ISMARA results: TLX1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TLX1_NFIC

Z-value: 1.15

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Transcription factors associated with TLX1_NFIC

Gene Symbol	Gene ID	Gene Info
TLX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000107807.8	T cell leukemia homeobox 1
NFIC Ensembl NCBI GeneCards UniProt NextProt	ENSG00000141905.13	nuclear factor I C

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIC	hg19_v2_chr19_+_3366547_3366619	0.69	1.3e-01	Click!
TLX1	hg19_v2_chr10_+_102891048_102891078	0.45	3.7e-01	Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_79086088 Show fit	2.13	ENST00000370751.5 ENST00000342282.3	IFI44L Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon-induced protein 44-like
chr7_+_22766766 Show fit	1.45	ENST00000426291.1 ENST00000401651.1 ENST00000258743.5 ENST00000420258.2 ENST00000407492.1 ENST00000401630.3 ENST00000406575.1	IL6 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 6 (interferon, beta 2)
chrX_-_40005865 Show fit	0.91	ENST00000412952.1	BCOR Ensembl NCBI GeneCards UniProt NextProt Show fit	BCL6 corepressor
chr8_+_61822605 Show fit	0.83	ENST00000526936.1	AC022182.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC022182.1
chr21_+_17792672 Show fit	0.78	ENST00000602620.1	LINC00478 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 478
chr19_-_59010565 Show fit	0.55	ENST00000594786.1	SLC27A5 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 27 (fatty acid transporter), member 5
chr14_-_85996332 Show fit	0.53	ENST00000380722.1	RP11-497E19.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-497E19.1
chr6_-_33663474 Show fit	0.51	ENST00000594414.1	SBP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SBP1; Uncharacterized protein
chr1_-_153363452 Show fit	0.47	ENST00000368732.1 ENST00000368733.3	S100A8 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A8
chr7_+_143078652 Show fit	0.47	ENST00000354434.4 ENST00000449423.2	ZYX Ensembl NCBI GeneCards UniProt NextProt Show fit	zyxin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.4	GO:1990637	response to prolactin(GO:1990637)
0.2	0.9	GO:0000415	negative regulation of histone H3-K36 methylation(GO:0000415)
0.1	0.7	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.1	0.6	GO:1904124	mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.1	0.6	GO:0060481	lung goblet cell differentiation(GO:0060480) lobar bronchus epithelium development(GO:0060481)
0.1	0.6	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.6	GO:0031639	plasminogen activation(GO:0031639)
0.0	0.6	GO:0060445	branching involved in salivary gland morphogenesis(GO:0060445)
0.1	0.5	GO:0043932	ossification involved in bone remodeling(GO:0043932)
0.0	0.5	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)

Showing 1 to 10 of 84 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.8	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.7	GO:0042629	mast cell granule(GO:0042629)
0.1	0.6	GO:0043260	laminin-11 complex(GO:0043260)
0.1	0.6	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.1	0.4	GO:0072563	endothelial microparticle(GO:0072563)
0.1	0.4	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.3	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.3	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.3	GO:0097512	cardiac myofibril(GO:0097512)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.9	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.8	GO:0005044	scavenger receptor activity(GO:0005044)
0.2	0.7	GO:0008859	exoribonuclease II activity(GO:0008859)
0.0	0.7	GO:0019707	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1	0.6	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2	0.5	GO:0005055	laminin receptor activity(GO:0005055)
0.1	0.5	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.5	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.1	0.4	GO:0047888	fatty acid peroxidase activity(GO:0047888)

Showing 1 to 10 of 60 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	ST STAT3 PATHWAY	STAT3 Pathway
0.0	1.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.6	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	0.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.3	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	1.0	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.6	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.6	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors

Showing 1 to 8 of 8 entries

Results for TLX1_NFIC

Z-value: 1.15

Motif logo

Transcription factors associated with TLX1_NFIC

Activity-expression correlation:

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: