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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TBX19
Z-value: 0.99
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Transcription factors associated with TBX19
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX19 | hg19_v2_chr1_+_168250194_168250278 | -0.58 | 2.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_46531127 Show fit | 1.64 |
ENST00000601033.1
|
CTC-344H19.4 |
|
| chr7_+_134671234 Show fit | 0.74 |
ENST00000436302.2
ENST00000359383.3 ENST00000458078.1 ENST00000435976.2 ENST00000455283.2 |
ATP/GTP binding protein-like 3 |
|
| chr3_+_177534653 Show fit | 0.68 |
ENST00000436078.1
|
RP11-91K9.1 |
|
| chr2_-_113594279 Show fit | 0.67 |
ENST00000416750.1
ENST00000418817.1 ENST00000263341.2 |
interleukin 1, beta |
|
| chr6_-_133035185 Show fit | 0.64 |
ENST00000367928.4
|
vanin 1 |
|
| chr1_-_153283194 Show fit | 0.60 |
ENST00000290722.1
|
peptidoglycan recognition protein 3 |
|
| chr6_-_30684898 Show fit | 0.57 |
ENST00000422266.1
ENST00000416571.1 |
mediator of DNA-damage checkpoint 1 |
|
| chr6_-_2842087 Show fit | 0.57 |
ENST00000537185.1
|
serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
|
| chr19_+_46732988 Show fit | 0.57 |
ENST00000437936.1
|
IGF-like family member 1 |
|
| chr17_+_6659354 Show fit | 0.55 |
ENST00000574907.1
|
XIAP associated factor 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX19
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0032827 | negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714) |
| 0.1 | 0.7 | GO:0031622 | regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622) |
| 0.1 | 0.7 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.0 | 0.7 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.1 | 0.6 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.0 | 0.6 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.0 | 0.6 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.0 | 0.5 | GO:0046606 | negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606) |
| 0.1 | 0.4 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.0 | 0.4 | GO:0030728 | ovulation(GO:0030728) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 0.2 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.0 | 0.2 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 0.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 0.2 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.2 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 0.1 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.0 | 0.1 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.1 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 0.1 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 0.8 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.0 | 0.7 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.6 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 0.6 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.4 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.3 | GO:0003943 | N-acetylgalactosamine-4-sulfatase activity(GO:0003943) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.4 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.2 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.1 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |