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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TFCP2
Z-value: 1.46
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Transcription factors associated with TFCP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFCP2 | hg19_v2_chr12_-_51566592_51566695 | -0.42 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_61765315 Show fit | 1.14 |
ENST00000406957.1
ENST00000401558.2 |
exportin 1 (CRM1 homolog, yeast) |
|
| chr4_+_26859300 Show fit | 0.93 |
ENST00000494628.2
|
stromal interaction molecule 2 |
|
| chr2_-_61765732 Show fit | 0.87 |
ENST00000443240.1
ENST00000436018.1 |
exportin 1 (CRM1 homolog, yeast) |
|
| chr4_-_129207942 Show fit | 0.82 |
ENST00000503588.1
|
progesterone receptor membrane component 2 |
|
| chr14_-_71107921 Show fit | 0.80 |
ENST00000553982.1
ENST00000500016.1 |
CTD-2540L5.5 CTD-2540L5.6 |
|
| chrX_-_119693745 Show fit | 0.79 |
ENST00000371323.2
|
cullin 4B |
|
| chr10_+_6625605 Show fit | 0.77 |
ENST00000414894.1
ENST00000449648.1 |
PRKCQ antisense RNA 1 |
|
| chr1_+_206623784 Show fit | 0.73 |
ENST00000426388.1
|
SLIT-ROBO Rho GTPase activating protein 2 |
|
| chr8_+_95731904 Show fit | 0.63 |
ENST00000522422.1
|
dpy-19-like 4 (C. elegans) |
|
| chr1_-_145382434 Show fit | 0.62 |
ENST00000610154.1
|
RP11-458D21.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFCP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 1.6 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.1 | 1.1 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.1 | 1.0 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.1 | 0.9 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 0.9 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.0 | 0.9 | GO:0006312 | mitotic recombination(GO:0006312) |
| 0.1 | 0.8 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.0 | 0.8 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.2 | 0.7 | GO:0021816 | lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 1.5 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 0.8 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 0.8 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.7 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 0.5 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 0.5 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.0 | 0.5 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.4 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.0 | 0.4 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 1.2 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.0 | 1.0 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 0.9 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 0.9 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.8 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 0.7 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.5 | GO:0050816 | phosphothreonine binding(GO:0050816) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 2.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.2 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.7 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.7 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.4 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 2.0 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 0.9 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.0 | 0.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.6 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 0.5 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |