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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZIC3_ZIC4

Z-value: 0.76

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ZIC3
ENSG00000156925.7 Zic family member 3
ZIC4
ENSG00000174963.13 Zic family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC3hg19_v2_chrX_+_136648643_1366487110.463.6e-01Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_132312931 0.57 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr9_-_86955598 0.50 ENST00000376238.4
SLC28A3
solute carrier family 28 (concentrative nucleoside transporter), member 3
chr9_+_19408919 0.44 ENST00000380376.1
ACER2
alkaline ceramidase 2
chr19_+_45251804 0.41 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr11_-_67272794 0.37 ENST00000436757.2
ENST00000356404.3
PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr20_+_34203794 0.36 ENST00000374273.3
SPAG4
sperm associated antigen 4
chr7_-_994302 0.36 ENST00000265846.5
ADAP1
ArfGAP with dual PH domains 1
chr5_+_76506706 0.34 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
PDE8B
phosphodiesterase 8B
chr11_+_69061594 0.30 ENST00000441339.2
ENST00000308946.3
ENST00000535407.1
MYEOV
myeloma overexpressed
chr2_+_37571717 0.29 ENST00000338415.3
ENST00000404976.1
QPCT
glutaminyl-peptide cyclotransferase
chr19_-_58609570 0.27 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
ZSCAN18
zinc finger and SCAN domain containing 18
chr19_+_13906250 0.27 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr12_-_48152853 0.27 ENST00000171000.4
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr14_+_24630465 0.25 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr16_+_50313426 0.25 ENST00000569265.1
ADCY7
adenylate cyclase 7
chr16_+_2570340 0.24 ENST00000568263.1
ENST00000293971.6
ENST00000302956.4
ENST00000413459.3
ENST00000566706.1
ENST00000569879.1
AMDHD2
amidohydrolase domain containing 2
chr16_-_88717482 0.24 ENST00000261623.3
CYBA
cytochrome b-245, alpha polypeptide
chr6_+_32006159 0.24 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr7_+_65540853 0.24 ENST00000380839.4
ENST00000395332.3
ENST00000362000.5
ENST00000395331.3
ASL
argininosuccinate lyase
chr17_+_45331184 0.23 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr1_-_32801825 0.23 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr1_+_43148059 0.23 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr7_+_150020329 0.22 ENST00000323078.7
LRRC61
leucine rich repeat containing 61
chr1_+_180875711 0.22 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr7_+_79763271 0.21 ENST00000442586.1
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr11_-_60719213 0.21 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr11_+_58938903 0.21 ENST00000532982.1
DTX4
deltex homolog 4 (Drosophila)
chr15_+_73976715 0.20 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276
CD276 molecule
chr21_-_45196326 0.19 ENST00000291568.5
CSTB
cystatin B (stefin B)
chr19_-_1174226 0.19 ENST00000587024.1
ENST00000361757.3
SBNO2
strawberry notch homolog 2 (Drosophila)
chr19_+_17970693 0.19 ENST00000600147.1
ENST00000599898.1
RPL18A
ribosomal protein L18a
chr2_+_37571845 0.18 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr7_+_150758642 0.18 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr10_+_71561630 0.18 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr19_+_49617581 0.18 ENST00000391864.3
LIN7B
lin-7 homolog B (C. elegans)
chr7_+_150758304 0.18 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr9_+_140083099 0.18 ENST00000322310.5
SSNA1
Sjogren syndrome nuclear autoantigen 1
chr9_-_140082983 0.18 ENST00000323927.2
ANAPC2
anaphase promoting complex subunit 2
chr7_+_150020363 0.17 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr11_+_64692143 0.17 ENST00000164133.2
ENST00000532850.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr7_+_65540780 0.17 ENST00000304874.9
ASL
argininosuccinate lyase
chrX_-_102319092 0.17 ENST00000372728.3
BEX1
brain expressed, X-linked 1
chr17_-_4890919 0.16 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2
calmodulin binding transcription activator 2
chr1_+_3370990 0.16 ENST00000378378.4
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr17_+_27894180 0.16 ENST00000583940.1
TP53I13
tumor protein p53 inducible protein 13
chr1_-_45308616 0.16 ENST00000447098.2
ENST00000372192.3
PTCH2
patched 2
chr16_-_74808710 0.16 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr16_+_2059872 0.16 ENST00000567649.1
NPW
neuropeptide W
chr19_-_18717627 0.16 ENST00000392386.3
CRLF1
cytokine receptor-like factor 1
chr16_-_2059797 0.16 ENST00000563630.1
ZNF598
zinc finger protein 598
chr22_+_43506747 0.15 ENST00000216115.2
BIK
BCL2-interacting killer (apoptosis-inducing)
chr19_+_17970677 0.15 ENST00000222247.5
RPL18A
ribosomal protein L18a
chr22_+_29702572 0.15 ENST00000407647.2
ENST00000416823.1
ENST00000428622.1
GAS2L1
growth arrest-specific 2 like 1
chr19_-_40791302 0.15 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr1_-_31381528 0.15 ENST00000339394.6
SDC3
syndecan 3
chr16_-_29466285 0.15 ENST00000330978.3
BOLA2
bolA family member 2
chr11_-_65667997 0.15 ENST00000312562.2
ENST00000534222.1
FOSL1
FOS-like antigen 1
chr11_-_65667884 0.15 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1
FOS-like antigen 1
chr8_-_145060593 0.14 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr9_+_116638562 0.14 ENST00000374126.5
ENST00000288466.7
ZNF618
zinc finger protein 618
chr20_-_62129163 0.14 ENST00000298049.7
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr14_+_71108460 0.14 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9
chr16_-_30205627 0.14 ENST00000305321.4
BOLA2B
bolA family member 2B
chr5_-_176924562 0.14 ENST00000359895.2
ENST00000355572.2
ENST00000355841.2
ENST00000393551.1
ENST00000505074.1
ENST00000356618.4
ENST00000393546.4
PDLIM7
PDZ and LIM domain 7 (enigma)
chr9_-_117880477 0.14 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
TNC
tenascin C
chr18_+_2846972 0.14 ENST00000254528.3
EMILIN2
elastin microfibril interfacer 2
chr22_-_39636914 0.14 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr19_-_48753028 0.14 ENST00000522431.1
CARD8
caspase recruitment domain family, member 8
chr11_+_73675873 0.13 ENST00000537753.1
ENST00000542350.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr3_-_49203744 0.13 ENST00000321895.6
CCDC71
coiled-coil domain containing 71
chr9_+_132565454 0.13 ENST00000427860.1
TOR1B
torsin family 1, member B (torsin B)
chr16_+_89989687 0.13 ENST00000315491.7
ENST00000555576.1
ENST00000554336.1
ENST00000553967.1
TUBB3
Tubulin beta-3 chain
chr1_+_43148625 0.13 ENST00000436427.1
YBX1
Y box binding protein 1
chr7_-_92107229 0.13 ENST00000603053.1
ERVW-1
endogenous retrovirus group W, member 1
chr16_+_2039946 0.13 ENST00000248121.2
ENST00000568896.1
SYNGR3
synaptogyrin 3
chr9_-_139581848 0.13 ENST00000538402.1
ENST00000371694.3
AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase 2
chr3_-_87039662 0.13 ENST00000494229.1
VGLL3
vestigial like 3 (Drosophila)
chr20_+_55967129 0.13 ENST00000371219.2
RBM38
RNA binding motif protein 38
chr17_-_4871085 0.13 ENST00000575142.1
ENST00000206020.3
SPAG7
sperm associated antigen 7
chr3_-_134093395 0.12 ENST00000249883.5
AMOTL2
angiomotin like 2
chr17_+_7531281 0.12 ENST00000575729.1
ENST00000340624.5
SHBG
sex hormone-binding globulin
chr7_+_149571045 0.12 ENST00000479613.1
ENST00000606024.1
ENST00000464662.1
ENST00000425642.2
ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr1_+_156024552 0.12 ENST00000368304.5
ENST00000368302.3
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr9_-_98279241 0.12 ENST00000437951.1
ENST00000375274.2
ENST00000430669.2
ENST00000468211.2
PTCH1
patched 1
chr15_+_75074410 0.12 ENST00000439220.2
CSK
c-src tyrosine kinase
chr19_-_37096139 0.12 ENST00000585983.1
ENST00000585960.1
ENST00000586115.1
ZNF529
zinc finger protein 529
chr9_+_131580734 0.12 ENST00000372642.4
ENDOG
endonuclease G
chr3_-_134093738 0.12 ENST00000506107.1
AMOTL2
angiomotin like 2
chr11_-_64014379 0.12 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr17_-_6616678 0.12 ENST00000381074.4
ENST00000293800.6
ENST00000572352.1
ENST00000576323.1
ENST00000573648.1
SLC13A5
solute carrier family 13 (sodium-dependent citrate transporter), member 5
chr12_-_57400227 0.12 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr17_-_78194147 0.12 ENST00000534910.1
ENST00000326317.6
SGSH
N-sulfoglucosamine sulfohydrolase
chr17_+_78194261 0.12 ENST00000572725.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr11_-_71159458 0.11 ENST00000355527.3
DHCR7
7-dehydrocholesterol reductase
chr11_-_66139570 0.11 ENST00000311161.7
SLC29A2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr1_-_151119087 0.11 ENST00000341697.3
ENST00000368914.3
SEMA6C
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr2_+_219187871 0.11 ENST00000258362.3
PNKD
paroxysmal nonkinesigenic dyskinesia
chr1_+_2407754 0.11 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr16_+_58497587 0.11 ENST00000569404.1
ENST00000569539.1
ENST00000564126.1
ENST00000565304.1
ENST00000567667.1
NDRG4
NDRG family member 4
chr1_+_155293702 0.11 ENST00000368347.4
RUSC1
RUN and SH3 domain containing 1
chr16_+_2570431 0.11 ENST00000563556.1
AMDHD2
amidohydrolase domain containing 2
chr16_+_4364762 0.11 ENST00000262366.3
GLIS2
GLIS family zinc finger 2
chr2_+_85132749 0.11 ENST00000233143.4
TMSB10
thymosin beta 10
chr16_-_30204987 0.11 ENST00000569282.1
ENST00000567436.1
BOLA2B
bolA family member 2B
chr7_-_5570229 0.11 ENST00000331789.5
ACTB
actin, beta
chr22_+_39493207 0.11 ENST00000348946.4
ENST00000442487.3
ENST00000421988.2
APOBEC3H
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
chr1_-_159915386 0.11 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr9_-_139581875 0.11 ENST00000371696.2
AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase 2
chr10_+_71561649 0.11 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr17_-_4890649 0.11 ENST00000361571.5
CAMTA2
calmodulin binding transcription activator 2
chr1_+_28995258 0.11 ENST00000361872.4
ENST00000294409.2
GMEB1
glucocorticoid modulatory element binding protein 1
chr11_-_57004658 0.11 ENST00000606794.1
APLNR
apelin receptor
chr6_-_10419871 0.11 ENST00000319516.4
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_-_49122384 0.10 ENST00000550973.1
ENST00000550645.1
ENST00000549273.1
ENST00000552588.1
RPL18
ribosomal protein L18
chr19_-_2151523 0.10 ENST00000350812.6
ENST00000355272.6
ENST00000356926.4
ENST00000345016.5
AP3D1
adaptor-related protein complex 3, delta 1 subunit
chr5_-_180018540 0.10 ENST00000292641.3
SCGB3A1
secretoglobin, family 3A, member 1
chr11_-_66139617 0.10 ENST00000544554.1
ENST00000546034.1
SLC29A2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr3_+_71803201 0.10 ENST00000304411.2
GPR27
G protein-coupled receptor 27
chr11_-_67276100 0.10 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr2_+_105760549 0.10 ENST00000436841.1
ENST00000452037.1
ENST00000438148.1
AC104655.3
AC104655.3
chr19_+_984313 0.10 ENST00000251289.5
ENST00000587001.2
ENST00000607440.1
WDR18
WD repeat domain 18
chr19_+_10362882 0.10 ENST00000393733.2
ENST00000588502.1
MRPL4
mitochondrial ribosomal protein L4
chr19_+_5823813 0.10 ENST00000303212.2
NRTN
neurturin
chr19_+_10362577 0.10 ENST00000592514.1
ENST00000307422.5
ENST00000253099.6
ENST00000590150.1
ENST00000590669.1
MRPL4
mitochondrial ribosomal protein L4
chr14_+_29236269 0.10 ENST00000313071.4
FOXG1
forkhead box G1
chr5_+_176731572 0.10 ENST00000503853.1
PRELID1
PRELI domain containing 1
chr3_-_129035120 0.10 ENST00000333762.4
H1FX
H1 histone family, member X
chr5_+_145316120 0.10 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr2_-_96811170 0.10 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr20_+_3776936 0.10 ENST00000439880.2
CDC25B
cell division cycle 25B
chr17_-_76124812 0.10 ENST00000592063.1
ENST00000589271.1
ENST00000322933.4
ENST00000589553.1
TMC6
transmembrane channel-like 6
chr11_-_407103 0.10 ENST00000526395.1
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr4_-_140477910 0.10 ENST00000404104.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr7_-_150020578 0.10 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr2_-_242626127 0.09 ENST00000445261.1
DTYMK
deoxythymidylate kinase (thymidylate kinase)
chr17_-_70053866 0.09 ENST00000540802.1
RP11-84E24.2
RP11-84E24.2
chr17_-_1083078 0.09 ENST00000574266.1
ENST00000302538.5
ABR
active BCR-related
chrX_+_105066524 0.09 ENST00000243300.9
ENST00000428173.2
NRK
Nik related kinase
chr1_+_156024525 0.09 ENST00000368305.4
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr12_+_49932886 0.09 ENST00000257981.6
KCNH3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chrX_+_153686614 0.09 ENST00000369682.3
PLXNA3
plexin A3
chr15_+_75074385 0.09 ENST00000220003.9
CSK
c-src tyrosine kinase
chr17_-_78194124 0.09 ENST00000570427.1
ENST00000570923.1
SGSH
N-sulfoglucosamine sulfohydrolase
chr19_+_33685490 0.09 ENST00000253193.7
LRP3
low density lipoprotein receptor-related protein 3
chr22_-_50683381 0.09 ENST00000439308.2
TUBGCP6
tubulin, gamma complex associated protein 6
chr6_+_32006042 0.09 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr9_-_34662651 0.09 ENST00000259631.4
CCL27
chemokine (C-C motif) ligand 27
chr19_-_40791211 0.09 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr22_-_19466643 0.09 ENST00000474226.1
UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr2_+_219264762 0.09 ENST00000452977.1
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr17_+_77030267 0.09 ENST00000581774.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr9_-_123639445 0.09 ENST00000312189.6
PHF19
PHD finger protein 19
chr16_-_402639 0.09 ENST00000262320.3
AXIN1
axin 1
chr15_+_31619013 0.09 ENST00000307145.3
KLF13
Kruppel-like factor 13
chr3_-_9811595 0.09 ENST00000256460.3
CAMK1
calcium/calmodulin-dependent protein kinase I
chr19_-_1863567 0.09 ENST00000250916.4
KLF16
Kruppel-like factor 16
chr17_-_39183452 0.09 ENST00000361883.5
KRTAP1-5
keratin associated protein 1-5
chr14_+_105886275 0.09 ENST00000405646.1
MTA1
metastasis associated 1
chr19_-_50063907 0.08 ENST00000598296.1
NOSIP
nitric oxide synthase interacting protein
chr14_+_105886150 0.08 ENST00000331320.7
ENST00000406191.1
MTA1
metastasis associated 1
chr10_+_6779326 0.08 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chr16_+_777739 0.08 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr12_-_51419924 0.08 ENST00000541174.2
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr11_-_71159380 0.08 ENST00000525346.1
ENST00000531364.1
ENST00000529990.1
ENST00000527316.1
ENST00000407721.2
DHCR7
7-dehydrocholesterol reductase
chr6_-_29595779 0.08 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_+_99775520 0.08 ENST00000317296.5
ENST00000422690.1
ENST00000439782.1
STAG3
stromal antigen 3
chr16_+_56691838 0.08 ENST00000394501.2
MT1F
metallothionein 1F
chr16_+_89753070 0.08 ENST00000353379.7
ENST00000505473.1
ENST00000564192.1
CDK10
cyclin-dependent kinase 10
chr1_+_228194693 0.08 ENST00000284523.1
ENST00000366753.2
WNT3A
wingless-type MMTV integration site family, member 3A
chr19_-_40791160 0.08 ENST00000358335.5
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr7_-_5569588 0.08 ENST00000417101.1
ACTB
actin, beta
chrX_+_51927919 0.08 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr21_+_45725050 0.08 ENST00000403390.1
PFKL
phosphofructokinase, liver
chr19_-_49314169 0.08 ENST00000597011.1
ENST00000601681.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr19_-_49314269 0.08 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr17_-_78194716 0.08 ENST00000576707.1
SGSH
N-sulfoglucosamine sulfohydrolase
chr20_-_62601218 0.08 ENST00000369888.1
ZNF512B
zinc finger protein 512B
chr16_+_29818857 0.08 ENST00000567444.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_+_105050794 0.08 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr13_-_52378231 0.08 ENST00000280056.2
ENST00000444610.2
DHRS12
dehydrogenase/reductase (SDR family) member 12
chr4_-_168155417 0.08 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr16_+_58497567 0.08 ENST00000258187.5
NDRG4
NDRG family member 4
chr17_+_39421591 0.08 ENST00000391355.1
KRTAP9-6
keratin associated protein 9-6
chr1_+_157963391 0.08 ENST00000359209.6
ENST00000416935.2
KIRREL
kin of IRRE like (Drosophila)
chr17_-_79481666 0.08 ENST00000575659.1
ACTG1
actin, gamma 1
chr6_-_29600832 0.08 ENST00000377016.4
ENST00000376977.3
ENST00000377034.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr11_-_96239990 0.07 ENST00000511243.2
JRKL-AS1
JRKL antisense RNA 1
chr20_+_3777078 0.07 ENST00000340833.4
CDC25B
cell division cycle 25B
chr2_+_23608064 0.07 ENST00000486442.1
KLHL29
kelch-like family member 29
chr11_-_64545941 0.07 ENST00000377387.1
SF1
splicing factor 1
chr16_+_30205225 0.07 ENST00000345535.4
ENST00000251303.6
SLX1A
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr10_-_131762105 0.07 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr2_+_103236004 0.07 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr2_+_238768187 0.07 ENST00000254661.4
ENST00000409726.1
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr3_+_100053542 0.07 ENST00000394140.4
NIT2
nitrilase family, member 2
chr1_+_67773527 0.07 ENST00000541374.1
ENST00000544434.1
IL12RB2
interleukin 12 receptor, beta 2
chr1_-_114355083 0.07 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr19_-_31840130 0.07 ENST00000558569.1
TSHZ3
teashirt zinc finger homeobox 3
chr11_-_66139199 0.07 ENST00000357440.2
SLC29A2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr15_-_91565743 0.07 ENST00000535843.1
VPS33B
vacuolar protein sorting 33 homolog B (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.4 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.1 0.5 GO:0015855 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.6 GO:0042756 drinking behavior(GO:0042756)
0.1 0.1 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.1 0.2 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 0.2 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.1 0.4 GO:0071486 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.3 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.0 0.2 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.2 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.1 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.0 0.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.3 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 0.2 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 0.1 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.3 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0048007 synaptic vesicle recycling via endosome(GO:0036466) antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:1900241 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.2 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
0.0 0.1 GO:0048320 forebrain anterior/posterior pattern specification(GO:0021797) axial mesoderm formation(GO:0048320)
0.0 0.1 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.2 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.0 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0003404 optic vesicle morphogenesis(GO:0003404) optic cup structural organization(GO:0003409) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.0 0.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.0 0.3 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.1 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.2 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 0.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.0 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.0 0.3 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.0 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.0 0.1 GO:0002432 granuloma formation(GO:0002432)
0.0 0.1 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.0 0.4 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.0 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.0 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.1 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.0 0.1 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.2 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.2 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:2000855 mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) positive regulation of mineralocorticoid secretion(GO:2000857) regulation of aldosterone secretion(GO:2000858) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:1901536 negative regulation of DNA demethylation(GO:1901536)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.4 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0006528 asparagine metabolic process(GO:0006528)
0.0 0.0 GO:0051795 apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) uterine wall breakdown(GO:0042704) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.0 0.1 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.0 0.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.1 GO:0042374 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.0 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.3 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.2 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0019031 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.0 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.0 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0000923 equatorial microtubule organizing center(GO:0000923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.5 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.1 0.3 GO:0016826 N-sulfoglucosamine sulfohydrolase activity(GO:0016250) hydrolase activity, acting on acid sulfur-nitrogen bonds(GO:0016826)
0.0 0.3 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.3 GO:0005119 smoothened binding(GO:0005119)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.2 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.4 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.2 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:0071633 dihydroceramidase activity(GO:0071633)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.0 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.0 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.0 GO:0070984 SET domain binding(GO:0070984)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.0 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)