ISMARA results: TAF1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TAF1

Z-value: 2.49

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Transcription factors associated with TAF1

Gene Symbol	Gene ID	Gene Info
TAF1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000147133.11	TATA-box binding protein associated factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TAF1	hg19_v2_chrX_+_70586082_70586114	0.88	1.9e-02	Click!

Activity profile of TAF1 motif

Sorted Z-values of TAF1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_58603482 Show fit	2.74	ENST00000585368.1	APPBP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr4_-_76439483 Show fit	2.30	ENST00000380840.2 ENST00000513257.1 ENST00000507014.1	RCHY1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
chr19_-_56110859 Show fit	1.90	ENST00000221665.3 ENST00000592585.1	FIZ1 Ensembl NCBI GeneCards UniProt NextProt Show fit	FLT3-interacting zinc finger 1
chr20_+_52824367 Show fit	1.89	ENST00000371419.2	PFDN4 Ensembl NCBI GeneCards UniProt NextProt Show fit	prefoldin subunit 4
chr4_-_76439596 Show fit	1.82	ENST00000451788.1 ENST00000512706.1	RCHY1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
chr9_+_96928516 Show fit	1.78	ENST00000602703.1	RP11-2B6.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-2B6.3
chr20_+_56884752 Show fit	1.62	ENST00000244040.3	RAB22A Ensembl NCBI GeneCards UniProt NextProt Show fit	RAB22A, member RAS oncogene family
chr8_+_125486939 Show fit	1.53	ENST00000303545.3	RNF139 Ensembl NCBI GeneCards UniProt NextProt Show fit	ring finger protein 139
chr14_+_103800513 Show fit	1.50	ENST00000560338.1 ENST00000560763.1 ENST00000558316.1 ENST00000558265.1	EIF5 Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation initiation factor 5
chr8_+_42911552 Show fit	1.26	ENST00000525699.1 ENST00000529687.1	FNTA Ensembl NCBI GeneCards UniProt NextProt Show fit	farnesyltransferase, CAAX box, alpha

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TAF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.5	GO:0070987	error-free translesion synthesis(GO:0070987)
0.1	4.2	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	3.2	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.2	3.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.2	2.6	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.2	2.5	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	2.3	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.5	2.2	GO:0060392	negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2	2.2	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.1	2.2	GO:0006999	nuclear pore organization(GO:0006999)

Showing 1 to 10 of 415 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	4.1	GO:0005811	lipid particle(GO:0005811)
0.2	3.5	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	3.5	GO:0005875	microtubule associated complex(GO:0005875)
0.0	3.0	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.1	2.7	GO:0097227	sperm annulus(GO:0097227)
0.1	2.6	GO:0030992	intraciliary transport particle B(GO:0030992)
0.3	2.5	GO:0016272	prefoldin complex(GO:0016272)
0.0	2.4	GO:0005801	cis-Golgi network(GO:0005801)
0.0	2.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)

Showing 1 to 10 of 199 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	GO:0019003	GDP binding(GO:0019003)
0.0	4.0	GO:0003777	microtubule motor activity(GO:0003777)
0.0	2.9	GO:0035064	methylated histone binding(GO:0035064)
0.1	2.7	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.1	2.6	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.5	2.5	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	2.5	GO:0003684	damaged DNA binding(GO:0003684)
0.0	2.4	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0	2.4	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	2.4	GO:0002039	p53 binding(GO:0002039)

Showing 1 to 10 of 250 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	4.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	4.3	PID AURORA B PATHWAY	Aurora B signaling
0.0	3.7	PID PLK1 PATHWAY	PLK1 signaling events
0.0	2.5	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	2.2	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	2.1	PID BARD1 PATHWAY	BARD1 signaling events
0.0	1.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	1.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	1.6	PID RAC1 PATHWAY	RAC1 signaling pathway

Showing 1 to 10 of 36 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.9	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.0	4.8	REACTOME CHROMOSOME MAINTENANCE	Genes involved in Chromosome Maintenance
0.0	3.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	2.5	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.1	2.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	2.5	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.1	2.4	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	2.3	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	1.8	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.8	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras

Showing 1 to 10 of 70 entries

Results for TAF1

Z-value: 2.49

Motif logo

Transcription factors associated with TAF1

Activity-expression correlation:

Activity profile of TAF1 motif

Sorted Z-values of TAF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TAF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: