Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for TBP
Z-value: 2.42
Motif logo
Transcription factors associated with TBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBP | hg19_v2_chr6_+_170863421_170863484 | -0.80 | 5.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153013588 Show fit | 5.40 |
ENST00000360379.3
|
small proline-rich protein 2D |
|
| chr1_-_153044083 Show fit | 4.27 |
ENST00000341611.2
|
small proline-rich protein 2B |
|
| chr11_-_18270182 Show fit | 4.09 |
ENST00000528349.1
ENST00000526900.1 ENST00000529528.1 ENST00000414546.2 ENST00000256733.4 |
serum amyloid A2 |
|
| chr11_+_18287721 Show fit | 3.90 |
ENST00000356524.4
|
serum amyloid A1 |
|
| chr11_+_18287801 Show fit | 3.89 |
ENST00000532858.1
ENST00000405158.2 |
serum amyloid A1 |
|
| chr19_+_10381769 Show fit | 3.60 |
ENST00000423829.2
ENST00000588645.1 |
intercellular adhesion molecule 1 |
|
| chr4_-_74904398 Show fit | 3.04 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr4_+_74606223 Show fit | 2.79 |
ENST00000307407.3
ENST00000401931.1 |
interleukin 8 |
|
| chr1_-_153363452 Show fit | 2.69 |
ENST00000368732.1
ENST00000368733.3 |
S100 calcium binding protein A8 |
|
| chr1_+_153330322 Show fit | 2.63 |
ENST00000368738.3
|
S100 calcium binding protein A9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.2 | 7.8 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.2 | 6.4 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.2 | 4.5 | GO:0002544 | chronic inflammatory response(GO:0002544) |
| 0.1 | 3.7 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.6 | 3.6 | GO:0097368 | membrane to membrane docking(GO:0022614) establishment of Sertoli cell barrier(GO:0097368) |
| 0.0 | 3.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.9 | 2.7 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.8 | 2.5 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.1 | 2.5 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.3 | 11.8 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 4.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 4.2 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 4.2 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 4.1 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 4.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 3.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 2.8 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.3 | 2.3 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.5 | 6.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.8 | 5.3 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 5.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 3.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 3.4 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 2.8 | GO:0002020 | protease binding(GO:0002020) |
| 0.4 | 2.5 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.1 | 2.3 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 6.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 3.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 2.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 1.4 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.9 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.2 | 8.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 7.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 4.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 3.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 2.1 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.2 | 2.0 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |