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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZNF740_ZNF219
Z-value: 0.81
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Transcription factors associated with ZNF740_ZNF219
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF740 | hg19_v2_chr12_+_53574464_53574539 | 0.61 | 2.0e-01 | Click! |
| ZNF219 | hg19_v2_chr14_-_21562671_21562702 | -0.55 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_110500826 Show fit | 0.69 |
ENST00000265601.3
ENST00000447287.1 ENST00000444391.1 |
WAS protein family, member 1 |
|
| chr17_-_58469591 Show fit | 0.68 |
ENST00000589335.1
|
ubiquitin specific peptidase 32 |
|
| chr17_-_27277615 Show fit | 0.65 |
ENST00000583747.1
ENST00000584236.1 |
PHD finger protein 12 |
|
| chr14_+_38065052 Show fit | 0.55 |
ENST00000556845.1
|
tetratricopeptide repeat domain 6 |
|
| chr1_+_164528866 Show fit | 0.52 |
ENST00000420696.2
|
pre-B-cell leukemia homeobox 1 |
|
| chr1_+_6845578 Show fit | 0.51 |
ENST00000467404.2
ENST00000439411.2 |
calmodulin binding transcription activator 1 |
|
| chr17_-_58469329 Show fit | 0.48 |
ENST00000393003.3
|
ubiquitin specific peptidase 32 |
|
| chr2_+_149402989 Show fit | 0.46 |
ENST00000397424.2
|
enhancer of polycomb homolog 2 (Drosophila) |
|
| chr19_-_48673465 Show fit | 0.45 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr2_-_55277654 Show fit | 0.44 |
ENST00000337526.6
ENST00000317610.7 ENST00000357732.4 |
reticulon 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF740_ZNF219
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.0 | 1.0 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 1.0 | GO:0043486 | histone exchange(GO:0043486) |
| 0.0 | 0.9 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 0.8 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 0.8 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.0 | 0.7 | GO:0000715 | nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 0.1 | 0.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.0 | 0.6 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.5 | GO:0006850 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 1.0 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 0.9 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 0.8 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.6 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.6 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.5 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 1.0 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 0.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.8 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.8 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.2 | 0.5 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
| 0.1 | 0.5 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.4 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.0 | 0.4 | GO:0003696 | satellite DNA binding(GO:0003696) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.2 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 0.9 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.6 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.6 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |
| 0.0 | 0.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.3 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.2 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |