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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TCF3_MYOG
Z-value: 1.07
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Transcription factors associated with TCF3_MYOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF3 | hg19_v2_chr19_-_1650666_1650744 | -0.38 | 4.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_39258461 Show fit | 3.26 |
ENST00000440582.1
|
keratin associated protein 4-16, pseudogene |
|
| chr2_+_114163945 Show fit | 0.68 |
ENST00000453673.3
|
immunoglobulin kappa variable 1/OR2-108 (non-functional) |
|
| chrX_-_107018969 Show fit | 0.56 |
ENST00000372383.4
|
TSC22 domain family, member 3 |
|
| chr15_+_90735145 Show fit | 0.53 |
ENST00000559792.1
|
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B |
|
| chr2_-_17981462 Show fit | 0.53 |
ENST00000402989.1
ENST00000428868.1 |
structural maintenance of chromosomes 6 |
|
| chr3_+_69788576 Show fit | 0.51 |
ENST00000352241.4
ENST00000448226.2 |
microphthalmia-associated transcription factor |
|
| chr3_-_165555200 Show fit | 0.50 |
ENST00000479451.1
ENST00000540653.1 ENST00000488954.1 ENST00000264381.3 |
butyrylcholinesterase |
|
| chr4_+_108815402 Show fit | 0.50 |
ENST00000503385.1
|
sphingomyelin synthase 2 |
|
| chr1_-_119869846 Show fit | 0.46 |
ENST00000457719.1
|
RP11-418J17.3 |
|
| chr1_-_219615984 Show fit | 0.45 |
ENST00000420762.1
|
RP11-95P13.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF3_MYOG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.0 | 0.9 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 0.0 | 0.9 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.9 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.1 | 0.8 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.2 | 0.6 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.0 | 0.6 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.0 | 0.6 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.1 | 0.5 | GO:0009820 | alkaloid metabolic process(GO:0009820) |
| 0.1 | 0.5 | GO:0034165 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.7 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 0.5 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.0 | 0.5 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 0.4 | GO:0070695 | FHF complex(GO:0070695) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.8 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 0.7 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 0.6 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.2 | 0.6 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.0 | 0.6 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.6 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.6 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 0.5 | GO:0033265 | acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265) |
| 0.1 | 0.5 | GO:0047493 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 1.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.8 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.7 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 0.7 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.5 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.5 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.5 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.5 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.4 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |