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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZEB1
Z-value: 1.09
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31610064_31610159 | -0.30 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_220306238 Show fit | 0.90 |
ENST00000435853.1
|
SPEG complex locus |
|
| chr2_-_241835561 Show fit | 0.83 |
ENST00000388934.4
|
chromosome 2 open reading frame 54 |
|
| chr11_+_64004888 Show fit | 0.60 |
ENST00000541681.1
|
vascular endothelial growth factor B |
|
| chr8_-_11660077 Show fit | 0.56 |
ENST00000533405.1
|
Uncharacterized protein |
|
| chr17_+_63096903 Show fit | 0.55 |
ENST00000582940.1
|
RP11-160O5.1 |
|
| chr16_-_74808710 Show fit | 0.50 |
ENST00000219368.3
ENST00000544337.1 |
fatty acid 2-hydroxylase |
|
| chr6_-_47445214 Show fit | 0.49 |
ENST00000604014.1
|
RP11-385F7.1 |
|
| chr3_+_113667354 Show fit | 0.49 |
ENST00000491556.1
|
zinc finger, DHHC-type containing 23 |
|
| chr19_+_6464243 Show fit | 0.46 |
ENST00000600229.1
ENST00000356762.3 |
crumbs homolog 3 (Drosophila) |
|
| chr20_-_62199427 Show fit | 0.45 |
ENST00000427522.2
|
helicase with zinc finger 2, transcriptional coactivator |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.0 | 1.2 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 0.9 | GO:0038129 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.1 | 0.8 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
| 0.1 | 0.8 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.0 | 0.8 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.0 | 0.8 | GO:0030220 | platelet formation(GO:0030220) |
| 0.0 | 0.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.6 | GO:0007571 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 1.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 1.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.7 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 0.6 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.1 | 0.5 | GO:0097361 | CIA complex(GO:0097361) |
| 0.0 | 0.5 | GO:0044453 | nuclear membrane part(GO:0044453) |
| 0.0 | 0.4 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.4 | GO:0032426 | stereocilium tip(GO:0032426) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 0.9 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 0.8 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 0.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 0.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 0.7 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.1 | 0.7 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.2 | 0.6 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.8 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.7 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.7 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.3 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.9 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.7 | REACTOME SIGNALING BY NOTCH3 | Genes involved in Signaling by NOTCH3 |
| 0.0 | 0.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.5 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.5 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |