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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZNF524
Z-value: 1.08
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Transcription factors associated with ZNF524
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF524 | hg19_v2_chr19_+_56111680_56111735 | 0.64 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_54372877 Show fit | 3.89 |
ENST00000414489.1
|
myeloid-associated differentiation marker |
|
| chr19_+_36134528 Show fit | 0.87 |
ENST00000591135.1
|
ets variant 2 |
|
| chr19_+_50015870 Show fit | 0.85 |
ENST00000599701.1
|
Fc fragment of IgG, receptor, transporter, alpha |
|
| chr7_-_155437075 Show fit | 0.83 |
ENST00000401694.1
|
Protein LOC100506302 |
|
| chr14_+_105559784 Show fit | 0.75 |
ENST00000548104.1
|
RP11-44N21.1 |
|
| chr17_+_7253667 Show fit | 0.57 |
ENST00000570504.1
ENST00000574499.1 |
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
|
| chr19_-_54984354 Show fit | 0.53 |
ENST00000301200.2
|
CDC42 effector protein (Rho GTPase binding) 5 |
|
| chr5_-_73936544 Show fit | 0.51 |
ENST00000509127.2
|
ectodermal-neural cortex 1 (with BTB domain) |
|
| chr17_-_79304150 Show fit | 0.49 |
ENST00000574093.1
|
transmembrane protein 105 |
|
| chr19_+_50016411 Show fit | 0.44 |
ENST00000426395.3
ENST00000600273.1 ENST00000599988.1 |
Fc fragment of IgG, receptor, transporter, alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF524
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.0 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.5 | 1.5 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.2 | 1.2 | GO:0009440 | cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440) |
| 0.1 | 0.9 | GO:2000382 | positive regulation of mesoderm development(GO:2000382) |
| 0.1 | 0.9 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.0 | 0.7 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.1 | 0.6 | GO:0006562 | proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) |
| 0.2 | 0.5 | GO:1901076 | positive regulation of engulfment of apoptotic cell(GO:1901076) |
| 0.0 | 0.5 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
| 0.0 | 0.5 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.6 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 0.5 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.1 | 0.5 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 0.5 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.5 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 0.5 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.2 | 0.8 | GO:0016784 | 3-mercaptopyruvate sulfurtransferase activity(GO:0016784) |
| 0.0 | 0.7 | GO:0031005 | filamin binding(GO:0031005) |
| 0.2 | 0.6 | GO:0003842 | 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842) |
| 0.0 | 0.6 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 0.5 | GO:0034188 | apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.1 | 0.5 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.1 | 0.5 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.0 | 0.5 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.5 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.2 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.1 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 0.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.1 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.6 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 0.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.5 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.5 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.5 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |