ISMARA results: STAT5A

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for STAT5A

Z-value: 0.86

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Transcription factors associated with STAT5A

Gene Symbol	Gene ID	Gene Info
STAT5A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000126561.12	signal transducer and activator of transcription 5A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT5A	hg19_v2_chr17_+_40440481_40440561	-0.15	7.7e-01	Click!

Activity profile of STAT5A motif

Sorted Z-values of STAT5A motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_133656995 Show fit	0.64	ENST00000356456.5	ZNF140 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 140
chr20_+_58571419 Show fit	0.59	ENST00000244049.3 ENST00000350849.6 ENST00000456106.1	CDH26 Ensembl NCBI GeneCards UniProt NextProt Show fit	cadherin 26
chr13_+_20268547 Show fit	0.51	ENST00000601204.1	AL354808.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	AL354808.2
chr8_-_123139423 Show fit	0.43	ENST00000523792.1	RP11-398G24.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-398G24.2
chr3_-_165555200 Show fit	0.41	ENST00000479451.1 ENST00000540653.1 ENST00000488954.1 ENST00000264381.3	BCHE Ensembl NCBI GeneCards UniProt NextProt Show fit	butyrylcholinesterase
chr3_-_4927447 Show fit	0.38	ENST00000449914.1	AC018816.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr16_+_70207686 Show fit	0.38	ENST00000541793.2 ENST00000314151.8 ENST00000565806.1 ENST00000569347.2 ENST00000536907.2	CLEC18C Ensembl NCBI GeneCards UniProt NextProt Show fit	C-type lectin domain family 18, member C
chr10_+_6625605 Show fit	0.38	ENST00000414894.1 ENST00000449648.1	PRKCQ-AS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	PRKCQ antisense RNA 1
chr2_+_181988620 Show fit	0.38	ENST00000428474.1 ENST00000424655.1	AC104820.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC104820.2
chr11_-_111320706 Show fit	0.38	ENST00000531398.1	POU2AF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	POU class 2 associating factor 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1	0.4	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.1	0.4	GO:0009820	alkaloid metabolic process(GO:0009820)
0.1	0.4	GO:1902998	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0	0.4	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.1	0.3	GO:0006433	prolyl-tRNA aminoacylation(GO:0006433)
0.1	0.3	GO:0019521	aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.1	0.3	GO:2000501	regulation of natural killer cell chemotaxis(GO:2000501)
0.1	0.3	GO:0061552	vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) sensory neuron axon guidance(GO:0097374) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1	0.3	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)

Showing 1 to 10 of 147 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.6	GO:0005818	astral microtubule(GO:0000235) aster(GO:0005818)
0.0	0.6	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.6	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	0.4	GO:0097224	sperm connecting piece(GO:0097224)
0.1	0.4	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.4	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.4	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.4	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.3	GO:0097443	sorting endosome(GO:0097443)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.5	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.5	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.5	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.1	0.4	GO:0033265	acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.1	0.4	GO:0047273	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0	0.4	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.4	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.4	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1	0.3	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)

Showing 1 to 10 of 92 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.6	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.6	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.5	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.4	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.4	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions

Showing 1 to 10 of 20 entries

Results for STAT5A

Z-value: 0.86

Motif logo

Transcription factors associated with STAT5A

Activity-expression correlation:

Activity profile of STAT5A motif

Sorted Z-values of STAT5A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: