ISMARA results: WRNIP1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for WRNIP1

Z-value: 1.13

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Transcription factors associated with WRNIP1

Gene Symbol	Gene ID	Gene Info
WRNIP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000124535.11	WRN helicase interacting protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
WRNIP1	hg19_v2_chr6_+_2765595_2765797	-0.58	2.3e-01	Click!

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_50990785 Show fit	1.20	ENST00000595005.1	CTD-2545M3.8 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTD-2545M3.8
chr4_-_74904398 Show fit	1.07	ENST00000296026.4	CXCL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-X-C motif) ligand 3
chr2_+_228678550 Show fit	1.03	ENST00000409189.3 ENST00000358813.4	CCL20 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 20
chr10_+_12391685 Show fit	0.90	ENST00000378845.1	CAMK1D Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium/calmodulin-dependent protein kinase ID
chr17_-_42994283 Show fit	0.89	ENST00000593179.1	GFAP Ensembl NCBI GeneCards UniProt NextProt Show fit	glial fibrillary acidic protein
chr1_-_47655686 Show fit	0.88	ENST00000294338.2	PDZK1IP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZK1 interacting protein 1
chr1_-_153363452 Show fit	0.86	ENST00000368732.1 ENST00000368733.3	S100A8 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A8
chr12_-_96793142 Show fit	0.81	ENST00000552262.1 ENST00000551816.1 ENST00000552496.1	CDK17 Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclin-dependent kinase 17
chr7_-_41740181 Show fit	0.78	ENST00000442711.1	INHBA Ensembl NCBI GeneCards UniProt NextProt Show fit	inhibin, beta A
chr19_-_35626104 Show fit	0.77	ENST00000310123.3 ENST00000392225.3	LGI4 Ensembl NCBI GeneCards UniProt NextProt Show fit	leucine-rich repeat LGI family, member 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.2	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	3.1	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1	2.8	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
0.0	2.5	GO:0018149	peptide cross-linking(GO:0018149)
0.0	2.2	GO:0001706	endoderm formation(GO:0001706)
0.1	2.0	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.0	1.8	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.0	1.7	GO:0006735	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2	1.5	GO:0035932	mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) regulation of aldosterone secretion(GO:2000858)
0.1	1.5	GO:0030223	neutrophil differentiation(GO:0030223)

Showing 1 to 10 of 1,182 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.9	GO:0072562	blood microparticle(GO:0072562)
0.0	3.3	GO:0042734	presynaptic membrane(GO:0042734)
0.1	3.0	GO:0030673	axolemma(GO:0030673)
0.0	2.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	2.1	GO:0005581	collagen trimer(GO:0005581)
0.0	2.1	GO:0034774	secretory granule lumen(GO:0034774)
0.0	2.0	GO:0001533	cornified envelope(GO:0001533)
0.1	1.7	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	1.7	GO:0001669	acrosomal vesicle(GO:0001669)
0.0	1.6	GO:0002102	podosome(GO:0002102)

Showing 1 to 10 of 352 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	3.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	2.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	2.1	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1	2.0	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	1.7	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	1.7	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	1.6	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	1.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1	1.5	GO:0005176	ErbB-2 class receptor binding(GO:0005176)

Showing 1 to 10 of 669 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	4.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	3.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	2.9	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	2.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	2.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	2.2	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	2.0	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	1.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 79 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.6	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	3.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	3.2	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	3.0	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0	2.9	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	2.6	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	2.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	2.0	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	1.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions

Showing 1 to 10 of 131 entries

Results for WRNIP1

Z-value: 1.13

Motif logo

Transcription factors associated with WRNIP1

Activity-expression correlation:

Activity profile of WRNIP1 motif

Sorted Z-values of WRNIP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of WRNIP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: