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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TBX4
Z-value: 1.01
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Transcription factors associated with TBX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX4 | hg19_v2_chr17_+_59529743_59529798 | 0.15 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_75746664 Show fit | 0.62 |
ENST00000557139.1
|
FBJ murine osteosarcoma viral oncogene homolog |
|
| chr7_+_107220899 Show fit | 0.61 |
ENST00000379117.2
ENST00000473124.1 |
B-cell receptor-associated protein 29 |
|
| chr9_+_40028620 Show fit | 0.55 |
ENST00000426179.1
|
AL353791.1 |
|
| chr11_+_73358594 Show fit | 0.44 |
ENST00000227214.6
ENST00000398494.4 ENST00000543085.1 |
pleckstrin homology domain containing, family B (evectins) member 1 |
|
| chr1_+_154378049 Show fit | 0.43 |
ENST00000512471.1
|
interleukin 6 receptor |
|
| chr10_-_16563870 Show fit | 0.42 |
ENST00000298943.3
|
complement component 1, q subcomponent-like 3 |
|
| chr2_-_85895295 Show fit | 0.40 |
ENST00000428225.1
ENST00000519937.2 |
surfactant protein B |
|
| chr9_-_75567962 Show fit | 0.39 |
ENST00000297785.3
ENST00000376939.1 |
aldehyde dehydrogenase 1 family, member A1 |
|
| chr11_+_86511569 Show fit | 0.39 |
ENST00000441050.1
|
protease, serine, 23 |
|
| chr1_+_154377669 Show fit | 0.38 |
ENST00000368485.3
ENST00000344086.4 |
interleukin 6 receptor |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.2 | 0.8 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 0.8 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.1 | 0.6 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.0 | 0.6 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.1 | 0.4 | GO:0061624 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.1 | 0.3 | GO:0010615 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) positive regulation of connective tissue replacement(GO:1905205) |
| 0.1 | 0.3 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.0 | 0.3 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 0.0 | 0.3 | GO:0001712 | ectodermal cell fate commitment(GO:0001712) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.6 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 0.4 | GO:0097486 | multivesicular body lumen(GO:0097486) |
| 0.1 | 0.3 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 0.0 | 0.3 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.2 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.3 | 0.8 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.0 | 0.7 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 0.4 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.0 | 0.4 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.0 | 0.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 0.3 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.0 | 0.3 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 0.0 | 0.3 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.4 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |