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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TFEC_MITF_ARNTL_BHLHE41
Z-value: 1.20
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Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000105967.11 | transcription factor EC | |
| ENSG00000187098.10 | melanocyte inducing transcription factor | |
| ENSG00000133794.13 | aryl hydrocarbon receptor nuclear translocator like | |
| ENSG00000123095.5 | basic helix-loop-helix family member e41 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BHLHE41 | hg19_v2_chr12_-_26278030_26278060 | 0.58 | 2.3e-01 | Click! |
| MITF | hg19_v2_chr3_+_69811858_69811881 | 0.57 | 2.4e-01 | Click! |
| TFEC | hg19_v2_chr7_-_115608304_115608352 | 0.53 | 2.7e-01 | Click! |
| ARNTL | hg19_v2_chr11_+_13299186_13299432 | 0.40 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFEC_MITF_ARNTL_BHLHE41
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.4 | 2.0 | GO:0043321 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.1 | 2.0 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.4 | 1.5 | GO:0022007 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.2 | 1.4 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 1.4 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.3 | 1.3 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
| 0.0 | 1.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.4 | 1.2 | GO:0043181 | vacuolar sequestering(GO:0043181) |
| 0.2 | 1.2 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 2.3 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.3 | 2.0 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.0 | 2.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 1.6 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.3 | 1.5 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.0 | 1.5 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 1.3 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.0 | 1.1 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 1.0 | GO:0033503 | HULC complex(GO:0033503) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 1.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.1 | 1.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 1.4 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.3 | 1.3 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.0 | 1.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 1.3 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 1.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 1.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.4 | 1.2 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.5 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.0 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 1.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.4 | REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.1 | 1.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 1.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 1.1 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 1.0 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.7 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.5 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |