ISMARA results: TCF12

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TCF12_ASCL2

Z-value: 1.51

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Transcription factors associated with TCF12_ASCL2

Gene Symbol	Gene ID	Gene Info
TCF12 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000140262.13	transcription factor 12
ASCL2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000183734.4	achaete-scute family bHLH transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF12	hg19_v2_chr15_+_57210961_57211030	-0.43	3.9e-01	Click!
ASCL2	hg19_v2_chr11_-_2292182_2292212	-0.12	8.2e-01	Click!

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_-_21905120 Show fit	1.81	ENST00000331505.5	RIMBP3C Ensembl NCBI GeneCards UniProt NextProt Show fit	RIMS binding protein 3C
chr17_-_73761222 Show fit	1.77	ENST00000437911.1 ENST00000225614.2	GALK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	galactokinase 1
chr16_-_31076332 Show fit	1.20	ENST00000539836.3 ENST00000535577.1 ENST00000442862.2	ZNF668 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 668
chr1_+_27668505 Show fit	1.17	ENST00000318074.5	SYTL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin-like 1
chr15_+_89182156 Show fit	1.03	ENST00000379224.5	ISG20 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon stimulated exonuclease gene 20kDa
chr16_-_4039001 Show fit	1.02	ENST00000576936.1	ADCY9 Ensembl NCBI GeneCards UniProt NextProt Show fit	adenylate cyclase 9
chr17_+_80193644 Show fit	0.97	ENST00000582946.1	SLC16A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 16 (monocarboxylate transporter), member 3
chr9_+_140445651 Show fit	0.94	ENST00000371443.5	MRPL41 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitochondrial ribosomal protein L41
chr15_+_31658349 Show fit	0.93	ENST00000558844.1	KLF13 Ensembl NCBI GeneCards UniProt NextProt Show fit	Kruppel-like factor 13
chr17_+_39421591 Show fit	0.91	ENST00000391355.1	KRTAP9-6 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin associated protein 9-6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.1	GO:1901545	cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.4	2.1	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.1	2.0	GO:0031581	hemidesmosome assembly(GO:0031581)
0.6	1.8	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	1.7	GO:1902476	chloride transmembrane transport(GO:1902476)
0.4	1.6	GO:0098968	neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.0	1.4	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	1.3	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	1.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	1.1	GO:0031069	hair follicle morphogenesis(GO:0031069)

Showing 1 to 10 of 424 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	GO:0035580	specific granule lumen(GO:0035580)
0.0	2.0	GO:0034707	chloride channel complex(GO:0034707)
0.1	1.7	GO:0030056	hemidesmosome(GO:0030056)
0.0	1.7	GO:0015030	Cajal body(GO:0015030)
0.0	1.6	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.2	1.5	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.0	1.5	GO:0045095	keratin filament(GO:0045095)
0.0	1.2	GO:0031528	microvillus membrane(GO:0031528)
0.1	1.0	GO:0061689	tricellular tight junction(GO:0061689)
0.2	0.9	GO:0043260	laminin-11 complex(GO:0043260)

Showing 1 to 10 of 120 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	2.3	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.7	2.1	GO:0008859	exoribonuclease II activity(GO:0008859)
0.1	2.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.4	1.8	GO:0004335	galactokinase activity(GO:0004335)
0.0	1.7	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	1.6	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	1.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	1.1	GO:0070001	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0	1.1	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)

Showing 1 to 10 of 237 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	1.6	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	1.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.1	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.9	PID INSULIN PATHWAY	Insulin Pathway
0.0	0.9	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	0.8	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.5	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	0.5	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.4	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 10 of 24 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	2.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	1.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	1.7	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	1.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.1	1.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	1.0	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	1.0	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.1	0.9	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels

Showing 1 to 10 of 51 entries

Results for TCF12_ASCL2

Z-value: 1.51

Motif logo

Transcription factors associated with TCF12_ASCL2

Activity-expression correlation:

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: