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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZBTB33_CHD2
Z-value: 2.23
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD2 | hg19_v2_chr15_+_93426514_93426562 | 0.83 | 3.9e-02 | Click! |
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | 0.72 | 1.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 2.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.2 | 2.3 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 2.3 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 0.0 | 2.2 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.4 | 2.0 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.1 | 2.0 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 1.8 | GO:1901189 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.4 | 1.7 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 0.0 | 1.7 | GO:0006692 | prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.3 | 3.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 2.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 2.0 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 1.9 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.2 | 1.8 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 1.5 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 1.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.4 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 2.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 2.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.3 | 2.0 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.6 | 1.9 | GO:0030626 | U12 snRNA binding(GO:0030626) |
| 0.1 | 1.8 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 1.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.8 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.3 | 1.7 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.2 | 1.4 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.0 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 1.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 2.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 2.2 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 2.0 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 2.0 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 1.8 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.4 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.1 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 1.0 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |