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avrg: NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SIX6

Z-value: 0.58

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
ENSG00000184302.6 SIX6

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_71104588 0.62 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr3_+_186742464 0.47 ENST00000416235.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr8_-_82598067 0.42 ENST00000523942.1
ENST00000522997.1
IMPA1
inositol(myo)-1(or 4)-monophosphatase 1
chr9_+_93759317 0.41 ENST00000563268.1
RP11-367F23.2
RP11-367F23.2
chr11_-_104916034 0.20 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
CARD16
caspase recruitment domain family, member 16
chr11_+_74699703 0.18 ENST00000529024.1
ENST00000544263.1
NEU3
sialidase 3 (membrane sialidase)
chr1_+_160709076 0.18 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr1_+_160709029 0.17 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr1_+_40942887 0.16 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr1_+_160709055 0.15 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr10_+_91061712 0.15 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_67142710 0.13 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr12_+_122018697 0.12 ENST00000541574.1
RP13-941N14.1
RP13-941N14.1
chr5_+_55147205 0.11 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr3_+_8543561 0.11 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr12_+_133707570 0.11 ENST00000416488.1
ENST00000540096.2
ZNF268
CTD-2140B24.4
zinc finger protein 268
Zinc finger protein 268
chr11_-_104972158 0.11 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr2_-_134326009 0.10 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr16_+_22524379 0.10 ENST00000536620.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr9_-_21142144 0.10 ENST00000380229.2
IFNW1
interferon, omega 1
chr12_-_14849470 0.10 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr20_+_54987305 0.09 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr1_+_179263308 0.09 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chrX_+_12809463 0.09 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr8_+_1993173 0.09 ENST00000523438.1
MYOM2
myomesin 2
chr18_-_69246167 0.09 ENST00000566582.1
RP11-510D19.1
RP11-510D19.1
chr20_+_54987168 0.08 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr5_-_78281775 0.08 ENST00000396151.3
ENST00000565165.1
ARSB
arylsulfatase B
chr16_+_28648975 0.08 ENST00000529716.1
NPIPB8
nuclear pore complex interacting protein family, member B8
chr22_+_20877924 0.07 ENST00000445189.1
MED15
mediator complex subunit 15
chr2_+_27760247 0.07 ENST00000447166.1
AC109829.1
Uncharacterized protein
chr14_-_46185155 0.07 ENST00000555442.1
RP11-369C8.1
RP11-369C8.1
chr10_+_81891416 0.07 ENST00000372270.2
PLAC9
placenta-specific 9
chr15_-_51397473 0.07 ENST00000327536.5
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr7_-_123198284 0.06 ENST00000355749.2
NDUFA5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr14_-_31926595 0.06 ENST00000547378.1
RP11-176H8.1
Uncharacterized protein
chr1_-_150669604 0.06 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr16_+_19467772 0.06 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chr7_-_81635106 0.06 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr12_+_40787194 0.06 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr9_-_135230336 0.06 ENST00000224140.5
ENST00000372169.2
ENST00000393220.1
SETX
senataxin
chr8_+_1993152 0.05 ENST00000262113.4
MYOM2
myomesin 2
chr9_+_109685630 0.05 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr6_+_37012607 0.05 ENST00000423336.1
COX6A1P2
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr20_+_34802295 0.05 ENST00000432603.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr12_+_119616447 0.05 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr18_-_69246186 0.05 ENST00000568095.1
RP11-510D19.1
RP11-510D19.1
chr12_+_19282643 0.05 ENST00000317589.4
ENST00000355397.3
ENST00000359180.3
ENST00000309364.4
ENST00000540972.1
ENST00000429027.2
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr8_+_32579321 0.05 ENST00000522402.1
NRG1
neuregulin 1
chrX_-_18238999 0.05 ENST00000380033.4
ENST00000380030.3
BEND2
BEN domain containing 2
chr19_-_16008880 0.05 ENST00000011989.7
ENST00000221700.6
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr5_+_115420688 0.05 ENST00000274458.4
COMMD10
COMM domain containing 10
chr11_+_122709200 0.05 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr6_+_80816342 0.05 ENST00000369760.4
ENST00000356489.5
ENST00000320393.6
BCKDHB
branched chain keto acid dehydrogenase E1, beta polypeptide
chr19_+_31658405 0.05 ENST00000589511.1
CTC-439O9.3
CTC-439O9.3
chr2_-_228497888 0.04 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr19_+_46000479 0.04 ENST00000456399.2
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr4_+_113739244 0.04 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chr9_-_23821842 0.04 ENST00000544538.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr8_-_124553437 0.04 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr5_+_140201183 0.04 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr10_-_61720640 0.04 ENST00000521074.1
ENST00000444900.1
C10orf40
chromosome 10 open reading frame 40
chr11_+_34999328 0.04 ENST00000526309.1
PDHX
pyruvate dehydrogenase complex, component X
chr12_-_46385811 0.04 ENST00000419565.2
SCAF11
SR-related CTD-associated factor 11
chr2_-_71222466 0.03 ENST00000606025.1
AC007040.11
Uncharacterized protein
chr1_-_182369751 0.03 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr10_-_79397479 0.03 ENST00000404771.3
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr12_-_121476750 0.03 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr15_+_63414760 0.03 ENST00000557972.1
LACTB
lactamase, beta
chr14_+_21525981 0.03 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr3_-_9994021 0.03 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr1_+_212738676 0.03 ENST00000366981.4
ENST00000366987.2
ATF3
activating transcription factor 3
chr9_-_67786624 0.03 ENST00000455764.2
FAM27E3
family with sequence similarity 27, member E3
chr17_-_5342380 0.03 ENST00000225698.4
C1QBP
complement component 1, q subcomponent binding protein
chr14_+_21510385 0.03 ENST00000298690.4
RNASE7
ribonuclease, RNase A family, 7
chr2_+_62132781 0.03 ENST00000311832.5
COMMD1
copper metabolism (Murr1) domain containing 1
chr1_+_156119466 0.03 ENST00000414683.1
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr22_-_17702729 0.02 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
CECR1
cat eye syndrome chromosome region, candidate 1
chr19_-_14628645 0.02 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr18_+_158327 0.02 ENST00000582707.1
USP14
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr3_+_125694347 0.02 ENST00000505382.1
ENST00000511082.1
ROPN1B
rhophilin associated tail protein 1B
chr1_-_157014865 0.02 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr1_-_10003372 0.02 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr3_+_8543393 0.02 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr1_-_36235559 0.02 ENST00000251195.5
CLSPN
claspin
chr11_+_74699942 0.02 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
NEU3
sialidase 3 (membrane sialidase)
chr20_-_4990931 0.02 ENST00000379333.1
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr3_-_196242233 0.02 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chrX_+_8433376 0.02 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr12_-_11091862 0.02 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr12_-_121477039 0.02 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr9_-_99382065 0.02 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr6_+_127898312 0.02 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr5_+_40909354 0.02 ENST00000313164.9
C7
complement component 7
chr10_-_14614311 0.02 ENST00000479731.1
ENST00000468492.1
FAM107B
family with sequence similarity 107, member B
chr2_-_62081148 0.01 ENST00000404929.1
FAM161A
family with sequence similarity 161, member A
chr12_+_133614062 0.01 ENST00000540031.1
ENST00000536123.1
ZNF84
zinc finger protein 84
chr11_+_112041253 0.01 ENST00000532612.1
AP002884.3
AP002884.3
chr10_-_75008620 0.01 ENST00000372950.4
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr12_-_498620 0.01 ENST00000399788.2
ENST00000382815.4
KDM5A
lysine (K)-specific demethylase 5A
chr2_+_177134134 0.01 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr12_-_10601963 0.01 ENST00000543893.1
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr15_+_58430567 0.01 ENST00000536493.1
AQP9
aquaporin 9
chr16_-_21436459 0.01 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr7_-_44530479 0.01 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr8_+_26247878 0.01 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr5_-_117897751 0.00 ENST00000515704.1
ENST00000506769.1
CTD-2281M20.1
CTD-2281M20.1
chr16_+_66410244 0.00 ENST00000562048.1
ENST00000568155.2
CDH5
cadherin 5, type 2 (vascular endothelium)
chr13_-_46679185 0.00 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr11_-_45307817 0.00 ENST00000020926.3
SYT13
synaptotagmin XIII
chr22_+_18721427 0.00 ENST00000342888.3
AC008132.1
Uncharacterized protein
chr17_-_6524159 0.00 ENST00000589033.1
KIAA0753
KIAA0753
chr15_+_58430368 0.00 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr8_+_32579341 0.00 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chrX_+_128674213 0.00 ENST00000371113.4
ENST00000357121.5
OCRL
oculocerebrorenal syndrome of Lowe
chr1_-_161015663 0.00 ENST00000534633.1
USF1
upstream transcription factor 1
chr4_+_189321881 0.00 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.1 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.3 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.0 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031403 lithium ion binding(GO:0031403)
0.1 0.2 GO:0052796 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 0.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.1 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.3 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.0 GO:0018685 alkane 1-monooxygenase activity(GO:0018685) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.0 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.0 0.0 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation