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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZKSCAN3

Z-value: 0.40

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_283177610.731.0e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39786962 1.14 ENST00000333625.2
IFNL1
interferon, lambda 1
chr14_-_106069247 0.33 ENST00000479229.1
RP11-731F5.1
RP11-731F5.1
chr2_+_191745560 0.23 ENST00000338435.4
GLS
glutaminase
chr2_-_61244550 0.23 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr12_-_3982548 0.22 ENST00000397096.2
ENST00000447133.3
ENST00000450737.2
PARP11
poly (ADP-ribose) polymerase family, member 11
chr19_+_39759154 0.18 ENST00000331982.5
IFNL2
interferon, lambda 2
chr5_-_95297534 0.17 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr17_-_62499334 0.15 ENST00000579996.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr1_+_93913665 0.14 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
FNBP1L
formin binding protein 1-like
chr1_+_226250379 0.14 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr11_-_111320706 0.14 ENST00000531398.1
POU2AF1
POU class 2 associating factor 1
chr12_-_3982511 0.14 ENST00000427057.2
ENST00000228820.4
PARP11
poly (ADP-ribose) polymerase family, member 11
chr6_+_116850174 0.13 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr12_+_109535373 0.13 ENST00000242576.2
UNG
uracil-DNA glycosylase
chr16_-_832926 0.12 ENST00000293892.3
MSLNL
mesothelin-like
chr4_-_169239921 0.11 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr19_+_52873166 0.10 ENST00000424032.2
ENST00000600321.1
ENST00000344085.5
ENST00000597976.1
ENST00000422689.2
ZNF880
zinc finger protein 880
chr2_+_191221240 0.10 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chr18_-_74728998 0.10 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr5_+_65018017 0.09 ENST00000380985.5
ENST00000502464.1
NLN
neurolysin (metallopeptidase M3 family)
chr15_+_41624892 0.09 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr1_-_115259337 0.08 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr12_+_109535923 0.08 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr3_-_10052849 0.08 ENST00000437616.1
ENST00000429065.2
AC022007.5
AC022007.5
chr6_-_35656712 0.07 ENST00000357266.4
ENST00000542713.1
FKBP5
FK506 binding protein 5
chr2_-_175351744 0.07 ENST00000295500.4
ENST00000392552.2
ENST00000392551.2
GPR155
G protein-coupled receptor 155
chr17_-_60142609 0.07 ENST00000397786.2
MED13
mediator complex subunit 13
chr2_+_191745535 0.07 ENST00000320717.3
GLS
glutaminase
chrX_+_153775869 0.07 ENST00000424839.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_+_93913713 0.06 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr3_-_122512619 0.06 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr5_-_65017921 0.05 ENST00000381007.4
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chrX_-_135338503 0.05 ENST00000370663.5
MAP7D3
MAP7 domain containing 3
chr10_+_21823079 0.04 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr11_-_61062762 0.04 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr8_+_123793633 0.04 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr9_+_127023704 0.04 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr10_+_21823243 0.03 ENST00000307729.7
ENST00000377091.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr19_-_49258606 0.03 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr1_-_19811132 0.02 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr5_+_140079919 0.02 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr3_+_50316458 0.02 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chr5_-_114598548 0.02 ENST00000379615.3
ENST00000419445.1
PGGT1B
protein geranylgeranyltransferase type I, beta subunit
chr14_-_80697396 0.02 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chr16_-_1429010 0.02 ENST00000513783.1
UNKL
unkempt family zinc finger-like
chr1_-_28415075 0.02 ENST00000373863.3
ENST00000436342.2
ENST00000540618.1
ENST00000545175.1
EYA3
eyes absent homolog 3 (Drosophila)
chr2_-_167232484 0.02 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr19_+_32836499 0.02 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr2_-_61244308 0.02 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr1_-_28415204 0.02 ENST00000373871.3
EYA3
eyes absent homolog 3 (Drosophila)
chr1_+_156123318 0.01 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr7_+_155089486 0.01 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr16_-_832054 0.00 ENST00000543963.1
MSLNL
mesothelin-like
chr19_-_42348692 0.00 ENST00000330743.3
ENST00000601246.1
LYPD4
LY6/PLAUR domain containing 4
chrX_-_153775426 0.00 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr7_-_155089251 0.00 ENST00000609974.1
AC144652.1
AC144652.1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.0 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:0060623 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.0 0.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.2 GO:0045008 depyrimidination(GO:0045008)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.1 GO:0001740 Barr body(GO:0001740)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.1 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0 0.1 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)