ISMARA results: TFDP1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFDP1

Z-value: 0.93

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Transcription factors associated with TFDP1

Gene Symbol	Gene ID	Gene Info
TFDP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000198176.8	transcription factor Dp-1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TFDP1	hg19_v2_chr13_+_114238997_114239077	0.74	9.2e-02	Click!

Activity profile of TFDP1 motif

Sorted Z-values of TFDP1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_96928516 Show fit	1.06	ENST00000602703.1	RP11-2B6.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-2B6.3
chr1_+_6845578 Show fit	0.77	ENST00000467404.2 ENST00000439411.2	CAMTA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calmodulin binding transcription activator 1
chr1_+_6845497 Show fit	0.46	ENST00000473578.1 ENST00000557126.1	CAMTA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calmodulin binding transcription activator 1
chr2_+_149402009 Show fit	0.44	ENST00000457184.1	EPC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	enhancer of polycomb homolog 2 (Drosophila)
chr19_-_48673465 Show fit	0.40	ENST00000598938.1	LIG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ligase I, DNA, ATP-dependent
chr10_+_104678102 Show fit	0.33	ENST00000433628.2	CNNM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclin M2
chr11_+_85956182 Show fit	0.33	ENST00000327320.4 ENST00000351625.6 ENST00000534595.1	EED Ensembl NCBI GeneCards UniProt NextProt Show fit	embryonic ectoderm development
chr17_+_64961026 Show fit	0.31	ENST00000262138.3	CACNG4 Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium channel, voltage-dependent, gamma subunit 4
chr17_+_42634844 Show fit	0.30	ENST00000315323.3	FZD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	frizzled family receptor 2
chr17_+_17942684 Show fit	0.30	ENST00000376345.3	GID4 Ensembl NCBI GeneCards UniProt NextProt Show fit	GID complex subunit 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TFDP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.9	GO:0050885	neuromuscular process controlling balance(GO:0050885)
0.1	0.7	GO:0070601	centromeric sister chromatid cohesion(GO:0070601)
0.0	0.5	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.1	0.4	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)
0.0	0.4	GO:0060022	hard palate development(GO:0060022)
0.0	0.4	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.4	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.0	0.4	GO:0051256	mitotic spindle midzone assembly(GO:0051256)
0.0	0.4	GO:0016075	rRNA catabolic process(GO:0016075)

Showing 1 to 10 of 221 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0031415	NatA complex(GO:0031415)
0.0	0.4	GO:0001739	sex chromatin(GO:0001739)
0.0	0.4	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.4	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.4	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.4	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.4	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.4	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.4	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.1	0.3	GO:0034676	integrin alpha6-beta4 complex(GO:0034676)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0019003	GDP binding(GO:0019003)
0.0	0.7	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.7	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.5	GO:0031386	protein tag(GO:0031386)
0.1	0.4	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.4	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.4	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.3	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.3	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.3	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)

Showing 1 to 10 of 114 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.9	PID NECTIN PATHWAY	Nectin adhesion pathway
0.6	PID ALK2 PATHWAY	ALK2 signaling events
0.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.3	PID CDC42 PATHWAY	CDC42 signaling events
0.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	PID ALK1 PATHWAY	ALK1 signaling events
0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	ST P38 MAPK PATHWAY	p38 MAPK Pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.7	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.5	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.5	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.5	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.4	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.4	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.4	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.3	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins

Showing 1 to 10 of 24 entries

Results for TFDP1

Z-value: 0.93

Motif logo

Transcription factors associated with TFDP1

Activity-expression correlation:

Activity profile of TFDP1 motif

Sorted Z-values of TFDP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFDP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: