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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SRF
Z-value: 0.68
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg19_v2_chr6_+_43139037_43139094 | 0.70 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_11907829 Show fit | 0.61 |
ENST00000376480.3
|
natriuretic peptide A |
|
| chr9_+_92219919 Show fit | 0.47 |
ENST00000252506.6
ENST00000375769.1 |
growth arrest and DNA-damage-inducible, gamma |
|
| chr5_+_137801160 Show fit | 0.44 |
ENST00000239938.4
|
early growth response 1 |
|
| chr22_+_36784632 Show fit | 0.35 |
ENST00000424761.1
|
RP4-633O19__A.1 |
|
| chr20_+_35169885 Show fit | 0.32 |
ENST00000279022.2
ENST00000346786.2 |
myosin, light chain 9, regulatory |
|
| chr4_-_87028478 Show fit | 0.30 |
ENST00000515400.1
ENST00000395157.3 |
mitogen-activated protein kinase 10 |
|
| chr7_-_94285402 Show fit | 0.28 |
ENST00000428696.2
ENST00000445866.2 |
sarcoglycan, epsilon |
|
| chr1_+_167599330 Show fit | 0.28 |
ENST00000367854.3
ENST00000361496.3 |
RCSD domain containing 1 |
|
| chr3_-_123339418 Show fit | 0.28 |
ENST00000583087.1
|
myosin light chain kinase |
|
| chr19_-_47975106 Show fit | 0.26 |
ENST00000539381.1
ENST00000594353.1 ENST00000542837.1 |
solute carrier family 8 (sodium/calcium exchanger), member 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:1902304 | positive regulation of potassium ion export(GO:1902304) |
| 0.0 | 0.6 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.1 | 0.5 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.0 | 0.5 | GO:0071474 | cellular hyperosmotic response(GO:0071474) |
| 0.1 | 0.4 | GO:0050720 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) |
| 0.0 | 0.3 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.0 | 0.3 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 0.0 | 0.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.3 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.2 | GO:0035284 | rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 0.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.1 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.0 | 0.1 | GO:0031523 | Myb complex(GO:0031523) |
| 0.0 | 0.1 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.1 | GO:0044294 | dendritic growth cone(GO:0044294) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.5 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 0.4 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.0 | 0.3 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 0.3 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.1 | GO:0005119 | smoothened binding(GO:0005119) |
| 0.0 | 0.1 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.0 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.6 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.2 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |