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PRJDB7713: Age associated transcriptome analysis in 5 tissues of zebrafish
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Results for alx1
Z-value: 1.19
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Transcription factors associated with alx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| alx1 | dr11_v1_chr18_+_16246806_16246806 | -0.13 | 2.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of alx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 78.3 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 3.8 | 22.8 | GO:0071691 | cardiac muscle thin filament assembly(GO:0071691) |
| 0.1 | 14.2 | GO:0001933 | negative regulation of protein phosphorylation(GO:0001933) |
| 1.5 | 13.7 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 1.0 | 12.4 | GO:0006603 | phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314) |
| 0.6 | 11.3 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 0.7 | 10.0 | GO:0051445 | regulation of meiotic cell cycle(GO:0051445) |
| 0.0 | 9.9 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.9 | 9.2 | GO:0043046 | DNA methylation involved in gamete generation(GO:0043046) |
| 0.5 | 8.6 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 78.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.3 | 28.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 19.4 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 19.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 15.6 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 13.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 2.7 | 13.4 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.5 | 13.0 | GO:0043186 | P granule(GO:0043186) |
| 0.0 | 10.6 | GO:0044429 | mitochondrial part(GO:0044429) |
| 0.2 | 9.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 16.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 3.2 | 15.8 | GO:0009374 | biotin binding(GO:0009374) |
| 0.0 | 13.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.2 | 13.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 1.0 | 12.4 | GO:0004111 | creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775) |
| 0.8 | 11.3 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.3 | 10.4 | GO:0015036 | disulfide oxidoreductase activity(GO:0015036) |
| 0.2 | 10.4 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.1 | 10.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 12.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 9.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 9.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 4.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.8 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.8 | 22.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 13.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 10.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 6.6 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 6.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 5.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 4.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.5 | 3.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |