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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for STAT4
Z-value: 0.78
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Transcription factors associated with STAT4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT4 | hg19_v2_chr2_-_192015697_192015743 | -0.87 | 2.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_44331555 Show fit | 0.50 |
ENST00000590950.1
|
zinc finger protein 283 |
|
| chr19_+_56905024 Show fit | 0.41 |
ENST00000591172.1
ENST00000589888.1 ENST00000587979.1 ENST00000585659.1 ENST00000593109.1 |
ZNF582 antisense RNA 1 (head to head) |
|
| chr3_-_50649192 Show fit | 0.36 |
ENST00000443053.2
ENST00000348721.3 |
cytokine inducible SH2-containing protein |
|
| chr5_+_137203541 Show fit | 0.36 |
ENST00000421631.2
|
myotilin |
|
| chr5_+_127039075 Show fit | 0.34 |
ENST00000514853.2
|
CTC-228N24.1 |
|
| chr22_-_31536480 Show fit | 0.34 |
ENST00000215885.3
|
phospholipase A2, group III |
|
| chr6_+_139349903 Show fit | 0.34 |
ENST00000461027.1
|
ABRA C-terminal like |
|
| chr8_+_86999516 Show fit | 0.32 |
ENST00000521564.1
|
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 |
|
| chr17_+_1666108 Show fit | 0.30 |
ENST00000570731.1
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
|
| chr2_-_214017151 Show fit | 0.29 |
ENST00000452786.1
|
IKAROS family zinc finger 2 (Helios) |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0061566 | dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571) |
| 0.1 | 0.4 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.0 | 0.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.3 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
| 0.1 | 0.3 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 0.3 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.0 | 0.3 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.0 | 0.3 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 0.2 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.1 | 0.2 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.3 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.3 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 0.2 | GO:0032783 | ELL-EAF complex(GO:0032783) |
| 0.0 | 0.2 | GO:0002081 | outer acrosomal membrane(GO:0002081) |
| 0.0 | 0.2 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 0.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.2 | GO:0032059 | muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059) |
| 0.0 | 0.1 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 0.4 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.0 | 0.4 | GO:0050145 | nucleoside phosphate kinase activity(GO:0050145) |
| 0.0 | 0.4 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.4 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 0.3 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.3 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.2 | GO:0004823 | leucine-tRNA ligase activity(GO:0004823) |
| 0.1 | 0.2 | GO:1990404 | protein ADP-ribosylase activity(GO:1990404) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.3 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |