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avrg: NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for IRX6_IRX4

Z-value: 0.59

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
ENSG00000159387.7 IRX6
ENSG00000113430.5 IRX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_18830030.404.3e-01Click!
IRX6hg19_v2_chr16_+_55357672_553576720.276.0e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr4_+_141264597 0.35 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr1_+_63989004 0.30 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr12_-_123728548 0.22 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr14_-_23623577 0.16 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr21_-_48024986 0.15 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chr14_-_23624511 0.13 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr16_+_777739 0.13 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr16_+_777246 0.13 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr16_+_776936 0.11 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr8_-_17555164 0.11 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr11_-_35547572 0.11 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr1_-_3566590 0.11 ENST00000424367.1
ENST00000378322.3
WRAP73
WD repeat containing, antisense to TP73
chr1_-_201438282 0.10 ENST00000367311.3
ENST00000367309.1
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr1_+_26644441 0.09 ENST00000374213.2
CD52
CD52 molecule
chr12_+_32655048 0.09 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr7_+_6121296 0.09 ENST00000428901.1
AC004895.4
AC004895.4
chr12_-_10282836 0.08 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr7_-_16844611 0.08 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr4_-_104119528 0.08 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr1_-_3566627 0.08 ENST00000419924.2
ENST00000270708.7
WRAP73
WD repeat containing, antisense to TP73
chr12_-_10282742 0.07 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr1_-_8763278 0.07 ENST00000468247.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr3_-_27498235 0.07 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr10_-_115904361 0.07 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr4_-_153303658 0.07 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_-_104119488 0.07 ENST00000514974.1
CENPE
centromere protein E, 312kDa
chr7_-_55583740 0.06 ENST00000453256.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr15_+_66585555 0.06 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr6_-_33679452 0.06 ENST00000374231.4
ENST00000607484.1
ENST00000374214.3
UQCC2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr1_+_212475148 0.06 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr2_+_160590469 0.06 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chrX_-_19988382 0.05 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr14_+_56127989 0.05 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr6_+_149887377 0.05 ENST00000367419.5
GINM1
glycoprotein integral membrane 1
chr5_+_36608280 0.05 ENST00000513646.1
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr18_-_28622774 0.05 ENST00000434452.1
DSC3
desmocollin 3
chr12_-_76462713 0.04 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr12_+_32655110 0.04 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr20_+_44330651 0.04 ENST00000305479.2
WFDC13
WAP four-disulfide core domain 13
chr15_-_64665911 0.04 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr2_+_113829895 0.04 ENST00000393197.2
IL1F10
interleukin 1 family, member 10 (theta)
chr8_-_101724989 0.03 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr15_+_66585879 0.03 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr3_+_171561127 0.03 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr17_-_29641084 0.03 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr3_-_168865522 0.03 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr14_+_56127960 0.03 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chr5_+_66675200 0.03 ENST00000503106.1
RP11-434D9.1
RP11-434D9.1
chr15_+_41057818 0.03 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr17_-_29641104 0.02 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr4_+_144312659 0.02 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr11_+_114166536 0.02 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr5_-_177207634 0.02 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr17_-_47723943 0.02 ENST00000510476.1
ENST00000503676.1
SPOP
speckle-type POZ protein
chr3_-_9994021 0.02 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr4_+_113558612 0.02 ENST00000505034.1
ENST00000324052.6
LARP7
La ribonucleoprotein domain family, member 7
chr3_+_111630451 0.02 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr18_-_47376197 0.02 ENST00000592688.1
MYO5B
myosin VB
chr7_+_871559 0.01 ENST00000421580.1
SUN1
Sad1 and UNC84 domain containing 1
chr12_-_88423164 0.01 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr10_+_90660832 0.01 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr1_+_170904612 0.01 ENST00000367759.4
ENST00000367758.3
MROH9
maestro heat-like repeat family member 9
chr1_+_53308398 0.01 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr15_+_81225699 0.01 ENST00000560027.1
KIAA1199
KIAA1199
chr4_+_41361616 0.00 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr8_-_67976509 0.00 ENST00000518747.1
COPS5
COP9 signalosome subunit 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0060480 lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.2 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0008267 poly-glutamine tract binding(GO:0008267)