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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZNF711_TFAP2A_TFAP2D
Z-value: 2.91
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Transcription factors associated with ZNF711_TFAP2A_TFAP2D
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000147180.12 | zinc finger protein 711 | |
| ENSG00000137203.6 | transcription factor AP-2 alpha | |
| ENSG00000008197.4 | transcription factor AP-2 delta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF711 | hg19_v2_chrX_+_84499081_84499115 | 0.89 | 1.9e-02 | Click! |
| TFAP2A | hg19_v2_chr6_-_10415470_10415508 | 0.40 | 4.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_128145498 Show fit | 3.29 |
ENST00000409179.2
|
mitogen-activated protein kinase kinase kinase 2 |
|
| chr1_+_6052700 Show fit | 3.28 |
ENST00000378092.1
ENST00000445501.1 |
potassium voltage-gated channel, shaker-related subfamily, beta member 2 |
|
| chr12_-_104531945 Show fit | 3.24 |
ENST00000551446.1
|
nuclear transcription factor Y, beta |
|
| chr21_+_38338737 Show fit | 3.06 |
ENST00000430068.1
|
AP000704.5 |
|
| chr1_+_35734616 Show fit | 2.90 |
ENST00000441447.1
|
zinc finger, MYM-type 4 |
|
| chr2_-_178129551 Show fit | 2.87 |
ENST00000430047.1
|
nuclear factor, erythroid 2-like 2 |
|
| chrX_-_108868390 Show fit | 2.80 |
ENST00000372101.2
|
KCNE1-like |
|
| chr4_-_56412713 Show fit | 2.74 |
ENST00000435527.2
|
clock circadian regulator |
|
| chr15_+_63414760 Show fit | 2.69 |
ENST00000557972.1
|
lactamase, beta |
|
| chr19_-_48673465 Show fit | 2.64 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF711_TFAP2A_TFAP2D
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.7 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.3 | 8.1 | GO:0051383 | kinetochore organization(GO:0051383) |
| 1.0 | 7.0 | GO:0043387 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 0.2 | 7.0 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) centromere complex assembly(GO:0034508) |
| 0.2 | 6.5 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.5 | 5.8 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.1 | 5.5 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.2 | 5.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.2 | 5.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 5.2 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 10.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 9.3 | GO:0044438 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.0 | 8.3 | GO:0005813 | centrosome(GO:0005813) |
| 0.2 | 8.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 7.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 7.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 7.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 6.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 6.5 | GO:0000139 | Golgi membrane(GO:0000139) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 11.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 9.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.2 | 7.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 7.1 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 6.9 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 6.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 6.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 5.9 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 5.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 10.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 10.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 9.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 8.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 7.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 7.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 5.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 4.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 4.8 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 9.9 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 7.0 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.2 | 6.9 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.1 | 6.6 | REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS | Genes involved in TGF-beta receptor signaling activates SMADs |
| 0.1 | 6.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 6.1 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 5.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 5.5 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 5.2 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |