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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish

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Results for arnt2

Z-value: 4.32

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Transcription factors associated with arnt2

Gene Symbol Gene ID Gene Info
ENSDARG00000103697 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
arnt2dr11_v1_chr7_+_10701770_107017700.887.0e-32Click!

Activity profile of arnt2 motif

Sorted Z-values of arnt2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_35382482 93.46 ENSDART00000135284
visinin-like 1a
chr9_-_44295071 92.52 ENSDART00000011837
neuronal differentiation 1
chr13_+_27314795 73.90 ENSDART00000128726
eukaryotic translation elongation factor 1 alpha 1a
chr11_+_7324704 62.33 ENSDART00000031937
DIRAS family, GTP-binding RAS-like 1a
chr5_-_23429228 60.22 ENSDART00000049291
glutamate receptor, ionotropic, AMPA 3a
chr5_+_23118470 54.80 ENSDART00000149893
neurite extension and migration factor a
chr5_+_32162684 54.26 ENSDART00000134472
TAO kinase 3b
chr19_+_10396042 53.58 ENSDART00000028048
ENSDART00000151735
NECAP endocytosis associated 1
chr24_-_11325849 52.32 ENSDART00000182485
myosin VIIA and Rab interacting protein
chr18_+_7345417 51.39 ENSDART00000041429
GLI pathogenesis-related 1b
chr21_+_6751760 49.24 ENSDART00000135914
olfactomedin 1b
chr19_-_10243148 48.17 ENSDART00000148073
shisa family member 7
chr19_+_17259912 47.99 ENSDART00000078951
si:ch211-30b16.2
chr11_+_30513656 47.84 ENSDART00000008594
transmembrane protein 178
chr5_+_55626693 45.50 ENSDART00000168908
ENSDART00000161412
neurotrophic tyrosine kinase, receptor, type 2b
chr20_+_27331008 44.08 ENSDART00000141486
protein phosphatase 4, regulatory subunit 4
chr10_+_22012389 43.40 ENSDART00000035188
Kv channel interacting protein 1 b
chr4_-_12007404 43.18 ENSDART00000092250
BTB (POZ) domain containing 11a
chr1_-_22757145 42.93 ENSDART00000134719
prominin 1 b
chr17_+_15535501 42.60 ENSDART00000002932
myristoylated alanine-rich protein kinase C substrate b
chr21_+_6751405 42.41 ENSDART00000037265
ENSDART00000146371
olfactomedin 1b
chr16_-_12953739 42.11 ENSDART00000103894
calcium channel, voltage-dependent, gamma subunit 8b
chr15_-_12319065 40.75 ENSDART00000162973
ENSDART00000170543
FXYD domain containing ion transport regulator 6
chr5_-_16983336 40.52 ENSDART00000038740
polypeptide N-acetylgalactosaminyltransferase 9
chr2_+_47581997 37.57 ENSDART00000112579
secretogranin II (chromogranin C), b
chr12_-_22540943 37.19 ENSDART00000172310
zinc finger and BTB domain containing 4
chr23_-_8373676 36.74 ENSDART00000105135
ENSDART00000158531
opiate receptor-like 1
chr24_-_3419998 36.66 ENSDART00000066839
solute carrier family 35, member G2b
chr22_-_21150845 35.38 ENSDART00000027345
transmembrane protein 59-like
chr21_+_30194904 35.30 ENSDART00000137023
ENSDART00000078403
si:ch211-59d17.3
chr9_+_32978302 35.17 ENSDART00000007630
nescient helix loop helix 2
chr21_+_28958471 35.12 ENSDART00000144331
ENSDART00000005929
protein phosphatase 3, catalytic subunit, alpha isozyme
chr21_-_41305748 34.98 ENSDART00000170457
neuronal vesicle trafficking associated 2
chr14_+_8275115 34.62 ENSDART00000129055
neuregulin 2b
chr25_+_19954576 34.06 ENSDART00000149335
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr1_+_33969015 33.89 ENSDART00000042984
ENSDART00000146530
eph receptor A6
chr1_+_14283692 33.74 ENSDART00000017679
protein phosphatase 2, regulatory subunit B, gamma a
chr13_+_12299997 33.41 ENSDART00000108535
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr19_+_15571290 33.07 ENSDART00000131134
forkhead box O6 b
chr14_-_7885707 32.95 ENSDART00000029981
protein phosphatase 3, catalytic subunit, beta isozyme
chr21_+_5169154 32.91 ENSDART00000102559
zgc:122979
chr1_+_49814461 32.86 ENSDART00000132405
lymphoid enhancer-binding factor 1
chr2_+_42724404 32.70 ENSDART00000075392
brain abundant, membrane attached signal protein 1
chr23_-_26077038 32.52 ENSDART00000126299
GDP dissociation inhibitor 1
chr7_-_56793739 32.40 ENSDART00000082842
si:ch211-146m13.3
chr1_+_8662530 32.20 ENSDART00000054989
fascin actin-bundling protein 1b
chr15_+_36156986 32.03 ENSDART00000059791
somatostatin 1, tandem duplicate 1
chr1_+_36436936 31.79 ENSDART00000124112
POU class 4 homeobox 2
chr14_-_34276574 31.61 ENSDART00000021437
glutamate receptor, ionotropic, AMPA 1a
chr1_-_45633955 31.44 ENSDART00000044057
septin 3
chr12_-_14922955 31.15 ENSDART00000002078
neurogenic differentiation 2
chr4_+_10888762 30.92 ENSDART00000136049
synaptotagmin X
chr7_+_25858380 30.87 ENSDART00000148780
ENSDART00000079218
myotubularin related protein 1a
chr5_+_36415978 30.54 ENSDART00000084464
family with sequence similarity 155, member B
chr13_-_30027730 30.23 ENSDART00000044009
stearoyl-CoA desaturase b
chr9_-_23217196 29.85 ENSDART00000083567
kinesin family member 5C
chr2_+_45382433 29.81 ENSDART00000142251
WD repeat domain 47a
chr17_-_22067451 29.59 ENSDART00000156872
tau tubulin kinase 1b
chr6_+_13920479 29.59 ENSDART00000155480
protein tyrosine phosphatase, receptor type, Nb
chr5_+_36611128 29.15 ENSDART00000097684
neuro-oncological ventral antigen 1
chr17_-_17447899 28.98 ENSDART00000156928
ENSDART00000109034
neurexin 3a
chr14_+_36220479 28.85 ENSDART00000148319
paired-like homeodomain 2
chr16_-_13004166 28.85 ENSDART00000133735
calcium channel, voltage-dependent, gamma subunit 7b
chr21_+_6780340 28.43 ENSDART00000139493
ENSDART00000140478
olfactomedin 1b
chr18_-_44610992 28.39 ENSDART00000125968
ENSDART00000185836
sprouty-related, EVH1 domain containing 3
chr11_+_36989696 28.30 ENSDART00000045888
transketolase a
chr18_+_2837563 28.23 ENSDART00000171495
ENSDART00000160228
family with sequence similarity 168, member A
chr4_-_4780667 28.09 ENSDART00000133973
si:ch211-258f14.2
chr19_-_9882821 28.00 ENSDART00000147128
calcium channel, voltage-dependent, gamma subunit 7a
chr20_-_47731768 27.98 ENSDART00000031167
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr1_-_22834824 27.84 ENSDART00000043556
LIM domain binding 2b
chr17_+_52822831 27.79 ENSDART00000193368
Meis homeobox 2a
chr6_-_26559921 27.76 ENSDART00000104532
SRY (sex determining region Y)-box 14
chr6_+_33537267 27.63 ENSDART00000040334
phosphoinositide-3-kinase, regulatory subunit 3b (gamma)
chr8_-_11640240 27.60 ENSDART00000091752
formin binding protein 1a
chr2_+_31957554 27.42 ENSDART00000012413
ANKH inorganic pyrophosphate transport regulator b
chr16_-_13662514 27.22 ENSDART00000146348
shisa family member 7a
chr20_+_20637866 27.21 ENSDART00000060203
ENSDART00000079079
reticulon 1b
chr1_+_6171585 27.02 ENSDART00000024358
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr1_+_25783801 26.87 ENSDART00000102455
guanylate cyclase 1 soluble subunit alpha 1
chr10_-_19801821 26.83 ENSDART00000148013
GDNF family receptor alpha 2b
chr15_+_33070939 26.79 ENSDART00000164928
mab-21-like 1
chr1_+_33383971 26.72 ENSDART00000150043
dehydrogenase/reductase (SDR family) X-linked
chr4_-_27350820 26.71 ENSDART00000145806
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr3_-_62380146 26.58 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr9_-_6661657 26.43 ENSDART00000133178
ENSDART00000113914
ENSDART00000061593
POU class 3 homeobox 3a
chr7_+_20629411 26.37 ENSDART00000173710
si:dkey-19b23.15
chr7_+_10701770 26.36 ENSDART00000167323
aryl-hydrocarbon receptor nuclear translocator 2
chr4_+_9279784 26.32 ENSDART00000014897
SLIT-ROBO Rho GTPase activating protein 1b
chr11_-_24428237 25.96 ENSDART00000189107
ENSDART00000103752
dishevelled segment polarity protein 1b
chr16_+_1802307 25.87 ENSDART00000180026
glutamate ionotropic receptor kainate type subunit 2
chr5_-_32092856 25.53 ENSDART00000086181
ENSDART00000181677
calcium binding protein 7b
chr5_-_22952156 25.21 ENSDART00000111146
si:ch211-26b3.4
chr11_+_34824099 25.19 ENSDART00000037017
ENSDART00000146944
solute carrier family 38, member 3a
chr5_-_28915130 25.08 ENSDART00000078592
neural proliferation, differentiation and control, 1b
chr17_-_45552602 24.64 ENSDART00000154844
ENSDART00000034432
sushi domain containing 4
chr5_-_71460556 24.38 ENSDART00000108804
bone morphogenetic protein/retinoic acid inducible neural-specific 1
chr5_+_3501859 24.37 ENSDART00000080486
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1
chr23_-_44494401 24.28 ENSDART00000114640
ENSDART00000148532
actin-like 6B
chr17_+_19630272 23.92 ENSDART00000104895
regulator of G protein signaling 7a
chr2_+_49522178 23.86 ENSDART00000056254
signal transducing adaptor family member 2a
chr15_-_18574716 23.83 ENSDART00000142010
ENSDART00000019006
neural cell adhesion molecule 1b
chr1_+_33383644 23.66 ENSDART00000187194
dehydrogenase/reductase (SDR family) X-linked
chr8_+_26868105 23.60 ENSDART00000005337
ribosomal modification protein rimK-like family member A
chr6_-_18698006 23.57 ENSDART00000170128
rhomboid, veinlet-like 3 (Drosophila)
chr17_-_20287530 23.28 ENSDART00000078703
ENSDART00000191289
adducin 3 (gamma) b
chr19_+_41006975 23.21 ENSDART00000138555
ENSDART00000049842
CAS1 domain containing 1
chr16_-_33059246 23.05 ENSDART00000171718
ENSDART00000168305
ENSDART00000166401
synaptosomal-associated protein 91
chr25_-_36282539 23.02 ENSDART00000073398
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10b
chr2_-_10188598 22.79 ENSDART00000189122
diencephalon/mesencephalon homeobox 1a
chr10_+_29963518 22.51 ENSDART00000011317
ENSDART00000099964
ENSDART00000182990
ENSDART00000113912
neurotrimin
chr6_+_4872883 22.24 ENSDART00000186730
ENSDART00000092290
ENSDART00000151674
protocadherin 9
chr8_+_10561922 22.12 ENSDART00000133348
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5-like
chr3_+_46628885 21.94 ENSDART00000006602
phosphodiesterase 4A, cAMP-specific
chr12_+_35119762 21.85 ENSDART00000085774
si:ch73-127m5.1
chr9_-_20372977 21.82 ENSDART00000113418
immunoglobulin superfamily, member 3
chr2_+_21090317 21.36 ENSDART00000109568
ENSDART00000139633
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b
chr19_-_10395683 21.34 ENSDART00000109488
zgc:194578
chr19_+_30387999 21.23 ENSDART00000145396
tetraspanin 13b
chr21_+_17110598 21.12 ENSDART00000101282
ENSDART00000191864
breakpoint cluster region
chr9_+_29643036 21.06 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr23_+_13124085 20.99 ENSDART00000139475
sterile alpha motif domain containing 10b
chr13_-_20518632 20.71 ENSDART00000165310
gdnf family receptor alpha 1a
chr8_+_49778486 20.36 ENSDART00000131732
neurotrophic tyrosine kinase, receptor, type 2a
chr17_+_9310259 20.09 ENSDART00000186158
ENSDART00000190329
neuronal PAS domain protein 3
chr4_+_7888047 19.84 ENSDART00000104676
calcium/calmodulin-dependent protein kinase 1Da
chr14_+_19258702 19.72 ENSDART00000187087
ENSDART00000005738
SLIT and NTRK-like family, member 2
chr18_+_49411417 19.64 ENSDART00000028944
zmp:0000001073
chr15_+_15856178 19.53 ENSDART00000080338
dual specificity phosphatase 14
chr2_-_15040345 19.52 ENSDART00000109657
si:dkey-10f21.4
chr25_+_1591964 19.41 ENSDART00000093277
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr11_+_30161699 19.36 ENSDART00000190504
cyclin-dependent kinase-like 5
chr19_+_26718074 19.23 ENSDART00000134455
zgc:100906
chr11_-_3959477 19.09 ENSDART00000045971
polybromo 1
chr11_-_36963988 18.89 ENSDART00000168288
calcium channel, voltage-dependent, L type, alpha 1D subunit, a
chr5_+_27583445 18.80 ENSDART00000136488
zinc finger, matrin-type 4a
chr13_+_12120664 18.77 ENSDART00000130007
ENSDART00000079443
gamma-aminobutyric acid type A receptor alpha2 subunit a
chr8_-_17771755 18.69 ENSDART00000063592
protein kinase C, zeta
chr13_+_35925490 18.67 ENSDART00000046115
major facilitator superfamily domain containing 2aa
chr10_+_17850934 18.58 ENSDART00000113666
ENSDART00000145936
PHD finger protein 24
chr17_+_28340138 18.49 ENSDART00000033943
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr3_+_14768364 18.48 ENSDART00000090235
ENSDART00000139001
nuclear factor I/Xb
chr1_-_22756898 18.48 ENSDART00000158915
prominin 1 b
chr14_-_47314340 18.34 ENSDART00000164851
follistatin-like 5
chr1_+_37195465 18.19 ENSDART00000043855
ENSDART00000192580
ENSDART00000181666
doublecortin-like kinase 2a
chr7_-_38340674 18.12 ENSDART00000075782
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10a
chr16_-_23885482 18.11 ENSDART00000132243
oxidative stress induced growth inhibitor family member 2
chr1_+_31942961 17.86 ENSDART00000007522
anosmin 1a
chr20_+_37844035 17.77 ENSDART00000041397
feline leukemia virus subgroup C cellular receptor 1
chr2_+_25929619 17.77 ENSDART00000137746
solute carrier family 7, member 14a
chr13_+_12739283 17.76 ENSDART00000102279
leucine rich repeat and Ig domain containing 2b
chr25_+_13406069 17.62 ENSDART00000010495
zinc and ring finger 1
chr1_-_16507812 17.47 ENSDART00000169081
myotubularin related protein 7b
chr6_-_39489190 17.45 ENSDART00000151299
sodium channel, voltage gated, type VIII, alpha subunit b
chr12_+_9703172 17.40 ENSDART00000091489
protein phosphatase 1, regulatory subunit 9Bb
chr1_-_22512063 17.32 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr15_-_31516558 17.26 ENSDART00000156427
ENSDART00000156072
ENSDART00000156047
high mobility group box 1b
chr17_-_42218652 17.23 ENSDART00000081396
ENSDART00000190007
NK2 homeobox 2a
chr21_+_23953181 17.06 ENSDART00000145541
ENSDART00000065599
ENSDART00000112869
cell adhesion molecule 1a
chr4_-_4780510 17.04 ENSDART00000109609
si:ch211-258f14.2
chr13_+_24022963 17.04 ENSDART00000028285
piggyBac transposable element derived 5
chr9_-_44289636 16.81 ENSDART00000110411
ceramide kinase-like
chr18_-_46208581 16.70 ENSDART00000141278
si:ch211-14c7.2
chr10_+_23060391 16.65 ENSDART00000079711
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1a
chr14_+_32022272 16.64 ENSDART00000105760
zic family member 6
chr12_+_19305390 16.64 ENSDART00000183987
ENSDART00000066391
casein kinase 1, epsilon
chr6_-_48473694 16.58 ENSDART00000154237
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr18_-_23875219 16.57 ENSDART00000059976
nuclear receptor subfamily 2, group F, member 2
chr1_-_7917062 16.51 ENSDART00000177068
monocyte to macrophage differentiation-associated 2b
chr14_+_33722950 16.38 ENSDART00000075312
apelin
chr1_+_37195919 16.30 ENSDART00000159684
ENSDART00000172742
ENSDART00000158395
doublecortin-like kinase 2a
chr17_-_33289304 16.28 ENSDART00000135118
ENSDART00000040346
EFR3 homolog Ba (S. cerevisiae)
chr15_+_28482862 16.23 ENSDART00000015286
ENSDART00000154320
ankyrin repeat domain 13B
chr24_-_11050070 16.10 ENSDART00000191320
ENSDART00000030409
ENSDART00000191248
ENSDART00000191943
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr13_-_20519001 15.80 ENSDART00000168955
gdnf family receptor alpha 1a
chr2_-_32352946 15.77 ENSDART00000144870
ENSDART00000077151
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a
chr18_-_23875370 15.71 ENSDART00000130163
nuclear receptor subfamily 2, group F, member 2
chr23_-_16692312 15.57 ENSDART00000046784
FK506 binding protein 1Ab
chr5_-_34185497 15.57 ENSDART00000146321
fibrinogen C domain containing 1
chr5_-_34185115 15.55 ENSDART00000192771
fibrinogen C domain containing 1
chr10_-_26744131 15.55 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr19_+_30388186 15.50 ENSDART00000103474
tetraspanin 13b
chr19_-_28130658 15.46 ENSDART00000079114
iroquois homeobox 1b
chr8_+_23147609 15.40 ENSDART00000180284
GID complex subunit 8 homolog a (S. cerevisiae)
chr24_-_31846366 15.38 ENSDART00000155295
STEAP family member 2, metalloreductase
chr8_+_14710542 15.32 ENSDART00000132899
calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr3_-_19091024 15.22 ENSDART00000188485
ENSDART00000110554
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr7_-_49800755 15.17 ENSDART00000180072
four jointed box 1
chr22_-_20105969 14.95 ENSDART00000088687
relaxin/insulin-like family peptide receptor 3.2b
chr8_+_49778756 14.87 ENSDART00000083790
neurotrophic tyrosine kinase, receptor, type 2a
chr1_+_37196106 14.82 ENSDART00000008756
ENSDART00000157503
ENSDART00000162971
ENSDART00000191004
ENSDART00000078206
ENSDART00000045111
doublecortin-like kinase 2a
chr24_-_18179535 14.79 ENSDART00000186112
contactin associated protein like 2a
chr12_-_48943467 14.68 ENSDART00000191829

chr2_-_24603325 14.67 ENSDART00000113356
CREB regulated transcription coactivator 1a
chr4_-_17055782 14.61 ENSDART00000134595
SRY (sex determining region Y)-box 5
chr14_-_33328031 14.56 ENSDART00000137997
septin 6
chr19_-_1023051 14.56 ENSDART00000158429
transmembrane protein 42b
chr4_-_4706893 14.47 ENSDART00000093005

chr2_-_33687214 14.41 ENSDART00000147439
ATPase H+ transporting V0 subunit b
chr15_-_19128705 14.40 ENSDART00000152428
Rho GTPase activating protein 32a

Network of associatons between targets according to the STRING database.

First level regulatory network of arnt2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
26.9 80.7 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
15.9 47.8 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
13.7 41.1 GO:0042940 D-amino acid transport(GO:0042940) D-alanine transport(GO:0042941) D-serine transport(GO:0042942)
13.7 54.8 GO:2000048 negative regulation of cell-substrate adhesion(GO:0010812) negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
12.5 62.3 GO:0061551 trigeminal ganglion development(GO:0061551)
12.4 37.2 GO:0060031 mediolateral intercalation(GO:0060031)
10.6 31.8 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
9.9 49.3 GO:0006972 hyperosmotic response(GO:0006972)
9.5 37.8 GO:0006867 asparagine transport(GO:0006867)
9.1 45.4 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
8.4 75.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
8.2 24.6 GO:2000257 complement activation, alternative pathway(GO:0006957) regulation of protein activation cascade(GO:2000257)
7.8 31.1 GO:0060074 synapse maturation(GO:0060074)
7.6 30.2 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
6.6 112.2 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
6.2 18.5 GO:0021611 facial nerve formation(GO:0021611)
5.8 28.9 GO:0061072 iris morphogenesis(GO:0061072)
5.7 17.2 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
5.7 28.3 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
5.6 16.8 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) regulation of apoptotic cell clearance(GO:2000425)
5.5 44.1 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
4.7 28.4 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
4.7 18.7 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
4.6 13.7 GO:0045830 response to protozoan(GO:0001562) TRIF-dependent toll-like receptor signaling pathway(GO:0035666) defense response to protozoan(GO:0042832) regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
4.5 45.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
4.4 17.8 GO:0097037 heme export(GO:0097037)
4.4 13.2 GO:0032847 regulation of cellular pH reduction(GO:0032847) synaptic vesicle lumen acidification(GO:0097401) regulation of synaptic vesicle lumen acidification(GO:1901546)
4.3 29.9 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
4.2 16.6 GO:0006843 mitochondrial citrate transport(GO:0006843)
4.2 49.9 GO:0050714 positive regulation of protein secretion(GO:0050714)
4.1 16.5 GO:0046324 regulation of glucose import(GO:0046324)
3.9 11.7 GO:0006178 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
3.8 15.4 GO:0015677 copper ion import(GO:0015677)
3.8 26.4 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
3.7 26.0 GO:0090179 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
3.7 25.8 GO:0002931 response to ischemia(GO:0002931)
3.5 10.6 GO:0036314 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
3.4 26.9 GO:0090594 inflammatory response to wounding(GO:0090594)
3.1 6.2 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
3.1 9.2 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) retrograde trans-synaptic signaling by nitric oxide(GO:0098924)
3.1 39.7 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
3.0 14.8 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
2.9 44.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
2.9 23.3 GO:0060976 coronary vasculature development(GO:0060976)
2.9 8.6 GO:0030043 actin filament fragmentation(GO:0030043)
2.8 8.5 GO:0097264 self proteolysis(GO:0097264)
2.8 36.7 GO:0019233 sensory perception of pain(GO:0019233)
2.8 25.1 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
2.7 80.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
2.6 92.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
2.5 17.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
2.5 7.4 GO:1990120 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
2.4 24.4 GO:0071300 cellular response to retinoic acid(GO:0071300)
2.3 7.0 GO:0016264 gap junction assembly(GO:0016264)
2.3 7.0 GO:0061194 tongue development(GO:0043586) tongue morphogenesis(GO:0043587) taste bud development(GO:0061193) taste bud morphogenesis(GO:0061194) taste bud formation(GO:0061195)
2.2 6.7 GO:0015874 norepinephrine transport(GO:0015874)
2.2 44.1 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
2.2 13.2 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
2.2 11.0 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
2.1 27.6 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
2.1 10.4 GO:0007412 axon target recognition(GO:0007412)
2.0 10.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
2.0 6.0 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
1.9 9.4 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
1.8 8.9 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
1.7 10.2 GO:0035881 amacrine cell differentiation(GO:0035881)
1.7 16.7 GO:0009303 rRNA transcription(GO:0009303)
1.6 29.0 GO:0007413 axonal fasciculation(GO:0007413)
1.6 4.8 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
1.6 11.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
1.6 7.9 GO:0021767 mammillary body development(GO:0021767)
1.6 32.8 GO:0045773 positive regulation of axon extension(GO:0045773)
1.5 10.7 GO:0048739 cardiac muscle fiber development(GO:0048739)
1.5 9.2 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
1.5 6.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
1.5 7.5 GO:0010586 miRNA metabolic process(GO:0010586)
1.5 13.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
1.5 39.6 GO:0048263 determination of dorsal identity(GO:0048263)
1.5 11.6 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
1.3 22.8 GO:1902866 regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
1.3 14.6 GO:0050936 xanthophore differentiation(GO:0050936)
1.3 30.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
1.3 6.5 GO:0046485 ether lipid metabolic process(GO:0046485)
1.3 18.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
1.2 6.1 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
1.2 37.6 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
1.2 6.0 GO:0042766 nucleosome mobilization(GO:0042766)
1.2 6.0 GO:0023041 neuronal signal transduction(GO:0023041)
1.1 56.3 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
1.1 4.6 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
1.1 9.1 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
1.1 10.9 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
1.1 11.8 GO:0032196 transposition(GO:0032196)
1.0 68.0 GO:0006414 translational elongation(GO:0006414)
1.0 9.4 GO:0098787 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
1.0 39.5 GO:0006284 base-excision repair(GO:0006284)
1.0 17.5 GO:0086010 membrane depolarization during action potential(GO:0086010)
1.0 2.0 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
1.0 9.2 GO:0048635 negative regulation of muscle organ development(GO:0048635)
1.0 6.9 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
1.0 42.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
1.0 4.9 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
1.0 30.9 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
1.0 6.7 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.9 3.8 GO:2000815 regulation of mRNA stability involved in response to stress(GO:0010610) regulation of mRNA stability involved in response to oxidative stress(GO:2000815)
0.9 28.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.9 19.8 GO:1990798 pancreas regeneration(GO:1990798)
0.9 48.3 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.9 6.1 GO:1903651 positive regulation of cytoplasmic transport(GO:1903651)
0.9 29.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.8 4.2 GO:0051701 interaction with host(GO:0051701)
0.8 18.8 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.8 24.3 GO:0043967 histone H4 acetylation(GO:0043967)
0.8 5.7 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.8 6.3 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.8 10.9 GO:0035269 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311) protein O-linked mannosylation(GO:0035269)
0.7 4.4 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.7 2.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.7 8.1 GO:2001222 regulation of neuron migration(GO:2001222)
0.7 8.7 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.7 25.9 GO:0021854 limbic system development(GO:0021761) hypothalamus development(GO:0021854)
0.7 2.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.7 57.9 GO:0051017 actin filament bundle assembly(GO:0051017)
0.7 4.2 GO:0051491 response to selenium ion(GO:0010269) positive regulation of filopodium assembly(GO:0051491)
0.7 6.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.7 6.2 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.7 5.5 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.6 7.7 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.6 28.5 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.6 6.9 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.6 12.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.6 3.1 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.6 11.7 GO:1902017 regulation of cilium assembly(GO:1902017)
0.6 36.5 GO:0048484 enteric nervous system development(GO:0048484)
0.6 16.5 GO:0019835 cytolysis(GO:0019835)
0.5 19.4 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.5 36.9 GO:0030308 negative regulation of cell growth(GO:0030308)
0.5 33.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.5 6.0 GO:0030431 sleep(GO:0030431)
0.5 10.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.5 1.5 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.5 26.3 GO:0030336 negative regulation of cell migration(GO:0030336)
0.5 27.1 GO:0031638 zymogen activation(GO:0031638)
0.5 14.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) synaptic vesicle budding(GO:0070142)
0.5 48.7 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.5 8.6 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.5 16.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.5 2.8 GO:0006004 fucose metabolic process(GO:0006004)
0.5 4.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.5 35.2 GO:0048675 axon extension(GO:0048675)
0.5 8.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.4 12.9 GO:0016925 protein sumoylation(GO:0016925)
0.4 3.1 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.4 13.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.4 6.1 GO:0030225 macrophage differentiation(GO:0030225)
0.4 2.6 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.4 9.9 GO:0070593 dendrite self-avoidance(GO:0070593)
0.4 2.5 GO:0032218 riboflavin transport(GO:0032218)
0.4 25.9 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.4 5.2 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.4 2.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.4 45.5 GO:0021782 glial cell development(GO:0021782)
0.4 4.0 GO:0006611 protein export from nucleus(GO:0006611)
0.4 2.6 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.3 9.1 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.3 7.7 GO:0048264 determination of ventral identity(GO:0048264)
0.3 36.4 GO:0051260 protein homooligomerization(GO:0051260)
0.3 10.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.3 21.7 GO:0009880 embryonic pattern specification(GO:0009880)
0.3 7.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.3 9.5 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.3 5.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.3 9.2 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.3 16.6 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.3 107.4 GO:0006897 endocytosis(GO:0006897)
0.3 10.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.3 32.5 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.2 12.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.2 1.5 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.2 8.4 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.2 0.9 GO:0043620 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618) regulation of DNA-templated transcription in response to stress(GO:0043620)
0.2 5.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 47.8 GO:0007411 axon guidance(GO:0007411)
0.2 17.4 GO:0019722 calcium-mediated signaling(GO:0019722)
0.2 13.8 GO:0055088 lipid homeostasis(GO:0055088)
0.2 20.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.2 12.6 GO:0021510 spinal cord development(GO:0021510)
0.2 46.9 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 0.6 GO:1903225 negative regulation of endodermal cell fate specification(GO:0042664) negative regulation of endodermal cell differentiation(GO:1903225)
0.2 4.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.7 GO:0010889 regulation of sequestering of triglyceride(GO:0010889) positive regulation of sequestering of triglyceride(GO:0010890) sequestering of triglyceride(GO:0030730)
0.2 42.7 GO:0006470 protein dephosphorylation(GO:0006470)
0.2 6.9 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 1.1 GO:0034504 protein localization to nucleus(GO:0034504)
0.2 16.3 GO:1990778 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.1 0.7 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.0 GO:0003160 endocardium morphogenesis(GO:0003160)
0.1 6.6 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 4.2 GO:0060914 heart formation(GO:0060914)
0.1 37.1 GO:0043413 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.1 47.0 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.1 1.5 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 20.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 8.5 GO:0051607 defense response to virus(GO:0051607)
0.1 12.5 GO:0006865 amino acid transport(GO:0006865)
0.1 6.2 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 3.9 GO:0051298 centrosome duplication(GO:0051298)
0.1 7.3 GO:0001817 regulation of cytokine production(GO:0001817)
0.1 5.4 GO:0042472 ear morphogenesis(GO:0042471) inner ear morphogenesis(GO:0042472)
0.1 24.9 GO:0007268 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916)
0.1 0.4 GO:0032387 negative regulation of intracellular transport(GO:0032387)
0.1 28.7 GO:0007420 brain development(GO:0007420)
0.1 0.9 GO:0045116 protein neddylation(GO:0045116)
0.1 7.4 GO:0048511 rhythmic process(GO:0048511)
0.1 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 31.7 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 23.3 GO:0006886 intracellular protein transport(GO:0006886)
0.0 0.7 GO:0006000 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 1.3 GO:0003205 cardiac chamber development(GO:0003205)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.1 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.0 0.5 GO:0018210 peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 68.1 GO:0005955 calcineurin complex(GO:0005955)
10.9 32.8 GO:0032839 dendrite cytoplasm(GO:0032839)
7.7 61.4 GO:0071914 prominosome(GO:0071914)
6.4 279.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
4.4 26.6 GO:0070062 extracellular exosome(GO:0070062)
3.5 10.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
3.5 10.4 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
3.3 13.2 GO:0043291 RAVE complex(GO:0043291)
3.0 14.8 GO:0033010 paranodal junction(GO:0033010)
2.6 34.1 GO:0033270 paranode region of axon(GO:0033270) juxtaparanode region of axon(GO:0044224)
2.5 7.4 GO:0042382 paraspeckles(GO:0042382)
2.4 19.1 GO:0016586 RSC complex(GO:0016586)
2.3 27.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
2.2 92.6 GO:0030125 clathrin vesicle coat(GO:0030125)
2.1 29.9 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
2.1 8.5 GO:0060171 stereocilium membrane(GO:0060171)
2.1 14.4 GO:0001650 fibrillar center(GO:0001650)
2.0 7.8 GO:0016460 myosin II complex(GO:0016460)
1.9 40.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.7 25.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
1.5 52.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
1.5 6.1 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
1.4 8.6 GO:0031258 lamellipodium membrane(GO:0031258)
1.4 45.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.3 14.5 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
1.3 24.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
1.3 40.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
1.2 7.4 GO:0016589 NURF complex(GO:0016589)
1.2 46.0 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
1.2 53.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
1.1 6.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
1.0 14.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.9 47.7 GO:0030426 growth cone(GO:0030426)
0.9 18.9 GO:0009925 basal plasma membrane(GO:0009925)
0.9 7.7 GO:0032021 NELF complex(GO:0032021)
0.8 12.1 GO:0000792 heterochromatin(GO:0000792)
0.7 13.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.7 17.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.7 42.6 GO:0032432 actin filament bundle(GO:0032432)
0.7 5.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 13.2 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.6 59.8 GO:0014069 postsynaptic density(GO:0014069)
0.6 10.7 GO:0043204 perikaryon(GO:0043204)
0.6 9.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.6 10.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.5 87.2 GO:0099503 secretory vesicle(GO:0099503)
0.5 47.8 GO:0030141 secretory granule(GO:0030141)
0.5 126.7 GO:0030424 axon(GO:0030424)
0.5 13.2 GO:0042734 presynaptic membrane(GO:0042734)
0.5 27.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.4 43.2 GO:0000786 nucleosome(GO:0000786)
0.4 24.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 29.9 GO:0005871 kinesin complex(GO:0005871)
0.4 97.4 GO:0045202 synapse(GO:0045202)
0.4 9.2 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 5.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.3 26.8 GO:0043235 receptor complex(GO:0043235)
0.3 11.9 GO:0000781 chromosome, telomeric region(GO:0000781)
0.3 125.9 GO:0043005 neuron projection(GO:0043005)
0.3 1.8 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 10.9 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 5.9 GO:0071141 SMAD protein complex(GO:0071141)
0.2 2.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 15.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 26.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 3.2 GO:0044545 NSL complex(GO:0044545)
0.2 5.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 73.1 GO:0000139 Golgi membrane(GO:0000139)
0.2 4.8 GO:0030133 transport vesicle(GO:0030133)
0.2 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.2 8.7 GO:0016592 mediator complex(GO:0016592)
0.2 18.0 GO:0016607 nuclear speck(GO:0016607)
0.2 24.0 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 90.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 13.7 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.1 4.0 GO:0031941 filamentous actin(GO:0031941)
0.1 48.8 GO:0005768 endosome(GO:0005768)
0.1 6.3 GO:0005643 nuclear pore(GO:0005643)
0.1 8.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 133.6 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 5.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 4.5 GO:0016342 catenin complex(GO:0016342)
0.1 1.7 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:0097361 CIA complex(GO:0097361)
0.0 277.7 GO:0016020 membrane(GO:0016020)
0.0 13.5 GO:0009986 cell surface(GO:0009986)
0.0 2.3 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 67.1 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
26.9 80.7 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
11.3 68.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
10.8 32.5 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
7.9 23.6 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
7.6 30.2 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
6.3 37.8 GO:0015182 L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182)
6.1 91.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
5.5 27.4 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
5.5 16.4 GO:0031704 apelin receptor binding(GO:0031704)
5.2 36.6 GO:0030274 LIM domain binding(GO:0030274)
4.7 28.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
4.0 31.8 GO:0001972 retinoic acid binding(GO:0001972)
3.9 11.7 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
3.8 15.4 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
3.8 26.4 GO:0019809 spermidine binding(GO:0019809)
3.7 33.3 GO:0004985 opioid receptor activity(GO:0004985)
3.5 10.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
3.3 13.3 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
3.3 62.7 GO:0008301 DNA binding, bending(GO:0008301)
3.2 9.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
3.1 30.9 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
2.5 17.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
2.5 35.0 GO:0032051 clathrin light chain binding(GO:0032051)
2.4 16.8 GO:0001727 lipid kinase activity(GO:0001727)
2.2 6.7 GO:0005333 dopamine transmembrane transporter activity(GO:0005329) dopamine:sodium symporter activity(GO:0005330) norepinephrine transmembrane transporter activity(GO:0005333) norepinephrine:sodium symporter activity(GO:0005334)
2.2 17.8 GO:0015232 heme transporter activity(GO:0015232)
2.1 34.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
2.1 56.3 GO:0017080 sodium channel regulator activity(GO:0017080)
2.0 6.0 GO:0009041 uridylate kinase activity(GO:0009041)
2.0 5.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
2.0 7.8 GO:0032034 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
1.8 23.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
1.7 41.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
1.6 36.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.6 9.4 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
1.5 57.2 GO:0019003 GDP binding(GO:0019003)
1.5 52.2 GO:0004890 GABA-A receptor activity(GO:0004890)
1.5 131.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.5 25.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
1.5 68.0 GO:0003746 translation elongation factor activity(GO:0003746)
1.5 14.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.5 26.9 GO:0004383 guanylate cyclase activity(GO:0004383)
1.4 10.0 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
1.4 12.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
1.4 11.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
1.4 7.0 GO:0060182 apelin receptor activity(GO:0060182)
1.4 9.6 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
1.4 10.9 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
1.4 9.5 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
1.3 17.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
1.3 22.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
1.3 9.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.3 6.5 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309) double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
1.3 7.6 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
1.2 52.3 GO:0017022 myosin binding(GO:0017022)
1.2 4.8 GO:0071253 connexin binding(GO:0071253)
1.1 41.1 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
1.1 14.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.1 8.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.1 7.5 GO:0030371 translation repressor activity(GO:0030371)
1.0 13.6 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.0 9.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
1.0 17.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.0 28.5 GO:0016208 AMP binding(GO:0016208)
1.0 12.9 GO:0061665 SUMO ligase activity(GO:0061665)
1.0 4.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
1.0 17.5 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
1.0 38.5 GO:0010857 calcium-dependent protein kinase activity(GO:0010857)
1.0 23.9 GO:0035591 signaling adaptor activity(GO:0035591)
0.9 102.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.9 5.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.9 30.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.9 29.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.9 10.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.9 27.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.9 6.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.8 11.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.8 32.9 GO:0051087 chaperone binding(GO:0051087)
0.8 10.9 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.8 69.9 GO:0030276 clathrin binding(GO:0030276)
0.8 13.7 GO:0005272 sodium channel activity(GO:0005272) cAMP binding(GO:0030552)
0.7 34.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.7 11.7 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.7 6.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.7 17.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.7 8.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.7 23.1 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.7 23.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.7 4.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.7 5.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.7 1.3 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.6 6.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.6 12.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.6 11.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.5 7.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.5 18.1 GO:0035064 methylated histone binding(GO:0035064)
0.5 4.6 GO:0005113 patched binding(GO:0005113)
0.5 7.6 GO:0038191 neuropilin binding(GO:0038191)
0.5 15.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.5 4.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.5 26.6 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.5 6.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.5 2.3 GO:0008142 oxysterol binding(GO:0008142)
0.4 2.2 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.4 11.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.4 7.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 57.0 GO:0060090 binding, bridging(GO:0060090)
0.4 2.5 GO:0032217 riboflavin transporter activity(GO:0032217)
0.4 8.2 GO:0097602 cullin family protein binding(GO:0097602)
0.4 21.1 GO:0015485 cholesterol binding(GO:0015485)
0.4 8.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.4 5.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.4 8.7 GO:0004860 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.3 10.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 21.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 9.4 GO:0017046 peptide hormone binding(GO:0017046)
0.3 3.0 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 9.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.3 104.4 GO:0005096 GTPase activator activity(GO:0005096)
0.3 21.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.3 6.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 2.8 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.3 9.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.3 1.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.3 6.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 2.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 11.5 GO:0032452 histone demethylase activity(GO:0032452)
0.2 1.5 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 24.6 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.2 20.9 GO:0003678 DNA helicase activity(GO:0003678)
0.2 12.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 5.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 33.6 GO:0005179 hormone activity(GO:0005179)
0.2 10.5 GO:0000049 tRNA binding(GO:0000049)
0.2 0.8 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.2 73.2 GO:0051015 actin filament binding(GO:0051015)
0.2 13.7 GO:0003823 antigen binding(GO:0003823)
0.2 0.8 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.2 11.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.2 8.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 13.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 8.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 10.6 GO:0005262 calcium channel activity(GO:0005262)
0.2 12.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 2.8 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 10.3 GO:0004527 exonuclease activity(GO:0004527)
0.1 143.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 7.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 10.0 GO:0042802 identical protein binding(GO:0042802)
0.1 5.2 GO:0045296 cadherin binding(GO:0045296)
0.1 9.1 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.1 62.9 GO:0046983 protein dimerization activity(GO:0046983)
0.1 6.3 GO:0046332 SMAD binding(GO:0046332)
0.1 17.0 GO:0001653 peptide receptor activity(GO:0001653) G-protein coupled peptide receptor activity(GO:0008528)
0.1 13.6 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 7.2 GO:0004519 endonuclease activity(GO:0004519)
0.1 15.3 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 12.5 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.7 GO:0008443 6-phosphofructo-2-kinase activity(GO:0003873) phosphofructokinase activity(GO:0008443)
0.1 2.7 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.1 40.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 7.6 GO:0019901 protein kinase binding(GO:0019901)
0.0 2.1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 5.8 GO:0008083 growth factor activity(GO:0008083)
0.0 9.2 GO:0003924 GTPase activity(GO:0003924)
0.0 2.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 7.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 68.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
1.3 59.8 SIG CHEMOTAXIS Genes related to chemotaxis
1.2 24.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
1.2 30.1 PID EPHA FWDPATHWAY EPHA forward signaling
1.2 18.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.9 21.1 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.5 13.7 PID CD40 PATHWAY CD40/CD40L signaling
0.5 27.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.5 8.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.4 10.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.4 27.2 PID CMYB PATHWAY C-MYB transcription factor network
0.4 7.5 PID ARF 3PATHWAY Arf1 pathway
0.3 20.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.3 6.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 8.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.3 2.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 5.2 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2 8.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 3.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.3 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 1.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.5 PID E2F PATHWAY E2F transcription factor network
0.0 1.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 92.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
4.0 68.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
3.7 18.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
2.8 27.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
2.5 10.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
2.2 33.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
1.9 17.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.8 25.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.7 13.3 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
1.4 9.9 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
1.2 9.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.2 8.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
1.2 11.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
1.1 8.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
1.1 41.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
1.0 11.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.9 11.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.9 13.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.8 31.6 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.8 36.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.7 7.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.7 2.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.6 45.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.6 12.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.6 19.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.6 28.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 12.8 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.5 13.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.5 6.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.4 6.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 5.2 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.3 12.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.3 1.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 28.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 4.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 7.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 4.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 8.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 0.9 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.1 6.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 0.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.4 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 3.0 REACTOME DNA REPAIR Genes involved in DNA Repair
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation