1 3.4 GO:0015562 inositol hexakisphosphate binding(GO:0000822) efflux transmembrane transporter activity(GO:0015562)
1.1 37.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.1 10.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
1.1 5.5 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
1.0 7.3 GO:0030274 LIM domain binding(GO:0030274)
1.0 16.6 GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
1.0 4.0 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
1.0 3.0 GO:0001734 mRNA (N6-adenosine)-methyltransferase activity(GO:0001734)
1.0 2.9 GO:0030623 U5 snRNA binding(GO:0030623)
1.0 5.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.9 13.7 GO:0051117 ATPase binding(GO:0051117)
0.9 7.0 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.9 4.3 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.8 11.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.8 3.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.8 7.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.8 4.7 GO:0032052 bile acid binding(GO:0032052)
0.8 2.3 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.7 8.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.7 6.7 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.7 22.2 GO:0030165 PDZ domain binding(GO:0030165)
0.7 2.2 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.7 7.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.7 4.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.7 3.4 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.7 2.0 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.7 26.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.6 3.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.6 5.1 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.6 6.9 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.6 3.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.6 4.2 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.6 10.7 GO:0005080 protein kinase C binding(GO:0005080)
0.6 4.7 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.6 6.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.6 9.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.6 2.2 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.6 5.6 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.5 4.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.5 13.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.5 6.1 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.5 4.0 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 3.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 4.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.5 22.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.5 7.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 2.2 GO:0050699 WW domain binding(GO:0050699)
0.4 2.7 GO:0001159 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.4 1.3 GO:0008517 folic acid transporter activity(GO:0008517)
0.4 4.8 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.4 6.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 26.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 5.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.4 4.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.4 1.6 GO:0070404 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.4 2.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.4 4.7 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.4 5.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 5.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.4 15.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.4 4.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.4 1.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.4 5.1 GO:0070840 dynein complex binding(GO:0070840)
0.4 5.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.4 2.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.4 5.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.4 4.9 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 3.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.3 1.4 GO:0070513 death domain binding(GO:0070513)
0.3 4.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 38.6 GO:0005179 hormone activity(GO:0005179)
0.3 30.2 GO:0043130 ubiquitin binding(GO:0043130)
0.3 3.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 9.1 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.3 15.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 3.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 1.8 GO:0004743 pyruvate kinase activity(GO:0004743)
0.3 8.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 5.9 GO:0035591 signaling adaptor activity(GO:0035591)
0.3 1.5 GO:0008430 selenium binding(GO:0008430)
0.3 1.6 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.3 3.1 GO:0005158 insulin receptor binding(GO:0005158)
0.3 26.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.3 6.8 GO:0015248 sterol transporter activity(GO:0015248)
0.3 14.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 3.7 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 3.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 1.2 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.2 4.8 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 10.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 14.2 GO:0030276 clathrin binding(GO:0030276)
0.2 2.4 GO:1990239 steroid hormone binding(GO:1990239)
0.2 1.8 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 2.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 3.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 1.3 GO:0051379 alpha2-adrenergic receptor activity(GO:0004938) epinephrine binding(GO:0051379)
0.2 11.1 GO:0008013 beta-catenin binding(GO:0008013)
0.2 2.9 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 7.6 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.2 2.1 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.2 3.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 13.5 GO:0003777 microtubule motor activity(GO:0003777)
0.2 1.9 GO:0043495 protein anchor(GO:0043495)
0.2 15.3 GO:0008201 heparin binding(GO:0008201)
0.2 1.7 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2 0.6 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 15.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 28.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.1 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.1 0.6 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 1.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 4.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.8 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 3.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.6 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.6 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 2.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 1.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 2.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 32.9 GO:0015631 tubulin binding(GO:0015631)
0.1 0.8 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 3.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.8 GO:0019809 spermidine binding(GO:0019809)
0.1 41.4 GO:0003924 GTPase activity(GO:0003924)
0.1 2.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 12.3 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 10.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 6.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 10.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 1.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 3.1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 13.2 GO:0000287 magnesium ion binding(GO:0000287)
0.1 4.0 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 3.5 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.1 1.3 GO:0019894 kinesin binding(GO:0019894)
0.1 2.8 GO:0051087 chaperone binding(GO:0051087)
0.1 0.4 GO:0045309 protein phosphorylated amino acid binding(GO:0045309) phosphoprotein binding(GO:0051219)
0.1 0.2 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 11.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 3.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 15.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.9 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 1.1 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 0.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 3.6 GO:0000149 SNARE binding(GO:0000149)
0.1 0.9 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 13.7 GO:0003682 chromatin binding(GO:0003682)
0.1 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 2.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.0 42.2 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 6.8 GO:0004497 monooxygenase activity(GO:0004497)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 2.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 7.1 GO:0000989 transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.3 GO:0032182 ubiquitin-like protein binding(GO:0032182)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 1.0 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.2 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 2.4 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 4.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 38.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.3 GO:0016791 phosphatase activity(GO:0016791)
0.0 7.4 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 38.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
1.2 18.8 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
1.1 14.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
1.0 21.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.7 5.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.6 7.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 4.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.6 10.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.6 7.8 PID S1P S1P3 PATHWAY S1P3 pathway
0.5 10.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.4 8.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 12.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 7.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 1.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 5.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 6.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 8.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 8.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 2.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 0.6 PID IL1 PATHWAY IL1-mediated signaling events
0.1 4.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 0.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 2.8 PID P73PATHWAY p73 transcription factor network
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.2 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.1 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
3.7 18.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.9 18.8 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
1.8 19.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
1.6 27.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
1.4 14.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
1.4 13.7 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
1.0 9.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.0 17.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.0 12.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.8 7.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.7 6.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.7 6.8 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.7 9.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.6 28.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.6 6.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.5 4.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.5 4.6 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.5 4.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 3.8 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.4 8.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 4.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 7.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 4.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3 2.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 4.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 5.9 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.2 29.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.2 5.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 1.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 2.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 7.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 1.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.9 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.2 2.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 1.6 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.2 1.0 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 5.2 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 2.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 2.1 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 8.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 0.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 6.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 2.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 13.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.0 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.1 0.7 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 2.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.8 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway