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avrg: NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PITX2

Z-value: 0.05

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
ENSG00000164093.11 PITX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544254_111544270-0.661.5e-01Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_+_70916119 0.09 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr3_-_49837254 0.07 ENST00000412678.2
ENST00000343366.4
ENST00000487256.1
CDHR4
cadherin-related family member 4
chr9_-_98268883 0.07 ENST00000551630.1
ENST00000548420.1
PTCH1
patched 1
chr14_+_75988851 0.06 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr4_-_68620053 0.06 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr16_-_12070468 0.06 ENST00000538896.1
RP11-166B2.1
Putative NPIP-like protein LOC729978
chr7_-_128415844 0.05 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr9_+_8858102 0.04 ENST00000447950.1
ENST00000430766.1
RP11-75C9.1
RP11-75C9.1
chr5_-_64920115 0.04 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr6_+_130339710 0.04 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr19_-_19314162 0.03 ENST00000420605.3
ENST00000544883.1
ENST00000538165.2
ENST00000331552.7
NR2C2AP
nuclear receptor 2C2-associated protein
chr17_+_4643300 0.03 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr17_+_4643337 0.03 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr2_-_65659762 0.03 ENST00000440972.1
SPRED2
sprouty-related, EVH1 domain containing 2
chrM_+_9207 0.03 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr3_+_139062838 0.03 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
MRPS22
mitochondrial ribosomal protein S22
chr1_-_31230650 0.03 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr1_+_205538165 0.03 ENST00000536357.1
MFSD4
major facilitator superfamily domain containing 4
chrX_-_48931648 0.03 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr11_-_75017734 0.03 ENST00000532525.1
ARRB1
arrestin, beta 1
chr22_-_39096661 0.03 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr1_-_165414414 0.03 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr15_+_41221536 0.03 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chr6_-_53013620 0.02 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr9_-_127358087 0.02 ENST00000475178.1
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr9_-_8857776 0.02 ENST00000481079.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr3_+_158787098 0.02 ENST00000397832.2
ENST00000451172.1
ENST00000482126.1
IQCJ
IQ motif containing J
chr12_+_7941989 0.02 ENST00000229307.4
NANOG
Nanog homeobox
chrX_-_33357558 0.02 ENST00000288447.4
DMD
dystrophin
chr11_-_36619771 0.02 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr17_-_40021656 0.02 ENST00000319121.3
KLHL11
kelch-like family member 11
chrX_+_107069063 0.02 ENST00000262843.6
MID2
midline 2
chr18_-_47017956 0.02 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr4_-_36245561 0.01 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_-_36429763 0.01 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr9_+_34458771 0.01 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr4_-_76912070 0.01 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chr11_-_119217365 0.01 ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
ENST00000445041.2
MFRP
C1QTNF5
membrane frizzled-related protein
C1q and tumor necrosis factor related protein 5
chr17_-_46657473 0.01 ENST00000332503.5
HOXB4
homeobox B4
chr19_+_2476116 0.01 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr3_+_158787041 0.01 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr17_-_4643161 0.01 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr6_-_160209471 0.01 ENST00000539948.1
TCP1
t-complex 1
chr11_+_61522844 0.01 ENST00000265460.5
MYRF
myelin regulatory factor
chr9_-_110251836 0.01 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr16_-_5116025 0.01 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89
chromosome 16 open reading frame 89
chr11_-_5248294 0.01 ENST00000335295.4
HBB
hemoglobin, beta
chr12_+_40787194 0.01 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr2_+_3622893 0.01 ENST00000407445.3
ENST00000403564.1
RPS7
ribosomal protein S7
chr10_-_61900762 0.01 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr10_-_49482907 0.01 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr13_-_95131923 0.01 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr17_+_79495397 0.01 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr13_+_73632897 0.01 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr1_+_201979645 0.00 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr18_-_3880051 0.00 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr2_+_201994569 0.00 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr7_-_122840015 0.00 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr16_+_58010339 0.00 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr8_-_10512569 0.00 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr3_-_69249863 0.00 ENST00000478263.1
ENST00000462512.1
FRMD4B
FERM domain containing 4B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.1 REACTOME OPSINS Genes involved in Opsins