ISMARA results: TBX3

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TBX3

Z-value: 0.77

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Transcription factors associated with TBX3

Gene Symbol	Gene ID	Gene Info
TBX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000135111.10	T-box transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX3	hg19_v2_chr12_-_115121962_115121987	-0.54	2.7e-01	Click!

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_22766766 Show fit	1.51	ENST00000426291.1 ENST00000401651.1 ENST00000258743.5 ENST00000420258.2 ENST00000407492.1 ENST00000401630.3 ENST00000406575.1	IL6 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 6 (interferon, beta 2)
chr6_+_32821924 Show fit	0.65	ENST00000374859.2 ENST00000453265.2	PSMB9 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 9
chr11_-_18258342 Show fit	0.54	ENST00000278222.4	SAA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum amyloid A4, constitutive
chr14_-_51863853 Show fit	0.52	ENST00000556762.1	RP11-255G12.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-255G12.3
chr1_-_153085984 Show fit	0.48	ENST00000468739.1	SPRR2F Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2F
chr2_-_113594279 Show fit	0.31	ENST00000416750.1 ENST00000418817.1 ENST00000263341.2	IL1B Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1, beta
chr1_-_183560011 Show fit	0.31	ENST00000367536.1	NCF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	neutrophil cytosolic factor 2
chr19_-_43835582 Show fit	0.30	ENST00000595748.1	CTC-490G23.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTC-490G23.2
chr11_-_327537 Show fit	0.27	ENST00000602735.1	IFITM3 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon induced transmembrane protein 3
chr20_+_34679725 Show fit	0.27	ENST00000432589.1	EPB41L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	erythrocyte membrane protein band 4.1-like 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.5	GO:0002384	hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.0	0.5	GO:0048102	autophagic cell death(GO:0048102)
0.0	0.5	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.3	GO:0031622	regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.0	0.3	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.1	0.2	GO:0032824	negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.1	0.2	GO:0098939	dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.1	0.2	GO:0048250	mitochondrial iron ion transport(GO:0048250)
0.0	0.2	GO:0046086	adenosine biosynthetic process(GO:0046086)
0.0	0.2	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)

Showing 1 to 10 of 38 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.5	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	0.7	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	0.5	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	0.5	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.3	GO:0032010	phagolysosome(GO:0032010)
0.0	0.2	GO:0031515	tRNA (m1A) methyltransferase complex(GO:0031515)
0.0	0.2	GO:0032044	DSIF complex(GO:0032044)
0.0	0.2	GO:0042825	TAP complex(GO:0042825)
0.0	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:0097635	extrinsic component of autophagosome membrane(GO:0097635)

Showing 1 to 10 of 14 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.5	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.7	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.5	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.5	GO:0042056	chemoattractant activity(GO:0042056)
0.1	0.3	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.3	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.3	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.1	0.2	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.2	GO:0004419	hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0	0.2	GO:0070259	tyrosyl-DNA phosphodiesterase activity(GO:0070259)

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators

Showing 1 to 3 of 3 entries

Results for TBX3

Z-value: 0.77

Motif logo

Transcription factors associated with TBX3

Activity-expression correlation:

Activity profile of TBX3 motif

Sorted Z-values of TBX3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: