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avrg: NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RFX5

Z-value: 0.31

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
ENSG00000143390.13 RFX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319283_1513193140.631.8e-01Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_33043703 0.30 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr19_+_50031547 0.19 ENST00000597801.1
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr19_-_49118067 0.14 ENST00000593772.1
FAM83E
family with sequence similarity 83, member E
chr6_+_32821924 0.13 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32812420 0.13 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr16_-_74808710 0.12 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chrX_+_125953746 0.12 ENST00000371125.3
CXorf64
chromosome X open reading frame 64
chr17_-_19265855 0.12 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
B9D1
B9 protein domain 1
chr17_+_27052892 0.11 ENST00000579671.1
ENST00000579060.1
NEK8
NIMA-related kinase 8
chr19_-_6057282 0.11 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr10_-_82116505 0.11 ENST00000372202.1
ENST00000421924.2
ENST00000453477.1
DYDC1
DPY30 domain containing 1
chr6_+_26383404 0.10 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr3_+_9850199 0.09 ENST00000452597.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr19_+_19496728 0.09 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr5_-_149792295 0.09 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_+_114473350 0.09 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr6_-_32908792 0.08 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr19_+_45417921 0.08 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr17_+_38137073 0.06 ENST00000541736.1
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr6_-_32557610 0.06 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_32634425 0.06 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr19_+_45418067 0.06 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr1_+_249132512 0.06 ENST00000505503.1
ZNF672
zinc finger protein 672
chr6_+_32812568 0.06 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32920794 0.06 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_-_32908765 0.06 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr3_+_9851558 0.05 ENST00000430718.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr22_-_30987837 0.05 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr17_-_19265982 0.05 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
B9D1
B9 protein domain 1
chr6_-_32821599 0.05 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_38137050 0.05 ENST00000264639.4
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr6_+_26383318 0.05 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr12_-_110841462 0.05 ENST00000455511.3
ENST00000450008.2
ANAPC7
anaphase promoting complex subunit 7
chrX_+_19362011 0.05 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr7_+_766320 0.05 ENST00000297440.6
ENST00000313147.5
HEATR2
HEAT repeat containing 2
chr19_+_19496624 0.04 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr5_+_119799927 0.04 ENST00000407149.2
ENST00000379551.2
PRR16
proline rich 16
chr16_+_67381263 0.04 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr6_-_30658745 0.04 ENST00000376420.5
ENST00000376421.5
NRM
nurim (nuclear envelope membrane protein)
chr11_+_66624527 0.04 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr22_+_44576770 0.04 ENST00000444313.3
ENST00000416291.1
PARVG
parvin, gamma
chr10_+_14880364 0.04 ENST00000441647.1
HSPA14
heat shock 70kDa protein 14
chr5_-_55412774 0.03 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr4_-_143226979 0.03 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_-_143227088 0.03 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr10_+_14880157 0.03 ENST00000378372.3
HSPA14
heat shock 70kDa protein 14
chr1_-_208417620 0.03 ENST00000367033.3
PLXNA2
plexin A2
chr19_-_51014345 0.03 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr16_+_57844549 0.03 ENST00000564282.1
CTD-2600O9.1
uncharacterized protein LOC388282
chr1_+_249132462 0.03 ENST00000306562.3
ZNF672
zinc finger protein 672
chr10_-_14880002 0.03 ENST00000465530.1
CDNF
cerebral dopamine neurotrophic factor
chr6_-_133079022 0.02 ENST00000525289.1
ENST00000326499.6
VNN2
vanin 2
chr16_+_67381289 0.02 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr6_+_26365387 0.02 ENST00000532865.1
ENST00000530653.1
ENST00000527417.1
BTN3A2
butyrophilin, subfamily 3, member A2
chr1_-_202936394 0.02 ENST00000367249.4
CYB5R1
cytochrome b5 reductase 1
chr3_+_196466710 0.02 ENST00000327134.3
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr2_-_201599892 0.02 ENST00000452787.1
AC007163.3
AC007163.3
chr6_-_30181156 0.02 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr4_+_88529681 0.02 ENST00000399271.1
DSPP
dentin sialophosphoprotein
chr3_+_9851384 0.02 ENST00000419081.1
ENST00000438596.1
ENST00000417065.1
ENST00000439814.1
ENST00000418745.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr13_-_47012325 0.02 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr11_-_118436707 0.02 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr3_-_169587621 0.01 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr2_+_173600565 0.01 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr3_+_66271489 0.01 ENST00000536651.1
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr8_+_101170134 0.01 ENST00000520643.1
SPAG1
sperm associated antigen 1
chr8_+_101170257 0.00 ENST00000251809.3
SPAG1
sperm associated antigen 1
chr2_-_242088850 0.00 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PASK
PAS domain containing serine/threonine kinase
chr2_+_173600514 0.00 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr19_+_10563567 0.00 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr1_-_79472365 0.00 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr9_+_43135095 0.00 ENST00000377437.2
AL513478.1
Uncharacterized protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.0 0.1 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.0 0.1 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070736 protein-glycine ligase activity, initiating(GO:0070736)
0.0 0.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0042605 peptide antigen binding(GO:0042605)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse