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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZNF384
Z-value: 2.36
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Transcription factors associated with ZNF384
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF384 | hg19_v2_chr12_-_6798025_6798102 | 0.47 | 3.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF384
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 2.9 | GO:0046520 | sphingoid biosynthetic process(GO:0046520) |
| 0.1 | 2.6 | GO:0010259 | multicellular organism aging(GO:0010259) |
| 0.1 | 2.2 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 2.0 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.2 | 1.9 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 1.9 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.0 | 1.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 1.9 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.2 | 1.7 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.3 | 3.5 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 3.3 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 2.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.5 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 2.3 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 1.8 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 1.8 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.8 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 1.7 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.5 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 2.5 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 2.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 2.2 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 2.1 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 2.0 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 2.0 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 1.8 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 1.8 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 1.7 | GO:0043422 | protein kinase B binding(GO:0043422) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.8 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 1.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.2 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 4.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.2 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 2.0 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 1.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 1.8 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 1.8 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |