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avrg: NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFAP2E

Z-value: 0.55

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
ENSG00000116819.6 TFAP2E

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.749.1e-02Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr15_+_23810903 0.30 ENST00000564592.1
MKRN3
makorin ring finger protein 3
chr8_+_22250334 0.20 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr20_+_36888551 0.17 ENST00000418004.1
ENST00000451435.1
BPI
bactericidal/permeability-increasing protein
chr9_-_34662651 0.15 ENST00000259631.4
CCL27
chemokine (C-C motif) ligand 27
chr12_-_15942309 0.14 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr1_-_231175964 0.13 ENST00000366654.4
FAM89A
family with sequence similarity 89, member A
chr11_-_82612549 0.12 ENST00000528082.1
ENST00000533126.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr19_-_35981358 0.11 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr3_+_50192833 0.11 ENST00000426511.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr12_-_15942503 0.11 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr1_+_104068312 0.10 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr1_+_104068562 0.10 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr2_-_45236540 0.10 ENST00000303077.6
SIX2
SIX homeobox 2
chr12_+_53443963 0.10 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_+_38893047 0.10 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr20_-_30539773 0.09 ENST00000202017.4
PDRG1
p53 and DNA-damage regulated 1
chr6_+_292051 0.09 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr12_+_75784850 0.09 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr16_-_72698834 0.08 ENST00000570152.1
ENST00000561611.2
ENST00000570035.1
AC004158.2
AC004158.2
chr22_+_22676808 0.08 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr7_+_100464760 0.08 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr17_+_72428218 0.08 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_74070853 0.07 ENST00000329003.3
GALR2
galanin receptor 2
chr11_-_82612727 0.07 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr10_-_98273668 0.07 ENST00000357947.3
TLL2
tolloid-like 2
chr6_+_13272904 0.07 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr9_+_19230433 0.07 ENST00000434457.2
ENST00000602925.1
DENND4C
DENN/MADD domain containing 4C
chr11_-_82612678 0.07 ENST00000534631.1
ENST00000531801.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr19_+_3572925 0.07 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
HMG20B
high mobility group 20B
chr2_-_174828892 0.07 ENST00000418194.2
SP3
Sp3 transcription factor
chrX_+_152990302 0.07 ENST00000218104.3
ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr3_+_4535025 0.07 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr19_+_54960358 0.07 ENST00000439657.1
ENST00000376514.2
ENST00000376526.4
ENST00000436479.1
LENG8
leukocyte receptor cluster (LRC) member 8
chr4_-_82393052 0.07 ENST00000335927.7
ENST00000504863.1
ENST00000264400.2
RASGEF1B
RasGEF domain family, member 1B
chr19_-_11039188 0.06 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr11_+_63974135 0.06 ENST00000544997.1
ENST00000345728.5
ENST00000279227.5
FERMT3
fermitin family member 3
chr6_-_88411911 0.06 ENST00000257787.5
AKIRIN2
akirin 2
chr11_-_65325430 0.06 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr2_+_241375069 0.06 ENST00000264039.2
GPC1
glypican 1
chr22_+_38146987 0.06 ENST00000418339.1
TRIOBP
TRIO and F-actin binding protein
chr3_-_48632593 0.06 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr11_-_61062762 0.05 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr3_+_105086056 0.05 ENST00000472644.2
ALCAM
activated leukocyte cell adhesion molecule
chr19_-_11039261 0.05 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr8_+_17780483 0.05 ENST00000517730.1
ENST00000518537.1
ENST00000523055.1
ENST00000519253.1
PCM1
pericentriolar material 1
chr19_-_39264072 0.05 ENST00000599035.1
ENST00000378626.4
LGALS7
lectin, galactoside-binding, soluble, 7
chr10_-_98480243 0.05 ENST00000339364.5
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr5_-_179498703 0.05 ENST00000522208.2
RNF130
ring finger protein 130
chr11_+_118478313 0.05 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr5_-_179719048 0.05 ENST00000523583.1
ENST00000393360.3
ENST00000455781.1
ENST00000347470.4
ENST00000452135.2
ENST00000343111.6
MAPK9
mitogen-activated protein kinase 9
chr19_-_54676884 0.05 ENST00000376591.4
TMC4
transmembrane channel-like 4
chr19_-_54676846 0.04 ENST00000301187.4
TMC4
transmembrane channel-like 4
chr1_+_211433275 0.04 ENST00000367005.4
RCOR3
REST corepressor 3
chr9_-_21077939 0.04 ENST00000380232.2
IFNB1
interferon, beta 1, fibroblast
chr17_+_36584662 0.04 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr15_+_23810853 0.04 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr6_+_42531798 0.04 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr8_+_17780346 0.04 ENST00000325083.8
PCM1
pericentriolar material 1
chr20_-_25371412 0.04 ENST00000339157.5
ENST00000376542.3
ABHD12
abhydrolase domain containing 12
chr2_-_177502254 0.04 ENST00000339037.3
AC017048.3
long intergenic non-protein coding RNA 1116
chr1_+_901847 0.04 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1
pleckstrin homology domain containing, family N member 1
chr5_-_179499086 0.03 ENST00000261947.4
RNF130
ring finger protein 130
chr16_+_69600058 0.03 ENST00000393742.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr17_+_48423453 0.03 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
XYLT2
xylosyltransferase II
chr13_-_76056250 0.03 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr12_-_65153175 0.03 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
GNS
glucosamine (N-acetyl)-6-sulfatase
chr4_+_154387480 0.03 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
KIAA0922
KIAA0922
chr16_+_69599861 0.03 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr19_+_3572758 0.03 ENST00000416526.1
HMG20B
high mobility group 20B
chr17_+_40932610 0.03 ENST00000246914.5
WNK4
WNK lysine deficient protein kinase 4
chr17_+_37824217 0.03 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr16_+_69599899 0.03 ENST00000567239.1
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr2_-_24149977 0.02 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr1_+_17248418 0.02 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr10_+_99894380 0.02 ENST00000370584.3
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr19_-_10613862 0.02 ENST00000592055.1
KEAP1
kelch-like ECH-associated protein 1
chr19_+_38794797 0.02 ENST00000301246.5
ENST00000588605.1
C19orf33
chromosome 19 open reading frame 33
chr14_-_64010046 0.02 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr17_+_37824411 0.02 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr1_-_201346761 0.02 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
TNNT2
troponin T type 2 (cardiac)
chr7_-_100065686 0.02 ENST00000423266.1
ENST00000456330.1
TSC22D4
TSC22 domain family, member 4
chr1_+_233749739 0.02 ENST00000366621.3
KCNK1
potassium channel, subfamily K, member 1
chr1_-_114355083 0.02 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr10_-_112678904 0.02 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBIP1
BBSome interacting protein 1
chr17_-_42188598 0.02 ENST00000591714.1
HDAC5
histone deacetylase 5
chrX_+_131157322 0.02 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4
Serine/threonine-protein kinase MST4
chr3_+_155860751 0.02 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr2_+_74741569 0.01 ENST00000233638.7
TLX2
T-cell leukemia homeobox 2
chr20_+_55205825 0.01 ENST00000544508.1
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr10_+_99894399 0.01 ENST00000298999.3
ENST00000314594.5
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr19_+_4969116 0.01 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B
lysine (K)-specific demethylase 4B
chr2_+_38893208 0.01 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr13_-_27334879 0.01 ENST00000405846.3
GPR12
G protein-coupled receptor 12
chrX_+_131157290 0.01 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr19_-_46389359 0.01 ENST00000302165.3
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr20_+_58508817 0.01 ENST00000358293.3
FAM217B
family with sequence similarity 217, member B
chr5_-_179499108 0.01 ENST00000521389.1
RNF130
ring finger protein 130
chr7_-_129251459 0.01 ENST00000608694.1
RP11-448A19.1
RP11-448A19.1
chrX_+_49028265 0.01 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr10_-_108924284 0.01 ENST00000344440.6
ENST00000263054.6
SORCS1
sortilin-related VPS10 domain containing receptor 1
chr11_-_35441524 0.01 ENST00000395750.1
ENST00000449068.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_-_140624499 0.01 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr11_-_66056596 0.01 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chrX_-_118826784 0.01 ENST00000394616.4
SEPT6
septin 6
chr6_+_37787262 0.00 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr12_+_53773944 0.00 ENST00000551969.1
ENST00000327443.4
SP1
Sp1 transcription factor
chr17_-_31620006 0.00 ENST00000225823.2
ASIC2
acid-sensing (proton-gated) ion channel 2
chr4_-_101439242 0.00 ENST00000296420.4
EMCN
endomucin
chr11_-_6633799 0.00 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr11_+_82612740 0.00 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82
chromosome 11 open reading frame 82
chr3_-_55521323 0.00 ENST00000264634.4
WNT5A
wingless-type MMTV integration site family, member 5A
chrX_+_51636629 0.00 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr17_+_29158962 0.00 ENST00000321990.4
ATAD5
ATPase family, AAA domain containing 5
chr11_-_71753188 0.00 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chr17_-_42992856 0.00 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.2 GO:0097168 mesenchymal stem cell proliferation(GO:0097168)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.0 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.0 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.0 0.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 0.2 GO:0015684 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.2 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.0 GO:0030158 protein xylosyltransferase activity(GO:0030158)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway