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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TBX21_TBR1
Z-value: 0.70
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Transcription factors associated with TBX21_TBR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBR1 | hg19_v2_chr2_+_162272605_162272753 | 0.01 | 9.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_142315294 Show fit | 0.71 |
ENST00000464320.1
|
plastin 1 |
|
| chr1_-_153029980 Show fit | 0.59 |
ENST00000392653.2
|
small proline-rich protein 2A |
|
| chr7_+_107220660 Show fit | 0.50 |
ENST00000465919.1
ENST00000445771.2 ENST00000479917.1 ENST00000421217.1 ENST00000457837.1 |
B-cell receptor-associated protein 29 |
|
| chr1_-_153066998 Show fit | 0.46 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr1_-_156786634 Show fit | 0.39 |
ENST00000392306.2
ENST00000368199.3 |
SH2 domain containing 2A |
|
| chr2_+_228678550 Show fit | 0.36 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr15_-_80263506 Show fit | 0.36 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr7_-_127032741 Show fit | 0.35 |
ENST00000393313.1
ENST00000265827.3 ENST00000434602.1 |
zinc finger protein 800 |
|
| chr11_+_93754513 Show fit | 0.32 |
ENST00000315765.9
|
hephaestin-like 1 |
|
| chr1_+_35734616 Show fit | 0.32 |
ENST00000441447.1
|
zinc finger, MYM-type 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX21_TBR1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 1.0 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.0 | 0.5 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.1 | 0.4 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 0.4 | GO:0045226 | extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) |
| 0.1 | 0.4 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
| 0.1 | 0.4 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.0 | 0.4 | GO:0014805 | smooth muscle adaptation(GO:0014805) |
| 0.0 | 0.4 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 0.4 | GO:0033630 | positive regulation of cell adhesion mediated by integrin(GO:0033630) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 1.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.4 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.0 | 0.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.3 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.2 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.0 | 0.2 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.1 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.0 | 0.1 | GO:0035101 | FACT complex(GO:0035101) |
| 0.0 | 0.1 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 0.4 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 0.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 0.4 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.0 | 0.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.4 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 0.3 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.0 | 0.3 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.3 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.1 | 0.2 | GO:0031433 | telethonin binding(GO:0031433) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.5 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.2 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |